| 1 | MRE11A, STING1
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| DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
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| Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.
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| Proc Natl Acad Sci U S A 110(8):2969-74. doi: 10.1073/pnas.1222694110. Epub 2013 Feb 6. 2013
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| 2 | MRE11A, RBBP8
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| Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
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| Buis J, Stoneham T, Spehalski E, Ferguson DO.
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| Nat Struct Mol Biol 19(2):246-52. doi: 10.1038/nsmb.2212.
2012
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| 3 | MRE11A
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| The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.
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| Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, Hébert J, Ferguson DO, Masson JY, Richard S.
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| Cell Res 22(2):305-20. doi: 10.1038/cr.2011.128. Epub 2011 Aug 9.
2012
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| 4 | MRE11A, RAD50
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| ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.
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| Majka J, Alford B, Ausio J, Finn RM, McMurray CT.
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| J Biol Chem 287(4):2328-41. doi: 10.1074/jbc.M111.307041. Epub 2011 Nov 18.
2012
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| 5 | MRE11A, RAD50
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| The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
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| Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.
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| Cell 145(1):54-66.
2011
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| 6 | BRCA2, MRE11A, RAD51
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| Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.
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| Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M.
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| Cell 145(4):529-42. Erratum in: Cell. 2011 Jun 10;145(6):993.
2011
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| 7 | AKT1, ATM, MRE11A, RNF168
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| MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
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| Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
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| Cell Cycle 10(13):2218-32. Epub 2011 Jul 1.
2011
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| 8 | MRE11A
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| Crystal structure of human Mre11: understanding tumorigenic mutations.
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| Park YB, Chae J, Kim YC, Cho Y.
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| Structure 19(11):1591-602.
2011
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| 9 | MRE11A
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| Causal link between microsatellite instability and hMRE11 dysfunction in human cancers.
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| Wu X, Xu Y, Chai W, Her C.
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| Mol Cancer Res 9(11):1443-8. Epub 2011 Aug 17. Review.
2011
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| 10 | MRE11A
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| Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
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| Dmitrieva NI, Malide D, Burg MB.
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| Am J Physiol Regul Integr Comp Physiol 301(3):R632-40. Epub 2011 Jun 15.
2011
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| 11 | BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51c, TP53
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| Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
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| Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
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| Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17.
2011
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| 12 | ATM, MRE11A
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| ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
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| Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K.
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| Cell Cycle 9(14):2866-77. Epub 2010 Jul 12.
2010
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| 13 | MRE11A
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| Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.
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| Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS.
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| Nat Struct Mol Biol 16(8):819-24. Epub 2009 Jul 26.
2009
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| 14 | MRE11A
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| The mre11 complex and the response to dysfunctional telomeres.
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| Attwooll CL, Akpinar M, Petrini JH.
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| Mol Cell Biol 29(20):5540-51. Epub 2009 Aug 10.
2009
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| 15 | ATLD, MRE11A
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| Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
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| Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO.
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| Cell 135(1):85-96.
2008
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| 16 | MRE11A
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| Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
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| Williams RS, Moncalian G, Williams JS, Yamada Y, Limbo O, Shin DS, Groocock LM, Cahill D, Hitomi C, Guenther G, Moiani D, Carney JP, Russell P, Tainer JA.
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| Cell 135(1):97-109.
2008
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| 17 | MRE11A
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| A glycine-arginine domain in control of the human MRE11 DNA repair protein.
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| Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson JY.
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| Mol Cell Biol 28(9):3058-69. Epub 2008 Feb 19.PMID: 18285453 2008
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| 18 | MRE11A, NBS1, ATM
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| The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
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| Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.
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| Nature 447(7141):218-21. Epub 2007 Apr 11. 2007
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| 19 | MRE11A, TERF1, RAD50, NBS1
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| MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
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| Wu Y, Xiao S, Zhu XD.
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| Nat Struct Mol Biol 14(9):832-40. Epub 2007 Aug 12. 2007
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| 20 | MRE11A, MRE11B, RAD50
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| The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
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| Lee AY, Liu E, Wu X.
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| J Biol Chem 282(44):32243-55. Epub 2007 Aug 22.
2007
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| 21 | MRE11A, ATLD, ATM
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| Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
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| Fernet M, Gribaa M, Salih MA, Seidahmed MZ, Hall J, Koenig M.
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| Hum Mol Genet 14(2):307-18. Epub 2004 Dec 01. 2005
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| 22 | MRE11A, ATLD
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| MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
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| Delia D, Piane M, Buscemi G, Savio C, Palmeri S, Lulli P, Carlessi L, Fontanella E, Chessa L.
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| Hum Mol Genet 13(18):2155-63. Epub 2004 Jul 21. 2004
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| 23 | MRE11A
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| The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements.
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| Lobachev KS, Gordenin DA, Resnick MA.
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| Cell 108(2):183-93. 2002
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| 24 | BLM, MRE11A, NBS1, RAD50, WRN, NBN
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| Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
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| Franchitto A, Pichierri P.
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| Hum Mol Genet 11(20):2447-53. 2002
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| 25 | MRE11A
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| Human MRE11 is inactivated in mismatch repair-deficient cancers.
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| Giannini G, Ristori E, Cerignoli F, Rinaldi C, Zani M, Viel A, Ottini L, Crescenzi M, Martinotti S, Bignami M, Frati L, Screpanti I, Gulino A.
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| EMBO Rep 3(3):248-54. Epub 2002 Feb 15. 2002
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| 26 | MRE11A
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| DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways.
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| de Jager M, Dronkert ML, Modesti M, Beerens CE, Kanaar R, van Gent DC.
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| Nucleic Acids Res 29(6):1317-25. 2001
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| 27 | ANKRD49, MRE11A
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| hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.
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| Pitts SA, Kullar HS, Stankovic T, Stewart GS, Last JI, Bedenham T, Armstrong SJ, Piane M, Chessa L, Taylor AM, Byrd PJ.
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| Hum Mol Genet 10(11):1155-62. 2001
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| 28 | MRE11A, RAD50, TERF2
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| Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
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| Zhu XD, Kuster B, Mann M, Petrini JH, Lange Td.
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| Nat Genet 25(3):347-52. 2000
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| 29 | ATLD, MRE11A
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| The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.
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| Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG, Raams A, Byrd PJ, Petrini JH, Taylor AM.
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| Cell 99(6):577-87 1999
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| 30 | XRCC6, MRE11A
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| Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.
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| Goedecke W, Eijpe M, Offenberg HH, van Aalderen M, Heyting C.
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| Nat Genet 23(2):194-8. 1999
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| 31 | MRE11A, NBS1, NBN
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| Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
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| Trujillo KM, Yuan SS, Lee EY, Sung P.
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| J Biol Chem 273(34):21447-50. 1998
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| 32 | MRE11A
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| The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
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| Paull TT, Gellert M.
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| Mol Cell 1(7):969-79. 1998
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| 33 | MRE11A, NBS1, NBN
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| The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
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| Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH.
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| Cell 93(3):477-86. 1998
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| 34 | MRE11A, MRE11R
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| Isolation and characterization of the human MRE11 homologue.
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| Petrini JHJ, et al.
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| Genomics 29 : 80-86. 1995
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| 35 | RAD52, RAD51, MRE11A
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| Complex formation in yeast double-strand break repair : participation ofRad51, Rad52, Rad55 and Rad57 proteins.
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| Hays SL, et al.
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| Proc Natl Acad Sci U S A 92 : 6925-6929. 1995
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