| 1 | BCL11B, MSX2
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| Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development.
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| Li Z, Chen G, Yang Y, Guo W, Tian W.
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| Mol Med Rep 15(1):297-304. doi: 10.3892/mmr.2016.6030. Epub 2016 Dec 12.
2017
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| 2 | MSX2, NODAL, SOX2
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| MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling.
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| Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Feng S, Han M, Xu Y, Wang F, Zhou J.
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| Cell Res 25(12):1314-32. doi: 10.1038/cr.2015.118.
2015
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| 3 | DLX5, DLX6, MSX1, MSX2
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| BMP-Mediated Functional Cooperation between Dlx5;Dlx6 and Msx1;Msx2 during Mammalian Limb Development.
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| Vieux-Rochas M, Bouhali K, Mantero S, Garaffo G, Provero P, Astigiano S, Barbieri O, Caratozzolo MF, Tullo A, Guerrini L, Lallemand Y, Robert B, Levi G, Merlo GR.
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| PLoS One 8(1):e51700. doi: 10.1371/journal.pone.0051700. Epub 2013 Jan 29.
2013
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| 4 | HR, MSX2
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| Hairless down-regulates expression of Msx2 and its related target genes in hair follicles.
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| Kim BK, Yoon SK.
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| J Dermatol Sci 71(3):203-9. doi: 10.1016/j.jdermsci.2013.04.019. Epub 2013 Apr 28.
2013
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| 5 | DLX5, EPHA5, EPHA7, MSX2
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| Dlx5 and Msx2 regulate mouse anterior neural tube closure through ephrinA5-EphA7.
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| Lee J, Corcoran A, Han M, Gardiner DM, Muneoka K.
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| Dev Growth Differ 55(3):341-9. doi: 10.1111/dgd.12044. Epub 2013 Feb 21.
2013
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| 6 | AMBN, MSX2
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| Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation
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| Atsawasuwan P, Lu X, Ito Y, Zhang Y, Evans CA, Luan X.
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| PLoS One. Apr 4;8(4):e52800. doi: 10.1371/journal.pone.0052800. 2013
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| 7 | DUP5QD, MSX2
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| Microduplications upstream of MSX2 are associated with a phenocopy of cleidocranial dysplasia.
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| Ott CE, Hein H, Lohan S, Hoogeboom J, Foulds N, Grünhagen J, Stricker S, Villavicencio-Lorini P, Klopocki E, Mundlos S.
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| J Med Genet 49(7):437-41. Epub 2012 Jun 20.
2012
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| 8 | MSX2
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| MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
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| Satoh K, Hamada S, Shimosegawa T.
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| Front Physiol 3:430. doi: 10.3389/fphys.2012.00430. Epub 2012 Nov 14.
2012
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| 9 | FOXC1, MSX2
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| Initiation of early osteoblast differentiation events through the direct transcriptional regulation of Msx2 by FOXC1.
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| Mirzayans F, Lavy R, Penner-Chea J, Berry FB.
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| PLoS One 7(11):e49095. doi: 10.1371/journal.pone.0049095. Epub 2012 Nov 7.
2012
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| 10 | DLX3, DLX5, GPNMB, MSX2
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| Homeodomain transcription factors regulate BMP-2-induced osteoactivin transcription in osteoblasts.
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| Singh M, Del Carpio-Cano FE, Monroy MA, Popoff SN, Safadi FF.
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| J Cell Physiol 227(1):390-9. doi: 10.1002/jcp.22791.
2012
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| 11 | FOXD3, MSX1, MSX2, PAX7, ZIC1
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| Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome.
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| Simões-Costa MS, McKeown SJ, Tan-Cabugao J, Sauka-Spengler T, Bronner ME.
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| PLoS Genet 8(12):e1003142. doi: 10.1371/journal.pgen.1003142. Epub 2012 Dec 20.
2012
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| 12 | DUP5QD, MSX2
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| Ventricular noncompaction and absent thumbs in a newborn with tetrasomy 5q35.2-5q35.3: An association with Hunter-McAlpine syndrome?
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| Sellars EA, Zimmerman SL, Smolarek T, Hopkin RJ.
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| Am J Med Genet A 155(6):1409-13. doi: 10.1002/ajmg.a.33997. Epub 2011 May 12.
2011
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| 13 | MSX1, MSX2
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| Msx1 and Msx2 in limb mesenchyme modulate digit number and identity.
