Citations for
1MDM2, ZEB2
ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage.
Guo Q, Xie M, Guo M, Yan F, Li L, Liu R.
Cell Cycle. Sep;20(17):1692-1707. doi: 10.1080/15384101.2021.1959702. Epub 2021 Aug 2. 2021
2MDM2, MDM4
Mdm4 supports DNA replication in a p53-independent fashion.
Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M.
Oncogene. Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. 2020
3MDM2, RPS2
Ribosomal protein S2 interplays with MDM2 to induce p53.
Cho J, Park J, Shin SC, Kim JH, Kim EE, Song EJ.
Biochem Biophys Res Commun. Mar 5;523(2):542-547. doi: 10.1016/j.bbrc.2020.01.038. Epub 2020 Jan 10. 2020
4FRS2, MDM2
Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.
He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H.
Am J Surg Pathol 42(9):1143-1155. doi: 10.1097/PAS.0000000000001125. 2018
5MDM2, TP53, TRIM65
Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells.
Chen G, Zhou T, Liu Y, Yu Z.
Biochem Biophys Res Commun 506(3):698-702. doi: 10.1016/j.bbrc.2018.10.130. Epub 2018 Oct 27. 2018
6MDM2, RNF2
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.
Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M.
Proc Natl Acad Sci U S A 115(48):E11311-E11320. doi: 10.1073/pnas.1809592115. Epub 2018 Nov 9. 2018
7MDM2, MDM4
Regulation of kidney development by the Mdm2/Mdm4-p53 axis
El-Dahr S, Hilliard S, Saifudeen Z.
J Mol Cell Biol. Feb 1;9(1):26-33. doi: 10.1093/jmcb/mjx005. 2017
8HSP90B1, MDM2, TP53
Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.
Wu B, Chu X, Feng C, Hou J, Fan H, Liu N, Li C, Kong X, Ye X, Meng S.
Cancer Lett 359(2):325-34. doi: 10.1016/j.canlet.2015.01.034. Epub 2015 Jan 28. 2015
9ASF1A, MDM2, UBE2A, UBE2B
A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.
Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL.
Oncotarget 6(30):29599-613. doi: 10.18632/oncotarget.5011. 2015
10AKT1S1, MDM2, RPL11
Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.
Havel JJ, Li Z, Cheng D, Peng J, Fu H.
Oncogene 34(12):1487-98. doi: 10.1038/onc.2014.91. Epub 2014 Apr 7. 2015
11ADGRB1, DLG4, MDM2
BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.
Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG.
J Clin Invest. Apr;125(4):1497-508. doi: 10.1172/JCI74603. Epub 2015 Mar 9. 2015
12MDM2, RBBP6, TP53
The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning
Hull R, Oosthuysen B, Cajee UF, Mokgohloa L, Nweke E, Antunes RJ, Coetzer TH, Ntwasa M.
Int J Mol Sci. May 6;16(5):10242-66. doi: 10.3390/ijms160510242. 2015
13MDM2, NEDD8, TP53, UBE2M
Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.
Batuello CN, Hauck PM, Gendron JM, Lehman JA, Mayo LD.
Proc Natl Acad Sci U S A. Feb 10;112(6):1749-54. doi: 10.1073/pnas.1416656112. Epub 2015 Jan 26 2015
14MDM2, MDM4, TP53
The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury
Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Marine JC, Puttagunta R, Di Giovanni S.
Brain Jul;138(Pt 7):1843-62. doi: 10.1093/brain/awv125. Epub 2015 May 16. Erratum in: Brain. 2016 Jan;139(Pt 1):e7. Magali, Cucchiari 2015
15MDM2, MDM4
Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.
Yu Q, Li Y, Mu K, Li Z, Meng Q, Wu X, Wang Y, Li L.
Diagn Pathol 9(1):71. doi: 10.1186/1746-1596-9-71. 2014
16CCNG1, MDM2, NOTCH3, TP53
Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma.
Giovannini C, Minguzzi M, Baglioni M, Fornari F, Giannone F, Ravaioli M, Cescon M, Chieco P, Bolondi L, Gramantieri L.
Oncotarget 5(21):10607-20. 2014
17EID1, MDM2, PCID2
Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.
Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z.
Stem Cells 32(3):623-35. doi: 10.1002/stem.1580. 2014
18MDM2, PIAS3, TP53
p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth.
Zhao Z, Wu L, Shi H, Wu C.
Mol Med Rep 9(5):1903-8. doi: 10.3892/mmr.2014.1993. Epub 2014 Feb 27. 2014
19DNAJB1, MDM2
DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner.
Qi M, Zhang J, Zeng W, Chen X.
