| 1 | FAM193A, MDM4
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| FAM193A is a positive regulator of p53 activity
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| Szwarc MM, Guarnieri AL, Joshi M, Duc HN, Laird MC, Pandey A, Khanal S, Dohm E, Bui AK, Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM.
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| Cell Rep. Mar 28;42(3):112230. doi: 10.1016/j.celrep.2023.112230. Epub 2023 Mar 9. 2023
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| 2 | MDM4
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| MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53
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| Zhang X, Yamamoto Y, Wang X, Sato M, Imanishi M, Sugaya A, Hirose M, Endo S, Moriwaki T, Yamato K, Hyodo I.
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| Anticancer Res. Mar;41(3):1475-1483. doi: 10.21873/anticanres.14906 2021
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| 3 | MDM4, PRPF19, TP53
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| PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA
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| Yano K, Takahashi RU, Shiotani B, Abe J, Shidooka T, Sudo Y, Yamamoto Y, Kan S, Sakagami H, Tahara H.
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| J Biol Chem. Jul;297(1):100882. doi: 10.1016/j.jbc.2021.100882. Epub 2021 Jun 16. 2021
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| 4 | MDM2, MDM4
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| Mdm4 supports DNA replication in a p53-independent fashion.
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| Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M.
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| Oncogene. Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. 2020
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| 5 | BMFS6, MDM4, TP53
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| Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance
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| Toufektchan E, Lejour V, Durand R, Giri N, Draskovic I, Bardot B, Laplante P, Jaber S, Alter BP, Londono-Vallejo JA, Savage SA, Toledo F.
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| Sci Adv. Apr 10;6(15):eaay3511. doi: 10.1126/sciadv.aay3511. 2020
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| 6 | MDM4
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| The long and the short of it: the MDM4 tail so far
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| Haupt S, Mejía-Hernández JO, Vijayakumaran R, Keam SP, Haupt Y.
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| J Mol Cell Biol. Mar 1;11(3):231-244. doi: 10.1093/jmcb/mjz007. Erratum in: J Mol Cell Biol. 2019 Dec 19;11(12):1104. 2019
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| 7 | MDM2, MDM4
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| Regulation of kidney development by the Mdm2/Mdm4-p53 axis
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| El-Dahr S, Hilliard S, Saifudeen Z.
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| J Mol Cell Biol. Feb 1;9(1):26-33. doi: 10.1093/jmcb/mjx005. 2017
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| 8 | MDM4, MTOR
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| MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.
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| Mancini F, Teveroni E, Di Conza G, Monteleone V, Arisi I, Pellegrino M, Buttarelli M, Pieroni L, D'Onofrio M, Urbani A, Pontecorvi A, Mazzone M, Moretti F
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| Mol Cancer. Mar 7;16(1):55. doi: 10.1186/s12943-017-0626-7. 2017
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| 9 | MDM4
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| Novel Therapeutic Approach for Hematologic Malignancies
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| Cao L, Fan L, Xu W, Li JY.
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| Curr Cancer Drug Targets. ;15(9):769-80. doi: 10.2174/156800961509151110124616 2015
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| 10 | MDM2, MDM4, TP53
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| The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury
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| Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Marine JC, Puttagunta R, Di Giovanni S.
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| Brain Jul;138(Pt 7):1843-62. doi: 10.1093/brain/awv125. Epub 2015 May 16. Erratum in: Brain. 2016 Jan;139(Pt 1):e7. Magali, Cucchiari 2015
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| 11 | MDM2, MDM4
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| Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.
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| Yu Q, Li Y, Mu K, Li Z, Meng Q, Wu X, Wang Y, Li L.
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| Diagn Pathol 9(1):71. doi: 10.1186/1746-1596-9-71.
2014
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| 12 | MDM4
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| Mdmx promotes genomic instability independent of p53 and Mdm2.
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| Carrillo AM, Bouska A, Arrate MP, Eischen CM.
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| Oncogene 0. doi: 10.1038/onc.2014.27. [Epub ahead of print]
2014
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| 13 | MDM4
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| AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity.
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| He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl GM, Lu H.