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| Bensoussan-Trigano V, Lallemand Y, Saint Cloment C, Robert B.
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| Dev Dyn 240(5):1190-202. doi: 10.1002/dvdy.22619. Epub 2011 Apr 4.
2011
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| 14 | FOXN1, MSX2
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| Msx2 and Foxn1 regulate nail homeostasis.
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| Cai J, Ma L.
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| Genesis 49(6):449-59. doi: 10.1002/dvg.20744. Epub 2011 May 31.
2011
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| 15 | MSX2
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| MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.
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| Zhai Y, Iura A, Yeasmin S, Wiese AB, Wu R, Feng Y, Fearon ER, Cho KR.
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| Oncogene 30(40):4152-62. doi: 10.1038/onc.2011.123. Epub 2011 Apr 18.
2011
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| 16 | MSX1, MSX2
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| Msx1 and Msx2 promote meiosis initiation.
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| Le Bouffant R, Souquet B, Duval N, Duquenne C, Hervé R, Frydman N, Robert B, Habert R, Livera G.
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| Development 138(24):5393-402. doi: 10.1242/dev.068452. Epub 2011 Nov 9.
2011
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| 17 | MSX2, TNF
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| Msx2 is required for TNF-α-induced canonical Wnt signaling in 3T3-L1 preadipocytes.
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| Qadir AS, Lee HL, Baek KH, Park HJ, Woo KM, Ryoo HM, Baek JH.
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| Biochem Biophys Res Commun 408(3):399-404. doi: 10.1016/j.bbrc.2011.04.029. Epub 2011 Apr 13.
2011
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| 18 | ATOH7, MSX2
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| Msx2 alters the timing of retinal ganglion cells fate commitment and differentiation.
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| Jiang SY, Wang JT.
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| Biochem Biophys Res Commun 395(4):524-9. Epub 2010 Apr 13. 2010
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| 19 | DEL11QD, DEL7P21, DEL9P, DUP5Q35, FGFR2, FGFR3, MSX2, TWIST
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| Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.
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| Wilkie AO, Byren JC, Hurst JA, Jayamohan J, Johnson D, Knight SJ, Lester T, Richards PG, Twigg SR, Wall SA.
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| Pediatrics 126(2):e391-400. Epub 2010 Jul 19.PMID: 20643727 2010
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| 20 | ENPP1, FGF2, MSX2
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| FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.
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| Li Y, Liu J, Hudson M, Kim S, Hatch NE.
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| J Cell Biochem 111(5):1346-58. doi: 10.1002/jcb.22861. 2010
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| 21 | MSX1, MSX2
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| Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head.
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| Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE.
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| Dev Biol 343(1-2):28-39. Epub 2010 Apr 14.
2010
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| 22 | GNRH1, MSX1, MSX2, NDN, PWS
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| Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development.
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| Miller NL, Wevrick R, Mellon PL.
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| Hum Mol Genet 18(2):248-60. Epub 2008 Oct 17.
2009
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| 23 | DUP5Q34, MSX2
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| Craniosynostosis in a patient with 2q37.3 deletion 5q34 duplication: Association of extra copy of MSX2 with craniosynostosis.
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| Kariminejad A, Kariminejad R, Tzschach A, Ullmann R, Ahmed A, Asghari-Roodsari A, Salehpour S, Afroozan F, Ropers HH, Kariminejad MH.
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| Am J Med Genet A 149A(7):1544-1549. [Epub ahead of print]
2009
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| 24 | MSX1, MSX2
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| Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb.
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| Lallemand Y, Bensoussan V, Cloment CS, Robert B.
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| Dev Biol 331(2):189-98. Epub 2009 May 5.
2009
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| 25 | FOXN1, MSX2
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| Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation.
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| Cai J, Lee J, Kopan R, Ma L.
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| Dev Biol 326(2):420-30. Epub 2008 Dec 7.
2009
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| 26 | MSX2
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| Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese.
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| Furuichi T, Maeda K, Chou CT, Liu YF, Liu TC, Miyamoto Y, Takahashi A, Mori K, Ikari K, Kamatani N, Kurosawa H, Inoue H, Tsai SF, Ikegawa S.
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| J Hum Genet 53(5):419-24. Epub 2008 Feb 26. 2008
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| 27 | CRS2, MSX2
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| The Boston-type craniosynostosis mutation MSX2 (P148H) results in enhanced susceptibility of MSX2 to ubiquitin-dependent degradation.