Biochim Biophys Acta 1839(1):62-9. doi: 10.1016/j.bbagrm.2013.12.003. Epub 2013 Dec 19. 2014
20MDM2, TP53, XAF1
XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
Lee MG, Han J, Jeong SI, Her NG, Lee JH, Ha TK, Kang MJ, Ryu BK, Chi SG.
Proc Natl Acad Sci U S A 111(43):15532-7. doi: 10.1073/pnas.1411746111. Epub 2014 Oct 13. 2014
21FUBP1, MDM2
The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.
Jacob AG, Singh RK, Mohammad F, Bebee TW, Chandler DS.
J Biol Chem. Jun 20;289(25):17350-64. doi: 10.1074/jbc.M114.554717. Epub 2014 May 5 2014
22MDM2, RPS26
The ribosomal protein S26 regulates p53 activity in response to DNA damage. .
Cui D, Li L, Lou H, Sun H, Ngai SM, Shao G, Tang J.
Oncogene Apr 24;33(17):2225-35. doi: 10.1038/onc.2013.170. Epub 2013 Jun 3. 2014
23AXIN1, MDM2
MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.
He Y, Lian G, Lin S, Ye Z, Li Q.
PLoS One 8(6):e67529. Print 2013. 2013
24MDM2, MDM4
MDMX contains an autoinhibitory sequence element.
Bista M, Petrovich M, Fersht AR.
Proc Natl Acad Sci U S A 110(44):17814-9. doi: 10.1073/pnas.1317398110. Epub 2013 Oct 14. 2013
25MDM2, MDM4
MDMX contains an autoinhibitory sequence element.
Bista M, Petrovich M, Fersht AR.
Proc Natl Acad Sci U S A 110(44):17814-9. doi: 10.1073/pnas.1317398110. Epub 2013 Oct 14. 2013
26MDM2, MDM4, RPL37, RPS15, RPS20
Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
Daftuar L, Zhu Y, Jacq X, Prives C.
PLoS One 8(7):e68667. doi: 10.1371/journal.pone.0068667. Print 2013. 2013
27MDM2
Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.
Ranaweera RS, Yang X.
J Biol Chem 288(26):18939-46. doi: 10.1074/jbc.M113.454470. Epub 2013 May 13. 2013
28MDM2, RASSF6
The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein.
Iwasa H, Kudo T, Maimaiti S, Ikeda M, Maruyama J, Nakagawa K, Hata Y.
J Biol Chem 288(42):30320-9. doi: 10.1074/jbc.M113.507384. Epub 2013 Sep 3. 2013
29DNAJC7, MDM2, NR1I3, TP53
Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2.
Kubo N, Wu D, Yoshihara Y, Sang M, Nakagawara A, Ozaki T.
Biochem Biophys Res Commun 430(3):1034-9. doi: 10.1016/j.bbrc.2012.11.121. Epub 2012 Dec 21. 2013
30MDM2, RPS14
Ribosomal protein S14 negatively regulates c-Myc activity.
Zhou X, Hao Q, Liao JM, Liao P, Lu H.
J Biol Chem 288(30):21793-801. doi: 10.1074/jbc.M112.445122. Epub 2013 Jun 17. 2013
31MDM2, RPS25
Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop
Zhang X, Wang W, Wang H, Wang MH, Xu W, Zhang R.
Oncogene May 30;32(22):2782-91. doi: 10.1038/onc.2012.289. Epub 2012 Jul 9. 2013
32MDM2, RPL11, TP53
Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.
Dai MS, Challagundla KB, Sun XX, Palam LR, Zeng SX, Wek RC, Lu H.
J Biol Chem 287(21):17120-9. Epub 2012 Mar 30. 2012
33APOC3, MDM2
Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition.
Yang Z, Zhang Y, Wang L.
Biochem Biophys Res Commun 417(2):744-6. Epub 2011 Dec 16. 2012
34MDM2, RPL11
Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner.
Mahata B, Sundqvist A, Xirodimas DP.
Oncogene 31(25):3060-71. doi: 10.1038/onc.2011.482. Epub 2011 Nov 14. 2012
35MDM2, TP53
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.
Dolezelova P, Cetkovska K, Vousden KH, Uldrijan S.
FEBS Lett 586(16):2225-31. doi: 10.1016/j.febslet.2012.05.034. Epub 2012 May 31. 2012
36MDM2, MDM4
Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.
McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA.
PLoS One 7(8):e42739. doi: 10.1371/journal.pone.0042739. Epub 2012 Aug 20. 2012
37MDM2, MDM4
Regulation of p53: a collaboration between Mdm2 and Mdmx.
Pei D, Zhang Y, Zheng J.
Oncotarget 3(3):228-35. Review. 2012
38MDM2, MDM4
MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.
Biderman L, Poyurovsky MV, Assia Y, Manley JL, Prives C.
