Citations for
HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.
Ma H, Su L, Yue H, Yin X, Zhao J, Zhang S, Kung H, Xu Z, Miao J.
Sci Rep 5:15121. doi: 10.1038/srep15121. 2015
Metallothionein 2A genetic polymorphism and its correlation to coronary heart disease.
Yang XY, Sun JH, Ke HY, Chen YJ, Xu M, Luo GH.
Eur Rev Med Pharmacol Sci 18(24):3747-53. 2014
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A.
Sato S, Shirakawa H, Tomita S, Tohkin M, Gonzalez FJ, Komai M.
Toxicol Appl Pharmacol 273(1):90-9. doi: 10.1016/j.taap.2013.08.017. Epub 2013 Aug 28. 2013
Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients.
Haynes V, Connor T, Tchernof A, Vidal H, Dubois S.
Mol Genet Metab 108(1):90-4. doi: 10.1016/j.ymgme.2012.10.012. Epub 2012 Oct 18. 2013
Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients.
Werynska B, Pula B, Muszczynska-Bernhard B, Gomulkiewicz A, Piotrowska A, Prus R, Podhorska-Okolow M, Jankowska R, Dziegiel P.
Exp Mol Pathol 94(1):301-8. doi: 10.1016/j.yexmp.2012.10.006. Epub 2012 Oct 9. 2013
Increased metallothionein I/II expression in patients with temporal lobe epilepsy.
Peixoto-Santos JE, Galvis-Alonso OY, Velasco TR, Kandratavicius L, Assirati JA, Carlotti CG, Scandiuzzi RC, Serafini LN, Leite JP.
PLoS One 7(9):e44709. doi: 10.1371/journal.pone.0044709. Epub 2012 Sep 18. 2012
The effects of metallothionein 2A polymorphism on placental cadmium accumulation: Is metallothionein a modifiying factor in transfer of micronutrients to the fetus?
Tekin D, Kayaaltı Z, Aliyev V, Söylemezoğlu T.
J Appl Toxicol 32(4):270-5. doi: 10.1002/jat.1661. Epub 2011 Feb 15. 2012
Downregulation of metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue.
Yan DW, Fan JW, Yu ZH, Li MX, Wen YG, Li DW, Zhou CZ, Wang XL, Wang Q, Tang HM, Peng ZH.
Biochim Biophys Acta 1822(6):918-26. doi: 10.1016/j.bbadis.2012.02.021. Epub 2012 Mar 9. 2012
The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels.
Kayaaltı Z, Aliyev V, Söylemezoğlu T.
Toxicol Appl Pharmacol 256(1):1-7. doi: 10.1016/j.taap.2011.06.023. Epub 2011 Jul 13. 2011
Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells.
Kim HG, Kim JY, Han EH, Hwang YP, Choi JH, Park BH, Jeong HG.
FEBS Lett 585(2):421-8. doi: 10.1016/j.febslet.2010.12.030. Epub 2010 Dec 25. 2011
11MT1A, MT1F, MT2A
Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
Toh PP, Li JJ, Yip GW, Lo SL, Guo CH, Phan TT, Bay BH.
Exp Dermatol 19(11):987-93. doi: 10.1111/j.1600-0625.2010.01124.x. Epub 2010 Aug 31. 2010
12MT1A, MT2A
The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population.
Kayaaltı Z, Söylemezoğlu T.
Mol Biol Rep ol Biol Rep. 2009 Jul 2. [Epub ahead of print] 2009
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Lim D, Jocelyn KM, Yip GW, Bay BH.
Cancer Lett 276(1):109-17. Epub 2008 Dec 4. 2009
Transthyretin interacts with metallothionein 2.
Gonçalves I, Quintela T, Baltazar G, Almeida MR, Saraiva MJ, Santos CR.
Biochemistry 47(8):2244-51. Epub 2008 Feb 1. 2008
15MT1A, MT2A
Metal exchange in metallothioneins: a novel structurally significant Cd(5) species in the alpha domain of human metallothionein 1a.
Rigby Duncan KE, Kirby CW, Stillman MJ.
FEBS J 275(9):2227-39. 2008
Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress.
Feng W, Benz FW, Cai J, Pierce WM, Kang YJ.
J Biol Chem 281(2):681-7. Epub 2005 Oct 21. 2006
17MT1A, MT2A
Effect of metallothionein on cell viability and its interactions with cadmium and zinc in HEK293 cells.
Li J, Liu Y, Ru B.
Cell Biol Int 29(10):843-8. 2005
Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria.
Costello LC, Guan Z, Franklin RB, Feng P.
J Inorg Biochem 98(4):664-6. 2004
ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis.
Cui Y, Wang J, Zhang X, Lang R, Bi M, Guo L, Lu SH.
Biochem Biophys Res Commun 302(4):904-15. 2003
20MT1E, MT1F, MT1G, MT1H, MT1L, MT2A
Identification and spatial analysis of metallothioneins expressed by the adult human lens.
Oppermann B, Zhang W, Magabo K, Kantorow M.
Invest Ophthalmol Vis Sci 42(1):188-93. 2001
A BamHI RFLP at MT2A on human chromosome 16.
Bates LJ, et al.
Nucleic Acids Res 16 : 9071. 1988
22MT2A, FRA16A, FRA16B
Linkage analysis of markers near fragile sites on human chromosome 16.
Mulley JC, et al.
(HGM9) Cytogenet Cell Genet 46 : 665. 1987
23MT1@, MT2A
A 5' flanking region of the metallothionein, MT2A, gene identifies two moderately frequent RFLPs.
Hyland VJ, et al.
Nucleic Acids Res 15 : 1350. 1987
24MT1@, MT2A
Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.
Le Beau MM, et al.
Nature 313 : 709-711. 1985
Human metallothionein genes are clustered on chromosome 16.
Karin M, et al.
Proc Natl Acad Sci U S A 81 : 5494-5498. 1984
26MT1@, MT2A, MT2P1, MTL1, MTL2, MTL3, MTL4
Chromosomal location of human metallothionein genes : implications for Menkes' disease.
Schmidt CJ, et al.
Science 224 : 1104-1106. 1984