| 1 | MSH2, MSH3, MSH6
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| Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
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| Radhakrishnan R, Li Y, Xiang S, Yuan F, Yuan Z, Telles E, Fang J, Coppola D, Shibata D, Lane WS, Zhang Y, Zhang X, Seto E.
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| J Biol Chem 290(37):22795-804. doi: 10.1074/jbc.M114.612945. Epub 2015 Jul 28.
2015
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| 2 | MSH2, MSH6
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| Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate.
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| Honda M, Okuno Y, Hengel SR, Martín-López JV, Cook CP, Amunugama R, Soukup RJ, Subramanyam S, Fishel R, Spies M.
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| Proc Natl Acad Sci U S A 111(3):E316-25. doi: 10.1073/pnas.1312988111. Epub 2014 Jan 6.
2014
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| 3 | MSH6
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| Human MSH6 Deficiency Is Associated with Impaired Antibody Maturation.
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| Gardès P, Forveille M, Alyanakian MA, Aucouturier P, Ilencikova D, Leroux D, Rahner N, Mazerolles F, Fischer A, Kracker S, Durandy A.
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| J Immunol 188(4):2023-9. Epub 2012 Jan 16.
2012
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| 4 | MSH2, MSH6
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| Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.
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| Kantelinen J, Kansikas M, Candelin S, Hampel H, Smith B, Holm L, Kariola R, Nyström M.
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| Hum Mutat 33(8):1294-301. doi: 10.1002/humu.22119. Epub 2012 Jun 11.
2012
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| 5 | HNPCC5, MSH6
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| Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
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| Raskin L, Schwenter F, Freytsis M, Tischkowitz M, Wong N, Chong G, Narod S, Levine D, Bogomolniy F, Aronson M, Thibodeau S, Hunt K, Rennert G, Gallinger S, Gruber S, Foulkes W.
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| Clin Genet 79(6):512-522. doi: 10.1111/j.1399-0004.2010.01594.x. Epub 2010 Dec 14.
2011
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| 6 | BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51c, TP53
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| Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
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| Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
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| Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17.
2011
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| 7 | MSH2, MSH6
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| Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex.
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| Hargreaves VV, Shell SS, Mazur DJ, Hess MT, Kolodner RD.
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| J Biol Chem 285(12):9301-10. Epub 2010 Jan 20.PMID: 20089866 2010
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| 8 | MSH6
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| Risks of Lynch syndrome cancers for MSH6 mutation carriers.
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| Baglietto L, Lindor NM, Dowty JG, White DM, Wagner A, Gomez Garcia EB, Vriends AH; Dutch Lynch Syndrome Study Group, Cartwright NR, Barnetson RA, Farrington SM, Tenesa A, Hampel H, Buchanan D, Arnold S, Young J, Walsh MD, Jass J, Macrae F, Antill Y, Winship IM, Giles GG, Goldblatt J, Parry S, Suthers G, Leggett B, Butz M, Aronson M, Poynter JN, Baron JA, Le Marchand L, Haile R, Gallinger S, Hopper JL, Potter J, de la Chapelle A, Vasen HF, Dunlop MG, Thibodeau SN, Jenkins MA.
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| J Natl Cancer Inst 102(3):193-201. Epub 2009 Dec 22.PMID: 20028993 2010
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| 9 | MSH2, MSH6
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| Nucleosome remodeling by hMSH2-hMSH6.
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| Javaid S, Manohar M, Punja N, Mooney A, Ottesen JJ, Poirier MG, Fishel R.
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| Mol Cell 36(6):1086-94.PMID: 20064472 2009
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| 10 | MLH1, MSH2, MSH6, PMS2
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| Germ-line mutations in mismatch repair genes associated with prostate cancer.
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| Grindedal EM, Møller P, Eeles R, Stormorken AT, Bowitz-Lothe IM, Landrø SM, Clark N, Kvåle R, Shanley S, Maehle L.
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| Cancer Epidemiol Biomarkers Prev 18(9):2460-7. Epub 2009 Sep 1.PMID: 19723918 2009
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| 11 | MSH6
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| MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer.