Mol Cell Biol 32(7):1214-25. doi: 10.1128/MCB.06150-11. Epub 2012 Jan 30. 2012
39MDM2, TTF1
The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation.
Lessard F, Stefanovsky V, Tremblay MG, Moss T.
Nucleic Acids Res 40(12):5357-67. doi: 10.1093/nar/gks198. Epub 2012 Mar 1. 2012
40MDM2, RWDD3, SKI, SRSF1, UBE2I
Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
Ding B, Sun Y, Huang J.
J Biol Chem 287(18):14621-30. doi: 10.1074/jbc.M111.301523. Epub 2012 Mar 12. 2012
41MDM2, NUMB
MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism.
Sczaniecka M, Gladstone K, Pettersson S, McLaren L, Huart AS, Wallace M.
J Biol Chem 287(17):14052-68. doi: 10.1074/jbc.M111.303875. Epub 2012 Feb 15. 2012
42GORAB, MDM2
SCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathway.
Liu Y, Chen Y, Lu X, Wang Y, Duan Y, Cheng C, Shen A.
Mol Biol Cell 23(23):4506-14. doi: 10.1091/mbc.E12-05-0362. Epub 2012 Oct 10. 2012
43MDM2, SENP3, TP53
The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation.
Nishida T, Yamada Y.
Biochem Biophys Res Commun 406(2):285-91. Epub 2011 Feb 18. 2011
44MDM2, UBE4B
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.
Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP.
Nat Med 17(3):347-55. Epub 2011 Feb 13. 2011
45GNL3L, MDM2
GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
Meng L, Hsu JK, Tsai RY.
Oncogene 30(14):1716-26. Epub 2010 Dec 6. 2011
46MDM2, SUV39H1
Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.
Cross B, Chen L, Cheng Q, Li B, Yuan ZM, Chen J.
J Biol Chem 286(18):16018-29. Epub 2011 Mar 17. 2011
47ARRB2, MDM2
Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.
Yin C, Zhang R, Xu Y, Chen Q, Xie X.
Mol Biol Cell 22(9):1608-16. Epub 2011 Mar 9. 2011
48MDM2, SENP2
SUMO-specific protease 2 in Mdm2-mediated regulation of p53.
Jiang M, Chiu SY, Hsu W.
Cell Death Differ 18(6):1005-15. Epub 2010 Dec 24. 2011
49MDM2, UBE4B
UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation.
Wu H, Leng RP.
Cell Cycle 10(12):1912-5. Epub 2011 Jun 15. Review. 2011
50MDM2, MDM4
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.
Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM.
Proc Natl Acad Sci U S A 108(29):12001-6. Epub 2011 Jul 5. 2011
51MDM2, RPL11
Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation.
Zhang Q, Xiao H, Chai SC, Hoang QQ, Lu H.
J Biol Chem 286(44):38264-74. Epub 2011 Sep 8. 2011
52ARRB1, MDM2
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.
Nature 477(7364):349-53. doi: 10.1038/nature10368. 2011
53MDM2
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.
Stindt MH, Carter S, Vigneron AM, Ryan KM, Vousden KH.
Cell Cycle 10(18):3176-88. Epub 2011 Sep 15. 2011
54BAIAP2L1, MDM2, TP53
Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.
Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X.
PLoS One 6(8):e23571. doi: 10.1371/journal.pone.0023571. Epub 2011 Aug 24. 2011
55MDM2
MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
Zhou S, Gu L, He J, Zhang H, Zhou M.
Mol Cell Biol 31(24):4928-37. doi: 10.1128/MCB.06085-11. Epub 2011 Oct 10. 2011
56MDM2
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
Cheng Q, Cross B, Li B, Chen L, Li Z, Chen J.
Mol Cell Biol 31(24):4951-63. doi: 10.1128/MCB.05553-11. Epub 2011 Oct 10. 2011
57MDM2, MDM4
A critical role for noncoding 5S rRNA in regulating Mdmx stability.
Li M, Gu W.
Mol Cell 43(6):1023-32. doi: 10.1016/j.molcel.2011.08.020. 2011
58MDM2, NME2
MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility
Polanski R, Maguire M, Nield PC, Jenkins RE, Park BK, Krawczynska K, Devling T, Ray-Sinha A, Rubbi CP, Vlatkovic N, Boyd MT.
Carcinogenesis. Aug;32(8):1133-42. doi: 10.1093/carcin/bgr070. Epub 2011 Apr 18. 2011
59MDM2, RPL23
Inhibition of the p53-MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer.
Zhang Y, Shi Y, Li X, Du W, Luo G, Gou Y, Wang X, Guo X, Liu J, Ding J, Wu K, Fan D.