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| Yoon WJ, Cho YD, Cho KH, Woo KM, Baek JH, Cho JY, Kim GS, Ryoo HM.
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| J Biol Chem 283(47):32751-61. Epub 2008 Sep 10.
2008
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| 28 | MSX2, TWIST1
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| Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells.
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| Satoh K, Hamada S, Kimura K, Kanno A, Hirota M, Umino J, Fujibuchi W, Masamune A, Tanaka N, Miura K, Egawa S, Motoi F, Unno M, Vonderhaar BK, Shimosegawa T.
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| Am J Pathol 172(4):926-39. Epub 2008 Mar 18.
2008
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| 29 | EFNB1, FGFR1, FGFR2, FGFR3, MSX2, RAB23, TWIST1
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| Genetics of craniosynostosis: genes, syndromes, mutations and genotype-phenotype correlations.
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| Passos-Bueno MR, Serti Eacute AE, Jehee FS, Fanganiello R, Yeh E.
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| Front Oral Biol 12:107-43. Review.
2008
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| 30 | ADCY5, EFNA5, ERC2, GFPT2, GIPC2, GNA14, HSPA4L, MAGI1, MN1, MSX2, MYO5B, OCLN, RSPO1, SALL1, ZNF382
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| Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.
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| Kuang SQ, Tong WG, Yang H, Lin W, Lee MK, Fang ZH, Wei Y, Jelinek J, Issa JP, Garcia-Manero G.
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| Leukemia 22(8):1529-38. Epub 2008 Jun 5.PMID: 18528427 2008
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| 31 | CRS2, MSX2, DUP5QD
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| Syndromic craniosynostosis due to complex chromosome 5 rearrangement and MSX2 gene triplication.
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| Bernardini L, Castori M, Capalbo A, Mokini V, Mingarelli R, Simi P, Bertuccelli A, Novelli A, Dallapiccola B.
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| Am J Med Genet A 143A(24):2937-2943 [Epub ahead of print] 2007
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| 32 | MSX2, CRS2, DUP5QD
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| Craniosynostosis associated with distal 5q-trisomy: Further evidence that extra copy of MSX2 gene leads to craniosynostosis.
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| Wang JC, Steinraths M, Dang L, Lomax B, Eydoux P, Stockley T, Yong SL, Van Allen MI.
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| Am J Med Genet A 143A(24):2931-2936 [Epub ahead of print] 2007
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| 33 | TWIST1, MSX2, EFNA4
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| Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis.
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| Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE Jr.
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| Hum Mol Genet 15(8):1319-28. Epub 2006 Mar 15. 2006
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| 34 | ALX4, DEL11PP, MSX2, PFM1, PFM2
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| Enlarged parietal foramina caused by mutations in the homeobox genes ALX4 and MSX2: from genotype to phenotype.
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| Mavrogiannis LA, Taylor IB, Davies SJ, Ramos FJ, Olivares JL, Wilkie AO.
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| Eur J Hum Genet 14(2):151-8. 2006
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| 35 | ALX4, PFM1, MNX1, SCRA, VSX1, KTCN1, VSX2, MCIA, SOPT, HESX1, HOXD13, PSDY2, MSX2, PFM2, SIX3, HPE2, DCS, SHOX
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| Homeodomain revisited: a lesson from disease-causing mutations.
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| Chi YI.
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| Hum Genet 116(6):433-44. Epub 2005 Feb 23. 2005
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| 36 | MSX2, PFM2
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| A novel mutation in the MSX2 gene in a family with foramina parietalia permagna (FPP).
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| Spruijt L, Verdyck P, Van Hul W, Wuyts W, de Die-Smulders C.
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| Am J Med Genet A 139A(1):45-47. 2005
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| 37 | ALX4, MSX2, PFM1, PFM2
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| Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation.
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| Antonopoulou I, Mavrogiannis LA, Wilkie AO, Morriss-Kay GM.
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| J Anat 204(6):487-99.
2004
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| 38 | ALX1, GATA1, MSX2, RUNX2
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| Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells.
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| Qi H, Aguiar DJ, Williams SM, La Pean A, Pan W, Verfaillie CM.