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| Mol Cell Biol 34(2):148-57. doi: 10.1128/MCB.00670-13. Epub 2013 Nov 4.
2014
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| 14 | JMJD6, MDM4, TP53
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| JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation.
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| Wang F, He L, Huangyang P, Liang J, Si W, Yan R, Han X, Liu S, Gui B, Li W, Miao D, Jing C, Liu Z, Pei F, Sun L, Shang Y.
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| PLoS Biol 12(3):e1001819. doi: 10.1371/journal.pbio.1001819. eCollection 2014 Mar.
2014
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| 15 | MDM2, MDM4
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| MDMX contains an autoinhibitory sequence element.
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| Bista M, Petrovich M, Fersht AR.
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| Proc Natl Acad Sci U S A 110(44):17814-9. doi: 10.1073/pnas.1317398110. Epub 2013 Oct 14.
2013
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| 16 | MDM2, MDM4
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| MDMX contains an autoinhibitory sequence element.
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| Bista M, Petrovich M, Fersht AR.
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| Proc Natl Acad Sci U S A 110(44):17814-9. doi: 10.1073/pnas.1317398110. Epub 2013 Oct 14.
2013
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| 17 | MDM4, PRMT5
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| Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.
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| Bezzi M, Teo SX, Muller J, Mok WC, Sahu SK, Vardy LA, Bonday ZQ, Guccione E.
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| Genes Dev 27(17):1903-16. doi: 10.1101/gad.219899.113.
2013
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| 18 | MDM2, MDM4, RPL37, RPS15, RPS20
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| Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
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| Daftuar L, Zhu Y, Jacq X, Prives C.
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| PLoS One 8(7):e68667. doi: 10.1371/journal.pone.0068667. Print 2013.
2013
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| 19 | CSNK1A1, MDM4
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| Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.
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| Wu S, Chen L, Becker A, Schonbrunn E, Chen J.
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| Mol Cell Biol 32(23):4821-32. doi: 10.1128/MCB.00851-12. Epub 2012 Oct 1.
2012
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| 20 | MDM2, MDM4
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| Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.
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| McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA.
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| PLoS One 7(8):e42739. doi: 10.1371/journal.pone.0042739. Epub 2012 Aug 20.
2012
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| 21 | MDM4
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| MDM4 is a key therapeutic target in cutaneous melanoma.
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| Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC.
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| Nat Med 18(8):1239-47. doi: 10.1038/nm.2863. Epub 2012 Jul 22.
2012
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| 22 | MDM2, MDM4
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| Regulation of p53: a collaboration between Mdm2 and Mdmx.
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| Pei D, Zhang Y, Zheng J.
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| Oncotarget 3(3):228-35. Review.
2012
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| 23 | MDM2, MDM4
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| MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.
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| Biderman L, Poyurovsky MV, Assia Y, Manley JL, Prives C.
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| Mol Cell Biol 32(7):1214-25. doi: 10.1128/MCB.06150-11. Epub 2012 Jan 30.
2012
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| 24 | MDM4
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| MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.
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| Ménendez S, Goh AM, Camus S, Ng KW, Kua N, Badal V, Lane DP.
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| Cell Cycle 10(7):1100-8. Epub 2011 Apr 1.
2011
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| 25 | MDM2, MDM4
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| The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.
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| Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM.
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| Proc Natl Acad Sci U S A 108(29):12001-6. Epub 2011 Jul 5.
2011
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| 26 | MDM2, MDM4
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| A critical role for noncoding 5S rRNA in regulating Mdmx stability.
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| Li M, Gu W.
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| Mol Cell 43(6):1023-32. doi: 10.1016/j.molcel.2011.08.020.
2011
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| 27 | MDM4, YWHAG
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| 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.
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| Lee JH, Lu H.
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| J Biol Chem 286(7):5136-42. doi: 10.1074/jbc.M110.190470. Epub 2010 Dec 9.
2011
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| 28 | MDM2, MDM4, USP2
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| MdmX is a substrate for the deubiquitinating enzyme USP2a.
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| Allende-Vega N, Sparks A, Lane DP, Saville MK.