J Gene Med 12(2):147-56.PMID: 20020415 2010
60MDM2, MDM4, USP2
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Allende-Vega N, Sparks A, Lane DP, Saville MK.
Oncogene 29(3):432-41. Epub 2009 Oct 19. 2010
61DAXX, MDM2, USP7
Daxx is reciprocally regulated by Mdm2 and Hausp.
Tang J, Qu L, Pang M, Yang X.
Biochem Biophys Res Commun 393(3):542-5. Epub 2010 Feb 12.PMID: 20153724 2010
62ATM, DYRK2, MDM2
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K.
J Biol Chem 285(7):4909-19. Epub 2009 Dec 4. 2010
63CDK4, MDM2
Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma.
Mejia-Guerrero S, Quejada M, Gokgoz N, Gill M, Parkes RK, Wunder JS, Andrulis IL.
Genes Chromosomes Cancer 49(6):518-25.PMID: 20196171 2010
64MDM2, MDM4
Identification and characterization of the first small molecule inhibitor of MDMX.
Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA.
J Biol Chem 285(14):10786-96. Epub 2010 Jan 15. 2010
65MDM2
Mdm2 facilitates the association of p53 with the proteasome.
Kulikov R, Letienne J, Kaur M, Grossman SR, Arts J, Blattner C.
Proc Natl Acad Sci U S A 107(22):10038-43. Epub 2010 May 17.PMID: 20479273 2010
66ATF3, MDM2
MDM2 mediates ubiquitination and degradation of activating transcription factor 3.
Mo P, Wang H, Lu H, Boyd DD, Yan C.
J Biol Chem 285(35):26908-15. Epub 2010 Jun 30.PMID: 20592017 2010
67MDM2
MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Chen L, Li Z, Zwolinska AK, Smith MA, Cross B, Koomen J, Yuan ZM, Jenuwein T, Marine JC, Wright KL, Chen J.
EMBO J. 29(15):2538-52. 2010
68DHRS2, MDM2, MYB, TP53
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
Deisenroth C, Thorner AR, Enomoto T, Perou CM, Zhang Y.
Mol Cell Biol 30(16):3981-93. Epub 2010 Jun 14.PMID: 20547751 2010
69MDM2, MDM4, SMURF1, SMURF2
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.
J Biol Chem 285(30):22818-30. Epub 2010 May 18. 2010
70MDM2, S100A1, S100A2, S100A4, S100A6, S100B
S100 proteins interact with the N-terminal domain of MDM2.
van Dieck J, Lum JK, Teufel DP, Fersht AR.
FEBS Lett 584(15):3269-74. Epub 2010 Jun 19.PMID: 20591429 2010
71GORAB, MDM2, RCHY1
A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination.
Yan J, Zhang D, Di Y, Shi H, Rao H, Huo K.
FEBS Lett 584(15):3275-8. Epub 2010 Jun 23.PMID: 20598683 2010
72MDM2, TP53
The C terminus of p53 binds the N-terminal domain of MDM2.
Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, Byeon IJ, Gabizon R, Mattia M, Zupnick A, Brown LM, Friedler A, Prives C.
Nat Struct Mol Biol 17(8):982-9. Epub 2010 Jul 18. 2010
73MDM2, MDM4
HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.
Phillips A, Teunisse A, Lam S, Lodder K, Darley M, Emaduddin M, Wolf A, Richter J, de Lange J, Verlaan-de Vries M, Lenos K, Böhnke A, Bartel F, Blaydes JP, Jochemsen AG.
J Biol Chem 285(38):29111-27. Epub 2010 Jul 20. 2010
74MDM2
MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells.
Kubo N, Okoshi R, Nakashima K, Shimozato O, Nakagawara A, Ozaki T.
Biochem Biophys Res Commun 403(3-4):405-11. Epub 2010 Nov 17. 2010
75AKT1, MDM2, RAC1, SPRY2
Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts.
Lito P, Mets BD, Appledorn DM, Maher VM, McCormick JJ.
J Biol Chem 284(2):848-54. Epub 2008 Nov 13. 2009
76MDM2
A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity.
Wawrzynow B, Pettersson S, Zylicz A, Bramham J, Worrall E, Hupp TR, Ball KL.
J Biol Chem 284(17):11517-11530. Epub 2009 Feb 2. 2009
77MDM2, RYBP
RYBP stabilizes p53 by modulating MDM2.
Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R.
EMBO Rep 10(2):166-72. Epub 2008 Dec 19. 2009
78FKBP3, MDM2
FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, Milne D, Fuller-Pace F, Meek D.
FEBS Lett 583(4):621-6. Epub 2009 Jan 21. 2009
79MDM2, XRCC6
Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.
