| 1 | MYCN, SKP2
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| SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.
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| Evans L, Chen L, Milazzo G, Gherardi S, Perini G, Willmore E, Newell DR, Tweddle DA.
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| Cancer Lett ancer Lett. 2015 Apr 2. pii: S0304-3835(15)00246-3. doi: 10.1016/j.canlet.2015.03.044. [Epub ahead of print]
2015
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| 2 | MYCN
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| Multiple mechanisms of MYCN dysregulation in Wilms tumour.
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| Williams RD, Chagtai T, Alcaide-German M, Apps J, Wegert J, Popov S, Vujanic G, van Tinteren H, van den Heuvel-Eibrink MM, Kool M, de Kraker J, Gisselsson D, Graf N, Gessler M, Pritchard-Jones K.
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| Oncotarget ncotarget. 2015 Jan 31. [Epub ahead of print]
2015
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| 3 | MYCN, OTX2
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| Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea.
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| Vendrell V, López-Hernández I, Durán Alonso MB, Feijoo-Redondo A, Abello G, Gálvez H, Giráldez F, Lamonerie T, Schimmang T.
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| Development 142(16):2792-800. doi: 10.1242/dev.122465. Epub 2015 Jul 9.
2015
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| 4 | KDM4B, MYCN
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| The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.
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| Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM.
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| J Natl Cancer Inst. Apr 29;107(6):djv080. doi: 10.1093/jnci/djv080. Print 2015 Jun 2015
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| 5 | MYCN, SULF2
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| MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival.
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| Solari V, Borriello L, Turcatel G, Shimada H, Sposto R, Fernandez GE, Asgharzadeh S, Yates EA, Turnbull JE, DeClerck YA.
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| Cancer Res 74(21):5999-6009. doi: 10.1158/0008-5472.CAN-13-2513. Epub 2014 Aug 27.
2014
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| 6 | MYCN, TRIM32
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| Trim32 facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells.
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| Izumi H, Kaneko Y.
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| Cancer Res 74(19):5620-30. doi: 10.1158/0008-5472.CAN-14-0169. Epub 2014 Aug 6.
2014
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| 7 | KDM5B, MYCN
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| Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein.
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| Zhang L, Sokolowski N, Atmadibrata B, Liu T.
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| Oncol Rep 31(4):1935-9. doi: 10.3892/or.2014.3006. Epub 2014 Jan 30.
2014
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| 8 | MYCN
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| MYCN is a novel oncogenic target in pediatric T-cell acute lymphoblastic leukemia.
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| Astolfi A, Vendemini F, Urbini M, Melchionda F, Masetti R, Franzoni M, Libri V, Serravalle S, Togni M, Paone G, Montemurro L, Bressanin D, Chiarini F, Martelli AM, Tonelli R, Pession A.
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| Oncotarget 5(1):120-30.
2014
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| 9 | BIRC5, MYCN
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| MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts.
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| Hipp NI, Christner L, Wirth T, Mueller-Klieser W, Walenta S, Schröck E, Debatin KM, Beltinger C.
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| Carcinogenesis 35(2):479-88. doi: 10.1093/carcin/bgt341. Epub 2013 Oct 15.
2014
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| 10 | ALK, MYCN
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| MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells.
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| Schulte JH, Lindner S, Bohrer A, Maurer J, De Preter K, Lefever S, Heukamp L, Schulte S, Molenaar J, Versteeg R, Thor T, Künkele A, Vandesompele J, Speleman F, Schorle H, Eggert A, Schramm A.
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| Oncogene 32(8):1059-65. doi: 10.1038/onc.2012.106. Epub 2012 Apr 9.
2013
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| 11 | MYC, MYCN, SIRT2
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| The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
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| Liu PY, Xu N, Malyukova A, Scarlett CJ, Sun YT, Zhang XD, Ling D, Su SP, Nelson C, Chang DK, Koach J, Tee AE, Haber M, Norris MD, Toon C, Rooman I, Xue C, Cheung BB, Kumar S, Marshall GM, Biankin AV, Liu T.
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| Cell Death Differ 20(3):503-14. doi: 10.1038/cdd.2012.147. Epub 2012 Nov 23.
2013
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| 12 | MYCN, PIGV, UPF3B
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| Human intellectual disability genes form conserved functional modules in Drosophila.
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| Oortveld MA, Keerthikumar S, Oti M, Nijhof B, Fernandes AC, Kochinke K, Castells-Nobau A, van Engelen E, Ellenkamp T, Eshuis L, Galy A, van Bokhoven H, Habermann B, Brunner HG, Zweier C, Verstreken P, Huynen MA, Schenck A.
