| 1 | MSX1
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| Msx1 is essential for proper rostral tip formation of the mouse mandible.
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| Shibuya S, Nakatomi M, Kometani-Gunjigake K, Nakao-Kuroishi K, Matsuyama K, Kataoka S, Toyono T, Seta Y, Kawamoto T.
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| Biochem Biophys Res Commun. Jan 29;642:75-82. doi: 10.1016/j.bbrc.2022.12.047. Epub 2022 Dec 18. 2023
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| 2 | DKK2, MSX1
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| MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity.
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| Lee JM, Qin C, Chai OH, Lan Y, Jiang R, Kwon HE
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| J Dent Res. Jul;101(7):832-839. doi: 10.1177/00220345211070583. Epub 2022 Feb 3 2022
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| 3 | FTA1, MSX1
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| MSX1 involved selective tooth agenesis and abnormal labial frenum, pedigree, and retrospective study.
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| Zhu Y, Zhang Y, Dong J, Ruan W, Yang S, Huang P, Duan X.
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| Oral Dis. Dec 7. doi: 10.1111/odi.14459. Epub ahead of print. 2022
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| 4 | MSX1
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| Msx1 cooperates with Runx1 for inhibiting myoblast differentiation.
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| Zhou G, Yang Y, Zhang X, Wang J.
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| Protein Expr Purif. Mar;179:105797. doi: 10.1016/j.pep.2020.105797. Epub 2020 Nov 24. 2021
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| 5 | MSX1
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| The C-terminal region including the MH6 domain of Msx1 regulates skeletal development.
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| Ichihara A, Yasue A, Mitsui SN, Arai D, Minegishi Y, Oyadomari S, Imoto I, Tanaka E.
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| Biochem Biophys Res Commun. May 21;526(1):62-69. doi: 10.1016/j.bbrc.2020.03.068. Epub 2020 Mar 16. 2020
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| 6 | MSX1
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| Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis.
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| Ma Z, Shi H, Shen Y, Li H, Yang Y, Yang J, Zhao H, Wang G, Wang J
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| Cell Biosci. Apr 11;9:34. doi: 10.1186/s13578-019-0296-9. Erratum in: Cell Biosci. 2023 Mar 11;13(1):54. 2019
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| 7 | MSX1, MYF5, PKN1
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| The homeoprotein Msx1 cooperates with Pkn1 to prevent terminal differentiation in myogenic precursor cells
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| Zhu X, Li M, Jia X, Hou W, Yang J, Zhao H, Wang G, Wang J.
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| Biochimie. Jul;162:55-65. doi: 10.1016/j.biochi.2019.04.003. Epub 2019 Apr 6. 2019
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| 8 | MSX1
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| MSX1 induces G0/G1 arrest and apoptosis by suppressing Notch signaling and is frequently methylated in cervical cancer
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| Yue Y, Zhou K, Li J, Jiang S, Li C, Men H.
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| Onco Targets Ther. Aug 10;11:4769-4780. doi: 10.2147/OTT.S165144 2018
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| 9 | BMP4, MSX1, OSR2
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| Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists
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| Jia S, Kwon HE, Lan Y, Zhou J, Liu H, Jiang R.
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| Dev Biol. Dec 1;420(1):110-119. doi: 10.1016/j.ydbio.2016.10.001. Epub 2016 Oct 3 2016
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| 10 | MSX1
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| Msx1 role in craniofacial bone morphogenesis.
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| Nassif A, Senussi I, Meary F, Loiodice S, Hotton D, Robert B, Bensidhoum M, Berdal A, Babajko S.
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| Bone. Sep;66:96-104. doi: 10.1016/j.bone.2014.06.003. Epub 2014 Jun 11. 2014
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| 11 | DLX5, DLX6, MSX1, MSX2
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| BMP-Mediated Functional Cooperation between Dlx5;Dlx6 and Msx1;Msx2 during Mammalian Limb Development.
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| Vieux-Rochas M, Bouhali K, Mantero S, Garaffo G, Provero P, Astigiano S, Barbieri O, Caratozzolo MF, Tullo A, Guerrini L, Lallemand Y, Robert B, Levi G, Merlo GR.
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| PLoS One 8(1):e51700. doi: 10.1371/journal.pone.0051700. Epub 2013 Jan 29.
2013
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| 12 | BMP4, DKK2, MSX1, OSR2
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| Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.
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| Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R.
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| Development 140(2):423-32. doi: 10.1242/dev.081927.