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| Curtin K, Samowitz WS, Wolff RK, Caan BJ, Ulrich CM, Potter JD, Slattery ML.
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| Mol Carcinog 48(11):989-94.PMID: 19582761 2009
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| 12 | MSH6, HNPCC5, MUTYH
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| No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
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| Steinke V, Rahner N, Morak M, Keller G, Schackert HK, Gšrgens H, Schmiegel W, Royer-Pokora B, Dietmaier W, Kloor M, Engel C, Propping P, Aretz S; for The German HNPCC Consortium.
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| Eur J Hum Genet 16(5):587-592. Epub 2008 Feb 27. 2008
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| 13 | CMMRD, MLH1, MSH2, MSH6, PMS2
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| Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg?
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| Wimmer K, Etzler J.
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| Hum Genet 124(2):105-22. Epub 2008 Aug 18. Review. 2008
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| 14 | APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
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| Inherited susceptibility to common cancers.
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| Foulkes WD.
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| N Engl J Med 359(20):2143-53. No abstract available.
2008
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| 15 | CMMRD, MSH6
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| Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.
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| Cyr JL, Heinen CD.
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| J Biol Chem 283(46):31641-8. Epub 2008 Sep 11.
2008
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| 16 | MSH6
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| Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA.
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| Laguri C, Duband-Goulet I, Friedrich N, Axt M, Belin P, Callebaut I, Gilquin B, Zinn-Justin S, Couprie J.
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| Biochemistry 47(23):6199-207. Epub 2008 May 17.PMID: 18484749 2008
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| 17 | MSH6
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| Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.
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| Barrera-Oro J, Liu TY, Gorden E, Kucherlapati R, Shao C, Tischfield JA.
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| Mutat Res 642(1-2):74-9. Epub 2008 Apr 30.
2008
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| 18 | HNPCC1, HNPCC2, HNPCC3, HNPCC4, HNPCC5, HNPCC6, HNPCC7, MLH1, MSH2, MSH6, PMS2
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| Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).
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| Vasen HF, Moslein G, Alonso A, Bernstein I, Bertario L, Blanco I, Burn J, Capella G, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Mecklin JP, Moller P, Nagengast F, Parc Y, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Wijnen J.
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| J Med Genet 44(6):353-62. Epub 2007 Feb 27. 2007
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| 19 | MSH6
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| Multiple functions for the N-terminal region of Msh6.
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| Clark AB, Deterding L, Tomer KB, Kunkel TA.
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| Nucleic Acids Res 35(12):4114-23. Epub 2007 Jun 12. 2007
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| 20 | CMMRD, MLH1, MSH2, MSH6, PMS2
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| Biallelic germline mutations of mismatch-repair genes: a possible cause for multiple pediatric malignancies.
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| Poley JW, Wagner A, Hoogmans MM, Menko FH, Tops C, Kros JM, Reddingius RE, Meijers-Heijboer H, Kuipers EJ, Dinjens WN; Rotterdam Initiative on Gastrointestinal Hereditary Tumors.
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| Cancer 109(11):2349-56.
2007
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| 21 | MSH6
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| MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease.
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| Pinto C, Veiga I, Pinheiro M, Mesquita B, Jeronimo C, Sousa O, Fragoso M, Santos L, Moreira-Dias L, Baptista M, Lopes C, Castedo S, Teixeira MR.
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| Br J Cancer 95(6):752-6. Epub 2006 Aug 29. 2006
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| 22 | BRIX1, CAPNS1, MSH6, RAI14, RNF39, SMC4, ST6GALNAC5, TMSB10
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| Gene expression profiling of dysplastic differentiation in cervical epithelial cells harboring human papillomavirus 16.
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| Ranamukhaarachchi DG, Unger ER, Vernon SD, Lee D, Rajeevan MS.
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| Genomics 85(6):727-38. 2005
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| 23 | MSH2, MLH1, MSH6, PMS2, HNPCC1, HNPCC2, HNPCC5, HNPCC4
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| Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC).
