Citations for
1MMP14, PTK2, TGFB1I1
Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.
Dave JM, Abbey CA, Duran CL, Seo H, Johnson GA, Bayless KJ.
J Cell Sci 129(4):743-56. doi: 10.1242/jcs.170571. Epub 2016 Jan 14. 2016
2BST2, MMP14
MT1-MMP Inhibits the Activity of Bst-2 via Their Cytoplasmic Domains Dependent Interaction.
Fan L, Liu L, Zhu C, Zhu Q, Lu S, Liu P.
Int J Mol Sci 17(6). pii: E818. doi: 10.3390/ijms17060818. 2016
3CD81, MMP14
The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways.
Hong IK, Byun HJ, Lee J, Jin YJ, Wang SJ, Jeoung DI, Kim YM, Lee H.
J Biol Chem 289(22):15691-704. doi: 10.1074/jbc.M113.534206. Epub 2014 Apr 14. 2014
4BRCA2, MMP14
Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP).
Wali N, Hosokawa K, Malik S, Saito H, Miyaguchi K, Imajoh-Ohmi S, Miki Y, Nakanishi A.
Biochem Biophys Res Commun 443(4):1148-54. doi: 10.1016/j.bbrc.2013.12.103. 2014
5CLIC3, MMP14
CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.
Macpherson IR, Rainero E, Mitchell LE, van den Berghe PV, Speirs C, Dozynkiewicz MA, Chaudhary S, Kalna G, Edwards J, Timpson P, Norman JC.
J Cell Sci 127(Pt 18):3893-901. doi: 10.1242/jcs.135947. Epub 2014 Jul 11. 2014
6MMP14
MT1-MMP prevents growth inhibition by three dimensional fibronectin matrix.
Takino T, Guo L, Domoto T, Sato H.
Biochem Biophys Res Commun 436(3):503-8. doi: 10.1016/j.bbrc.2013.05.134. Epub 2013 Jun 10. 2013
7EPHA2, MMP14
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiäinen M, Gstaiger M, Lehti K.
J Cell Biol 201(3):467-84. doi: 10.1083/jcb.201205176. 2013
8MMP14
Matrix metalloproteinase-14 is a negative prognostic marker for patients with gastric cancer.
He L, Chu D, Li X, Zheng J, Liu S, Li J, Zhao Q, Ji G.
Dig Dis Sci 58(5):1264-70. doi: 10.1007/s10620-012-2513-9. Epub 2013 Jan 13. 2013
9MMP14, MMP2, TACR1
Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP).
Mou L, Kang Y, Zhou Y, Zeng Q, Song H, Wang R.
J Biol Chem 288(1):306-18. doi: 10.1074/jbc.M112.389783. Epub 2012 Nov 19. 2013
10MMP14, WASH1
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
Monteiro P, Rossé C, Castro-Castro A, Irondelle M, Lagoutte E, Paul-Gilloteaux P, Desnos C, Formstecher E, Darchen F, Perrais D, Gautreau A, Hertzog M, Chavrier P.
J Cell Biol 203(6):1063-79. 2013
11MMP14, MMP17
MT-MMPs in pre-eclamptic placenta: relationship to soluble endoglin production.
Kaitu'u-Lino TJ, Tuohey L, Ye L, Palmer K, Skubisz M, Tong S.
Placenta 34(2):168-73. doi: 10.1016/j.placenta.2012.11.034. Epub 2012 Dec 20. 2013
12MMP14, MMP19
Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma.
Wang L, Yuan J, Tu Y, Mao X, He S, Fu G, Zong J, Zhang Y.
Clin Transl Oncol 15(2):139-45. doi: 10.1007/s12094-012-0900-5. Epub 2012 Jul 19. 2013
13MMP14, MMP2, TIMP2
MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells
Lee H, Chang KW, Yang HY, Lin PW, Chen SU, Huang YL.
Biochem Biophys Res Commun. Jul 26;437(2):232-8. doi: 10.1016/j.bbrc.2013.06.046. Epub 2013 Jun 21. 2013
14MMP14, MMP2, WINCH1, WINCH2
Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome.
Evans BR, Mosig RA, Lobl M, Martignetti CR, Camacho C, Grum-Tokars V, Glucksman MJ, Martignetti JA.
