Citations for
1MLXIPL, SLC2A5, SLC9A3
ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome.
Oh AR, Sohn S, Lee J, Park JM, Nam KT, Hahm KB, Kim YB, Lee HJ, Cha JY.
Metabolism 85:286-297. doi: 10.1016/j.metabol.2018.04.006. Epub 2018 Apr 15. 2018
2AR, MLXIPL
Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer.
Wang XL, Wen XF, Li RB, Liu B, Qiu GM, Wen JL, Wang YM.
Tumour Biol 35(8):8143-8. doi: 10.1007/s13277-014-2085-8. Epub 2014 May 21. 2014
3FOXO1, MLXIPL, TNXIP
FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells.
Kibbe C, Chen J, Xu G, Jing G, Shalev A.
J Biol Chem 288(32):23194-202. doi: 10.1074/jbc.M113.473082. Epub 2013 Jun 26. 2013
4MLXIPL, XYLB
Role of glucose-6-phosphate and xylulose-5-phosphate in the regulation of glucose-stimulated gene expression in the pancreatic β cell line, INS-1E.
Iizuka K, Wu W, Horikawa Y, Takeda J.
Endocr J 60(4):473-82. Epub 2012 Dec 18. 2013
5MLXIPL, SREBF1
Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.
Xu X, So JS, Park JG, Lee AH.
Semin Liver Dis 33(4):301-11. doi: 10.1055/s-0033-1358523. Epub 2013 Nov 12. Review. 2013
6MLXIPL, PPARGC1B
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.
Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN.
Mol Metab 2(3):194-204. doi: 10.1016/j.molmet.2013.05.001. eCollection 2013. 2013
7MLXIPL
Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies.
Nakagawa T, Ge Q, Pawlosky R, Wynn RM, Veech RL, Uyeda K.
J Biol Chem 288(39):28358-67. doi: 10.1074/jbc.M113.498550. Epub 2013 Aug 5. 2013
8MLXIPL, PPARA
Feedback looping between ChREBP and PPARα in the regulation of lipid metabolism in brown adipose tissues.
Iizuka K, Wu W, Horikawa Y, Saito M, Takeda J.
Endocr J 60(10):1145-53. Epub 2013 Jul 5. 2013
9MLXIPL
Novel insights into ChREBP regulation and function.
Filhoulaud G, Guilmeau S, Dentin R, Girard J, Postic C.
Trends Endocrinol Metab 24(5):257-68. doi: 10.1016/j.tem.2013.01.003. Epub 2013 Apr 15. Review. 2013
10FLII, MLXIPL
Flightless I homolog negatively regulates ChREBP activity in cancer cells.
Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X.
Int J Biochem Cell Biol 45(11):2688-97. doi: 10.1016/j.biocel.2013.09.004. Epub 2013 Sep 17. 2013
11MLXIPL, SRI
Roles of Ca2+ ions in the control of ChREBP nuclear translocation.
Leclerc I, Rutter GA, Meur G, Noordeen N.
J Endocrinol 213(2):115-22. Epub 2012 Mar 8. 2012
12MLXIPL, SRI
Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells.
Noordeen NA, Meur G, Rutter GA, Leclerc I.
Diabetes 61(3):574-85. Epub 2012 Feb 14. 2012
13CCND1, MLXIPL
Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α.
Hanse EA, Mashek DG, Becker JR, Solmonson AD, Mullany LK, Mashek MT, Towle HC, Chau AT, Albrecht JH.
Cell Cycle 11(14):2681-90. doi: 10.4161/cc.21019. Epub 2012 Jul 15. 2012
14MLXIPL
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB.
Nature 484(7394):333-8. doi: 10.1038/nature10986. 2012
15MLXIPL
Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein.
Ge Q, Huang N, Wynn RM, Li Y, Du X, Miller B, Zhang H, Uyeda K.
J Biol Chem 287(50):41914-21. doi: 10.1074/jbc.M112.418855. Epub 2012 Oct 18. 2012
16MLXIPL, RGS16
Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner.
Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM.
J Biol Chem 286(17):15116-25. Epub 2011 Feb 27. 2011
17MLXIPL, TXNIP
AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.
Shaked M, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.
PLoS One 6(12):e28804. doi: 10.1371/journal.pone.0028804. Epub 2011 Dec 14. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/23f84 2011
18MLXIPL
Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.
Fukasawa M, Ge Q, Wynn RM, Ishii S, Uyeda K.
Biochem Biophys Res Commun 391(2):1166-9. Epub 2009 Dec 17.PMID: 20025850 2010
19MLXIPL
Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP).
Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L.
Biochem Biophys Res Commun 395(3):395-400. Epub 2010 Apr 9.PMID: 20382127 2010
20MLXIPL, PDX1
ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells.
da Silva Xavier G, Sun G, Qian Q, Rutter GA, Leclerc I.
Biochem Biophys Res Commun 402(2):252-7. Epub 2010 Oct 8. 2010
21MLXIPL, PNPLA3, USF2
Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin.
Rae-Whitcombe SM, Kennedy D, Voyles M, Thompson MP.
Biochem Biophys Res Commun 402(4):767-72. Epub 2010 Oct 29. 2010
22MGEA5, MLXIPL
The role of O-linked GlcNAc modification on the glucose response of ChREBP.
Sakiyama H, Fujiwara N, Noguchi T, Eguchi H, Yoshihara D, Uyeda K, Suzuki K.
Biochem Biophys Res Commun 402(4):784-9. Epub 2010 Oct 29. 2010
23MLXIPL
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation.
Tong X, Zhao F, Mancuso A, Gruber JJ, Thompson CB.
Proc Natl Acad Sci U S A 106(51):21660-5. Epub 2009 Dec 7.PMID: 19995986 2009
24MLXIPL
MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe.
Vrablik M, Ceska R, Adamkova V, Peasey A, Pikhart H, Kubinova R, Marmot M, Bobak M, Hubacek JA.
Hum Genet 124(5):553-5. Epub 2008 Oct 23. 2008
25MLXIPL
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, G—mez PŽrez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR, Thompson JF.
Nat Genet 40(2):149-51. Epub 2008 Jan 13. 2008
26MLXIPL
Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module.
Li MV, Chang B, Imamura M, Poungvarin N, Chan L.
Diabetes 55(5):1179-89. 2006
27MLXIPL
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism.
Tsatsos NG, Towle HC.
Biochem Biophys Res Commun 340(2):449-56. Epub 2005 Dec 15. 2006
28MLX, MLXIPL, YWHAB, YWHAG, YWHAZ, YWHAQ
The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3.
Merla G, Howald C, Antonarakis SE, Reymond A.
Hum Mol Genet 13(14):1505-14. Epub 2004 May 26. 2004
29GTF2I, NCF1, POM121, EIF4H, MLXIPL, WBS
Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
DeSilva U, Elnitski L, Idol JR, Doyle JL, Gan W, Thomas JW, Schwartz S, Dietrich NL, Beckstrom-Sternberg SM, McDowell JC, Blakesley RW, Bouffard GG, Thomas PJ, Touchman JW, Miller W, Green ED.
Genome Res 12(1):3-15. 2002
30MLXIPL
WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.
Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A.
Hum Mol Genet 10(6):617-27. 2001
31MLXIPL
Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.
Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K.
Proc Natl Acad Sci U S A 98(24):13710-5. Epub 2001 Nov 6. 2001
32BCL7B, TBL2, MLXIPL
Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes.
Meng X, et al.
Hum Genet 103 : 590-599. 1998
33MLX, MLXIPL
TCFL4 : a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor.
Bjerknes M, et al.
Gene 181 : 7-11. 1996