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| van der Klift H, Wijnen J, Wagner A, Verkuilen P, Tops C, Otway R, Kohonen-Corish M, Vasen H, Oliani C, Barana D, Moller P, Delozier-Blanchet C, Hutter P, Foulkes W, Lynch H, Burn J, Moslein G, Fodde R.
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| Genes Chromosomes Cancer 44(2):123-38. 2005
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| 24 | MSH2, MLH1, MSH6, PMS2, MLH3, PMS1, HNPCC1, HNPCC2, HNPCC5, HNPCC4, HNPCC3, HNPCC6
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| Lynch syndrome genes.
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| Peltomaki P.
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| Fam Cancer 4(3):227-32. Review. 2005
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| 25 | MSH2, MSH6, HMGB1
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| Evidence for involvement of HMGB1 protein in human DNA mismatch repair.
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| Yuan F, Gu L, Guo S, Wang C, Li GM.
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| J Biol Chem 279(20):20935-40. Epub 2004 Mar 9. 2004
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| 26 | HNPCC1, HNPCC2, HNPCC3, HNPCC4, HNPCC5, HNPCC6, HNPCC7, MLH1, MSH2, MSH6, PMS2
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| Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database.
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| Peltomaki P, Vasen H.
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| Dis Markers 20(4-5):269-76. Review. 2004
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| 27 | MSH6
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| Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome.
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| Plaschke J, Ruschoff J, Schackert HK.
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| J Med Genet 40(8):597-600. 2003
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| 28 | BLM, MSH6
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| The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.
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| Pedrazzi G, Bachrati CZ, Selak N, Studer I, Petkovic M, Hickson ID, Jiricny J, Stagljar I.
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| Biol Chem 384(8):1155-64. 2003
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| 29 | MSH6
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| Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant.
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| Berends MJ, Wu Y, Sijmons RH, Mensink RG, van der Sluis T, Hordijk-Hos JM, de Vries EG, Hollema H, Karrenbeld A, Buys CH, van der Zee AG, Hofstra RM, Kleibeuker JH.
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| Am J Hum Genet 70(1):26-37. 2002
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| 30 | MSH6
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| Identification and functional characterization of the promoter region of the human MSH6 gene.
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| Szadkowski M, Jiricny J.
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| Genes Chromosomes Cancer 33(1):36-46. 2002
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| 31 | HNPCC5, MSH6
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| Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree.
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| Wagner A, Hendriks Y, Meijers-Heijboer EJ, de Leeuw WJ, Morreau H, Hofstra R, Tops C, Bik E, Brocker-Vriends AH, van Der Meer C, Lindhout D, Vasen HF, Breuning MH, Cornelisse CJ, van Krimpen C, Niermeijer MF, Zwinderman AH, Wijnen J, Fodde R.
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| J Med Genet 38(5):318-22. 2001
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| 32 | MSH6
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| Missense mutation of the hMSH6 and p53 genes in sporadic urothelial transitional cell carcinoma.
|
| Furihata M, Shuin T, Takeuchi T, Sonobe H, Ohtsuki Y, Akiyama Y, Yuasa Y.
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| Int J Oncol 16(3):491-6. 2000
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| 33 | MSH3, MSH6
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| The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
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| Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R.
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| Cancer Res 60(4):803-7. 2000
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| 34 | MLH1, MSH6, PMS1, PMS2, MSH2
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| Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer.
|
| Wang Q, et al.
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| Hum Genet 105(1-2):79-85. 1999
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| 35 | MSH6
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| Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer.
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| Verma L, et al.
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| J Med Genet 36(9):678-82 1999
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| 36 | HNPCC5, MSH6
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| hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden.
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| Planck M, Koul A, Fernebro E, Borg A, Kristoffersson U, Olsson H, Wenngren E, Mangell P, Nilbert M.