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| Proc Natl Acad Sci U S A 100(6):3305-10. 2003
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| 39 | FGFR1, FGFR2, FGFR3, MSX2, TWIST1
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| Craniosynostosis associated with ocular and distal limb defects is very likely caused by mutations in a gene different from FGFR, TWIST, and MSX2.
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| Passos-Bueno MR, Armelin LM, Alonso LG, Neustein I, Sertie AL, Abe K, Pavanello Rde C, Elkis LC, Koiffmann CP.
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| Am J Med Genet 2002
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| 40 | MSX2
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| Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation.
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| Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang Z, Maxson R, Maas R.
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| Nat Genet 24(4):391-5. 2000
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| 41 | MSX2, PFM2
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| Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification.
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| Wilkie AO, Tang Z, Elanko N, Walsh S, Twigg SR, Hurst JA, Wall SA, Chrzanowska KH, Maxson RE Jr.
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| Nat Genet 24(4):387-90. 2000
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| 42 | MSX2, PFM2
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| Identification of mutations in the MSX2 homeobox gene in families affected with foramina parietalia permagna.
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| Wuyts W, Reardon W, Preis S, Homfray T, Rasore-Quartino A, Christians H, Willems PJ, Van Hul W.
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| Hum Mol Genet 9(8):1251-5. 2000
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| 43 | MEOX2, MSX2
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| The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta.
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| Quinn LM, Latham SE, Kalionis B.
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| Placenta 21 Suppl A:S50-4. 2000
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| 44 | CRS2, MSX2
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| Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: a possible mechanism for MSX2-mediated craniosynostosis in humans.
|
| Liu YH, et al.
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| Dev Biol 205(2):260-74. 1999
|
| 45 | ACS1, ACS3, CRS10, CRS11, DEL7P21, CRS5A, CRS5B, CRS6, CRS7B, CRS8, BSCGS1, CRSCNS, FGFR1, FGFR2, FGFR3, MSX2, SADDAN, TWIST1
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| Craniosynostosis Syndromes: From Genes to Premature Fusion of Skull Bones.
|
| Hehr U, et al.
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| Mol Genet Metab 68(2):139-151. No abstract available 1999
|
| 46 | DLX4, DLX5, MSX2
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| Comparative study of MSX-2, DLX-5, and DLX-7 gene expression during early human tooth development.
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| Davideau JL, Demri P, Hotton D, Gu TT, MacDougall M, Sharpe P, Forest N, Berdal A.
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| Pediatr Res 46(6):650-6. 1999
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| 47 | MSX2, BMP4
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| Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis.
|
| Ferrari D, et al.
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| Dev Biol 197(1):12-24. 1998
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| 48 | MSX2
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| Characterization of two length cDNA for human MSX-2 from dental pulp-derived cells.
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| Iimura T, Takeda K, Goseki M, Maruoka Y, Sasaki S, Oida S.
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| DNA Seq 8(1-2):87-92. 1997
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| 49 | PIAS2, MSX2
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| Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA.
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| Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R.
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| Mech Dev 65(1-2):3-17. 1997
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| 50 | MEOX1, MSX1, MSX2
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| The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.
|
| Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C.
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| Differentiation 62(1):33-41.
1997
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| 51 | MSX2
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| Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene.
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| Takahashi C, et al.
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| Oncogene 12 : 2137-2146. 1996
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| 52 | MSX2
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| The molecular basis of Boston-type craniosynostosis : the pro148-His mutation in the N-terminal arm of the MSX2 homeodomain stabilizes DNA binding without altering nucleotide sequence preferences.
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| Ma L, et al.
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| Hum Mol Genet 5 : 1915-1920. 1996
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| 53 | MSX1, MSX2
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| Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy.
|
| Catron KM, et al.
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| Mech Dev 55(2):185-99. 1996
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| 54 | NKX2-5, MSX2
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| Assignment of cardiac homeobox gene CSX to human chromosome 5q34.
|
| Shiojima I, Komuro I, Inazawa J, Nakahori Y, Matsushita I, Abe T, NagaiR, Yazaki Y.
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| Genomics 27(1):204-6. 1995
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| 55 | MSX2, CRS2
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| A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis.
|
| Jabs EW, et al.
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| Cell 75 : 443-450. 1993
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| 56 | MSX2
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| Expression of a human homeobox-containing gene is regulated by 1,25(OH)2D3 in bone cells.
|
| Hodgkinson JE, et al.
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| Biochim Biophys Acta 1174 : 11-16. 1993
|