| 1 | HSPB7, JUN, MEF2A
|
| Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy.
|
| Tobin SW, Yang D, Girgis J, Farahzad A, Blais A, McDermott JC.
|
| J Cell Sci. Nov 1;129(21):4076-4090. doi: 10.1242/jcs.190009. Epub 2016 Sep 15. 2016
|
| 2 | CD74, MEF2A, PLAGL1, SLC2A4
|
| Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
|
| Liang Y, Yuan W, Zhu W, Zhu J, Lin Q, Zou X, Deng C, Fu Y, Zheng X, Yang M, Wu S, Yu X, Shan Z.
|
| Metabolism 64(12):1682-93. doi: 10.1016/j.metabol.2015.09.007. Epub 2015 Sep 12.
2015
|
| 3 | AKAP6, MEF2A, MYOG
|
| AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.
|
| Lee SW, Won JY, Yang J, Lee J, Kim SY, Lee EJ, Kim HS.
|
| Sci Rep 5:16523. doi: 10.1038/srep16523.
2015
|
| 4 | MEF2A, MEF2C, MEF2D
|
| Requirement of MEF2A, C, and D for skeletal muscle regeneration.
|
| Liu N, Nelson BR, Bezprozvannaya S, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN.
|
| Proc Natl Acad Sci U S A 111(11):4109-14. doi: 10.1073/pnas.1401732111. Epub 2014 Mar 3.
2014
|
| 5 | DIO3, MEF2A, MEG3
|
| MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration.
|
| Snyder CM, Rice AL, Estrella NL, Held A, Kandarian SC, Naya FJ.
|
| Development 140(1):31-42. doi: 10.1242/dev.081851. Epub 2012 Nov 15.
2013
|
| 6 | MEF2A, NR3C1
|
| Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-JUN in a neuronal context.
|
| Speksnijder N, Christensen KV, Didriksen M, De Kloet ER, Datson NA.
|
| J Mol Neurosci 48(1):209-18. doi: 10.1007/s12031-012-9809-2. Epub 2012 May 24.
2012
|
| 7 | MEF2A, MEF2C, MEF2D
|
| In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival.
|
| Akhtar MW, Kim MS, Adachi M, Morris MJ, Qi X, Richardson JA, Bassel-Duby R, Olson EN, Kavalali ET, Monteggia LM.
|
| PLoS One 7(4):e34863. doi: 10.1371/journal.pone.0034863. Epub 2012 Apr 9.
2012
|
| 8 | DLG4, FMR1, MEF2A, PCDH10
|
| Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.
|
| Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM.
|
| Cell 151(7):1581-94. doi: 10.1016/j.cell.2012.11.040.
2012
|
| 9 | MEF2A
|
| The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential.
|
| Callegari S, McKinnon RA, Andrews S, de Barros Lopes MA.
|
| FEBS Lett 585(8):1140-6. Epub 2011 Mar 21.
2011
|
| 10 | MEF2A, MEF2C, SOX10
|
| The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10.
|
| Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL.
|
| Development 138(12):2555-65.
2011
|
| 11 | CMYA5, MEF2A, XIRP2
|
| The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle.
|
| Ewen EP, Snyder CM, Wilson M, Desjardins D, Naya FJ.
|
| J Biol Chem 286(34):29644-53. Epub 2011 Jul 1.
2011
|
| 12 | MEF2A, MIR155
|
| miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation.
|
| Seok HY, Tatsuguchi M, Callis TE, He A, Pu WT, Wang DZ.
|
| J Biol Chem 286(41):35339-46. doi: 10.1074/jbc.M111.273276. Epub 2011 Aug 25.
2011
|
| 13 | HDAC4, MEF2A
|
| Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4.
|
| Backs J, Worst BC, Lehmann LH, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN.
|
| J Cell Biol 195(3):403-15. doi: 10.1083/jcb.201105063.