2013
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| 13 | BMP4, MSX1, TBX2
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| Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development
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| Saadi I, Das P, Zhao M, Raj L, Ruspita I, Xia Y, Papaioannou VE, Bei M
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| Development. Jul;140(13):2697-702. doi: 10.1242/dev.088393. Epub 2013 May 29 2013
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| 14 | DKK1, DNAJB6, MSX1
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| DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.
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| Menezes ME, Mitra A, Shevde LA, Samant RS.
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| Biochem J 444(3):573-80. doi: 10.1042/BJ20120205.
2012
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| 15 | FOXD3, MSX1, MSX2, PAX7, ZIC1
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| Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome.
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| Simões-Costa MS, McKeown SJ, Tan-Cabugao J, Sauka-Spengler T, Bronner ME.
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| PLoS Genet 8(12):e1003142. doi: 10.1371/journal.pgen.1003142. Epub 2012 Dec 20.
2012
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| 16 | MSX1, MSX2
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| Msx1 and Msx2 in limb mesenchyme modulate digit number and identity.
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| Bensoussan-Trigano V, Lallemand Y, Saint Cloment C, Robert B.
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| Dev Dyn 240(5):1190-202. doi: 10.1002/dvdy.22619. Epub 2011 Apr 4.
2011
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| 17 | MSX1, OSR2, PAX9
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| Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field.
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| Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby KM, Liu Z, Lan Y, Jiang R.
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| Dev Biol 353(2):344-53. Epub 2011 Mar 17.
2011
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| 18 | FTA1, MSX1, OLD, PAX9
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| PAX9 and MSX1 transcription factor genes in non-syndromic dental agenesis.
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| Paixćo-Cōrtes VR, Braga T, Salzano FM, Mundstock K, Mundstock CA, Bortolini MC.
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| Arch Oral Biol 56(4):337-44. Epub 2010 Dec 15.
2011
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| 19 | FOXE1, MSX1, TGFB3
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| MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1.
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| Venza I, Visalli M, Parrillo L, De Felice M, Teti D, Venza M.
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| Hum Mol Genet 20(5):1016-25. Epub 2010 Dec 20.
2011
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| 20 | MSX1, MSX2
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| Msx1 and Msx2 promote meiosis initiation.
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| Le Bouffant R, Souquet B, Duval N, Duquenne C, Hervé R, Frydman N, Robert B, Habert R, Livera G.
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| Development 138(24):5393-402. doi: 10.1242/dev.068452. Epub 2011 Nov 9.
2011
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| 21 | DLX5, MSX1
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| Msx1 and Dlx5 function synergistically to regulate frontal bone development.
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| Chung IH, Han J, Iwata J, Chai Y.
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| Genesis 48(11):645-55. doi: 10.1002/dvg.20671. Epub 2010 Nov 2.
2010
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| 22 | FTA1, MSX1, OLD, PAX9
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| Mutational analysis of MSX1 and PAX9 genes in Portuguese families with maxillary lateral incisor agenesis.
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| Pinho T, Silva-Fernandes A, Bousbaa H, Maciel P.
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| Eur J Orthod 32(5):582-8. Epub 2010 Jul 26.
2010
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| 23 | MSX1, MTHFR
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| MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
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| Jagomägi T, Nikopensius T, Krjutskov K, Tammekivi V, Viltrop T, Saag M, Metspalu A.
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| Eur J Oral Sci 118(3):213-20.
2010
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| 24 | MSX1, MSX2
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| Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head.
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| Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE.
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| Dev Biol 343(1-2):28-39. Epub 2010 Apr 14.
2010
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| 25 | GNRH1, MSX1, MSX2, NDN, PWS
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| Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development.
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| Miller NL, Wevrick R, Mellon PL.
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| Hum Mol Genet 18(2):248-60. Epub 2008 Oct 17.
2009
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| 26 | HYD1, MSX1, PAX9
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| Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9.
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| Wang Y, Groppe JC, Wu J, Ogawa T, Mues G, D'Souza RN, Kapadia H.
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| Hum Mol Genet 18(15):2863-74. Epub 2009 May 9.
2009
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| 27 | MSX1
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| Polymorphism in the Msx1 gene associated with hypodontia in a Brazilian family.
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| Silva ER, Reis-Filho CR, Napimoga MH, Alves JB.
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| J Oral Sci 51(3):341-5.
2009
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| 28 | MSX1, MSX2
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| Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb.
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| Lallemand Y, Bensoussan V, Cloment CS, Robert B.
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| Dev Biol 331(2):189-98. Epub 2009 May 5.
2009
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| 29 | OFC6, IRF6, FGFR1, MSX1
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| Identification of novel candidate genes associated with cleft lip and palate using array comparative genomic hybridisation.
