Citations for
1MSH2, MSH3, MSH6
Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
Radhakrishnan R, Li Y, Xiang S, Yuan F, Yuan Z, Telles E, Fang J, Coppola D, Shibata D, Lane WS, Zhang Y, Zhang X, Seto E.
J Biol Chem 290(37):22795-804. doi: 10.1074/jbc.M114.612945. Epub 2015 Jul 28. 2015
2MSH2, MSH6
Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate.
Honda M, Okuno Y, Hengel SR, Martín-López JV, Cook CP, Amunugama R, Soukup RJ, Subramanyam S, Fishel R, Spies M.
Proc Natl Acad Sci U S A 111(3):E316-25. doi: 10.1073/pnas.1312988111. Epub 2014 Jan 6. 2014
3MSH6
Human MSH6 Deficiency Is Associated with Impaired Antibody Maturation.
Gardès P, Forveille M, Alyanakian MA, Aucouturier P, Ilencikova D, Leroux D, Rahner N, Mazerolles F, Fischer A, Kracker S, Durandy A.
J Immunol 188(4):2023-9. Epub 2012 Jan 16. 2012
4MSH2, MSH6
Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.
Kantelinen J, Kansikas M, Candelin S, Hampel H, Smith B, Holm L, Kariola R, Nyström M.
Hum Mutat 33(8):1294-301. doi: 10.1002/humu.22119. Epub 2012 Jun 11. 2012
5HNPCC5, MSH6
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
Raskin L, Schwenter F, Freytsis M, Tischkowitz M, Wong N, Chong G, Narod S, Levine D, Bogomolniy F, Aronson M, Thibodeau S, Hunt K, Rennert G, Gallinger S, Gruber S, Foulkes W.
Clin Genet 79(6):512-522. doi: 10.1111/j.1399-0004.2010.01594.x. Epub 2010 Dec 14. 2011
6BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51c, TP53
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17. 2011
7MSH2, MSH6
Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex.
Hargreaves VV, Shell SS, Mazur DJ, Hess MT, Kolodner RD.
J Biol Chem 285(12):9301-10. Epub 2010 Jan 20.PMID: 20089866 2010
8MSH6
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
Baglietto L, Lindor NM, Dowty JG, White DM, Wagner A, Gomez Garcia EB, Vriends AH; Dutch Lynch Syndrome Study Group, Cartwright NR, Barnetson RA, Farrington SM, Tenesa A, Hampel H, Buchanan D, Arnold S, Young J, Walsh MD, Jass J, Macrae F, Antill Y, Winship IM, Giles GG, Goldblatt J, Parry S, Suthers G, Leggett B, Butz M, Aronson M, Poynter JN, Baron JA, Le Marchand L, Haile R, Gallinger S, Hopper JL, Potter J, de la Chapelle A, Vasen HF, Dunlop MG, Thibodeau SN, Jenkins MA.
J Natl Cancer Inst 102(3):193-201. Epub 2009 Dec 22.PMID: 20028993 2010
9MSH2, MSH6
Nucleosome remodeling by hMSH2-hMSH6.
Javaid S, Manohar M, Punja N, Mooney A, Ottesen JJ, Poirier MG, Fishel R.
Mol Cell 36(6):1086-94.PMID: 20064472 2009
10MLH1, MSH2, MSH6, PMS2
Germ-line mutations in mismatch repair genes associated with prostate cancer.
Grindedal EM, Møller P, Eeles R, Stormorken AT, Bowitz-Lothe IM, Landrø SM, Clark N, Kvåle R, Shanley S, Maehle L.
Cancer Epidemiol Biomarkers Prev 18(9):2460-7. Epub 2009 Sep 1.PMID: 19723918 2009
11MSH6
MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer.
Curtin K, Samowitz WS, Wolff RK, Caan BJ, Ulrich CM, Potter JD, Slattery ML.
Mol Carcinog 48(11):989-94.PMID: 19582761 2009
12MSH6, HNPCC5, MUTYH
No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
Steinke V, Rahner N, Morak M, Keller G, Schackert HK, Gšrgens H, Schmiegel W, Royer-Pokora B, Dietmaier W, Kloor M, Engel C, Propping P, Aretz S; for The German HNPCC Consortium.
Eur J Hum Genet 16(5):587-592. Epub 2008 Feb 27. 2008
13CMMRD, MLH1, MSH2, MSH6, PMS2
Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg?
Wimmer K, Etzler J.
Hum Genet 124(2):105-22. Epub 2008 Aug 18. Review. 2008
14APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
Inherited susceptibility to common cancers.
Foulkes WD.
N Engl J Med 359(20):2143-53. No abstract available. 2008
15CMMRD, MSH6
Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.
Cyr JL, Heinen CD.
J Biol Chem 283(46):31641-8. Epub 2008 Sep 11. 2008
16MSH6
Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA.
