| 1 | MUL1, UBXN7
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| Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein.
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| Cilenti L, Di Gregorio J, Ambivero CT, Andl T, Liao R, Zervos AS.
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| Sci Rep. Jan 31;10(1):1609. doi: 10.1038/s41598-020-58484-8 2020
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| 2 | MUL1
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| MUL1 E3 ligase regulates the antitumor effects of metformin in chemoresistant ovarian cancer cells via AKT degradation.
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| Lee J, An S, Jung JH, Kim K, Kim JY, An IS, Bae S.
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| Int J Oncol 54(5):1833-1842. doi: 10.3892/ijo.2019.4730. Epub 2019 Feb 27.
2019
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| 3 | MUL1
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| MUL1 gene polymorphisms and Parkinson's disease risk.
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| Taximaimaiti R, Li H.
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| Acta Neurol Scand 139(5):483-487. doi: 10.1111/ane.13081. Epub 2019 Mar 14.
2019
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| 4 | HSPA5, MUL1
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| HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer.
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| Kim SY, Kim HJ, Kim HJ, Kim DH, Han JH, Byeon HK, Lee K, Kim CH.
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| Autophagy 14(3):385-403. doi: 10.1080/15548627.2017.1414126. Epub 2018 Feb 21.
2018
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| 5 | MARCH5, MUL1
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| Ubiquitination at the mitochondria in neuronal health and disease.
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| Covill-Cooke C, Howden JH, Birsa N, Kittler JT.
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| Neurochem Int 117:55-64. doi: 10.1016/j.neuint.2017.07.003. Epub 2017 Jul 12. Review.
2018
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| 6 | AKT1, FOXO3, MUL1
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| FOXO3 induces ubiquitylation of AKT through MUL1 regulation.
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| Kim SY, Kim HJ, Byeon HK, Kim DH, Kim CH.
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| Oncotarget 8(66):110474-110489. doi: 10.18632/oncotarget.22793. eCollection 2017 Dec 15.
2017
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| 7 | MUL1, PRKN
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| Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1.
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| Rojansky R, Cha MY, Chan DC.
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| Elife 5. pii: e17896. doi: 10.7554/eLife.17896.
2016
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| 8 | MUL1, NFKB1
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| Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress.
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| Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T.
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| Int J Mol Med 37(6):1611-8. doi: 10.3892/ijmm.2016.2566. Epub 2016 Apr 14.
2016
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| 9 | ATG5, MUL1, ULK1
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| Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy.
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| Li J, Qi W, Chen G, Feng D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q, Zhu Y.
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| Autophagy 11(8):1216-29. doi: 10.1080/15548627.2015.1017180.
2015
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| 10 | HTRA2, MUL1
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| Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.
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| Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS.
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| Biochim Biophys Acta 1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5.
2014
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| 11 | GABARAP, MUL1, UBE2E3
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| Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP.
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| Ambivero CT, Cilenti L, Main S, Zervos AS.
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| Cell Signal 26(12):2921-9. doi: 10.1016/j.cellsig.2014.09.004. Epub 2014 Sep 16.
2014
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| 12 | DDX58, MUL1
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| Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.
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| Jenkins K, Khoo JJ, Sadler A, Piganis R, Wang D, Borg NA, Hjerrild K, Gould J, Thomas BJ, Nagley P, Hertzog PJ, Mansell A.
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| Immunol Cell Biol 91(4):321-30. doi: 10.1038/icb.2013.7. Epub 2013 Feb 12.
2013
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| 13 | AKT1, MUL1
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| Akt is negatively regulated by the MULAN E3 ligase.
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| Bae S, Kim SY, Jung JH, Yoon Y, Cha HJ, Lee H, Kim K, Kim J, An IS, Kim J, Um HD, Park IC, Lee SJ, Nam SY, Jin YW, Lee JH, An S.
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| Cell Res 22(5):873-85. doi: 10.1038/cr.2012.38. Epub 2012 Mar 13.
2012
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| 14 | MUL1
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| MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.
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| Braschi E, Zunino R, McBride HM.
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| EMBO Rep 10(7):748-54. Epub 2009 May 1.PMID: 19407830 2009
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| 15 | MUL1
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| GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.
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| Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB.
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| Cell Res 18(9):900-10.PMID: 18591963 2008
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