Am J Hum Genet 91(3):572-6. Epub 2012 Aug 23. 2012
15ADAM9, FGFR2, MMP14
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.
Chan KM, Wong HL, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z.
Dev Cell 22(6):1176-90. doi: 10.1016/j.devcel.2012.04.014. Epub 2012 May 24. 2012
16MMP14, VIM
Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.
Kwak HI, Kang H, Dave JM, Mendoza EA, Su SC, Maxwell SA, Bayless KJ.
Angiogenesis 15(2):287-303. doi: 10.1007/s10456-012-9262-4. Epub 2012 Mar 11. 2012
17MMP14
MT1-MMP modulates the mechanosensitivity of osteocytes.
Kulkarni RN, Bakker AD, Gruber EV, Chae TD, Veldkamp JB, Klein-Nulend J, Everts V.
Biochem Biophys Res Commun 417(2):824-9. doi: 10.1016/j.bbrc.2011.12.045. Epub 2011 Dec 19. 2012
18MMP14, MMP2, TIMP2
Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation?
Li R, Zhang JG, Churchill J, Sourial M, Southwell BR, Hutson JM.
J Pediatr Surg 47(9):1724-9. doi: 10.1016/j.jpedsurg.2012.03.062. 2012
19MMP14
Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization.
Zigrino P, Ayachi O, Schild A, Kaltenberg J, Zamek J, Nischt R, Koch M, Mauch C.
Eur J Cell Biol 91(10):748-56. doi: 10.1016/j.ejcb.2012.05.003. Epub 2012 Jun 18. 2012
20MMP14
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
Blood 119(23):5405-16. doi: 10.1182/blood-2011-11-390849. Epub 2012 Apr 27. 2012
21MMP14, MMP19
Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.
Jackson V, Olsson T, Kurtovic S, Folkersen L, Paloschi V, Wågsäter D, Franco-Cereceda A, Eriksson P.
J Thorac Cardiovasc Surg 144(2):459-66. doi: 10.1016/j.jtcvs.2011.08.043. Epub 2011 Sep 28. 2012
22MMP14, WASL
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.
Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM, Visegrády B, Insall RH, Oien K, Blyth K, Norman JC, Machesky LM.
J Cell Biol 199(3):527-44. doi: 10.1083/jcb.201203025. Epub 2012 Oct 22. 2012
23MMP14, PTK7
Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7).
Golubkov VS, Strongin AY.
J Biol Chem 287(50):42009-18. doi: 10.1074/jbc.M112.371153. Epub 2012 Oct 24. 2012
24MMP14
Matrix metalloproteinase 14 overexpression reduces corneal scarring.
Galiacy SD, Fournié P, Massoudi D, Ancèle E, Quintyn JC, Erraud A, Raymond-Letron I, Rolling F, Malecaze F.
Gene Ther 18(5):462-8. Epub 2010 Dec 16. 2011
25CD9, MMP14
Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy.
Kamisasanuki T, Tokushige S, Terasaki H, Khai NC, Wang Y, Sakamoto T, Kosai K.
Biochem Biophys Res Commun 413(1):128-35. Epub 2011 Aug 22. 2011
26APBA3, MMP14
Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion.
Hara T, Mimura K, Seiki M, Sakamoto T.
Biochem Biophys Res Commun 413(2):277-81. Epub 2011 Aug 27. 2011
27MMP14
MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin.
Shi F, Sottile J.
J Cell Sci 124(Pt 23):4039-50. doi: 10.1242/jcs.087858. Epub 2011 Dec 8. 2011
28MMP14
Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events.
Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE.
Blood 115(25):5259-69. Epub 2010 Mar 9.PMID: 20215637 2010
29MMP14
Membrane-type I matrix metalloproteinase-dependent regulation of rheumatoid arthritis synoviocyte function.
Sabeh F, Fox D, Weiss SJ.
J Immunol 184(11):6396-406. Epub 2010 May 5.PMID: 20483788 2010
30MMP14
Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.
Sounni NE, Rozanov DV, Remacle AG, Golubkov VS, Noel A, Strongin AY.
Int J Cancer 126(5):1067-78. Erratum in: Int J Cancer. 2010 Apr 15;126(8):2002. PMID: 19551841 2010
31MMP14
MT1-MMP controls human mesenchymal stem cell trafficking and differentiation.