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| PLoS Genet 9(10):e1003911. doi: 10.1371/journal.pgen.1003911. Epub 2013 Oct 31.
2013
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| 13 | GSTP1, MYCN
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| N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.
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| Fletcher JI, Gherardi S, Murray J, Burkhart CA, Russell A, Valli E, Smith J, Oberthuer A, Ashton LJ, London WB, Marshall GM, Norris MD, Perini G, Haber M.
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| Cancer Res 72(4):845-53. Epub 2011 Dec 27.
2012
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| 14 | LIN28B, MIRLET7A1, MYCN
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| LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
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| Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH.
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| Nat Genet 44(11):1199-206. doi: 10.1038/ng.2436. Epub 2012 Oct 7.
2012
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| 15 | CDKL5, MYCN
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| CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.
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| Valli E, Trazzi S, Fuchs C, Erriquez D, Bartesaghi R, Perini G, Ciani E.
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| Biochim Biophys Acta 1819(11-12):1173-85. doi: 10.1016/j.bbagrm.2012.08.001. Epub 2012 Aug 19.
2012
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| 16 | MYCN
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| Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.
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| Valentijn LJ, Koster J, Haneveld F, Aissa RA, van Sluis P, Broekmans ME, Molenaar JJ, van Nes J, Versteeg R.
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| Proc Natl Acad Sci U S A 109(47):19190-5. doi: 10.1073/pnas.1208215109. Epub 2012 Oct 22.
2012
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| 17 | ALK, MYCN
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| Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.
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| Schönherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B.
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| Oncogene 31(50):5193-200. doi: 10.1038/onc.2012.12. Epub 2012 Jan 30.
2012
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| 18 | MYCN, NGFR, NTRK1
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| A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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| Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G.
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| Cancer Res 71(2):404-12. Epub 2010 Dec 1.
2011
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| 19 | FRA2C, MYCN
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| The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.
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| Blumrich A, Zapatka M, Brueckner LM, Zheglo D, Schwab M, Savelyeva L.
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| Hum Mol Genet 20(8):1488-501. Epub 2011 Jan 21.
2011
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| 20 | MYCN
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| N-myc controls proliferation, morphogenesis, and patterning of the inner ear.
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| Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T.
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| J Neurosci 31(19):7178-89.
2011
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| 21 | BMI1, CADM1, KIF1B, MYCN
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| Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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| Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T.
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| Oncogene 29(18):2681-90. Epub 2010 Mar 1.PMID: 20190806 2010
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| 22 | MYCN
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| Pleiotropic role for MYCN in medulloblastoma.
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| Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L.
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| Genes Dev 24(10):1059-72.PMID: 20478998 2010
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| 23 | FBXW7, MYCN
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| Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.
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| Williams RD, Al-Saadi R, Chagtai T, Popov S, Messahel B, Sebire N, Gessler M, Wegert J, Graf N, Leuschner I, Hubank M, Jones C, Vujanic G, Pritchard-Jones K; Children's Cancer and Leukaemia Group; SIOP Wilms' Tumour Biology Group.
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| Clin Cancer Res 16(7):2036-45. Epub 2010 Mar 23.PMID: 20332316 2010
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| 24 | MYCN
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| MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors.
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| Mestdagh P, Fredlund E, Pattyn F, Schulte JH, Muth D, Vermeulen J, Kumps C, Schlierf S, De Preter K, Van Roy N, Noguera R, Laureys G, Schramm A, Eggert A, Westermann F, Speleman F, Vandesompele J.
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| Oncogene 29(9):1394-404. Epub 2009 Nov 30.PMID: 19946337 2010
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| 25 | MYCN, TP53
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| p53 is a direct transcriptional target of MYCN in neuroblastoma.
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| Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA.
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| Cancer Res 70(4):1377-88. Epub 2010 Feb 9.
2010
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| 26 | ESR1, MYCN
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| MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma.
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| Lovén J, Zinin N, Wahlström T, Müller I, Brodin P, Fredlund E, Ribacke U, Pivarcsi A, Pĺhlman S, Henriksson M.
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| Proc Natl Acad Sci U S A 107(4):1553-8. Epub 2010 Jan 4.
2010
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| 27 | BIRC7, MYCN
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| Expression and functional role of inhibitor-of-apoptosis protein livin (BIRC7) in neuroblastoma.
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| Dasgupta A, Alvarado CS, Xu Z, Findley HW.
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| Biochem Biophys Res Commun 400(1):53-9. Epub 2010 Aug 5.
