| 1 | LGALS3, MUC1, SP1, TACSTD2
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| Induction of Trop-2 expression through the binding of galectin-3 to MUC1.
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| Yamashita T, Mori Y, Alzaaqi SM, Yashiro M, Sawada T, Hirakawa K, Nakada H.
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| Biochem Biophys Res Commun. Aug 13;516(1):44-49. doi: 10.1016/j.bbrc.2019.06.003. Epub 2019 Jun 10. 2019
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| 2 | MUC1, MUC16
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| Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours.
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| Ricardo S, Marcos-Silva L, Pereira D, Pinto R, Almeida R, Söderberg O, Mandel U, Clausen H, Felix A, Lunet N, David L.
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| Mol Oncol 9(2):503-12. doi: 10.1016/j.molonc.2014.10.005. Epub 2014 Oct 22.
2015
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| 3 | MUC1, MUC4
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| Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma.
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| Kamikawa Y, Kanmura Y, Hamada T, Yamada N, Macha MA, Batra SK, Higashi M, Yonezawa S, Sugihara K.
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| Int J Clin Oncol nt J Clin Oncol. 2014 Jun 10. [Epub ahead of print]
2014
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| 4 | FLT3, MUC1
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| MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.
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| Liu S, Yin L, Stroopinsky D, Rajabi H, Puissant A, Stegmaier K, Avigan D, Kharbanda S, Kufe D, Stone R.
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| Blood 123(5):734-42. doi: 10.1182/blood-2013-04-493858. Epub 2013 Nov 26.
2014
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| 5 | MAPK8, MUC1
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| MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress.
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| Chen Q, Li D, Ren J, Li C, Xiao ZX.
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| Biochem Biophys Res Commun 440(1):179-83. doi: 10.1016/j.bbrc.2013.09.055. Epub 2013 Sep 18.
2013
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| 6 | MUC1
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| MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors.
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| Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S, Yonezawa S.
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| Oncogene 32(39):4614-21. doi: 10.1038/onc.2012.478. Epub 2012 Oct 29.
2013
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| 7 | MUC1, PPARG
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| PPARγ E3 ubiquitin ligase regulates MUC1-C oncoprotein stability.
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| Hou Y, Gao J, Xu H, Xu Y, Zhang Z, Xu Q, Zhang C.
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| Oncogene ncogene. 2013 Dec 2. doi: 10.1038/onc.2013.504. [Epub ahead of print]
2013
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| 8 | MUC1, SIGLEC9
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| Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.
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| Tanida S, Akita K, Ishida A, Mori Y, Toda M, Inoue M, Ohta M, Yashiro M, Sawada T, Hirakawa K, Nakada H.
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| J Biol Chem 288(44):31842-52. doi: 10.1074/jbc.M113.471318. Epub 2013 Sep 17.
2013
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| 9 | MCKD1, MUC1
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| Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.
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| Kirby A, Gnirke A, Jaffe DB, Bareová V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, Hůlková H, Sovová J, Vylet'al P, Antignac C, Guttman M, Handsaker RE, Perrin D, Steelman S, Sigurdsson S, Scheinman SJ, Sougnez C, Cibulskis K, Parkin M, Green T, Rossin E, Zody MC, Xavier RJ, Pollak MR, Alper SL, Lindblad-Toh K, Gabriel S, Hart PS, Regev A, Nusbaum C, Kmoch S, Bleyer AJ, Lander ES, Daly MJ.
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| Nat Genet 45(3):299-303. doi: 10.1038/ng.2543. Epub 2013 Feb 10.
2013
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| 10 | MUC1
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| Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms.
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| Zhang L, Vlad A, Milcarek C, Finn OJ.
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| Cancer Immunol Immunother 62(3):423-35. doi: 10.1007/s00262-012-1325-2. Epub 2012 Sep 2.
2013
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| 11 | MUC1
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| MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches.
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| Kufe DW.
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| Oncogene 32(9):1073-81. doi: 10.1038/onc.2012.158. Epub 2012 May 14. Review.
2013
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| 12 | MUC1, MUC2, MUC6
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| Genetic variation in MUC1, MUC2 and MUC6 genes and evolution of gastric cancer precursor lesions in a long-term follow-up in a high-risk area in Spain.
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| Marín F, Bonet C, Muńoz X, García N, Pardo ML, Ruiz-Liso JM, Alonso P, Capellŕ G, Sanz-Anquela JM, González CA, Sala N.