Laguri C, Duband-Goulet I, Friedrich N, Axt M, Belin P, Callebaut I, Gilquin B, Zinn-Justin S, Couprie J.
Biochemistry 47(23):6199-207. Epub 2008 May 17.PMID: 18484749 2008
17MSH6
Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.
Barrera-Oro J, Liu TY, Gorden E, Kucherlapati R, Shao C, Tischfield JA.
Mutat Res 642(1-2):74-9. Epub 2008 Apr 30. 2008
18HNPCC1, HNPCC2, HNPCC3, HNPCC4, HNPCC5, HNPCC6, HNPCC7, MLH1, MSH2, MSH6, PMS2
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).
Vasen HF, Moslein G, Alonso A, Bernstein I, Bertario L, Blanco I, Burn J, Capella G, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Mecklin JP, Moller P, Nagengast F, Parc Y, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Wijnen J.
J Med Genet 44(6):353-62. Epub 2007 Feb 27. 2007
19MSH6
Multiple functions for the N-terminal region of Msh6.
Clark AB, Deterding L, Tomer KB, Kunkel TA.
Nucleic Acids Res 35(12):4114-23. Epub 2007 Jun 12. 2007
20CMMRD, MLH1, MSH2, MSH6, PMS2
Biallelic germline mutations of mismatch-repair genes: a possible cause for multiple pediatric malignancies.
Poley JW, Wagner A, Hoogmans MM, Menko FH, Tops C, Kros JM, Reddingius RE, Meijers-Heijboer H, Kuipers EJ, Dinjens WN; Rotterdam Initiative on Gastrointestinal Hereditary Tumors.
Cancer 109(11):2349-56. 2007
21MSH6
MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease.
Pinto C, Veiga I, Pinheiro M, Mesquita B, Jeronimo C, Sousa O, Fragoso M, Santos L, Moreira-Dias L, Baptista M, Lopes C, Castedo S, Teixeira MR.
Br J Cancer 95(6):752-6. Epub 2006 Aug 29. 2006
22BRIX1, CAPNS1, MSH6, RAI14, RNF39, SMC4, ST6GALNAC5, TMSB10
Gene expression profiling of dysplastic differentiation in cervical epithelial cells harboring human papillomavirus 16.
Ranamukhaarachchi DG, Unger ER, Vernon SD, Lee D, Rajeevan MS.
Genomics 85(6):727-38. 2005
23MSH2, MLH1, MSH6, PMS2, HNPCC1, HNPCC2, HNPCC5, HNPCC4
Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC).
van der Klift H, Wijnen J, Wagner A, Verkuilen P, Tops C, Otway R, Kohonen-Corish M, Vasen H, Oliani C, Barana D, Moller P, Delozier-Blanchet C, Hutter P, Foulkes W, Lynch H, Burn J, Moslein G, Fodde R.
Genes Chromosomes Cancer 44(2):123-38. 2005
24MSH2, MLH1, MSH6, PMS2, MLH3, PMS1, HNPCC1, HNPCC2, HNPCC5, HNPCC4, HNPCC3, HNPCC6
Lynch syndrome genes.
Peltomaki P.
Fam Cancer 4(3):227-32. Review. 2005
25MSH2, MSH6, HMGB1
Evidence for involvement of HMGB1 protein in human DNA mismatch repair.
Yuan F, Gu L, Guo S, Wang C, Li GM.
J Biol Chem 279(20):20935-40. Epub 2004 Mar 9. 2004
26HNPCC1, HNPCC2, HNPCC3, HNPCC4, HNPCC5, HNPCC6, HNPCC7, MLH1, MSH2, MSH6, PMS2
Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database.
Peltomaki P, Vasen H.
Dis Markers 20(4-5):269-76. Review. 2004
27MSH6
Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome.
Plaschke J, Ruschoff J, Schackert HK.
J Med Genet 40(8):597-600. 2003
28BLM, MSH6
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.
Pedrazzi G, Bachrati CZ, Selak N, Studer I, Petkovic M, Hickson ID, Jiricny J, Stagljar I.
Biol Chem 384(8):1155-64. 2003
29MSH6
Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant.
Berends MJ, Wu Y, Sijmons RH, Mensink RG, van der Sluis T, Hordijk-Hos JM, de Vries EG, Hollema H, Karrenbeld A, Buys CH, van der Zee AG, Hofstra RM, Kleibeuker JH.
Am J Hum Genet 70(1):26-37. 2002
30MSH6
Identification and functional characterization of the promoter region of the human MSH6 gene.
Szadkowski M, Jiricny J.
Genes Chromosomes Cancer 33(1):36-46. 2002
31HNPCC5, MSH6
Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree.
