1 | BDNF, CYFIP1, EIF4E, MKNK1
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| BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.
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| Genheden M, Kenney JW, Johnston HE, Manousopoulou A, Garbis SD, Proud CG.
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| J Neurosci 35(3):972-84. doi: 10.1523/JNEUROSCI.2641-14.2015.
2015
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2 | CYFIP1, EIF4E, FMR1, MKNK1, MKNK2
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| The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
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| Beggs JE, Tian S, Jones GG, Xie J, Iadevaia V, Jenei V, Thomas G, Proud CG.
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| Biochem J 467(1):63-76. doi: 10.1042/BJ20141066.
2015
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3 | EIF4E, EIF4E3, MKNK1, MKNK2
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| MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
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| Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB.
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| Nat Commun 5:5413. doi: 10.1038/ncomms6413.
2014
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4 | MKNK1, MKNK2
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| Mnk kinase pathway: Cellular functions and biological outcomes.
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| Joshi S, Platanias LC.
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| World J Biol Chem 5(3):321-33. doi: 10.4331/wjbc.v5.i3.321. Review.
2014
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5 | MKNK1, PTF1A
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| Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
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| Cendrowski J, Sánchez-Arévalo Lobo VJ, Sendler M, Salas A, Kühn JP, Molero X, Fukunaga R, Mayerle J, Lerch MM, Real FX.
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| Gut ut. 2014 Jul 18. pii: gutjnl-2013-306068. doi: 10.1136/gutjnl-2013-306068. [Epub ahead of print]
2014
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6 | MKNK1, MKNK2
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| Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.
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| Lim S, Saw TY, Zhang M, Janes MR, Nacro K, Hill J, Lim AQ, Chang CT, Fruman DA, Rizzieri DA, Tan SY, Fan H, Chuah CT, Ong ST.
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| Proc Natl Acad Sci U S A 110(25):E2298-307. doi: 10.1073/pnas.1301838110. Epub 2013 Jun 4.
2013
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7 | MKNK1
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| Translational control of human neutrophil responses by MNK1.
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| Fortin CF, Mayer TZ, Cloutier A, McDonald PP.
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| J Leukoc Biol 94(4):693-703. doi: 10.1189/jlb.0113012. Epub 2013 Feb 11.
2013
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8 | MKNK1, MKNK2
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| Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
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| Gorentla BK, Krishna S, Shin J, Inoue M, Shinohara ML, Grayson JM, Fukunaga R, Zhong XP.
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| J Immunol 190(3):1026-37. doi: 10.4049/jimmunol.1200026. Epub 2012 Dec 26.
2013
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9 | BANK1, EIF4E, MKNK1, MKNK2
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| BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway.
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| Wu YY, Kumar R, Haque MS, Castillejo-López C, Alarcón-Riquelme ME.
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| J Immunol 191(12):6110-6. doi: 10.4049/jimmunol.1301203. Epub 2013 Nov 13.
2013
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10 | MKNK1
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| MNK1 kinase activity is required for abscission.
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| Rannou Y, Salaun P, Benaud C, Khan J, Dutertre S, Giet R, Prigent C.
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| J Cell Sci 125(Pt 12):2844-52. doi: 10.1242/jcs.058081. Epub 2012 Mar 27.
2012
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11 | HNRNPA1, MKNK1
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| MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1.
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| Ziaei S, Shimada N, Kucharavy H, Hubbard K.
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| Exp Cell Res 318(5):500-8. doi: 10.1016/j.yexcr.2011.12.015. Epub 2011 Dec 27.
2012
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12 | EIF4G1, MKNK1, PRKCA
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| Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
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| Dobrikov M, Dobrikova E, Shveygert M, Gromeier M.
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| Mol Cell Biol 31(14):2947-59. Epub 2011 May 16.
2011
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13 | EIF4E, MKNK1, MKNK2
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| Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.
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| Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma AK, Fish EN, Platanias LC.
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| J Biol Chem 286(8):6017-26. doi: 10.1074/jbc.M110.197921. Epub 2010 Dec 13.
2011
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14 | MKNK1, MKNK2
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| Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.
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| Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW.
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| Proc Natl Acad Sci U S A 107(32):13984-90. doi: 10.1073/pnas.1008136107. Epub 2010 Aug 2.
2010
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15 | EIF4E, EIF4G1, MKNK1, MKNK2
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| Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
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| Shveygert M, Kaiser C, Bradrick SS, Gromeier M.
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| Mol Cell Biol 30(21):5160-7. doi: 10.1128/MCB.00448-10. Epub 2010 Sep 7.
2010
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16 | MKNK1
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| The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity.
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| Goto S, Yao Z, Proud CG.
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| Biochem J 423(2):279-90.PMID: 19650764 2009
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17 | MKNK1
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| Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.
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| Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY.
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| Mol Cell Biol 27(21):7405-13. Epub 2007 Aug 27. 2007
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18 | MKNK1
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| Characterization of the activity of human MAP kinase-interacting kinase Mnk1b.
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| O'Loghlen A, Gonz‡lez VM, Jurado T, Salinas M, Mart’n ME.
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| Biochim Biophys Acta 1773(9):1416-27. Epub 2007 May 29. 2007
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19 | EIF4G1, MKNK1
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| Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.
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| Bellsolell L, Cho-Park PF, Poulin F, Sonenberg N, Burley SK.
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| Structure 14(5):913-23. 2006
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20 | MKNK1, SPRY2
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| Regulation of sprouty stability by Mnk1-dependent phosphorylation.
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| DaSilva J, Xu L, Kim HJ, Miller WT, Bar-Sagi D.
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| Mol Cell Biol 26(5):1898-907. 2006
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21 | HNRNPA1, MKNK1, MKNK2
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| hnRNP A1 relocalization to the stress granules reflects a role in the stress response.
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| Guil S, Long JC, Cáceres JF.
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| Mol Cell Biol 26(15):5744-58.
2006
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22 | MKNK1
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| Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
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| Parra JL, BuxadŽ M, Proud CG.
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| J Biol Chem 280(45):37623-33. Epub 2005 Sep 14. 2005
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23 | MKNK1
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| The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.
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| Worch J, Tickenbrock L, SchwŠble J, Steffen B, Cauvet T, Mlody B, Buerger H, Koeffler HP, Berdel WE, Serve H, MŸller-Tidow C.
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| Oncogene 23(57):9162-72. 2004
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24 | EIF4G1, MKNK1
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| Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.
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| Cuesta R, Xi Q, Schneider RJ.
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| EMBO J 19(13):3465-74. 2000
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25 | EIF4G1, MKNK1
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| Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
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| Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N.
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| EMBO J 18(1):270-9. 1999
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26 | MAPK1, MAPK3, MKNK1, MKNK2
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| Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
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| Waskiewicz AJ, Flynn A, Proud CG, Cooper JA.
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| EMBO J 16(8):1909-20. 1997
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27 | MKNK1
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| MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
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| Fukunaga R, Hunter T.
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| EMBO J 16(8):1921-33. 1997
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