Gama V, Gomez JA, Mayo LD, Jackson MW, Danielpour D, Song K, Haas AL, Laughlin MJ, Matsuyama S.
Cell Death Differ 16(5):758-69. Epub 2009 Feb 27. 2009
80FOXO1, FOXO3, MDM2
MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.
J Biol Chem 284(21):13987-4000. Epub 2009 Mar 25. 2009
81IRF2, MDM2
Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2.
Pettersson S, Kelleher M, Pion E, Wallace M, Ball KL.
Biochem J 418(3):575-85. 2009
82MDM2, SIVA1, TP53
Suppression of p53 activity by Siva1.
Du W, Jiang P, Li N, Mei Y, Wang X, Wen L, Yang X, Wu M.
Cell Death Differ 16(11):1493-504. Epub 2009 Jul 10.PMID: 19590512 2009
83HEXIM1, MDM2
Ubiquitination of HEXIM1 by HDM2.
Lau J, Lew QJ, Diribarne G, Michels AA, Dey A, Bensaude O, Lane DP, Chao SH.
Cell Cycle 8(14):2247-54.PMID: 19617712 2009
84MDM2, RPS7
Ribosomal protein S7 is both a regulator and a substrate of MDM2.
Zhu Y, Poyurovsky MV, Li Y, Biderman L, Stahl J, Jacq X, Prives C.
Mol Cell 35(3):316-26. doi: 10.1016/j.molcel.2009.07.014. 2009
85CA11, CCAR1, MDM2, SFN
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
Yang W, Dicker DT, Chen J, El-Deiry WS.
Cell Cycle 7(5):670-82. Epub 2008 Jan 31. 2008
86MDM2, RPL26
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.
Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M.
Mol Cell 32(2):180-9. 2008
87E2F1, MDM2
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.
Stevens C, Pettersson S, Wawrzynow B, Wallace M, Ball K, Zylicz A, Hupp TR.
FEBS J 275(19):4875-86. Epub 2008 Aug 27. 2008
88MDM2, VEGFA
Identification of HDM2 as a regulator of VEGF expression in cancer cells.
Narasimhan M, Rose R, Ramakrishnan R, Zell JA, Rathinavelu A.
Life Sci 82(25-26):1231-41. Epub 2008 May 27. 2008
89CK2, MDM2, TAF1
Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2.
Allende-Vega N, McKenzie L, Meek D.
Mol Cell Biochem 316(1-2):99-106. Epub 2008 Jun 12. 2008
90MDM2
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.
Lau LM, Nugent JK, Zhao X, Irwin MS.
Oncogene 27(7):997-1003. Epub 2007 Aug 13.PMID: 17700533 2008
91MDM2, MDM4
MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice.
Matijasevic Z, Steinman HA, Hoover K, Jones SN.
Mol Cell Biol 28(4):1265-73. Epub 2007 Nov 26.PMID: 18039860 2008
92COPS5, CSN5, MDM2
Roles for CSN5 in control of p53/MDM2 activities.
Zhang XC, Chen J, Su CH, Yang HY, Lee MH.
J Cell Biochem 103(4):1219-30.PMID: 17879958 2008
93MDM2, MDM4
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans.
Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL.
Cell Death Differ 15(5):841-8. Epub 2008 Jan 25.PMID: 18219319 2008
94MDM2
MDM2 regulates dihydrofolate reductase activity through monoubiquitination.
Maguire M, Nield PC, Devling T, Jenkins RE, Park BK, Polański R, Vlatković N, Boyd MT.
Cancer Res. 68(9):3232-42. 2008
95MDM2
Galphaq reduces cAMP production by decreasing Galphas protein abundance.
Tang T, Gao MH, Miyanohara A, Hammond HK.
Biochem Biophys Res Commun. 377(2):679-84. 2008
96MDM2
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.
Sehat B, Andersson S, Girnita L, Larsson O.
Cancer Res. 68(14):5669-77. 2008
97MDM2
Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.
Qiu W, Wu J, Walsh EM, Zhang Y, Chen CY, Fujita J, Xiao ZX.
Oncogene. 27(29):4034-43. 2008
98MDM2
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation.
Zhang Z, Zhang R.
EMBO J. 27(6):852-64. 2008
99MDM2, MDM4
Mdm2 and Mdm4 loss regulates distinct p53 activities.
Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G.
Mol Cancer Res 6(6):947-54.PMID: 18567799 2008
100MDM2
The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.
Ruijs MW, Schmidt MK, Nevanlinna H, Tommiska J, Aittomaki K, Pruntel R, Verhoef S, Van't Veer LJ.
Eur J Hum Genet 15(1):110-4. Epub 2006 Sep 27. 2007
101MDM2
Haplotype structure and selection of the MDM2 oncogene in humans.
