Citations for
1CD74, MEF2A, PLAGL1, SLC2A4
Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
Liang Y, Yuan W, Zhu W, Zhu J, Lin Q, Zou X, Deng C, Fu Y, Zheng X, Yang M, Wu S, Yu X, Shan Z.
Metabolism 64(12):1682-93. doi: 10.1016/j.metabol.2015.09.007. Epub 2015 Sep 12. 2015
2AKAP6, MEF2A, MYOG
AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.
Lee SW, Won JY, Yang J, Lee J, Kim SY, Lee EJ, Kim HS.
Sci Rep 5:16523. doi: 10.1038/srep16523. 2015
3MEF2A, MEF2C, MEF2D
Requirement of MEF2A, C, and D for skeletal muscle regeneration.
Liu N, Nelson BR, Bezprozvannaya S, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN.
Proc Natl Acad Sci U S A 111(11):4109-14. doi: 10.1073/pnas.1401732111. Epub 2014 Mar 3. 2014
4DIO3, MEF2A, MEG3
MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration.
Snyder CM, Rice AL, Estrella NL, Held A, Kandarian SC, Naya FJ.
Development 140(1):31-42. doi: 10.1242/dev.081851. Epub 2012 Nov 15. 2013
5MEF2A, NR3C1
Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-JUN in a neuronal context.
Speksnijder N, Christensen KV, Didriksen M, De Kloet ER, Datson NA.
J Mol Neurosci 48(1):209-18. doi: 10.1007/s12031-012-9809-2. Epub 2012 May 24. 2012
6MEF2A, MEF2C, MEF2D
In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival.
Akhtar MW, Kim MS, Adachi M, Morris MJ, Qi X, Richardson JA, Bassel-Duby R, Olson EN, Kavalali ET, Monteggia LM.
PLoS One 7(4):e34863. doi: 10.1371/journal.pone.0034863. Epub 2012 Apr 9. 2012
7DLG4, FMR1, MEF2A, PCDH10
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.
Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM.
Cell 151(7):1581-94. doi: 10.1016/j.cell.2012.11.040. 2012
8MEF2A
The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential.
Callegari S, McKinnon RA, Andrews S, de Barros Lopes MA.
FEBS Lett 585(8):1140-6. Epub 2011 Mar 21. 2011
9MEF2A, MEF2C, SOX10
The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10.
Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL.
Development 138(12):2555-65. 2011
10CMYA5, MEF2A, XIRP2
The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle.
Ewen EP, Snyder CM, Wilson M, Desjardins D, Naya FJ.
J Biol Chem 286(34):29644-53. Epub 2011 Jul 1. 2011
11MEF2A, MIR155
miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation.
Seok HY, Tatsuguchi M, Callis TE, He A, Pu WT, Wang DZ.
J Biol Chem 286(41):35339-46. doi: 10.1074/jbc.M111.273276. Epub 2011 Aug 25. 2011
12HDAC4, MEF2A
Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4.
Backs J, Worst BC, Lehmann LH, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN.
J Cell Biol 195(3):403-15. doi: 10.1083/jcb.201105063. 2011
13HDAC1, MEF2A, MEF2D
Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression.
Aude-Garcia C, Collin-Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C.
Biochem J 430(2):237-44. 2010
14MEF2A, XIRP2
Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.
McCalmon SA, Desjardins DM, Ahmad S, Davidoff KS, Snyder CM, Sato K, Ohashi K, Kielbasa OM, Mathew M, Ewen EP, Walsh K, Gavras H, Naya FJ.
Circ Res 106(5):952-60. Epub 2010 Jan 21. 2010
15HDAC4, MEF2A, MEF2B, MEF2C
The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
Cohen TJ, Barrientos T, Hartman ZC, Garvey SM, Cox GA, Yao TP.
FASEB J 23(1):99-106. Epub 2008 Sep 9. 2009
16ATP6V0D2, MEF2A, MITF, NFATC1
Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.
Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J.
J Biol Chem 284(21):14667-76. Epub 2009 Mar 25.PMID: 19321441 2009
17GNA13, MEF2A, MEF2B, MEF2C
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA.
Angiogenesis 12(1):1-15. Epub 2008 Dec 18.PMID: 19093215 2009
18MEF2A, NRF1
Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits.
Ramachandran B, Yu G, Gulick T.
J Biol Chem 283(18):11935-46. Epub 2008 Jan 24. 2008
19MEF2A
Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma.
Bai X, Wu L, Liang T, Liu Z, Li J, Li D, Xie H, Yin S, Yu J, Lin Q, Zheng S.
J Cancer Res Clin Oncol 134(1):83-91. Epub 2007 Jul 5. 2008
20CABIN1, MEF2A, MEF2B, MEF2C, MEF2D, SUV39H1
Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1.
Jang H, Choi DE, Kim H, Cho EJ, Youn HD.
J Biol Chem 282(15):11172-9. Epub 2006 Dec 17. 2007
21ATXN1, HDAC4, MEF2A, MEF2B, MEF2C, MEF2D
The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.