2010
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| 28 | MYCN
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| Positive auto-regulation of MYCN in human neuroblastoma.
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| Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A.
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| Biochem Biophys Res Commun 390(1):21-6. Epub 2009 Sep 18.
2009
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| 29 | MYCN
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| Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation.
|
| Murphy DM, Buckley PG, Bryan K, Das S, Alcock L, Foley NH, Prenter S, Bray I, Watters KM, Higgins D, Stallings RL.
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| PLoS One 4(12):e8154.
2009
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| 30 | DLL3, HUWE1, MYCN, NOTCH1
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| The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
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| Zhao X, D' Arca D, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, Lasorella A.
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| Dev Cell 17(2):210-21.
2009
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| 31 | ALK, MYCN, NBL2
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| Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization.
|
| Stock C, Bozsaky E, Watzinger F, Poetschger U, Orel L, Lion T, Kowalska A, Ambros PF.
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| Am J Pathol 172(1):203-14. Epub 2007 Dec 28. Erratum in: Am J Pathol. 2008 Apr;172(4):1153.
2008
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| 32 | MYCN, ODED1
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| Feingold syndrome associated with two novel MYCN mutations in sporadic and familial cases including monozygotic twins.
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| Blaumeiser B, Oehl-Jaschkowitz B, Borozdin W, Kohlhase J.
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| Am J Med Genet A 146A(17):2304-7. No abstract available. 2008
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| 33 | MYCN, ODED1
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| Genotype-phenotype correlations in MYCN-related Feingold syndrome.
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| Marcelis CL, Hol FA, Graham GE, Rieu PN, Kellermayer R, Meijer RP, Lugtenberg D, Scheffer H, van Bokhoven H, Brunner HG, de Brouwer AP.
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| Hum Mutat 29(9):1125-32. 2008
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| 34 | MYCN
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| The MYCN oncogene is a direct target of miR-34a.
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| Wei JS, Song YK, Durinck S, Chen QR, Cheuk AT, Tsang P, Zhang Q, Thiele CJ, Slack A, Shohet J, Khan J.
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| Oncogene 27(39):5204-13. Epub 2008 May 26.PMID: 18504438 2008
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| 35 | DKK3, MYCN
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| Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN.
|
| Koppen A, Ait-Aissa R, Koster J, Řra I, Bras J, van Sluis PG, Caron H, Versteeg R, Valentijn LJ.
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| Int J Cancer 122(7):1455-64.PMID: 18059033 2008
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| 36 | DDX1, MYCN
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| Concomitant DDX1 and MYCN gain in neuroblastoma.
|
| Defferrari R, Tonini GP, Conte M, Papio F, Sementa AR, Valent A, Schena F, Perri P, Mazzocco K.
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| Cancer Lett 256(1):56-63. Epub 2007 Jul 3. 2007
|
| 37 | CHARGE, CHD7, DEL22Q11, FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCJ, MYCN, ODED1, SALL1, TBS, TBX1, VACTERLH
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| Oesophageal atresia, tracheo-oesophageal fistula, and the VACTERL association: review of genetics and epidemiology.
|
| Shaw-Smith C.
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| J Med Genet 43(7):545-54. Epub 2005 Nov 18. Review. 2006
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| 38 | MDM2, MYCN, NBL
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| The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
|
| Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM.
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| Proc Natl Acad Sci U S A 102(3):731-6. Epub 2005 Jan 11. 2005
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| 39 | MYCN, ODED1
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| MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome.
|
| van Bokhoven H, Celli J, van Reeuwijk J, Rinne T, Glaudemans B, van Beusekom E, Rieu P, Newbury-Ecob RA, Chiang C, Brunner HG.
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| Nat Genet 37(5):465-7. Epub 2005 Apr 10. 2005
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| 40 | DNM2, MYCN, CNM2
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| Mutations in dynamin 2 cause dominant centronuclear myopathy.
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| Bitoun M, Maugenre S, Jeannet PY, Lacene E, Ferrer X, Laforet P, Martin JJ, Laporte J, Lochmuller H, Beggs AH, Fardeau M, Eymard B, Romero NB, Guicheney P.
|
| Nat Genet 37(11):1207-9. Epub 2005 Oct 16. 2005
|
| 41 | NBL, MYCN
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| MYCN-status in neuroblastoma: characteristics of tumours showing amplification, gain, and non-amplification.
|
| Spitz R, Hero B, Skowron M, Ernestus K, Berthold F.
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| Eur J Cancer 40(18):2753-9. 2004
|
| 42 | TPX2, MYCN, NBL
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| Repp86 expression and outcome in patients with neuroblastoma.
|
| Krams M, Heidebrecht HJ, Hero B, Berthold F, Harms D, Parwaresch R, Rudolph P.