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| Oncogene 29(3):432-41. Epub 2009 Oct 19.
2010
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| 29 | MDM2, MDM4
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| Identification and characterization of the first small molecule inhibitor of MDMX.
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| Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA.
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| J Biol Chem 285(14):10786-96. Epub 2010 Jan 15.
2010
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| 30 | MDM2, MDM4, SMURF1, SMURF2
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| Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
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| Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.
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| J Biol Chem 285(30):22818-30. Epub 2010 May 18.
2010
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| 31 | MDM2, MDM4
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| HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.
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| Phillips A, Teunisse A, Lam S, Lodder K, Darley M, Emaduddin M, Wolf A, Richter J, de Lange J, Verlaan-de Vries M, Lenos K, Böhnke A, Bartel F, Blaydes JP, Jochemsen AG.
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| J Biol Chem 285(38):29111-27. Epub 2010 Jul 20.
2010
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| 32 | MDM4
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| MDM4 overexpression contributes to synoviocyte proliferation in patients with rheumatoid arthritis.
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| Xu N, Wang Y, Li D, Chen G, Sun R, Zhu R, Sun S, Liu H, Yang G, Dong T.
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| Biochem Biophys Res Commun 401(3):417-21. Epub 2010 Sep 20.
2010
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| 33 | BCL2, MDM4, TP53
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| MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
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| Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F.
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| EMBO J 28(13):1926-39. Epub 2009 Jun 11.
2009
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| 34 | MDM2, MDM4
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| MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice.
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| Matijasevic Z, Steinman HA, Hoover K, Jones SN.
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| Mol Cell Biol 28(4):1265-73. Epub 2007 Nov 26.PMID: 18039860 2008
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| 35 | MDM2, MDM4
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| Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans.
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| Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL.
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| Cell Death Differ 15(5):841-8. Epub 2008 Jan 25.PMID: 18219319 2008
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| 36 | MDM2, MDM4
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| Mdm2 and Mdm4 loss regulates distinct p53 activities.
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| Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G.
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| Mol Cancer Res 6(6):947-54.PMID: 18567799 2008
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| 37 | MDM4, RB1, TP53
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| Inactivation of the p53 pathway in retinoblastoma.
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| Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA.
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| Nature 444(7115):61-6. 2006
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| 38 | MDM4
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| A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection.
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| Wang Z, Wang B, Tang K, Lee EJ, Chong SS, Lee CG.
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| Hum Mol Genet 14(14):2075-87. Epub 2005 Jun 8. 2005
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| 39 | MDM4
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| MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis.
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| Mancini F, Gentiletti F, D'Angelo M, Giglio S, Nanni S, D'Angelo C, Farsetti A, Citro G, Sacchi A, Pontecorvi A, Moretti F.
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| J Biol Chem 279(9):8169-80. Epub 2003 Dec 1. 2004
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| 40 | MDM4
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| MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination.
|
| Badciong JC, Haas AL.
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| J Biol Chem 277(51):49668-75. 2002
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| 41 | MDM4
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| Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
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| Riemenschneider MJ, Buschges R, Wolter M, Reifenberger J, Bostrom J, Kraus JA, Schlegel U, Reifenberger G.
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| Cancer Res 59(24):6091-6. 1999
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| 42 | MDM4
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| A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity.
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| Rallapalli R, Strachan G, Cho B, Mercer WE, Hall DJ.
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| J Biol Chem 274(12):8299-308. 1999
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| 43 | MDM4
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| Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.
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| Shvarts A, Bazuine M, Dekker P, Ramos YF, Steegenga WT, Merckx G, van Ham RC, van der Houven van Oordt W, van der Eb AJ, Jochemsen AG.
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| Genomics 43(1):34-42. 1997
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| 44 | BRCA1, DNTT, ECT2, MDM4, RAD9A, XPC, XRCC1
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| From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair.
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| Callebaut I, et al.
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| FEBS Lett 400(1):25-30. 1997
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| 45 | BRCA1, DNTT, ECT2, MDM4, RAD9A, XRCC1
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| A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.
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| Bork P, et al.
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| FASEB J 11(1):68-76. 1997
|