Lu C, Li XY, Hu Y, Rowe RG, Weiss SJ.
Blood 115(2):221-9. Epub 2009 Nov 9.PMID: 19901267 2010
32MMP14, MMP25
Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase.
Radichev IA, Remacle AG, Shiryaev SA, Purves AN, Johnson SL, Pellecchia M, Strongin AY.
J Biol Chem 285(21):16076-86. Epub 2010 Mar 22.PMID: 20308072 2010
33MMP14, TGFB1
Stromal regulation of vessel stability by MMP14 and TGFbeta.
Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM.
Dis Model Mech 3(5-6):317-32. Epub 2010 Mar 11.PMID: 20223936 2010
34FGFR4, MMP14
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K.
Proc Natl Acad Sci U S A 107(36):15786-91. Epub 2010 Aug 23.PMID: 20798051 2010
35KDR, MMP14, VEGFA
MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.
Eisenach PA, Roghi C, Fogarasi M, Murphy G, English WR.
J Cell Sci 123(Pt 23):4182-93. Epub 2010 Nov 9. 2010
36FURIN, GORASP2, MMP14
Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen.
Roghi C, Jones L, Gratian M, English WR, Murphy G.
FEBS J 277(15):3158-75. doi: 10.1111/j.1742-4658.2010.07723.x. Epub 2010 Jul 1. 2010
37MMP14
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H.
Proc Natl Acad Sci U S A 106(30):12530-5. Epub 2009 Jul 15. 2009
38MMP14
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression.
Nyalendo C, Sartelet H, Barrette S, Ohta S, Gingras D, Béliveau R.
BMC Cancer 9:422.PMID: 19961596 2009
39BCAM, MMP14
Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.
Niiya D, Egawa N, Sakamoto T, Kikkawa Y, Shinkawa T, Isobe T, Koshikawa N, Seiki M.
J Biol Chem 284(40):27360-9. Epub 2009 Aug 10.PMID: 19667067 2009
40MMP14, TIMP2
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.
D'Alessio S, Ferrari G, Cinnante K, Scheerer W, Galloway AC, Roses DF, Rozanov DV, Remacle AG, Oh ES, Shiryaev SA, Strongin AY, Pintucci G, Mignatti P.
J Biol Chem 283(1):87-99. Epub 2007 Nov 8.PMID: 17991754 2008
41ARHGAP5, MMP14, MMP2
p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2.
Guegan F, Tatin F, Leste-Lasserre T, Drutel G, Genot E, Moreau V.
J Cell Sci 121(Pt 12):2054-61. Epub 2008 May 27.PMID: 18505793 2008
42MMP14, SLC37A4
Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.
Fortier S, Labelle D, Sina A, Moreau R, Annabi B.
FEBS Lett 582(5):799-804. Epub 2008 Feb 11. 2008
43MMP14, NANOS1
The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression
Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, Berx G, van Roy F, Birembaut P, Nawrocki-Raby B.
Oncogene Jun 12;27(26):3692-9. doi: 10.1038/sj.onc.1211035. Epub 2008 Jan 28. 2008
44MMP14, SMAD1
Induction of Smad1 by MT1-MMP contributes to tumor growth.
Freudenberg JA, Chen WT.
Int J Cancer 121(5):966-77. 2007
45GDF15, MMP14
Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth.
Abd El-Aziz SH, Endo Y, Miyamaori H, Takino T, Sato H.
Cancer Sci 98(9):1330-5. Epub 2007 Jul 19. 2007
46BSG, MMP14
Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.
Egawa N, Koshikawa N, Tomari T, Nabeshima K, Isobe T, Seiki M.
J Biol Chem 281(49):37576-85. Epub 2006 Oct 18. 2006
47MMP14
MMP14 gene polymorphisms in chronic obstructive pulmonary disease.
Saitoh W, Sakamoto T, Hegab AE, Nomura A, Ishii Y, Morishima Y, Kai S, Iizuka T, Kiwamoto T, Matsuno Y, Massoud HH, Massoud HM, Hassanein KM, Sekizawa K.
Int J Mol Med 17(4):621-6. 2006
48MMP14
The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP).