Atwal GS, Bond GL, Metsuyanim S, Papa M, Friedman E, Distelman-Menachem T, Ben Asher E, Lancet D, Ross DA, Sninsky J, White TJ, Levine AJ, Yarden R.
Proc Natl Acad Sci U S A 104(11):4524-9. Epub 2007 Mar 5. 2007
102MDM2, TAF1
Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.
Allende-Vega N, Saville MK, Meek DW.
Oncogene 26(29):4234-42. Epub 2007 Jan 22. 2007
103MDM2
Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma.
Singer S, Socci ND, Ambrosini G, Sambol E, Decarolis P, Wu Y, O'Connor R, Maki R, Viale A, Sander C, Schwartz GK, Antonescu CR.
Cancer Res 67(14):6626-36. 2007
104MDM2
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK.
EMBO J. 26(4):976-86. 2007
105MDM2
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA.
Cancer Cell. 12(4):342-54. 2007
106MDM2
Roles for negative cell regulator 14-3-3sigma in control of MDM2 activities.
Yang HY, Wen YY, Lin YI, Pham L, Su CH, Yang H, Chen J, Lee MH.
Oncogene. 26(52):7355-62. 2007
107MDM2, TP53
The central region of HDM2 provides a second binding site for p53.
Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR.
Proc Natl Acad Sci U S A 103(5):1227-32. Epub 2006 Jan 23. 2006
108TP53, MDM2
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.
Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, Myklebost O, Heimbrook DC, Vassilev LT.
Proc Natl Acad Sci U S A 103(6):1888-93. Epub 2006 Jan 27. 2006
109ACAP1, ADAMTS16, COL9A3, DHH, MAPK13, MDM2, OGN, SLC26A7, SPRR2D, TESC
Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes.
Beverdam A, Koopman P.
Hum Mol Genet 15(3):417-31. Epub 2006 Jan 6. 2006
110MDM2, TP53
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome.
Bougeard G, Baert-Desurmont S, Tournier I, Vasseur S, Martin C, Brugieres L, Chompret A, Bressac-de Paillerets B, Stoppa-Lyonnet D, Bonaiti-Pellie C, Frebourg T.
J Med Genet 43(6):531-3. Epub 2005 Oct 28. 2006
111MDM2
A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination.
Ma J, Martin JD, Zhang H, Auger KR, Ho TF, Kirkpatrick RB, Grooms MH, Johanson KO, Tummino PJ, Copeland RA, Lai Z.
Biochemistry 45(30):9238-45. 2006
112MDM2
MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.
Ohmiya N, Taguchi A, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H.
J Clin Oncol 24(27):4434-40. 2006
113MDM2, TCAP
MDM2 interacts with and downregulates a sarcomeric protein, TCAP.
Tian LF, Li HY, Jin BF, Pan X, Man JH, Zhang PJ, Li WH, Liang B, Liu H, Zhao J, Gong WL, Zhou T, Zhang XM.
Biochem Biophys Res Commun 345(1):355-61. Epub 2006 May 2. 2006
114MDM2
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
Salcedo A, Mayor F Jr, Penela P.
EMBO J. 25(20):4752-62. 2006
115MDM2
Critical role for Daxx in regulating Mdm2.
Tang J, Qu LK, Zhang J, Wang W, Michaelson JS, Degenhardt YY, El-Deiry WS, Yang X.
Nat Cell Biol. 8(8):855-62. 2006
116MDM2
Molecular recognition of p53 and MDM2 by USP7/HAUSP.
Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.
Nat Struct Mol Biol. 13(3):285-91. 2006
117MDM2
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.
Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC.
Mol Cell Biol. 26(19):7269-82. 2006
118MDM2, MYCN, NBL
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM.
Proc Natl Acad Sci U S A 102(3):731-6. Epub 2005 Jan 11. 2005
119TP53, MDM2, MTBP
Regulation of p53 and MDM2 activity by MTBP.
Brady M, Vlatkovic N, Boyd MT.
Mol Cell Biol 25(2):545-53. 2005
120HIPK2,MDM2
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.
Di Stefano V, Mattiussi M, Sacchi A, D'Orazi G.
FEBS Lett 579(25):5473-80. Epub 2005 Sep 27. 2005
121MDM2
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53.
Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Nagao T, Sumitomo Y, Masuda T, Dawson S, Shimada Y, Mayer RJ, Fujita J.
Cancer Cell. 8(1):75-87. 2005
122MDM2
HDM2 negatively affects the Chk2-mediated phosphorylation of p53.
Bjørling-Poulsen M, Meek D, Issinger OG.
FEBS Lett. 579(12):2604-8. 2005
123MDM2
HDM2 phosphorylation by MAPKAP kinase 2.