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| J Clin Oncol 21(9):1810-8. 2003
|
| 43 | MYCN, SDC1
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| The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p.
|
| Kaukonen J, et al.
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| Hum Genet 99 : 295-297. 1997
|
| 44 | DDX1, MYCN
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| Relational mapping of MYCN and DDXI in band 2p24 and analysis of amplicon arrays in double minute chromosomes and homogeneously staining regions by use of free chromatin FISH.
|
| Pandita A, Godbout R, Zielenska M, Thorner P, Bayani J, Squire JA.
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| Genes Chromosomes Cancer 20(3):243-52. 1997
|
| 45 | DDX1, MYCN, NBL
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| Amplification of a DEAD box gene (DDXI) with the MYCN gene in neuroblastomas as a result of cosegregation of sequences flanking the MYCN locus.
|
| Noguchi T, et al.
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| Genes Chromosomes Cancer 15 : 129-133. 1996
|
| 46 | DDX1, MYCN, NBL
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| The DDXI gene maps within 400 kbp 5' to MYCN and is frequently coamplified in human neuroblastoma.
|
| Amler LC, et al.
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| Genes Chromosomes Cancer 15 : 134-137. 1996
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| 47 | MYCN, NBL
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| High-resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas.
|
| Reiter JL, et al.
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| Genomics 32 : 97-103. 1996
|
| 48 | DDX1, MYCN
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| Physical mapping of the DDX1 gene to 340 kb 5' of MYCN.
|
| Kuroba H, et al.
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| Oncogene 13 : 1561-1565. 1996
|
| 49 | MYCN
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| Loss of the N-myc oncogene in a patient with a small interstitial deletion of the short arm of chromosome 2.
|
| Saal HM, et al.
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| Am J Med Genet 66 : 373-377. 1996
|
| 50 | DDX1, MYCN, NBL
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| Co-amplification of MYCN and a DEAD box gene (DDX1) in primary neuroblastoma.
|
| Squire JA, et al.
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| Oncogene 10 : 1417-1422. 1995
|
| 51 | MYCN
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| High resolution mapping of the MYCN proto-oncogene at human chromosome 2p24.3 by fluorescence in situ hybridisation.
|
| Shibasaki Y.
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| Cytogenet Cell Genet 66 : 75-76. 1994
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| 52 | MYCN
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| Preferential amplification of the paternal allele of the N-myc gene inhuman neuroblastomas.
|
| Cheng JM, et al.
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| Nat Genet 4 : 191-194. 1993
|
| 53 | MYCN
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| Tetranucleotide repeat polymorphism at the human N-MYC gene (MYCN).
|
| Fougerousse F, et al.
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| Nucleic Acids Res 20 : 1165. 1992
|
| 54 | MYCN
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| Amplification of the N-myc oncogene in an adenocarcinoma cell line of the lung.
|
| Kashii T, et al.
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| Anticancer Res 12 : 621-624. 1992
|
| 55 | MYCN, NBL
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| High-resolution in situ hybridization technique using biotinylated NMYC oncogene probe reveals periodic structure of HSRs in human neuroblastoma.
|
| Garson JA, et al.
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| Cytogenet Cell Genet 45 : 10-15. 1987
|
| 56 | MYCN
|
| Human proto-oncogene N-myc encodes nuclear proteins that bind DNA.
|
| Ramsay G, et al.
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| Mol Cell Biol 6 : 4450-4457. 1986
|
| 57 | D2S11, D2S9, MYCN, NBL
|
| Differential amplification, assembly, and relocation of multiple DNAsequences in human neuroblastomas and neuroblastoma cell lines.
|
| Shiloh Y, et al.
|
| Proc Natl Acad Sci U S A 82 : 3761-3765. 1985
|
| 58 | MYCN, NBL
|
| Chromosome localization in normal human cells and neuroblastomas of agene related to c-myc.
|
| Schwab M, et al.
|
| Nature 308 : 288-291. 1984
|
| 59 | MYCN, NBL
|
| Isolation of amplified DNA sequences from IMR-32 human neuroblastomacells: Facilitation by fluorescence-activated flow sorting of metaphasechromosomes.
|
| Kanda N, et al.
|
| Proc Natl Acad Sci U S A 80 : 4069-4073. 1983
|
| 60 | MYCN, NBL
|
| Transposition and amplification of oncogene-related sequences in humanneuroblastomas.
|
| Kohl NE, et al.
|
| Cell 35 : 359-367. 1983
|