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| Carcinogenesis 33(5):1072-80. doi: 10.1093/carcin/bgs119. Epub 2012 Mar 7.
2012
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| 13 | MET, MUC1
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| MUC1 drives c-Met-dependent migration and scattering.
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| Horm TM, Bitler BG, Broka DM, Louderbough JM, Schroeder JA.
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| Mol Cancer Res 10(12):1544-54. doi: 10.1158/1541-7786.MCR-12-0296. Epub 2012 Nov 27.
2012
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| 14 | MUC1
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| The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes.
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| Kumar P, Lindberg L, Thirkill TL, Ji JW, Martsching L, Douglas GC.
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| PLoS One 7(8):e42712. doi: 10.1371/journal.pone.0042712. Epub 2012 Aug 8.
2012
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| 15 | BAX, MUC1
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| The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function.
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| Ahmad R, Alam M, Rajabi H, Kufe D.
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| J Biol Chem 287(25):20866-75. doi: 10.1074/jbc.M112.357293. Epub 2012 Apr 27.
2012
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| 16 | MUC1, PPARG
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| PPARγ inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism.
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| Park YS, Lillehoj EP, Kato K, Park CS, Kim KC.
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| Am J Physiol Lung Cell Mol Physiol 302(7):L679-87. doi: 10.1152/ajplung.00360.2011. Epub 2012 Jan 20.
2012
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| 17 | MUC1
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| MUC1 mucin is expressed on human T-regulatory cells: function in both co-stimulation and co-inhibition.
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| Konowalchuk JD, Agrawal B.
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| Cell Immunol 272(2):193-9. doi: 10.1016/j.cellimm.2011.10.012. Epub 2011 Oct 22.
2012
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| 18 | HIF1A, MUC1
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| MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
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| Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PK.
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| Proc Natl Acad Sci U S A 109(34):13787-92. doi: 10.1073/pnas.1203339109. Epub 2012 Aug 6.
2012
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| 19 | MUC1, PDGFA
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| MUC1 regulates PDGFA expression during pancreatic cancer progression.
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| Sahraei M, Roy LD, Curry JM, Teresa TL, Nath S, Besmer D, Kidiyoor A, Dalia R, Gendler SJ, Mukherjee P.
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| Oncogene 31(47):4935-45. doi: 10.1038/onc.2011.651. Epub 2012 Jan 23.
2012
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| 20 | EGFR, LGALS3, MUC1
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| Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells.
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| Merlin J, Stechly L, de Beaucé S, Monté D, Leteurtre E, van Seuningen I, Huet G, Pigny P.
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| Oncogene 30(22):2514-25. doi: 10.1038/onc.2010.631. Epub 2011 Jan 24.
2011
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| 21 | MUC1
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| MUC1 in mesenchymal-to-epithelial transition during human nephrogenesis: changing the fate of renal progenitor/stem cells?
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| Fanni D, Fanos V, Monga G, Gerosa C, Nemolato S, Locci A, Van Eyken P, Iacovidou N, Faa G.
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| J Matern Fetal Neonatal Med 24 Suppl 2:63-6.
2011
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| 22 | MUC1
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| Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal.
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| Kinlough CL, Poland PA, Gendler SJ, Mattila PE, Mo D, Weisz OA, Hughey RP.
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| J Biol Chem 286(45):39072-81. Epub 2011 Sep 20.
2011
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| 23 | MUC1
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| MUC1 expression is elevated in severe preeclamptic placentas and suppresses trophoblast cell invasion via β1-integrin signaling.
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| Shyu MK, Chen CW, Lin NY, Liao WC, Chen CH, Lin CJ, Huang HC, Lee JJ, Huang MJ, Tseng GF, Shih JC, Lee CN, Hsieh FJ, Huang MC.
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| J Clin Endocrinol Metab 96(12):3759-67. Epub 2011 Sep 14.
2011
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| 24 | MUC1
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| The cytoplasmic domain of MUC1 induces hyperplasia in the mammary gland and correlates with nuclear accumulation of β-catenin.
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| Li Y, Yi H, Yao Y, Liao X, Xie Y, Yang J, Yan Z, Wang L, Lu S, Kuang Y, Gu M, Fei J, Wang Z, Huang L.
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| PLoS One 6(4):e19102.
2011
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| 25 | MUC1
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| MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells.
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| Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, Kufe D.