2011
|
| 14 | HDAC1, MEF2A, MEF2D
|
| Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression.
|
| Aude-Garcia C, Collin-Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C.
|
| Biochem J 430(2):237-44. 2010
|
| 15 | MEF2A, XIRP2
|
| Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.
|
| McCalmon SA, Desjardins DM, Ahmad S, Davidoff KS, Snyder CM, Sato K, Ohashi K, Kielbasa OM, Mathew M, Ewen EP, Walsh K, Gavras H, Naya FJ.
|
| Circ Res 106(5):952-60. Epub 2010 Jan 21.
2010
|
| 16 | HDAC4, MEF2A, MEF2B, MEF2C
|
| The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
|
| Cohen TJ, Barrientos T, Hartman ZC, Garvey SM, Cox GA, Yao TP.
|
| FASEB J 23(1):99-106. Epub 2008 Sep 9.
2009
|
| 17 | ATP6V0D2, MEF2A, MITF, NFATC1
|
| Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.
|
| Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J.
|
| J Biol Chem 284(21):14667-76. Epub 2009 Mar 25.PMID: 19321441 2009
|
| 18 | GNA13, MEF2A, MEF2B, MEF2C
|
| Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
|
| Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA.
|
| Angiogenesis 12(1):1-15. Epub 2008 Dec 18.PMID: 19093215 2009
|
| 19 | MEF2A, NRF1
|
| Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits.
|
| Ramachandran B, Yu G, Gulick T.
|
| J Biol Chem 283(18):11935-46. Epub 2008 Jan 24.
2008
|
| 20 | MEF2A
|
| Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma.
|
| Bai X, Wu L, Liang T, Liu Z, Li J, Li D, Xie H, Yin S, Yu J, Lin Q, Zheng S.
|
| J Cancer Res Clin Oncol 134(1):83-91. Epub 2007 Jul 5.
2008
|
| 21 | CABIN1, MEF2A, MEF2B, MEF2C, MEF2D, SUV39H1
|
| Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1.
|
| Jang H, Choi DE, Kim H, Cho EJ, Youn HD.
|
| J Biol Chem 282(15):11172-9. Epub 2006 Dec 17. 2007
|
| 22 | ATXN1, HDAC4, MEF2A, MEF2B, MEF2C, MEF2D
|
| The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.
|
| Bolger TA, Zhao X, Cohen TJ, Tsai CC, Yao TP.
|
| J Biol Chem 282(40):29186-92. Epub 2007 Jul 23. 2007
|
| 23 | BMP2, MEF2A
|
| Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility.
|
| Wang YX, Qian LX, Liu D, Yao LL, Jiang Q, Yu Z, Gui YH, Zhong TP, Song HY.
|
| Cardiovasc Res 74(2):290-303. Epub 2007 Feb 12.
2007
|
| 24 | MEF2A, PIAS2
|
| PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis.
|
| Shalizi A, Bilimoria PM, Stegmüller J, Gaudillière B, Yang Y, Shuai K, Bonni A.
|
| J Neurosci 27(37):10037-46.
2007
|
| 25 | MEF2A, MEF2B, MEF2C, PTH, SOST
|
| Control of the SOST bone enhancer by PTH using MEF2 transcription factors.
|
| Leupin O, Kramer I, Collette NM, Loots GG, Natt F, Kneissel M, Keller H.
|
| J Bone Miner Res 22(12):1957-67.PMID: 17696759 2007
|
| 26 | MEF2A
|
| The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.
|
| Gonzalez P, Garcia-Castro M, Reguero JR, Batalla A, Ordonez AG, Palop RL, Lozano I, Montes M, Alvarez V, Coto E.
|
| J Med Genet 43(2):167-9. Epub 2005 Jun 15. 2006
|
| 27 | MEF2A, XIRP2
|
| Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.
|
| Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ.
|
| J Biol Chem 281(51):39370-9. Epub 2006 Oct 17.
2006
|
| 28 | MEF2A, PIAS1
|
| SUMO-1 modification of MEF2A regulates its transcriptional activity.
|
| Riquelme C, Barthel KK, Liu X.
|
| J Cell Mol Med 10(1):132-44.
