Citations for
1BDNF, CYFIP1, EIF4E, MKNK1
BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.
Genheden M, Kenney JW, Johnston HE, Manousopoulou A, Garbis SD, Proud CG.
J Neurosci 35(3):972-84. doi: 10.1523/JNEUROSCI.2641-14.2015. 2015
2CYFIP1, EIF4E, FMR1, MKNK1, MKNK2
The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
Beggs JE, Tian S, Jones GG, Xie J, Iadevaia V, Jenei V, Thomas G, Proud CG.
Biochem J 467(1):63-76. doi: 10.1042/BJ20141066. 2015
3EIF4E, EIF4E3, MKNK1, MKNK2
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB.
Nat Commun 5:5413. doi: 10.1038/ncomms6413. 2014
4MKNK1, MKNK2
Mnk kinase pathway: Cellular functions and biological outcomes.
Joshi S, Platanias LC.
World J Biol Chem 5(3):321-33. doi: 10.4331/wjbc.v5.i3.321. Review. 2014
5MKNK1, PTF1A
Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
Cendrowski J, Sánchez-Arévalo Lobo VJ, Sendler M, Salas A, Kühn JP, Molero X, Fukunaga R, Mayerle J, Lerch MM, Real FX.
Gut ut. 2014 Jul 18. pii: gutjnl-2013-306068. doi: 10.1136/gutjnl-2013-306068. [Epub ahead of print] 2014
6MKNK1, MKNK2
Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.
Lim S, Saw TY, Zhang M, Janes MR, Nacro K, Hill J, Lim AQ, Chang CT, Fruman DA, Rizzieri DA, Tan SY, Fan H, Chuah CT, Ong ST.
Proc Natl Acad Sci U S A 110(25):E2298-307. doi: 10.1073/pnas.1301838110. Epub 2013 Jun 4. 2013
7MKNK1
Translational control of human neutrophil responses by MNK1.
Fortin CF, Mayer TZ, Cloutier A, McDonald PP.
J Leukoc Biol 94(4):693-703. doi: 10.1189/jlb.0113012. Epub 2013 Feb 11. 2013
8MKNK1, MKNK2
Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
Gorentla BK, Krishna S, Shin J, Inoue M, Shinohara ML, Grayson JM, Fukunaga R, Zhong XP.
J Immunol 190(3):1026-37. doi: 10.4049/jimmunol.1200026. Epub 2012 Dec 26. 2013
9BANK1, EIF4E, MKNK1, MKNK2
BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway.
Wu YY, Kumar R, Haque MS, Castillejo-López C, Alarcón-Riquelme ME.
J Immunol 191(12):6110-6. doi: 10.4049/jimmunol.1301203. Epub 2013 Nov 13. 2013
10MKNK1
MNK1 kinase activity is required for abscission.
Rannou Y, Salaun P, Benaud C, Khan J, Dutertre S, Giet R, Prigent C.
J Cell Sci 125(Pt 12):2844-52. doi: 10.1242/jcs.058081. Epub 2012 Mar 27. 2012
11HNRNPA1, MKNK1
MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1.
Ziaei S, Shimada N, Kucharavy H, Hubbard K.
Exp Cell Res 318(5):500-8. doi: 10.1016/j.yexcr.2011.12.015. Epub 2011 Dec 27. 2012
12EIF4G1, MKNK1, PRKCA
Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Dobrikov M, Dobrikova E, Shveygert M, Gromeier M.
Mol Cell Biol 31(14):2947-59. Epub 2011 May 16. 2011
13EIF4E, MKNK1, MKNK2
Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.
Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma AK, Fish EN, Platanias LC.
J Biol Chem 286(8):6017-26. doi: 10.1074/jbc.M110.197921. Epub 2010 Dec 13. 2011
14MKNK1, MKNK2
Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.
Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW.
Proc Natl Acad Sci U S A 107(32):13984-90. doi: 10.1073/pnas.1008136107. Epub 2010 Aug 2. 2010
15EIF4E, EIF4G1, MKNK1, MKNK2
Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
Shveygert M, Kaiser C, Bradrick SS, Gromeier M.
Mol Cell Biol 30(21):5160-7. doi: 10.1128/MCB.00448-10. Epub 2010 Sep 7. 2010
16MKNK1
The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity.
Goto S, Yao Z, Proud CG.
Biochem J 423(2):279-90.PMID: 19650764 2009
17MKNK1
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.
Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY.
Mol Cell Biol 27(21):7405-13. Epub 2007 Aug 27. 2007
18MKNK1
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b.
O'Loghlen A, Gonz‡lez VM, Jurado T, Salinas M, Mart’n ME.
Biochim Biophys Acta 1773(9):1416-27. Epub 2007 May 29. 2007
19EIF4G1, MKNK1
Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.
Bellsolell L, Cho-Park PF, Poulin F, Sonenberg N, Burley SK.
Structure 14(5):913-23. 2006
20MKNK1, SPRY2
Regulation of sprouty stability by Mnk1-dependent phosphorylation.
DaSilva J, Xu L, Kim HJ, Miller WT, Bar-Sagi D.
Mol Cell Biol 26(5):1898-907. 2006
21HNRNPA1, MKNK1, MKNK2
hnRNP A1 relocalization to the stress granules reflects a role in the stress response.
Guil S, Long JC, Cáceres JF.
Mol Cell Biol 26(15):5744-58. 2006
22MKNK1
Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
Parra JL, BuxadŽ M, Proud CG.
J Biol Chem 280(45):37623-33. Epub 2005 Sep 14. 2005
23MKNK1
The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.
Worch J, Tickenbrock L, SchwŠble J, Steffen B, Cauvet T, Mlody B, Buerger H, Koeffler HP, Berdel WE, Serve H, MŸller-Tidow C.
Oncogene 23(57):9162-72. 2004
24EIF4G1, MKNK1
Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.
Cuesta R, Xi Q, Schneider RJ.
EMBO J 19(13):3465-74. 2000
25EIF4G1, MKNK1
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N.
EMBO J 18(1):270-9. 1999
26MAPK1, MAPK3, MKNK1, MKNK2
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA.
EMBO J 16(8):1909-20. 1997
27MKNK1
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
Fukunaga R, Hunter T.
EMBO J 16(8):1921-33. 1997