Wagner A, Hendriks Y, Meijers-Heijboer EJ, de Leeuw WJ, Morreau H, Hofstra R, Tops C, Bik E, Brocker-Vriends AH, van Der Meer C, Lindhout D, Vasen HF, Breuning MH, Cornelisse CJ, van Krimpen C, Niermeijer MF, Zwinderman AH, Wijnen J, Fodde R.
J Med Genet 38(5):318-22. 2001
32MSH6
Missense mutation of the hMSH6 and p53 genes in sporadic urothelial transitional cell carcinoma.
Furihata M, Shuin T, Takeuchi T, Sonobe H, Ohtsuki Y, Akiyama Y, Yuasa Y.
Int J Oncol 16(3):491-6. 2000
33MSH3, MSH6
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R.
Cancer Res 60(4):803-7. 2000
34MLH1, MSH6, PMS1, PMS2, MSH2
Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer.
Wang Q, et al.
Hum Genet 105(1-2):79-85. 1999
35MSH6
Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer.
Verma L, et al.
J Med Genet 36(9):678-82 1999
36HNPCC5, MSH6
hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden.
Planck M, Koul A, Fernebro E, Borg A, Kristoffersson U, Olsson H, Wenngren E, Mangell P, Nilbert M.
Int J Cancer 83(2):197-202 1999
37D2S123, D2S1248, D2S2153, D2S2227, D2S2251, D2S2292, D2S2378, D2S391, FSHR, LHCGR, MSH2, MSH6, PIGF, RPS27A, SPTBN1, VRK2
Genomic mapping of chromosomal region 2p15-p21 (D2S378-D2S391): integration of Genemap'98 within a framework of yeast and bacterial artificial chromosomes.
Kirschner LS, Taymans SE, Pack S, Pak E, Pike BL, Chandrasekharappa SC, Zhuang Z, Stratakis CA.
Genomics 62(1):21-33 1999
38APC, BRCA1, DPP4, MLH1, MSH2, MSH6, NF1, PMS2, RB1, TP53, VHL, WT1, FAP
Tumour suppressor gene mutations in humans and mice : parallels and contrasts.
Hooper ML.
EMBO J 17(23):6783-9. 1998
39MSH6
Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.
Imai Y, Inoue T, Ishikawa T.
Int J Cancer 78 : 576-580. 1998
40FGFR3, MSH6, WHSC1
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.
Chesi M, et al.
Blood 92 : 3025-3034. 1998
41MSH6, HNPCC1, MSH2, MTS
Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6.
Schmutte C, et al.
Cancer Res 58 : 5023-5026. 1998
42MSH6, MLH1, MSH2, MSH3
Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer.
Benachenhou N, et al.
Carcinogenesis 19 : 1925-1929. 1998
43MSH6, HNPCC5
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
Miyaki M, Konishi M, Tanaka K, Kikuchi-Yanoshita R, Muraoka M, Yasuno M, Igari T, Koike M, Chiba M, Mori T.
Nat Genet 17(3):271-2. 1997
44MSH6
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, Kolodner R, Kucherlapati R.
Cell 91(4):467-77. 1997
45MSH6, HNPCC2, HNPCC5, MSH3
Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas.
Yin J, Kong D, Wang S, Zou TT, Souza RF, Smolinski KN, Lynch PM, Hamilton SR, Sugimura H, Powell SM, Young J, Abraham JM, Meltzer SJ.
Hum Mutat 10(6):474-8. 1997
46MSH6
Alternative splicing of GTBP in normal human tissues.
Shiwaku HO, Wakatsuki S, Mori Y, Fukushige S, Horii A.
DNA Res 4(5):359-62. 1997
47MSH6, MSH2
The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch.
Gradia S, Acharya S, Fishel R.
Cell 91(7):995-1005. 1997
48MSH6, MSH2
Genetic and biochemical analysis of Msh2p-Msh6p : role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.
Alani E, et al.
Mol Cell Biol 17 : 2436-2447. 1997
49MSH2, MSH3, MSH6
MutS homologs in mammalian cells.
Fishel R, Wilson T.
Curr Opin Genet Dev 7(1):105-13. Review. 1997
50MSH6
Molecular cloning of the N-terminus of GTBP.
Nicolaides NC, et al.
Genomics 31 : 395-397. 1996
51MSH6, MSH2
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
Duckett DR, et al.
Proc Natl Acad Sci U S A 93 : 6443-6447. 1996
52MSH2, MSH3, MSH6
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R.
Proc Natl Acad Sci U S A 93(24):13629-34. 1996
53MSH6
GTBP, a 160-Kilodalton protein essential for mismatch-binding activity in human cells.
Palombo F, et al.
Science 268 : 1912-1914. 1995
54MSH6
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
Drummond JT, et al.
Science 268 : 1909-1912. 1995
55MSH6
Mutations of GTBP in genetically unstable cells.
Papadopoulos N, et al.
Science 268 : 1915-1917. 1995