2006
|
| 29 | MEF2A, MEF2C, MEF2D
|
| Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.
|
| Zhu B, Ramachandran B, Gulick T.
|
| J Biol Chem 280(31):28749-60. Epub 2005 Apr 15. 2005
|
| 30 | HAND1,MEF2A
|
| MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters.
|
| Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M.
|
| J Biol Chem 280(37):32272-8. Epub 2005 Jul 25. 2005
|
| 31 | MEF2A, DIH1
|
| Congenital diaphragmatic hernia: is 15q26.1-26.2 a candidate locus?
|
| Biggio JR Jr, Descartes MD, Carroll AJ, Holt RL.
|
| Am J Med Genet 126A(2):183-5. 2004
|
| 32 | MEF2A, ADCAD1
|
| Transcription factor MEF2A mutations in patients with coronary artery disease.
|
| Bhagavatula MR, Fan C, Shen GQ, Cassano J, Plow EF, Topol EJ, Wang Q.
|
| Hum Mol Genet 13(24):3181-8. Epub 2004 Dec 15. 2004
|
| 33 | MEF2A, MEF2B, MEF2C, MEF2D, NFATC2
|
| Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT).
|
| Pan F, Ye Z, Cheng L, Liu JO.
|
| J Biol Chem 279(15):14477-80. Epub 2004 Jan 13. 2004
|
| 34 | MEF2A, ADCAD1
|
| Mutation of MEF2A in an inherited disorder with features of coronary artery disease.
|
| Wang L, Fan C, Topol SE, Topol EJ, Wang Q.
|
| Science 302(5650):1578-81. 2003
|
| 35 | SLC2A4, MEF2A
|
| Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.
|
| Knight JB, Eyster CA, Griesel BA, Olson AL.
|
| Proc Natl Acad Sci U S A 100(25):14725-30. Epub 2003 Nov 20. 2003
|
| 36 | MEF2A, MEF2B, HDAC4
|
| Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity.
|
| Chan JK, Sun L, Yang XJ, Zhu G, Wu Z.
|
| J Biol Chem 278(26):23515-21. Epub 2003 Apr 21. 2003
|
| 37 | MYOD1, MEF2A, TWIST2
|
| Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.
|
| Gong XQ, Li L.
|
| J Biol Chem 277(14):12310-7. Epub 2002 Jan 23. 2002
|
| 38 | MEF2A, MEF2B, MEF2C
|
| Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.
|
| Lu J, McKinsey TA, Zhang CL, Olson EN.
|
| Mol Cell 6(2):233-44. 2000
|
| 39 | CITED1, CITED2, MEF2A, NR4A1
|
| Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis.
|
| Youn HD, Chatila TA, Liu JO.
|
| EMBO J 19(16):4323-31. 2000
|
| 40 | HDAC1, HDAC9, MEF2A
|
| MEF-2 function is modified by a novel co-repressor, MITR
|
| Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, Spohr G, Kouzarides T, Mohun TJ.
|
| EMBO J 18(18):5085-98. 1999
|
| 41 | MEF2A, MEF2B, MEF2C
|
| MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.
|
| Katoh Y, Molkentin JD, Dave V, Olson EN, Periasamy M.
|
| J Biol Chem 273(3):1511-8.PMID: 9430690 1998
|
| 42 | MEF2A, MEF2AP
|
| Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP.
|
| Suzuki E, et al.
|
| Cytogenet Cell Genet 73 : 244-249. 1996
|
| 43 | MEF2A
|
| MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells.
|
| Dodou E, et al.
|
| Nucleic Acids Res 23 : 4267-4274. 1995
|
| 44 | MEF2A, MEF2B, MEF2C, MEF2D
|
| Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.
|
| Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL.
|
| Genomics 29(3):704-11. 1995
|
| 45 | MEF2A, MEF2B, MEF2C, MEF2D
|
| A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.
|
| Gossett LA, Kelvin DJ, Sternberg EA, Olson EN.
|
| Mol Cell Biol 9(11):5022-33. 1989
|