| 1 | CREB1, IGF1, MSTN
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| The cAMP response element binding protein (CREB) is activated by insulin-like growth factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast.
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| Zuloaga R, Fuentes EN, Molina A, Valdés JA.
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| Biochem Biophys Res Commun 440(2):258-64. doi: 10.1016/j.bbrc.2013.09.067. Epub 2013 Sep 21.
2013
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| 2 | MET, MSTN, SMYD3
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| The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.
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| Proserpio V, Fittipaldi R, Ryall JG, Sartorelli V, Caretti G.
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| Genes Dev 27(11):1299-312. doi: 10.1101/gad.217240.113.
2013
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| 3 | AKIRIN1, MSTN
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| Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction.
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| Dong Y, Pan JS, Zhang L.
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| PLoS One 8(3):e58554. doi: 10.1371/journal.pone.0058554. Epub 2013 Mar 13.
2013
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| 4 | MSTN
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| Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cells.
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| Gao F, Kishida T, Ejima A, Gojo S, Mazda O.
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| Biochem Biophys Res Commun 431(2):309-14. doi: 10.1016/j.bbrc.2012.12.105. Epub 2013 Jan 4.
2013
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| 5 | MSTN
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| Expression of myostatin in neural cells of the olfactory system.
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| Iwasaki S, Miyake M, Watanabe H, Kitagawa E, Watanabe K, Ohwada S, Kitazawa H, Rose MT, Aso H.
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| Mol Neurobiol 47(1):1-8. doi: 10.1007/s12035-012-8342-1. Epub 2012 Sep 2.
2013
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| 6 | GDF11, MSTN, WFIKKN1, WFIKKN2
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| Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
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| Lee YS, Lee SJ.
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| Proc Natl Acad Sci U S A 110(39):E3713-22. doi: 10.1073/pnas.1309907110. Epub 2013 Sep 9.
2013
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| 7 | MSTN, UCN, UTS2
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| Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes.
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| Gruson D, Ginion A, Lause P, Ketelslegers JM, Thissen JP, Bertrand L.
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| Peptides 33(2):351-3. doi: 10.1016/j.peptides.2011.12.017. Epub 2012 Jan 8.
2012
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| 8 | DES, FBXO32, MSTN, VIM
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| Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.
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| Lokireddy S, Wijesoma IW, Sze SK, McFarlane C, Kambadur R, Sharma M.
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| Am J Physiol Cell Physiol 303(5):C512-29. doi: 10.1152/ajpcell.00402.2011. Epub 2012 Jun 6.
2012
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| 9 | FSTL3, MSTN
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| Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.
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| Cash JN, Angerman EB, Kattamuri C, Nolan K, Zhao H, Sidis Y, Keutmann HT, Thompson TB.
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| J Biol Chem 287(2):1043-53. doi: 10.1074/jbc.M111.270801. Epub 2011 Nov 3.
2012
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| 10 | MSTN
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| Myostatin facilitates slow and inhibits fast myosin heavy chain expression during myogenic differentiation.
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| Wang M, Yu H, Kim YS, Bidwell CA, Kuang S.
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| Biochem Biophys Res Commun 426(1):83-8. doi: 10.1016/j.bbrc.2012.08.040. Epub 2012 Aug 14.
2012
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| 11 | MSTN
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| The expression and potential functions of placental myostatin.
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| Peiris HN, Mitchell MD.
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| Placenta 33(11):902-7. doi: 10.1016/j.placenta.2012.06.021. Epub 2012 Jul 20. Review.
2012
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| 12 | MSTN
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| Myostatin is a novel tumoral factor that induces cancer cachexia.
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| Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.
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| Biochem J 446(1):23-36. doi: 10.1042/BJ20112024.
2012
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| 13 | MSTN
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| Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation.
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| Wang Q, McPherron AC.
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| J Physiol 590(Pt 9):2151-65. doi: 10.1113/jphysiol.2011.226001. Epub 2012 Mar 5.
2012
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| 14 | MSTN
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| Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-β signaling by decorin.
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| Zhang C, Tan CK, McFarlane C, Sharma M, Tan NS, Kambadur R.
