| 1 | METTL3
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| N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2.
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| Wang H, Xu B, Shi J.
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| Gene 722:144076. doi: 10.1016/j.gene.2019.144076. Epub 2019 Aug 24.
2020
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| 2 | METTL3, RAB2B
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| METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B
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| Hu Y, Li Y, Huang Y, Jin Z, Wang C, Wang H, Xu J.
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| Eur J Pharmacol. Jul 15;879:173134. doi: 10.1016/j.ejphar.2020.173134. Epub 2020 Apr 24. 2020
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| 3 | METTL3, MYD88
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| The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
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| Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J.
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| Mol Cell Biochem ol Cell Biochem. 2019 Oct 23. doi: 10.1007/s11010-019-03641-5. [Epub ahead of print]
2019
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| 4 | CDH1, METTL3, ZMYM1
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| METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.
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| Yue B, Song C, Yang L, Cui R, Cheng X, Zhang Z, Zhao G.
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| Mol Cancer 18(1):142. doi: 10.1186/s12943-019-1065-4.
2019
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| 5 | METTL3
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| ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner.
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| Liu Q, Zhao Y, Wu R, Jiang Q, Cai M, Bi Z, Liu Y, Yao Y, Feng J, Wang Y, Wang X.
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| RNA Biol 16(12):1785-1793. doi: 10.1080/15476286.2019.1658508. Epub 2019 Aug 27.
2019
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| 6 | METTL3
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| ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner.
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| Liu Q, Zhao Y, Wu R, Jiang Q, Cai M, Bi Z, Liu Y, Yao Y, Feng J, Wang Y, Wang X.
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| RNA Biol 16(12):1785-1793. doi: 10.1080/15476286.2019.1658508. Epub 2019 Aug 27.
2019
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| 7 | FASN, METTL3
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| METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism.
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| Xie W, Ma LL, Xu YQ, Wang BH, Li SM.
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| Biochem Biophys Res Commun 518(1):120-126. doi: 10.1016/j.bbrc.2019.08.018. Epub 2019 Aug 10.
2019
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| 8 | METTL3
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| Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation.
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| Lee H, Bao S, Qian Y, Geula S, Leslie J, Zhang C, Hanna JH, Ding L.
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| Nat Cell Biol 21(6):700-709. doi: 10.1038/s41556-019-0318-1. Epub 2019 May 6.
2019
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| 9 | METTL3
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| Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
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| Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X.
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| Nat Commun 10(1):1898. doi: 10.1038/s41467-019-09903-6.
2019
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| 10 | METTL3, VEGFA
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| Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.
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| Tian C, Huang Y, Li Q, Feng Z, Xu Q.
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| Int J Mol Sci 20(3). pii: E551. doi: 10.3390/ijms20030551.
2019
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| 11 | METTL3, TRAF6
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| Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
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| Zong X, Zhao J, Wang H, Lu Z, Wang F, Du H, Wang Y.
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| J Immunol 202(2):567-578. doi: 10.4049/jimmunol.1801151. Epub 2018 Dec 19.
2019
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| 12 | METTL14, METTL3
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| The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia.
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| Sun C, Chang L, Liu C, Chen X, Zhu X.
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| Mol Genet Genomic Med 7(10):e00933. doi: 10.1002/mgg3.933. Epub 2019 Aug 20.
2019
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| 13 | METTL14, METTL3, WTAP
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| Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site.
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| Selberg S, Blokhina D, Aatonen M, Koivisto P, Siltanen A, Mervaala E, Kankuri E, Karelson M.
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| Cell Rep 26(13):3762-3771.e5. doi: 10.1016/j.celrep.2019.02.100.
2019
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| 14 | METTL3
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| Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
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| Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, Jiang Y, Ye L, Chen Q, Zhou X, Lin S, Yuan Q.
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| Nat Commun 9(1):4772. doi: 10.1038/s41467-018-06898-4.
2018
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| 15 | METTL3
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| METTL3-mediated m6A modification is required for cerebellar development.
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| Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, Jiang GB, Wang HL, Tong WM, Li W, Wang XJ, Yang YG, Zhou Q.
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| PLoS Biol 16(6):e2004880. doi: 10.1371/journal.pbio.2004880. eCollection 2018 Jun.
2018
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| 16 | METTL3
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| SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
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| Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X, Yu J.
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| Nucleic Acids Res 46(10):5195-5208. doi: 10.1093/nar/gky156.
2018
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| 17 | LAMTOR5, METTL3
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| HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g.
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| Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W, Ye L.
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| Cancer Lett 415:11-19. doi: 10.1016/j.canlet.2017.11.018. Epub 2017 Nov 22.
2018
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| 18 | METTL14, METTL3, WTAP
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| The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.
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| Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K.
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| Mol Cell Biol 38(16). pii: e00116-18. doi: 10.1128/MCB.00116-18. Print 2018 Aug 15.
2018
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| 19 | METTL14, METTL3, WTAP
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| Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.
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| Schöller E, Weichmann F, Treiber T, Ringle S, Treiber N, Flatley A, Feederle R, Bruckmann A, Meister G.
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| RNA 24(4):499-512. doi: 10.1261/rna.064063.117. Epub 2018 Jan 18.
2018
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| 20 | METTL3
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| The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
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| Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG.
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| Nat Med 23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
2017
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| 21 | METTL3, MYOD1
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| The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
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| Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y.
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| Open Biol 7(9). pii: 170119. doi: 10.1098/rsob.170119.
2017
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| 22 | METTL14, METTL3
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| Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
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| Wang P, Doxtader KA, Nam Y.
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| Mol Cell 63(2):306-317. doi: 10.1016/j.molcel.2016.05.041. Epub 2016 Jun 30.
2016
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| 23 | METTL3
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| The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
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| Lin S, Choe J, Du P, Triboulet R, Gregory RI.
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| Mol Cell 62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
2016
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| 24 | METTL14, METTL3
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| Structural insights into the molecular mechanism of the m(6)A writer complex.
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| Śledź P, Jinek M.
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| Elife 5. pii: e18434. doi: 10.7554/eLife.18434.
2016
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| 25 | METTL14, METTL3
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| A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
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| Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C.
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| Nat Chem Biol 10(2):93-5. doi: 10.1038/nchembio.1432. Epub 2013 Dec 6.
2014
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| 26 | METTL14, METTL3, WTAP
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| Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.
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| Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, Adhikari S, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Dahal U, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang X, Rendtlew Danielsen JM, Liu F, Yang YG.
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| Cell Res 24(2):177-89. doi: 10.1038/cr.2014.3. Epub 2014 Jan 10.
2014
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| 27 | METTL3
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| RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
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| Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H.
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| Cell 155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
2013
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| 28 | METTL3
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| Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.
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| Hongay CF, Orr-Weaver TL.
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| Proc Natl Acad Sci U S A 108(36):14855-60. doi: 10.1073/pnas.1111577108. Epub 2011 Aug 22.
2011
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| 29 | METTL3
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| Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.
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| Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM.
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| RNA 3(11):1233-47. 1997
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