| 1 | MELK
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| Phillygenin, a MELK Inhibitor, Inhibits Cell Survival and Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells.
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| Li H, Chen M, Yang Z, Wang Q, Wang J, Jin D, Yang X, Chen F, Zhou X, Luo K.
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| Onco Targets Ther 13:2833-2842. doi: 10.2147/OTT.S238958. eCollection 2020.
2020
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| 2 | FOXM1, MELK
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| Maternal Embryonic Leucine Zipper Kinase Promotes Tumor Growth and Metastasis via Stimulating FOXM1 Signaling in Esophageal Squamous Cell Carcinoma.
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| Chen L, Wei Q, Bi S, Xie S.
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| Front Oncol 10:10. doi: 10.3389/fonc.2020.00010. eCollection 2020.
2020
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| 3 | FOXM1, MELK, TP53
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| Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.
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| Bollu LR, Shepherd J, Zhao D, Ma Y, Tahaney W, Speers C, Mazumdar A, Mills GB, Brown PH.
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| NPJ Breast Cancer 6:2. doi: 10.1038/s41523-019-0143-5. eCollection 2020.
2020
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| 4 | BUB1B, MELK
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| BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK.
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| Tian JH, Mu LJ, Wang MY, Zeng J, Long QZ, Guan B, Wang W, Jiang YM, Bai XJ, Du YF.
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| Anticancer Agents Med Chem nticancer Agents Med Chem. 2020 Jan 1. doi: 10.2174/1871520620666200101141934. [Epub ahead of print]
2020
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| 5 | CDKN1A, MELK
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| Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice.
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| Seong HA, Ha H.
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| Cell Death Dis 10(6):380. doi: 10.1038/s41419-019-1616-z.
2019
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| 6 | EZH2, MELK, USP36
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| MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma.
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| Li B, Yan J, Phyu T, Fan S, Chung TH, Mustafa N, Lin B, Wang L, Eichhorn PJA, Goh BC, Ng SB, Kappei D, Chng WJ.
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| Blood 134(23):2046-2058. doi: 10.1182/blood.2019000381.
2019
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| 7 | EZH2, MELK
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| EZH2 Phosphorylation Promotes Self-Renewal of Glioma Stem-Like Cells Through NF-κB Methylation.
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| Liu H, Sun Y, Qi X, Gordon RE, O'Brien JA, Yuan H, Zhang J, Wang Z, Zhang M, Song Y, Yu C, Gu C.
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| Front Oncol 9:641. doi: 10.3389/fonc.2019.00641. eCollection 2019.
2019
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| 8 | MELK, SOX2
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| MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells.
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| Ren L, Deng B, Saloura V, Park JH, Nakamura Y.
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| Oncol Rep 41(4):2540-2548. doi: 10.3892/or.2019.6988. Epub 2019 Jan 30.
2019
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| 9 | MELK
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| Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity.
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| Seong HA, Manoharan R, Ha H.
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| Cell Death Dis 9(5):471. doi: 10.1038/s41419-018-0489-x.
2018
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| 10 | MELK
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| MELK expression correlates with tumor mitotic activity but is not required for cancer growth.
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| Giuliano CJ, Lin A, Smith JC, Palladino AC, Sheltzer JM.
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| Elife 7. pii: e32838. doi: 10.7554/eLife.32838.
2018
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| 11 | MELK, ZNF622
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| Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways.
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| Seong HA, Manoharan R, Ha H.
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| Sci Rep 7:42502. doi: 10.1038/srep42502.
2017
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| 12 | MELK
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| MELK is a novel therapeutic target in high-risk neuroblastoma.
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| Guan S, Lu J, Zhao Y, Yu Y, Li H, Chen Z, Shi Z, Liang H, Wang M, Guo K, Chen X, Sun W, Bieerkehazhi S, Xu X, Sun S, Agarwal S, Yang J.
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| Oncotarget 9(2):2591-2602. doi: 10.18632/oncotarget.23515. eCollection 2018 Jan 5.
2017
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| 13 | MELK
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| p53-independent p21 induction by MELK inhibition.
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| Matsuda T, Kato T, Kiyotani K, Tarhan YE, Saloura V, Chung S, Ueda K, Nakamura Y, Park JH.
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| Oncotarget 8(35):57938-57947. doi: 10.18632/oncotarget.18488. eCollection 2017 Aug 29.
2017
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| 14 | MELK
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| Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis.
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| Takeuchi H, Saito H, Noda T, Miyamoto T, Yoshinaga T, Terahara K, Ishii H, Tsunetsugu-Yokota Y, Yamaoka S.
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| PLoS Pathog 13(7):e1006441. doi: 10.1371/journal.ppat.1006441. eCollection 2017 Jul.
2017
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| 15 | MELK
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| MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence.
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| Xia H, Kong SN, Chen J, Shi M, Sekar K, Seshachalam VP, Rajasekaran M, Goh BKP, Ooi LL, Hui KM.
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| Cancer Lett 383(1):85-93. doi: 10.1016/j.canlet.2016.09.017. Epub 2016 Sep 28.
2016
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| 16 | EIF4B, MELK
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| Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
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| Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ.