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| Blood 117(18):4863-70. Epub 2011 Mar 21.
2011
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| 26 | MUC1
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| MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.
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| Ahmad R, Rajabi H, Kosugi M, Joshi MD, Alam M, Vasir B, Kawano T, Kharbanda S, Kufe D.
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| Sci Signal 4(160):ra9.
2011
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| 27 | MUC1
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| MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition.
|
| Roy LD, Sahraei M, Subramani DB, Besmer D, Nath S, Tinder TL, Bajaj E, Shanmugam K, Lee YY, Hwang SI, Gendler SJ, Mukherjee P.
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| Oncogene 30(12):1449-59. Epub 2010 Nov 22.
2011
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| 28 | MUC1
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| Cytokine and progesterone receptor interplay in the regulation of MUC1 gene expression.
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| Dharmaraj N, Wang P, Carson DD.
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| Mol Endocrinol 24(12):2253-66. Epub 2010 Oct 20.
2010
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| 29 | MUC1
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| Expression of aberrantly glycosylated Mucin-1 in ovarian cancer.
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| Van Elssen CH, Frings PW, Bot FJ, Van de Vijver KK, Huls MB, Meek B, Hupperets P, Germeraad WT, Bos GM.
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| Histopathology 57(4):597-606. doi: 10.1111/j.1365-2559.2010.03667.x.
2010
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| 30 | MUC1
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| MUC1 oncogene amplification correlates with protein overexpression in invasive breast carcinoma cells.
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| Lacunza E, Baudis M, Colussi AG, Segal-Eiras A, Croce MV, Abba MC.
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| Cancer Genet Cytogenet 201(2):102-10.
2010
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| 31 | MUC1
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| MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.
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| Bitler BG, Goverdhan A, Schroeder JA.
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| J Cell Sci 123(Pt 10):1716-23. Epub 2010 Apr 20.
2010
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| 32 | CAMLG, MUC1
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| MUC1 mucin interacts with calcium-modulating cyclophilin ligand.
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| Guang W, Kim KC, Lillehoj EP.
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| Int J Biochem Cell Biol 41(6):1354-60. Epub 2008 Dec 14.PMID: 19135167 2009
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| 33 | MUC1
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| MUC1 is a substrate for gamma-secretase.
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| Julian J, Dharmaraj N, Carson DD.
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| J Cell Biochem 108(4):802-15.
2009
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| 34 | MUC1
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| MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.
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| Ahmad R, Raina D, Joshi MD, Kawano T, Ren J, Kharbanda S, Kufe D.
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| Cancer Res 69(17):7013-21. Epub 2009 Aug 25.
2009
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| 35 | MUC1, STAT3
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| MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion.
|
| Gao J, McConnell MJ, Yu B, Li J, Balko JM, Black EP, Johnson JO, Lloyd MC, Altiok S, Haura EB.
|
| Int J Oncol 35(2):337-45.
2009
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| 36 | MUC1
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| Genetic regulation of MUC1 alternative splicing in human tissues.
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| Ng W, Loh AX, Teixeira AS, Pereira SP, Swallow DM.
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| Br J Cancer 99(6):978-85.
2008
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| 37 | MUC1
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| MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells.
|
| Kawano T, Ahmad R, Nogi H, Agata N, Anderson K, Kufe D.
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| Int J Oncol 33(1):153-9.
2008
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| 38 | MUC1
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| MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cells.
|
| Kawano T, Ito M, Raina D, Wu Z, Rosenblatt J, Avigan D, Stone R, Kufe D.
|
| Cancer Res 67(24):11576-84.
2007
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| 39 | MUC1
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| MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling.
|
| Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, Kufe D.
|
| Nat Cell Biol 9(12):1419-27. Epub 2007 Nov 25.
2007
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| 40 | MUC1, MUC5AC, MUC6
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| Mucin expression profile in pancreatic cancer and the precursor lesions.
|
| Nagata K, Horinouchi M, Saitou M, Higashi M, Nomoto M, Goto M, Yonezawa S.
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| J Hepatobiliary Pancreat Surg 14(3):243-54. Epub 2007 May 29. Review.
2007
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| 41 | MUC1
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| Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue.
|
| Yuan SF, Li KZ, Wang L, Dou KF, Yan Z, Han W, Zhang YQ.
|
| World J Gastroenterol 11(30):4661-6. 2005
|
| 42 | MUC1
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| A novel protein derived from the MUC1 gene by alternative splicing and frameshifting.