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| Am J Physiol Cell Physiol 302(8):C1213-25. doi: 10.1152/ajpcell.00179.2011. Epub 2012 Jan 25.
2012
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| 15 | MSTN, TDGF1
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| Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.
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| Guardiola O, Lafuste P, Brunelli S, Iaconis S, Touvier T, Mourikis P, De Bock K, Lonardo E, Andolfi G, Bouché A, Liguori GL, Shen MM, Tajbakhsh S, Cossu G, Carmeliet P, Minchiotti G.
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| Proc Natl Acad Sci U S A 109(47):E3231-40. doi: 10.1073/pnas.1204017109. 2012
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| 16 | MSTN, MYH1, MYH4, MYH7
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| Myostatin facilitates slow and inhibits fast myosin heavy chain expression during myogenic differentiation
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| Wang M, Yu H, Kim YS, Bidwell CA, Kuang S.
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| Biochem Biophys Res Commun. Sep 14;426(1):83-8. doi: 10.1016/j.bbrc.2012.08.040. Epub 2012 Aug 14. 2012
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| 17 | MSTN
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| Myostatin induces autophagy in skeletal muscle in vitro.
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| Lee JY, Hopkinson NS, Kemp PR.
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| Biochem Biophys Res Commun 415(4):632-6. doi: 10.1016/j.bbrc.2011.10.124. Epub 2011 Nov 2.
2011
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| 18 | MSTN
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| Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development.
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| Chisada S, Okamoto H, Taniguchi Y, Kimori Y, Toyoda A, Sakaki Y, Takeda S, Yoshiura Y.
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| Dev Biol 359(1):82-94. doi: 10.1016/j.ydbio.2011.08.027. Epub 2011 Sep 7.
2011
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| 19 | FBXO32, MSTN
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| Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.
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| Lokireddy S, McFarlane C, Ge X, Zhang H, Sze SK, Sharma M, Kambadur R.
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| Mol Endocrinol 25(11):1936-49. doi: 10.1210/me.2011-1124. Epub 2011 Sep 29.
2011
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| 20 | KLF10, MSTN
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| Possible role of TIEG1 as a feedback regulator of myostatin and TGF-beta in myoblasts.
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| Miyake M, Hayashi S, Iwasaki S, Chao G, Takahashi H, Watanabe K, Ohwada S, Aso H, Yamaguchi T.
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| Biochem Biophys Res Commun 393(4):762-6. Epub 2010 Feb 18.PMID: 20171187 2010
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| 21 | MSTN
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| Myostatin Expression is Increased by Food Deprivation in a Muscle-Specific Manner and Contributes to Muscle Atrophy during Prolonged Food Deprivation in Mice.
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| Allen DL, Cleary AS, Lindsay SF, Loh A, Reed JM.
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| J Appl Physiol Appl Physiol. 2010 Jul 1. [Epub ahead of print]PMID: 20595541 2010
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| 22 | MSTN
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| Role of myostatin (GDF-8) signaling in the human anterior cruciate ligament.
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| Fulzele S, Arounleut P, Cain M, Herberg S, Hunter M, Wenger K, Hamrick MW.
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| J Orthop Res 28(8):1113-8.PMID: 20186835 2010
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| 23 | MSTN
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| Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure.
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| Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD.
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| Circulation 121(3):419-25. Epub 2010 Jan 11.PMID: 20065166 2010
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| 24 | FSTL3, MSTN
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| Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming.
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| Peiris HN, Ponnampalam AP, Osepchook CC, Mitchell MD, Green MP.
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| Am J Physiol Endocrinol Metab 298(4):E854-61. Epub 2010 Jan 26.
2010
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| 25 | BMP2, BMP4, GDF11, MSTN, TGFB1, WFIKKN1, WFIKKN2
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| WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity.
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| Szláma G, Kondás K, Trexler M, Patthy L.
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| FEBS J 277(24):5040-50. doi: 10.1111/j.1742-4658.2010.07909.x. Epub 2010 Nov 5.
2010
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| 26 | DEL2Q31, MSTN
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| 2q31.2q32.3 deletion syndrome: Report of an adult patient.