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| Osoegawa K, Vessere GM, Utami KH, Mansilla MA, Johnson MK, Riley BM, L'Heureux J, Pfundt R, Staaf J, van der Vliet WA, Lidral AC, Schoenmakers EF, Borg A, Schutte BC, Lammer EJ, Murray JC, de Jong PJ.
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| J Med Genet 45(2):81-6. Epub 2007 Sep 14. 2008
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| 30 | OFC1,OFC2,OFC3,OFC4,OFC5,OFC6,OFC7,OFC8,OFC9,OFC10,OFC11,IRF6, MSX1
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| Unraveling Human Cleft Lip and Palate Research.
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| Vieira AR.
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| J Dent Res 87(2):119-125. 2008
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| 31 | AI1C, AIH1, AIH2, AIH3, AIHHT, AIPH1, AIPH2, AMELX, AXIN1, DD2, DGI1, DLX3, DSPP, ENAM, FTA1, FTACC, KLK4, MMP20, MSX1, OLD, PAX9, STHAG5, ZNF22
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| The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders.
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| Bailleul-Forestier I, Molla M, Verloes A, Berdal A.
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| Eur J Med Genet 51(4):273-91. Epub 2008 Mar 26. Review.
2008
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| 32 | MSX1
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| The MSX1 allele 4 homozygous child exposed to smoking at periconception is most sensitive in developing nonsyndromic orofacial clefts.
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| van den Boogaard MJ, de Costa D, Krapels IP, Liu F, van Duijn C, Sinke RJ, Lindhout D, Steegers-Theunissen RP.
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| Hum Genet 124(5):525-34. Epub 2008 Oct 19.
2008
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| 33 | HEY1, MSX1, NOTCH3, PHOX2B
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| The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma.
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| Revet I, Huizenga G, Chan A, Koster J, Volckmann R, van Sluis P, Ųra I, Versteeg R, Geerts D.
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| Exp Cell Res 314(4):707-19. Epub 2008 Jan 16.PMID: 18201699 2008
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| 34 | MSX1, OFC5
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| Association of MSX1 with nonsyndromic cleft lip and palate in a Colombian population.
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| Otero L, Gutiˇrrez S, Ch‡ves M, Vargas C, Bˇrmudez L.
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| Cleft Palate Craniofac J 44(6):653-6. 2007
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| 35 | LMX1A, MSX1
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| Identification of intrinsic determinants of midbrain dopamine neurons.
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| Andersson E, Tryggvason U, Deng Q, Friling S, Alekseenko Z, Robert B, Perlmann T, Ericson J.
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| Cell 124(2):393-405. 2006
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| 36 | MSX1, PIAS1
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| PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.
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| Lee H, Quinn JC, Prasanth KV, Swiss VA, Economides KD, Camacho MM, Spector DL, Abate-Shen C.
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| Genes Dev 20(7):784-94. 2006
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| 37 | MSX1, OFC5
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| MSX1 mutations contribute to nonsyndromic cleft lip in a Thai population.
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| Tongkobpetch S, Siriwan P, Shotelersuk V.
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| J Hum Genet 51(8):671-6. Epub 2006 Jul 26. 2006
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| 38 | MSX1, OFC5
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| Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.
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| Vieira AR, Avila JR, Daack-Hirsch S, Dragan E, Fˇlix TM, Rahimov F, Harrington J, Schultz RR, Watanabe Y, Johnson M, Fang J, O'Brien SE, Orioli IM, Castilla EE, Fitzpatrick DR, Jiang R, Marazita ML, Murray JC.
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| PLoS Genet 1(6):e64. Epub 2005 Dec 2. 2005
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| 39 | FOXE1, HTAT, IRF6, MSX1, NECTIN1, OFC2, OFC5, OFC6, OFC6, SATB2, SCD5, TP63
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| Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts.
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| Stanier P, Moore GE.
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| Hum Mol Genet 13 Spec No 1:R73-81. Epub 2004 Jan 13. 2004
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| 40 | MSX1, HIST1H1B
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| MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis.
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| Lee H, Habas R, Abate-Shen C.
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| Science 304(5677):1675-8. 2004
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| 41 | MSX1, FTA1
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| A novel MSX1 mutation in hypodontia.
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| De Muynck S, Schollen E, Matthijs G, Verdonck A, Devriendt K, Carels C.
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| Am J Med Genet 128A(4):401-3. 2004
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| 42 | MSX1, WHSCR, WHS
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| MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontia.
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| Nieminen P, Kotilainen J, Aalto Y, Knuutila S, Pirinen S, Thesleff I.