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| Levitin F, Baruch A, Weiss M, Stiegman K, Hartmann ML, Yoeli-Lerner M, Ziv R, Zrihan-Licht S, Shina S, Gat A, Lifschitz B, Simha M, Stadler Y, Cholostoy A, Gil B, Greaves D, Keydar I, Zaretsky J, Smorodinsky N, Wreschner DH.
|
| J Biol Chem 280(11):10655-63. Epub 2004 Dec 28.
2005
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| 43 | MMP14, MUC1, ADAM17
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| MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.
|
| Thathiah A, Carson DD.
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| Biochem J 382(Pt 1):363-73. 2004
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| 44 | MUC1
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| Human DF3/MUC1 carcinoma-associated protein functions as an oncogene.
|
| Li Y, Liu D, Chen D, Kharbanda S, Kufe D.
|
| Oncogene 22(38):6107-10. 2003
|
| 45 | MUC1, MUC3B, MUC6
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| Expression of human mucin genes during normal and abnormal renal development.
|
| Leroy X, Devisme L, Buisine MP, Copin MC, Aubert S, Gosselin B, Aubert JP, Porchet N.
|
| Am J Clin Pathol 120(4):544-50. 2003
|
| 46 | MUC15, MUC1, MUC2, MUC3A, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC8, OVGP1, MUC12, MUC13, MUC16
|
| Isolation and characterization of MUC15, a novel cell membrane-associated mucin.
|
| Pallesen LT, Berglund L, Rasmussen LK, Petersen TE, Rasmussen JT.
|
| Eur J Biochem 269(11):2755-63. 2002
|
| 47 | MUC1
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| MUC1 gene polymorphism in the gastric carcinogenesis pathway.
|
| Silva F, Carvalho F, Peixoto A, Seixas M, Almeida R, Carneiro F, Mesquita P, Figueiredo C, Nogueira C, Swallow DM, Amorim A, David L.
|
| Eur J Hum Genet 9(7):548-52. 2001
|
| 48 | MUC1
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| Expression of mucin 1 (MUC1) in esophageal squamous-cell carcinoma: its relationship with prognosis.
|
| Sagara M, et al.
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| Int J Cancer 84(3):251-7. 1999
|
| 49 | MUC1
|
| MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.
|
| Jarrard JA, et al.
|
| Cancer Res 58 : 5582-5589. 1998
|
| 50 | MUC1, MUC2, MUC4, MUC5AC
|
| Mucin gene expression in ovarian cancers.
|
| Giuntoli RL, et al.
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| Cancer Res 58 : 5546-5550. 1998
|
| 51 | MUC1, MUC2, MUC7
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| Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma.
|
| Retz M, et al.
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| Cancer Res 58 : 5662-5666. 1998
|
| 52 | MUC1
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| Two additional polymorphisms within the hypervariable MUC1 gene : association of alleles either side of the VNTR region.
|
| Pratt WS, et al.
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| Ann Hum Genet 60 : 21-28. 1996
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| 53 | MUC1
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| A single nucleotide polymorphism in an exon dictates allele dependent differential splicing of episialin mRNA.
|
| Ligtenberg MJL, et al.
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| Nucleic Acids Res 19 : 297-301. 1991
|
| 54 | TSG1B, MUC1
|
| The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours.
|
| Gendler SJ, et al.
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| Int J Cancer 45 : 431-435. 1990
|
| 55 | D1S90, MUC1, NGF
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| Polymorphisms near chromosome 1cen.
|
| Anderson LA, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 951. 1989
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| 56 | MUC1, SPTA1
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| Close linkage of PUM and SPTA within chromosome band 1q21.
|
| Middleton-Price H, Gendler S, Malcolm S.
|
| Ann Hum Genet 52 : 273-278. 1988
|
| 57 | ACKR1, MUC1
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| Linkage between the expressed hypervariable gene locus PUM and the gene coding for the Duffy blood group FY.
|
| Swallow DM, Griffiths B, Noades J, Corney G.
|
| Ann Hum Genet 52 : 269-271. 1988
|
| 58 | MUC1
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| The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM.
|
| Swallow DM, et al.
|
| Nature 328 : 82-84. 1987
|
| 59 | MUC1
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| The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24.
|
| Swallow DM, et al.
|
| Ann Hum Genet 51 : 289-294. 1987
|