| 1 | ERCC4, MUS81
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| Regulation of Structure-Specific Endonucleases in Replication Stress.
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| Kim SM, Forsburg SL.
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| Genes (Basel) 9(12). pii: E634. doi: 10.3390/genes9120634. Review.
2018
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| 2 | DCLRE1C, ERCC1, ERCC4, MUS81
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| DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF.
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| Bétous R, Goullet de Rugy T, Pelegrini AL, Queille S, de Villartay JP, Hoffmann JS.
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| PLoS Genet 14(7):e1007541. doi: 10.1371/journal.pgen.1007541. eCollection 2018 Jul.
2018
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| 3 | EME1, MUS81, SLX4
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| Phosphorylation by CK2 regulates MUS81/EME1 in mitosis and after replication stress.
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| Palma A, Pugliese GM, Murfuni I, Marabitti V, Malacaria E, Rinalducci S, Minoprio A, Sanchez M, Mazzei F, Zolla L, Franchitto A, Pichierri P.
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| Nucleic Acids Res 46(10):5109-5124. doi: 10.1093/nar/gky280.
2018
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| 4 | EME1, MUS81, RAD51, RECQL5
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| RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
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| Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, Janscak P.
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| Mol Cell 66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006.
2017
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| 5 | EZH2, MUS81
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| EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
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| Rondinelli B, Gogola E, Yücel H, Duarte AA, van de Ven M, van der Sluijs R, Konstantinopoulos PA, Jonkers J, Ceccaldi R, Rottenberg S, D'Andrea AD.
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| Nat Cell Biol 19(11):1371-1378. doi: 10.1038/ncb3626. Epub 2017 Oct 16.
2017
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| 6 | BRCA2, MUS81
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| MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.
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| Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.
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| Nat Commun 8:15983. doi: 10.1038/ncomms15983. Erratum in: Nat Commun. 2017 Oct 26;8:16171.
2017
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| 7 | MUS81
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| Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability.
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| Hu L, Yang F, Lu L, Dai W.
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| Cell Cycle 16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
2017
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| 8 | EME1, MUS81, POLD3
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| RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.
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| Bhowmick R, Minocherhomji S, Hickson ID.
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| Mol Cell 64(6):1117-1126. doi: 10.1016/j.molcel.2016.10.037.
2016
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| 9 | ATRX, MUS81
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| Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
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| Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R.
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| Oncogene 35(37):4836-45. doi: 10.1038/onc.2016.16. Epub 2016 Feb 15.
2016
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| 10 | MUS81, SLX4
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| A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis.
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| Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J.
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| Dev Cell 39(6):740-755. doi: 10.1016/j.devcel.2016.11.017. Erratum in: Dev Cell. 2017 Feb 27;40(4):421-422.
2016
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| 11 | EME2, MUS81
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| Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage.
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| Técher H, Koundrioukoff S, Carignon S, Wilhelm T, Millot GA, Lopez BS, Brison O, Debatisse M.
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| Cell Rep 14(5):1114-1127. doi: 10.1016/j.celrep.2015.12.093. Epub 2016 Jan 21.
2016
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| 12 | MUS81
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| The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.
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| Fu H, Martin MM, Regairaz M, Huang L, You Y, Lin CM, Ryan M, Kim R, Shimura T, Pommier Y, Aladjem MI.
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| Nat Commun 6:6746. doi: 10.1038/ncomms7746.
2015
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| 13 | MUS81, SLX4
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| Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.
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| Nair N, Castor D, Macartney T, Rouse J.
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| DNA Repair (Amst) 24:131-137. doi: 10.1016/j.dnarep.2014.08.004. Epub 2014 Sep 16.
2014
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| 14 | EME1, EME2, MUS81
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| MUS81-EME2 promotes replication fork restart.
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| Pepe A, West SC.
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| Cell Rep 7(4):1048-55. doi: 10.1016/j.celrep.2014.04.007. Epub 2014 May 9.
2014
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| 15 | EME1, EME2, MUS81
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| Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.
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| Amangyeld T, Shin YK, Lee M, Kwon B, Seo YS.