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| J Dent Res 82(12):1013-7. 2003
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| 43 | FTA1, MSX1, OFC5
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| Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate.
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| Jezewski PA, Vieira AR, Nishimura C, Ludwig B, Johnson M, O'Brien SE, Daack-Hirsch S, Schultz RE, Weber A, Nepomucena B, Romitti PA, Christensen K, Orioli IM, Castilla EE, Machida J, Natsume N, Murray JC.
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| J Med Genet 40(6):399-407. 2003
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| 44 | FTA1, MSX1
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| A nonsense mutation in MSX1 causes Witkop syndrome.
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| Jumlongras D, Bei M, Stimson JM, Wang WF, DePalma SR, Seidman CE, Felbor U, Maas R, Seidman JG, Olsen BR.
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| Am J Hum Genet 69(1):67-74. 2001
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| 45 | MSX1, PAG1
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| Msx1 gene overexpression induces G1 phase cell arrest in human ovarian cancer cell line OVCAR3.
|
| Park J, Park K, Kim S, Lee JH.
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| Biochem Biophys Res Commun 281(5):1234-40. 2001
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| 46 | ECTD3, MSX1
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| A nonsense mutation in MSX1 causes Witkop syndrome.
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| Jumlongras D, Bei M, Stimson JM, Wang WF, DePalma SR, Seidman CE, Felbor U, Maas R, Seidman JG, Olsen BR.
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| Am J Hum Genet. Jul;69(1):67-74. doi: 10.1086/321271. Epub 2001 May 16. 2001
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| 47 | FTA1, MSX1, OFC5
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| MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans.
|
| van den Boogaard MJ, Dorland M, Beemer FA, van Amstel HK.
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| Nat Genet 24(4):342-3. 2000
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| 48 | FTA1, MSX1
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| Absence of mutations in the homeodomain of the MSX1 gene in patients with hypodontia.
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| Scarel RM, Trevilatto PC, Di Hipolito O Jr, Camargo LE, Line SR.
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| Am J Med Genet 92(5):346-9. 2000
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| 49 | MSX1, TGFB3, OFC5
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| Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.
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| Lidral AC, Romitti PA, Basart AM, Doetschman T, Leysens NJ, Daack-Hirsch S, Semina EV, Johnson LR, Machida J, Burds A, Parnell TJ, Rubenstein JL, Murray JC.
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| Am J Hum Genet 63 : 557-568. 1998
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| 50 | MSX1
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| Polymorphic variants within the homeobox gene MSX1 : a candidate gene for developmental disorders.
|
| Hollway GE, et al.
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| Clin Genet 54 : 152-154. 1998
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| 51 | MSX1
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| Association between homeobox-containing gene MSX1 and the occurrence of limb deficiency.
|
| Hwang SJ, et al.
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| Am J Med Genet 75(4):419-23. 1998
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| 52 | MEOX1, MSX1, MSX2
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| The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.
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| Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C.
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| Differentiation 62(1):33-41.
1997
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| 53 | FTA1, MSX1
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| A human MSX1 homeodomain missense mutation causes selective tooth agenesis.
|
| Vastardis H, et al.
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| Nat Genet 13 : 417-422. 1996
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| 54 | EVC, MSX1
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| Exclusion of the MSX1 homeobox gene as the gene for the Ellis van Creveld syndrome in the Amish.
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| Ide SE, et al.
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| Hum Genet 98 : 572-575. 1996
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| 55 | EDA, MSX1
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| Two genes for missing teeth.
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| Thesleff I.
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| Nat Genet 13 : 379-380. 1996
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| 56 | MSX1, MSX2
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| Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy.
|
| Catron KM, et al.
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| Mech Dev 55(2):185-99. 1996
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| 57 | MSX1
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| Characterization of the human HOX7 cDNA and identification of polymorphic markers.
|
| Padanilam BJ, et al.
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| Hum Mol Genet 1 : 407-410. 1992
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| 58 | MSX1
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| Structure and sequence of the human homeobox gene HOX7.
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| Hewitt JE, Clark LN, Ivens A, Williamson R.
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| Genomics 11(3):670-8. 1991
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| 59 | MSX1, WHS, WHSCR
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| The human homeobox gene HOX7 maps to chromosome 4p16.1 and may be implicated in Wolf-Hirschhorn syndrome.
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| Ivens A, et al.
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| Hum Genet 84 : 473-476. 1990
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| 60 | MSX1
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| Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis.
|
| Robert B, Sassoon D, Jacq B, Gehring W, Buckingham M.
|
| EMBO J 8(1):91-100. 1989
|