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| Proc Natl Acad Sci U S A 113(35):9810-5. doi: 10.1073/pnas.1606862113. Epub 2016 Aug 15.
2016
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| 17 | MELK
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| MELK-a conserved kinase: functions, signaling, cancer, and controversy.
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| Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I.
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| Clin Transl Med 4:11. doi: 10.1186/s40169-014-0045-y. eCollection 2015.
2015
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| 18 | MELK, STRAP
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| A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways.
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| Seong HA, Manoharan R, Ha H.
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| Cell Cycle 13(21):3357-74. doi: 10.4161/15384101.2014.952165.
2014
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| 19 | MELK
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| Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner.
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| Manoharan R, Seong HA, Ha H.
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| Free Radic Biol Med 63:313-24. doi: 10.1016/j.freeradbiomed.2013.05.020. Epub 2013 Jun 4.
2013
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| 20 | MELK
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| Maternal embryonic leucine zipper kinase (MELK): a novel regulator in cell cycle control, embryonic development, and cancer.
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| Jiang P, Zhang D.
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| Int J Mol Sci 14(11):21551-60. doi: 10.3390/ijms141121551. Review.
2013
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| 21 | MELK
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| Structural insight into maternal embryonic leucine zipper kinase (MELK) conformation and inhibition toward structure-based drug design.
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| Canevari G, Re Depaolini S, Cucchi U, Bertrand JA, Casale E, Perrera C, Forte B, Carpinelli P, Felder ER.
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| Biochemistry 52(37):6380-7. doi: 10.1021/bi4005864. Epub 2013 Sep 4.
2013
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| 22 | MELK
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| Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells.
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| Saito R, Nakauchi H, Watanabe S.
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| Cancer Sci 103(1):42-9. doi: 10.1111/j.1349-7006.2011.02104.x. Epub 2011 Oct 17.
2012
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| 23 | MELK
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| Cortical localization of maternal embryonic leucine zipper kinase (MELK) implicated in cytokinesis in early xenopus embryos.
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| Tassan JP.
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| Commun Integr Biol 4(4):483-5. Epub 2011 Jul 1.
2011
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| 24 | MELK
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| A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development.
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| Le Page Y, Chartrain I, Badouel C, Tassan JP.
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| J Cell Sci 124(Pt 6):958-68.
2011
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| 25 | MAP3K5, MELK, ZNF622
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| Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein.
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| Seong HA, Jung H, Manoharan R, Ha H.
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| J Biol Chem 286(36):31123-35. Epub 2011 Jul 19.
2011
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| 26 | MELK
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| A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development.
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| Le Page Y, Chartrain I, Badouel C, Tassan JP.
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| J Cell Sci 124(Pt 6):958-68. doi: 10.1242/jcs.069567.
2011
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| 27 | FAU, MELK
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| Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
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| Pickard MR, Green AR, Ellis IO, Caldas C, Hedge VL, Mourtada-Maarabouni M, Williams GT.
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| Breast Cancer Res 11(4):R60. Epub 2009 Aug 11.
2009
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| 28 | BCL2L14, FAU, MELK
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| Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
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| Pickard MR, Green AR, Ellis IO, Caldas C, Hedge VL, Mourtada-Maarabouni M, Williams GT.
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| Breast Cancer Res 11(4):R60. doi: 10.1186/bcr2350. Epub 2009 Aug 11.
2009
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| 29 | MELK
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| Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.
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| Marie SK, Okamoto OK, Uno M, Hasegawa AP, Oba-Shinjo SM, Cohen T, Camargo AA, Kosoy A, Carlotti CG Jr, Toledo S, Moreira-Filho CA, Zago MA, Simpson AJ, Caballero OL.
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| Int J Cancer 122(4):807-15.
2008
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| 30 | MELK
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| Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.
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| Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T.
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| Breast Cancer Res 9(1):R17.
2007
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| 31 | MELK
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| A mitochondrial-targeting signal is present in the non-catalytic domain of the MELK protein kinase.
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| Chartrain I, Blot J, Lerivray H, Guyot N, Tassan JP.
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| Cell Biol Int 31(2):196-201. Epub 2006 Oct 19.
2007
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| 32 | BCL2L14, MELK
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| Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.
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| Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T.
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| Breast Cancer Res 9(1):R17.
2007
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| 33 | MELK
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| Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.
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| Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI.
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| J Cell Biol 170(3):413-27.
2005
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| 34 | MELK, ZNF622
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| Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).
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| Seong HA, Gil M, Kim KT, Kim SJ, Ha H.
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| Biochem J 361(Pt 3):597-604.
2002
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| 35 | CCIN, CLTA, CREB3, GNE, IBM2, MELK, PAX5, RECK
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| Physical and transcriptional map of the hereditary inclusion body myopathy locus on chromosome 9p12-p13.
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| Eisenberg I, Hochner H, Shemesh M, Levi T, Potikha T, Sadeh M, Argov Z, Jackson CL, Mitrani-Rosenbaum S.
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| Eur J Hum Genet 9(7):501-9. 2001
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| 36 | MELK
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| New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.
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| Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL.
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| Mol Reprod Dev 47(2):148-56.
1997
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