Citations for
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.
Proc Natl Acad Sci U S A 110(8):2969-74. doi: 10.1073/pnas.1222694110. Epub 2013 Feb 6. 2013
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
Buis J, Stoneham T, Spehalski E, Ferguson DO.
Nat Struct Mol Biol 19(2):246-52. doi: 10.1038/nsmb.2212. 2012
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.
Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, Hébert J, Ferguson DO, Masson JY, Richard S.
Cell Res 22(2):305-20. doi: 10.1038/cr.2011.128. Epub 2011 Aug 9. 2012
4MRE11A, RAD50
ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.
Majka J, Alford B, Ausio J, Finn RM, McMurray CT.
J Biol Chem 287(4):2328-41. doi: 10.1074/jbc.M111.307041. Epub 2011 Nov 18. 2012
5MRE11A, RAD50
The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.
Cell 145(1):54-66. 2011
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.
Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M.
Cell 145(4):529-42. Erratum in: Cell. 2011 Jun 10;145(6):993. 2011
7AKT1, ATM, MRE11A, RNF168
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
Cell Cycle 10(13):2218-32. Epub 2011 Jul 1. 2011
Crystal structure of human Mre11: understanding tumorigenic mutations.
Park YB, Chae J, Kim YC, Cho Y.
Structure 19(11):1591-602. 2011
Causal link between microsatellite instability and hMRE11 dysfunction in human cancers.
Wu X, Xu Y, Chai W, Her C.
Mol Cancer Res 9(11):1443-8. Epub 2011 Aug 17. Review. 2011
Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
Dmitrieva NI, Malide D, Burg MB.
Am J Physiol Regul Integr Comp Physiol 301(3):R632-40. Epub 2011 Jun 15. 2011
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17. 2011
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K.
Cell Cycle 9(14):2866-77. Epub 2010 Jul 12. 2010
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.
Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS.
Nat Struct Mol Biol 16(8):819-24. Epub 2009 Jul 26. 2009
The mre11 complex and the response to dysfunctional telomeres.
Attwooll CL, Akpinar M, Petrini JH.
Mol Cell Biol 29(20):5540-51. Epub 2009 Aug 10. 2009
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO.
Cell 135(1):85-96. 2008
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Williams RS, Moncalian G, Williams JS, Yamada Y, Limbo O, Shin DS, Groocock LM, Cahill D, Hitomi C, Guenther G, Moiani D, Carney JP, Russell P, Tainer JA.
Cell 135(1):97-109. 2008
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson JY.
Mol Cell Biol 28(9):3058-69. Epub 2008 Feb 19.PMID: 18285453 2008
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.
Nature 447(7141):218-21. Epub 2007 Apr 11. 2007
19MRE11A, TERF1, RAD50, NBS1
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
Wu Y, Xiao S, Zhu XD.
Nat Struct Mol Biol 14(9):832-40. Epub 2007 Aug 12. 2007
20MRE11A, MRE11B, RAD50
The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
Lee AY, Liu E, Wu X.
J Biol Chem 282(44):32243-55. Epub 2007 Aug 22. 2007
Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
Fernet M, Gribaa M, Salih MA, Seidahmed MZ, Hall J, Koenig M.
Hum Mol Genet 14(2):307-18. Epub 2004 Dec 01. 2005
MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
Delia D, Piane M, Buscemi G, Savio C, Palmeri S, Lulli P, Carlessi L, Fontanella E, Chessa L.
Hum Mol Genet 13(18):2155-63. Epub 2004 Jul 21. 2004
The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements.
Lobachev KS, Gordenin DA, Resnick MA.
Cell 108(2):183-93. 2002
Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
Franchitto A, Pichierri P.
Hum Mol Genet 11(20):2447-53. 2002
Human MRE11 is inactivated in mismatch repair-deficient cancers.
Giannini G, Ristori E, Cerignoli F, Rinaldi C, Zani M, Viel A, Ottini L, Crescenzi M, Martinotti S, Bignami M, Frati L, Screpanti I, Gulino A.
EMBO Rep 3(3):248-54. Epub 2002 Feb 15. 2002
DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways.
de Jager M, Dronkert ML, Modesti M, Beerens CE, Kanaar R, van Gent DC.
Nucleic Acids Res 29(6):1317-25. 2001
hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.
Pitts SA, Kullar HS, Stankovic T, Stewart GS, Last JI, Bedenham T, Armstrong SJ, Piane M, Chessa L, Taylor AM, Byrd PJ.
Hum Mol Genet 10(11):1155-62. 2001
28MRE11A, RAD50, TERF2
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Zhu XD, Kuster B, Mann M, Petrini JH, Lange Td.
Nat Genet 25(3):347-52. 2000
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.
Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG, Raams A, Byrd PJ, Petrini JH, Taylor AM.
Cell 99(6):577-87 1999
Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.
Goedecke W, Eijpe M, Offenberg HH, van Aalderen M, Heyting C.
Nat Genet 23(2):194-8. 1999
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
Trujillo KM, Yuan SS, Lee EY, Sung P.
J Biol Chem 273(34):21447-50. 1998
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
Paull TT, Gellert M.
Mol Cell 1(7):969-79. 1998
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH.
Cell 93(3):477-86. 1998
34MRE11A, MRE11R
Isolation and characterization of the human MRE11 homologue.
Petrini JHJ, et al.
Genomics 29 : 80-86. 1995
35RAD52, RAD51, MRE11A
Complex formation in yeast double-strand break repair : participation ofRad51, Rad52, Rad55 and Rad57 proteins.
Hays SL, et al.
Proc Natl Acad Sci U S A 92 : 6925-6929. 1995