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| Int J Cancer 83(2):197-202 1999
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| 37 | D2S123, D2S1248, D2S2153, D2S2227, D2S2251, D2S2292, D2S2378, D2S391, FSHR, LHCGR, MSH2, MSH6, PIGF, RPS27A, SPTBN1, VRK2
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| Genomic mapping of chromosomal region 2p15-p21 (D2S378-D2S391): integration of Genemap'98 within a framework of yeast and bacterial artificial chromosomes.
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| Kirschner LS, Taymans SE, Pack S, Pak E, Pike BL, Chandrasekharappa SC, Zhuang Z, Stratakis CA.
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| Genomics 62(1):21-33 1999
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| 38 | APC, BRCA1, DPP4, MLH1, MSH2, MSH6, NF1, PMS2, RB1, TP53, VHL, WT1, FAP
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| Tumour suppressor gene mutations in humans and mice : parallels and contrasts.
|
| Hooper ML.
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| EMBO J 17(23):6783-9. 1998
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| 39 | MSH6
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| Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.
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| Imai Y, Inoue T, Ishikawa T.
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| Int J Cancer 78 : 576-580. 1998
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| 40 | FGFR3, MSH6, NSD2
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| The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.
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| Chesi M, et al.
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| Blood 92 : 3025-3034. 1998
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| 41 | MSH6, HNPCC1, MSH2, MTS
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| Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6.
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| Schmutte C, et al.
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| Cancer Res 58 : 5023-5026. 1998
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| 42 | MSH6, MLH1, MSH2, MSH3
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| Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer.
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| Benachenhou N, et al.
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| Carcinogenesis 19 : 1925-1929. 1998
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| 43 | MSH6, HNPCC5
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| Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
|
| Miyaki M, Konishi M, Tanaka K, Kikuchi-Yanoshita R, Muraoka M, Yasuno M, Igari T, Koike M, Chiba M, Mori T.
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| Nat Genet 17(3):271-2. 1997
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| 44 | MSH6
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| Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
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| Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, Kolodner R, Kucherlapati R.
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| Cell 91(4):467-77. 1997
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| 45 | MSH6, HNPCC2, HNPCC5, MSH3
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| Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas.
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| Yin J, Kong D, Wang S, Zou TT, Souza RF, Smolinski KN, Lynch PM, Hamilton SR, Sugimura H, Powell SM, Young J, Abraham JM, Meltzer SJ.
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| Hum Mutat 10(6):474-8. 1997
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| 46 | MSH6
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| Alternative splicing of GTBP in normal human tissues.
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| Shiwaku HO, Wakatsuki S, Mori Y, Fukushige S, Horii A.
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| DNA Res 4(5):359-62. 1997
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| 47 | MSH6, MSH2
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| The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch.
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| Gradia S, Acharya S, Fishel R.
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| Cell 91(7):995-1005. 1997
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| 48 | MSH6, MSH2
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| Genetic and biochemical analysis of Msh2p-Msh6p : role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.
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| Alani E, et al.
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| Mol Cell Biol 17 : 2436-2447. 1997
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| 49 | MSH2, MSH3, MSH6
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| MutS homologs in mammalian cells.
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| Fishel R, Wilson T.
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| Curr Opin Genet Dev 7(1):105-13. Review. 1997
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| 50 | MSH6
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| Molecular cloning of the N-terminus of GTBP.
|
| Nicolaides NC, et al.
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| Genomics 31 : 395-397. 1996
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| 51 | MSH6, MSH2
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| Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
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| Duckett DR, et al.
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| Proc Natl Acad Sci U S A 93 : 6443-6447. 1996
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| 52 | MSH2, MSH3, MSH6
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| hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
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| Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R.
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| Proc Natl Acad Sci U S A 93(24):13629-34. 1996
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| 53 | MSH6
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| GTBP, a 160-Kilodalton protein essential for mismatch-binding activity in human cells.
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| Palombo F, et al.
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| Science 268 : 1912-1914. 1995
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| 54 | MSH6
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| Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
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| Drummond JT, et al.
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| Science 268 : 1909-1912. 1995
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| 55 | MSH6
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| Mutations of GTBP in genetically unstable cells.
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| Papadopoulos N, et al.
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| Science 268 : 1915-1917. 1995
|