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| Prontera P, Bernardini L, Stangoni G, Capalbo A, Rogaia D, Ardisia C, Novelli A, Dallapiccola B, Donti E.
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| Am J Med Genet A 149A(4):706-12.
2009
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| 27 | MSTN
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| Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt.
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| Morissette MR, Cook SA, Buranasombati C, Rosenberg MA, Rosenzweig A.
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| Am J Physiol Cell Physiol 297(5):C1124-32. Epub 2009 Sep 16.PMID: 19759331 2009
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| 28 | MSTN
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| Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.
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| Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.
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| PLoS One 4(3):e4937. Epub 2009 Mar 19.PMID: 19295913 2009
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| 29 | MSTN
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| Myostatin directly regulates skeletal muscle fibrosis.
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| Li ZB, Kollias HD, Wagner KR.
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| J Biol Chem 283(28):19371-8. Epub 2008 May 3. 2008
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| 30 | MSTN
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| Myostatin promotes the terminal differentiation of embryonic muscle progenitors.
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| Manceau M, Gros J, Savage K, Thomé V, McPherron A, Paterson B, Marcelle C.
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| Genes Dev 22(5):668-81.PMID: 18316481 2008
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| 31 | MSTN
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| Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
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| Feldman BJ, Streeper RS, Farese RV Jr, Yamamoto KR.
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| Proc Natl Acad Sci U S A 103(42):15675-80. Epub 2006 Oct 9. 2006
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| 32 | MSTN
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| Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth.
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| Saunders MA, Good JM, Lawrence EC, Ferrell RE, Li WH, Nachman MW.
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| Am J Hum Genet 79(6):1089-97. Epub 2006 Oct 10. 2006
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| 33 | GPD1, GRB14, MSTN
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| GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.
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| Park JJ, Berggren JR, Hulver MW, Houmard JA, Hoffman EP.
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| Physiol Genomics 27(2):114-21. Epub 2006 Jul 18. 2006
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| 34 | MSTN, ACVR2A, ACVR2B
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| Regulation of muscle growth by multiple ligands signaling through activin type II receptors.
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| Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, Wright JF, Barker C, Ehrmantraut G, Holmstrom J, Trowell B, Gertz B, Jiang MS, Sebald SM, Matzuk M, Li E, Liang LF, Quattlebaum E, Stotish RL, Wolfman NM.
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| Proc Natl Acad Sci U S A 102(50):18117-22. Epub 2005 Dec 5. 2005
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| 35 | MSTN, SGTA
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| hSGT interacts with the N-terminal region of myostatin.
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| Wang H, Zhang Q, Zhu D.
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| Biochem Biophys Res Commun 311(4):877-83.
2003
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| 36 | MSTN
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| Myostatin knockout in mice increases myogenesis and decreases adipogenesis.
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| Lin J, Arnold HB, Della-Fera MA, Azain MJ, Hartzell DL, Baile CA.
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| Biochem Biophys Res Commun 291(3):701-6. 2002
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| 37 | MSTN
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| Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes.
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| Ferrell RE, Conte V, Lawrence EC, Roth SM, Hagberg JM, Hurley BF.
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| Genomics 62(2):203-7. 1999
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| 38 | BMP1, BMP15, BMP2, BMP3, GDF10, BMP4, BMP5, BMP6, BMP7, BMPR1A, BMPR1APS1, BMPR1B, BMPR2, GDF1, GDF2, GDF3, GDF5, MSTN, GDF9
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| Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
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| Constam DB, Robertson EJ.
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| J Cell Biol 144(1):139-49. 1999
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| 39 | MSTN
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| Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.
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| Gonzalez-Cadavid NF, et al.
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| Proc Natl Acad Sci U S A 95(25):14938-43. 1998
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| 40 | MSTN
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| Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.
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| McPherron AC, et al.
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| Nature 387 : 83-90. 1997
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| 41 | MSTN
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| A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle.
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| Grobet L, et al.
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| Nat Genet 17 : 71-74. 1997
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| 42 | MSTN
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| Comparative genome map of human and cattle.
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| Solinas-Toldo S, et al.
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| Genomics 27 : 489-496. 1995
|