Weber HO, Ludwig RL, Morrison D, Kotlyarov A, Gaestel M, Vousden KH.
Oncogene. 24(12):1965-72. 2005
124MDM2
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells.
Yang Y, Ludwig RL, Jensen JP, Pierre SA, Medaglia MV, Davydov IV, Safiran YJ, Oberoi P, Kenten JH, Phillips AC, Weissman AM, Vousden KH.
Cancer Cell. 7(6):547-59. 2005
125MDM2
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ 3rd, Chen J.
EMBO J. 24(18):3279-90. 2005
126RFWD2, MDM2, TP53, RCHY1
The ubiquitin ligase COP1 is a critical negative regulator of p53.
Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM.
Nature 429(6987):86-92. Epub 2004 Apr 21. 2004
127MDM2, TP53, NEDD8
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP.
Cell 118(1):83-97. 2004
128ZNF331, MDM2, TP53
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G.
Nat Med 10(12):1321-8. Epub 2004 Dec. 2004
129MDM2
Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs.
Liang H, Atkins H, Abdel-Fattah R, Jones SN, Lunec J.
Gene 338(2):217-23. 2004
130DHCR24, MDM2
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
Wu C, Miloslavskaya I, Demontis S, Maestro R, Galaktionov K.
Nature 432(7017):640-5. 2004
131MDM2, PML
PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP.
Nat Cell Biol. 6(7):665-72 2004
132MDM2
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth.
Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K, Xiao ZX.
J Biol Chem. 279(51):53317-22. 2004
133MDM2
Yin Yang 1 is a negative regulator of p53.
Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, Donohoe M, Luke MP, Calvo D, Grossman SR, Shi Y.
Cell. 117(7):859-72. 2004
134MDM2
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
Kurki S, Peltonen K, Latonen L, Kiviharju TM, Ojala PM, Meek D, Laiho M.
Cancer Cell. 5(5):465-75. 2004
135MDM2, PIM1
Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.
Ionov Y, Le X, Tunquist BJ, Sweetenham J, Sachs T, Ryder J, Johnson T, Lilly MB, Kraft AS.
Anticancer Res 23(1A):167-78. 2003
136HIF1A, MDM2
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function.
Chen D, Li M, Luo J, Gu W.
J Biol Chem. 278(16):13595-8. 2003
137MDM2
Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2.
Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G.
J Biol Chem. 278(8):6363-70. 2003
138MDM2
Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription.
Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP.
Curr Biol. 13(14):1234-9. 2003
139MDM2
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.
Girnita L, Girnita A, Larsson O.
Proc Natl Acad Sci U S A. 100(14):8247-52. 2003
140MDM2
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.
Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y.
Mol Cell Biol. 23(23):8902-12. 2003
141CDKN2A, MDM2
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.
Xirodimas DP, Chisholm J, Desterro JM, Lane DP, Hay RT.
FEBS Lett 528(1-3):207-11. 2002
142CDKN2A, MDM2
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Foster CJ, Lozano G.
Oncogene 21(22):3525-31. 2002
143MDM2
Phosphorylation of HDM2 by Akt.
Ashcroft M, Ludwig RL, Woods DB, Copeland TD, Weber HO, MacRae EJ, Vousden KH.
Oncogene. 21(13):1955-62. 2002
144MDM2
Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.
Goldberg Z, Vogt Sionov R, Berger M, Zwang Y, Perets R, Van Etten RA, Oren M, Taya Y, Haupt Y.
EMBO J. 21(14):3715-27. 2002
145MDM2
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.
Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C.
EMBO J. 21(15):4037-48. 2002
146MDM2
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.
Legube G, Linares LK, Lemercier C, Scheffner M, Khochbin S, Trouche D.
EMBO J. 21(7):1704-12. 2002
147MDM2
Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.
Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H.
J Biol Chem. 277(51):50131-6. 2002
148MDM2
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
Mayo LD, Donner DB.
Proc Natl Acad Sci U S A 98(20):11598-603. 2001
149CDK4, HMGA2, MDM2
Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases.
Forus A, Larramendy ML, Meza-Zepeda LA, Bjerkehagen B, Godager LH, Dahlberg AB, Saeter G, Knuutila S, Myklebost O.
Cancer Genet Cytogenet 125(2):100-11. 2001
150MDM2
MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells.
Saji S, Okumura N, Eguchi H, Nakashima S, Suzuki A, Toi M, Nozawa Y, Saji S, Hayashi S.
PubMed U.S. National Library of Medicine National Institutes of Health Search: SearchClear * Limits * Advanced search 281(1):259-65. 2001
151MDM2
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control.
Li L, Liao J, Ruland J, Mak TW, Cohen SN.