Remacle AG, Rozanov DV, Baciu PC, Chekanov AV, Golubkov VS, Strongin AY.
J Cell Sci 118(Pt 21):4975-84. Epub 2005 Oct 11. 2005
49PCNT, MMP14
Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.
Golubkov VS, Chekanov AV, Doxsey SJ, Strongin AY.
J Biol Chem 280(51):42237-41. Epub 2005 Oct 26. 2005
50MMP14
Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth.
Iida J, Wilhelmson KL, Price MA, Wilson CM, Pei D, Furcht LT, McCarthy JB.
J Invest Dermatol 122(1):167-76. 2004
51MMP14, MUC1, ADAM17
MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.
Thathiah A, Carson DD.
Biochem J 382(Pt 1):363-73. 2004
52MMP14, STX4
Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells.
Miyata T, Ohnishi H, Suzuki J, Yoshikumi Y, Ohno H, Mashima H, Yasuda H, Ishijima T, Osawa H, Satoh K, Sunada K, Kita H, Yamamoto H, Sugano K.
Biochem Biophys Res Commun 323(1):118-24. 2004
53MAZ, MMP14
Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.
Ray BK, Shakya A, Turk JR, Apte SS, Ray A.
Circ Res 95(11):1082-90. Epub 2004 Nov 4. 2004
54MMP1, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP2, MMP20, MMP21, MMP23A, MMP23B, MMP24, MMP25, MMP26, MMP27, MMP28, MMP3, MMP7, MMP8, MMP9
Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
Visse R, Nagase H.
Circ Res 92(8):827-39. Review. 2003
55MMP14
Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases.
Maquoi E, Peyrollier K, Noel A, Foidart JM, Frankenne F.
Biochem J 373(Pt 1):19-24. 2003
56MMP2, MMP14, TIMP2
Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation.
Ben-Yosef Y, Lahat N, Shapiro S, Bitterman H, Miller A.
Circ Res 90(7):784-91. 2002
57CTNNB1, MMP14
Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.
Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y.
Oncogene 21(38):5861-7. 2002
58MMP14
Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma.
Myoung H, Kim MJ, Hong SD, Lee JI, Lim CY, Hong SP.
Cancer Lett 185(2):201-9. 2002
59MMP14, MMP2
Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract.
Nakanishi K, Kawai T, Sato H, Aida S, Kasamatsu H, Aurues T, Ikeda T.
Hum Pathol 31(2):193-200. 2000
60MMP14
Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene.
Lohi J, Lehti K, Valtanen H, Parks WC, Keski-Oja J.
Gene 242(1-2):75-86. 2000
61MMP14, MMP2, TIMP2
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.
Hernandez-Barrantes S, Toth M, Bernardo MM, Yurkova M, Gervasi DC, Raz Y, Sang QA, Fridman R.
J Biol Chem 275(16):12080-9. 2000
62MMP14
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas.
Collier SA, Madigan MC, Penfold PL.
Curr Eye Res 21(2):662-8. 2000
63CSF2, MMP14, MMP2
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
Tomita T, Fujii M, Tokumaru Y, Imanishi Y, Kanke M, Yamashita T, Ishiguro R, Kanzaki J, Kameyama K, Otani Y.
Cancer Lett 156(1):83-91. 2000
64MMP2, MMP9, MMP14
Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.
Forsyth PA, et al.
Br J Cancer 79(11-12):1828-35. 1999
65MMP14
Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomas.
Chenard MP, et al.
Int J Cancer 82(2):208-12. 1999
66MMP14, MMP15, MMP16
Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.
Sato H, et al.
Genomics 39 : 412-413. 1997
67MMP14, MMP15, MMP16
Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16 and 8, respectively.
Mattei MG, et al.
Genomics 40 : 168-169. 1997
68MMP14
cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment.
Will H, et al.
Eur J Biochem 231 : 602-608. 1995
69MMP14
Assignment of the human membrane-type matrix metalloproteinase (MMP14) gene to 14q11-q12 by in situ hybridization.
Mignon C, et al.
Genomics 28 : 360-361. 1995
70MMP14
A matrix metalloproteinase expressed on the surface of invasive tumour cells.
Sato H, et al.
Nature 370 : 61-64. 1994