Bolger TA, Zhao X, Cohen TJ, Tsai CC, Yao TP.
J Biol Chem 282(40):29186-92. Epub 2007 Jul 23. 2007
22BMP2, MEF2A
Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility.
Wang YX, Qian LX, Liu D, Yao LL, Jiang Q, Yu Z, Gui YH, Zhong TP, Song HY.
Cardiovasc Res 74(2):290-303. Epub 2007 Feb 12. 2007
23MEF2A, PIAS2
PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis.
Shalizi A, Bilimoria PM, Stegmüller J, Gaudillière B, Yang Y, Shuai K, Bonni A.
J Neurosci 27(37):10037-46. 2007
24MEF2A, MEF2B, MEF2C, PTH, SOST
Control of the SOST bone enhancer by PTH using MEF2 transcription factors.
Leupin O, Kramer I, Collette NM, Loots GG, Natt F, Kneissel M, Keller H.
J Bone Miner Res 22(12):1957-67.PMID: 17696759 2007
25MEF2A
The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.
Gonzalez P, Garcia-Castro M, Reguero JR, Batalla A, Ordonez AG, Palop RL, Lozano I, Montes M, Alvarez V, Coto E.
J Med Genet 43(2):167-9. Epub 2005 Jun 15. 2006
26MEF2A, XIRP2
Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.
Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ.
J Biol Chem 281(51):39370-9. Epub 2006 Oct 17. 2006
27MEF2A, PIAS1
SUMO-1 modification of MEF2A regulates its transcriptional activity.
Riquelme C, Barthel KK, Liu X.
J Cell Mol Med 10(1):132-44. 2006
28MEF2A, MEF2C, MEF2D
Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.
Zhu B, Ramachandran B, Gulick T.
J Biol Chem 280(31):28749-60. Epub 2005 Apr 15. 2005
29HAND1,MEF2A
MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters.
Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M.
J Biol Chem 280(37):32272-8. Epub 2005 Jul 25. 2005
30MEF2A, DIH1
Congenital diaphragmatic hernia: is 15q26.1-26.2 a candidate locus?
Biggio JR Jr, Descartes MD, Carroll AJ, Holt RL.
Am J Med Genet 126A(2):183-5. 2004
31MEF2A, ADCAD1
Transcription factor MEF2A mutations in patients with coronary artery disease.
Bhagavatula MR, Fan C, Shen GQ, Cassano J, Plow EF, Topol EJ, Wang Q.
Hum Mol Genet 13(24):3181-8. Epub 2004 Dec 15. 2004
32MEF2A, MEF2B, MEF2C, MEF2D, NFATC2
Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT).
Pan F, Ye Z, Cheng L, Liu JO.
J Biol Chem 279(15):14477-80. Epub 2004 Jan 13. 2004
33MEF2A, ADCAD1
Mutation of MEF2A in an inherited disorder with features of coronary artery disease.
Wang L, Fan C, Topol SE, Topol EJ, Wang Q.
Science 302(5650):1578-81. 2003
34SLC2A4, MEF2A
Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.
Knight JB, Eyster CA, Griesel BA, Olson AL.
Proc Natl Acad Sci U S A 100(25):14725-30. Epub 2003 Nov 20. 2003
35MEF2A, MEF2B, HDAC4
Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity.
Chan JK, Sun L, Yang XJ, Zhu G, Wu Z.
J Biol Chem 278(26):23515-21. Epub 2003 Apr 21. 2003
36MYOD1, MEF2A, TWIST2
Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.
Gong XQ, Li L.
J Biol Chem 277(14):12310-7. Epub 2002 Jan 23. 2002
37MEF2A, MEF2B, MEF2C
Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.
Lu J, McKinsey TA, Zhang CL, Olson EN.
Mol Cell 6(2):233-44. 2000
38CITED1, CITED2, MEF2A, NR4A1
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis.
Youn HD, Chatila TA, Liu JO.
EMBO J 19(16):4323-31. 2000
39HDAC1, HDAC9, MEF2A
MEF-2 function is modified by a novel co-repressor, MITR
Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, Spohr G, Kouzarides T, Mohun TJ.
EMBO J 18(18):5085-98. 1999
40MEF2A, MEF2B, MEF2C
MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.
Katoh Y, Molkentin JD, Dave V, Olson EN, Periasamy M.
J Biol Chem 273(3):1511-8.PMID: 9430690 1998
41MEF2A, MEF2AP
Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP.
Suzuki E, et al.
Cytogenet Cell Genet 73 : 244-249. 1996
42MEF2A
MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells.
Dodou E, et al.
Nucleic Acids Res 23 : 4267-4274. 1995
43MEF2A, MEF2B, MEF2C, MEF2D
Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.
Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL.
Genomics 29(3):704-11. 1995
44MEF2A, MEF2B, MEF2C, MEF2D
A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.
Gossett LA, Kelvin DJ, Sternberg EA, Olson EN.
Mol Cell Biol 9(11):5022-33. 1989