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| Nucleic Acids Res 42(9):5846-62. doi: 10.1093/nar/gku237. Epub 2014 Apr 1.
2014
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| 16 | EME1, EME2, MUS81
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| Substrate specificity of the MUS81-EME2 structure selective endonuclease.
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| Pepe A, West SC.
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| Nucleic Acids Res 42(6):3833-45. doi: 10.1093/nar/gkt1333. Epub 2013 Dec 25.
2014
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| 17 | MUS81, RAD52
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| Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.
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| Murfuni I, Basile G, Subramanyam S, Malacaria E, Bignami M, Spies M, Franchitto A, Pichierri P.
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| PLoS Genet 9(10):e1003910. doi: 10.1371/journal.pgen.1003910. Epub 2013 Oct 31.
2013
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| 18 | EME1, MUS81, SLX1A, SLX1B, SLX4
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| Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.
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| Wyatt HD, Sarbajna S, Matos J, West SC.
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| Mol Cell 52(2):234-47. doi: 10.1016/j.molcel.2013.08.035. Epub 2013 Sep 26. 2013
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| 19 | EME1, MUS81, SLX1A, SLX1B, SLX4
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| Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.
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| Castor D, Nair N, Déclais AC, Lachaud C, Toth R, Macartney TJ, Lilley DM, Arthur JS, Rouse J.
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| Mol Cell 52(2):221-33. doi: 10.1016/j.molcel.2013.08.036. Epub 2013 Sep 26. 2013
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| 20 | GEN1, MUS81, SLX1A, SLX4
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| Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions.
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| Garner E, Kim Y, Lach FP, Kottemann MC, Smogorzewska A.
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| Cell Rep 5(1):207-15. doi: 10.1016/j.celrep.2013.08.041. Epub 2013 Sep 27. 2013
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| 21 | MUS81, WRN
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| The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.
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| Murfuni I, Nicolai S, Baldari S, Crescenzi M, Bignami M, Franchitto A, Pichierri P.
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| Oncogene 32(5):610-20. doi: 10.1038/onc.2012.80. Epub 2012 Mar 12.
2013
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| 22 | FBXO18, MUS81
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| FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
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| Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K, Hickson ID, Sørensen CS.
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| Nat Commun 4:1423. doi: 10.1038/ncomms2395.
2013
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| 23 | EME1, EME2, MUS81
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| A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.
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| Fadden AJ, Schalbetter S, Bowles M, Harris R, Lally J, Carr AM, McDonald NQ.
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| Nucleic Acids Res 41(21):9741-52. doi: 10.1093/nar/gkt760. Epub 2013 Aug 27.
2013
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| 24 | EME1, MUS81
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| Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.
|
| Gallo-Fernández M, Saugar I, Ortiz-Bazán MA, Vázquez MV, Tercero JA.
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| Nucleic Acids Res ucleic Acids Res. 2012 Jun 22. [Epub ahead of print]
2012
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| 25 | EME1, EME2, FEN1, MUS81
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| Human MUS81 complexes stimulate flap endonuclease 1.
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| Shin YK, Amangyeld T, Nguyen TA, Munashingha PR, Seo YS.
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| FEBS J 279(13):2412-30. doi: 10.1111/j.1742-4658.2012.08620.x. Epub 2012 Jun 8.
2012
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| 26 | DCLRE1B, GINS2, MUS81
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| Snm1B interacts with PSF2.
|
| Stringer JR, Counter CM.
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| PLoS One 7(11):e49626. doi: 10.1371/journal.pone.0049626. Epub 2012 Nov 26.
2012
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| 27 | MUS81, WEE1
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| Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.
|
| Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R.
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| J Cell Biol 194(4):567-79.
2011
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| 28 | MUS81
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| Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.
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| Regairaz M, Zhang YW, Fu H, Agama KK, Tata N, Agrawal S, Aladjem MI, Pommier Y.
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| J Cell Biol 195(5):739-49.
2011
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| 29 | CHEK2, MUS81
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| Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
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| El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.
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| PLoS Genet 7(5):e1001385. Epub 2011 May 19.