Proc Natl Acad Sci U S A. 98(4):1619-24. 2001
152MDM2
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G.
Nat Genet. 29(1):92-5. 2001
153MDM2
MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.
Ganguli G, Abecassis J, Wasylyk B.
EMBO J 19(19):5135-5147. 2000
154EP300, MDM2, TP53
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins.
Kobet E, Zeng X, Zhu Y, Keller D, Lu H.
Proc Natl Acad Sci U S A 97(23):12547-52. 2000
155MDM2
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM.
J Biol Chem 275(12):8945-51. 2000
156MDM2, POLE
MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon.
Vlatkovic N, Guerrera S, Li Y, Linn S, Haines DS, Boyd MT.
Nucleic Acids Res 28(18):3581-6. 2000
157MDM2, RANGAP1
SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.
Buschmann T, Fuchs SY, Lee CG, Pan ZQ, Ronai Z.
Cell 101(7):753-62. 2000
158MDM2, TP53
Functions of the MDM2 oncoprotein.
Freedman DA, et al.
Cell Mol Life Sci 55(1):96-107. 1999
159MDM2
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
Sharp DA, Kratowicz SA, Sank MJ, George DL.
J Biol Chem. 274(53):38189-96. 1999
160MDM2
Mdm2 binds p73 alpha without targeting degradation.
Bálint E, Bates S, Vousden KH.
Oncogene 18(27):3923-9. 1999
161MDM2
The human oncoprotein MDM2 arrests the cell cycle : elimination of its cell-cycle-inhibitory function induces tumorigenesis.
Brown DR, et al.
EMBO J 17 : 2513-2525. 1998
162BCL2, BCL8, BRINP1, CDK4, GLI1, MDM2, MYC, REL
Chromosomal and gene amplification in diffuse large B-cell lymphoma.
Rao PH, et al.
Blood 92 : 234-240. 1998
163MDM2
MDM2 amplification and loss of heterozygosity at Rb and p53 genes : no simultaneous alterations in the oncogenesis of liposarcomas.
Schneider-Stock R, Walter H, Radig K, Rys J, Bosse A, Kuhnen C, Hoang-Vu C, Roessner A.
J Cancer Res Clin Oncol 124 : 532-540. 1998
164MDM2
MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas.
Zietz C, et al.
Am J Pathol 153 : 1425-1433. 1998
165MDM2
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA.
Cell. 92(6):713-23. 1998
166MDM2
p300/MDM2 complexes participate in MDM2-mediated p53 degradation.
Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM.
Mol Cell. 2(4):405-15. 1998
167MDM2
The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
Mol Cell Biol. 18(7):3974-82. 1998
168MDM2
MDM-2 protein is expressed in different layers of normal human skin.
Dazard JE, et al.
Oncogene 14 : 1123-1128. 1997
169AGAP2, MDM2
Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.
Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS.
Genomics 42(2):295-301. 1997
170MDM2
The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter.
Léveillard T, Wasylyk B.
J Biol Chem. 272(49):30651-61. 1997
171CDK4, MDM2, TSPAN31
Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.
Reifenberger G, et al.
Cancer Res 56 : 5141-5145. 1996
172CDK4, DDIT3, GLI1, MDM2
Mapping of gene loci in the Q13-Q15 region of chromosome 12.
Mitchell ELD, et al.
Chromosome Res 3 : 261-262. 1995
173IFNG, MDM2
The gene coding for interferon-gamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene.
Bureau JF, et al.
Genomics 28 : 109-112. 1995
174MDM2
A functional p53-responsive intronic promoter is contained within the human mdm2 gene.
Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M.
Nucleic Acids Res 23(14):2584-92. 1995
175MDM2
Interaction between the retinoblastoma protein and the oncoprotein MDM2.
Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM.
Nature. 375(6533):694-8. 1995
176LIPO, MDM2
MDM2 gene amplification correlates with ring chromosomes in soft tissue tumors.
Nilbert M, et al.
Genes Chromosomes Cancer 9 : 261-265. 1994
177MDM2
A transcribed polymorphism and sub-localisation of MDM2.
Heighway J, et al.
Hum Genet 93 : 611-612. 1994
178MDM2
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.
Marechal V, Elenbaas B, Piette J, Nicolas JC, Levine AJ.
Mol Cell Biol. 14(11):7414-20. 1994
179MDM2
Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas : some amplica do not include MDM2.
Forus A, et al.
Cell Growth Differ 4 : 1065-1070. 1993
180MDM2
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.
Reifenberger G, et al.
Cancer Res 53 : 2736-2739. 1993
181MDM2
Amplification of a gene encoding a p53-associated protein in human sarcomas.
Oliner JD, et al.
Nature 358 : 80-83. 1992