2011
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| 30 | MUS81
|
| Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.
|
| Wu F, Shirahata A, Sakuraba K, Kitamura Y, Goto T, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K.
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| Cancer Sci 102(2):472-7. doi: 10.1111/j.1349-7006.2010.01790.x. Epub 2010 Dec 22.
2011
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| 31 | MUS81
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| Down-regulation of Mus81 as a potential marker for the malignancy of gastric cancer.
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| Wu F, Shirahata A, Sakuraba K, Kitamura Y, Goto T, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K.
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| Anticancer Res 30(12):5011-4.
2010
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| 32 | MUS81
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| Telomere recombination requires the MUS81 endonuclease.
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| Zeng S, Xiang T, Pandita TK, Gonzalez-Suarez I, Gonzalo S, Harris CC, Yang Q.
|
| Nat Cell Biol 11(5):616-23. Epub 2009 Apr 12.
2009
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| 33 | MUS81, SLX1A, SLX4
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| Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
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| Fekairi S, Scaglione S, Chahwan C, Taylor ER, Tissier A, Coulon S, Dong MQ, Ruse C, Yates JR 3rd, Russell P, Fuchs RP, McGowan CH, Gaillard PH.
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| Cell 138(1):78-89. 2009
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| 34 | MUS81, EME1
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| Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures.
|
| Taylor ER, McGowan CH.
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| Proc Natl Acad Sci U S A 105(10):3757-62. Epub 2008 Feb 29. 2008
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| 35 | EME1, MUS81, UHRF1
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| Interplay between Np95 and Eme1 in the DNA damage response.
|
| Mistry H, Gibson L, Yun JW, Sarras H, Tamblyn L, McPherson JP.
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| Biochem Biophys Res Commun 375(3):321-5. Epub 2008 Aug 8. 2008
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| 36 | MUS81, WRN
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| The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.
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| Muftuoglu M, Oshima J, von Kobbe C, Cheng WH, Leistritz DF, Bohr VA.
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| Hum Genet 124(4):369-77. Epub 2008 Sep 23. Review. 2008
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| 37 | MUS81, WRN
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| Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.
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| Franchitto A, Pirzio LM, Prosperi E, Sapora O, Bignami M, Pichierri P.
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| J Cell Biol 183(2):241-52. Epub 2008 Oct 13.
2008
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| 38 | ATRX, EME1, MUS81
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| Human Rad54 protein stimulates human Mus81-Eme1 endonuclease.
|
| Mazina OM, Mazin AV.
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| Proc Natl Acad Sci U S A 105(47):18249-54. Epub 2008 Nov 18.
2008
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| 39 | EME1, EME2, ERCC1, ERCC4, FAAP24, FANCM, MUS81
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| Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
|
| Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei AR, Laghmani el H, Joenje H, McDonald N, de Winter JP, Wang W, West SC.
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| Mol Cell 25(3):331-43. 2007
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| 40 | FANCB, MUS81
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| Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.
|
| Nomura Y, Adachi N, Koyama H.
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| Genes Cells 12(10):1111-22.PMID: 1790317 2007
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| 41 | MUS81
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| Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells.
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| Gao H, Chen XB, McGowan CH.
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| Mol Biol Cell 14(12):4826-34. 2003
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| 42 | MUS81
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| Identification and characterization of human MUS81-MMS4 structure-specific endonuclease.
|
| Ogrunc M, Sancar A.
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| J Biol Chem 278(24):21715-20. Epub 2003 Apr 09. 2003
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| 43 | EME1, EME2, MUS81
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| Identification and characterization of the human mus81-eme1 endonuclease.
|
| Ciccia A, Constantinou A, West SC.
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| J Biol Chem 278(27):25172-8. Epub 2003 Apr 29. 2003
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| 44 | MUS81
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| Human Mus81-associated endonuclease cleaves Holliday junctions in vitro.
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| Chen XB, Melchionna R, Denis CM, Gaillard PH, Blasina A, Van de Weyer I,Boddy MN, Russell P, Vialard J, McGowan CH.
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| Mol Cell 8(5):1117-27. 2001
|