| 1 | MDM2, ZEB2
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| ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage.
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| Guo Q, Xie M, Guo M, Yan F, Li L, Liu R.
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| Cell Cycle. Sep;20(17):1692-1707. doi: 10.1080/15384101.2021.1959702. Epub 2021 Aug 2. 2021
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| 2 | MDM2, MDM4
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| Mdm4 supports DNA replication in a p53-independent fashion.
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| Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M.
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| Oncogene. Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. 2020
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| 3 | MDM2, RPS2
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| Ribosomal protein S2 interplays with MDM2 to induce p53.
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| Cho J, Park J, Shin SC, Kim JH, Kim EE, Song EJ.
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| Biochem Biophys Res Commun. Mar 5;523(2):542-547. doi: 10.1016/j.bbrc.2020.01.038. Epub 2020 Jan 10. 2020
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| 4 | FRS2, MDM2
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| Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.
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| He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H.
|
| Am J Surg Pathol 42(9):1143-1155. doi: 10.1097/PAS.0000000000001125.
2018
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| 5 | MDM2, TP53, TRIM65
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| Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells.
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| Chen G, Zhou T, Liu Y, Yu Z.
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| Biochem Biophys Res Commun 506(3):698-702. doi: 10.1016/j.bbrc.2018.10.130. Epub 2018 Oct 27.
2018
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| 6 | MDM2, RNF2
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| Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.
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| Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M.
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| Proc Natl Acad Sci U S A 115(48):E11311-E11320. doi: 10.1073/pnas.1809592115. Epub 2018 Nov 9.
2018
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| 7 | MDM2, MDM4
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| Regulation of kidney development by the Mdm2/Mdm4-p53 axis
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| El-Dahr S, Hilliard S, Saifudeen Z.
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| J Mol Cell Biol. Feb 1;9(1):26-33. doi: 10.1093/jmcb/mjx005. 2017
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| 8 | HSP90B1, MDM2, TP53
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| Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.
|
| Wu B, Chu X, Feng C, Hou J, Fan H, Liu N, Li C, Kong X, Ye X, Meng S.
|
| Cancer Lett 359(2):325-34. doi: 10.1016/j.canlet.2015.01.034. Epub 2015 Jan 28.
2015
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| 9 | ASF1A, MDM2, UBE2A, UBE2B
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| A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.
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| Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL.
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| Oncotarget 6(30):29599-613. doi: 10.18632/oncotarget.5011.
2015
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| 10 | AKT1S1, MDM2, RPL11
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| Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.
|
| Havel JJ, Li Z, Cheng D, Peng J, Fu H.
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| Oncogene 34(12):1487-98. doi: 10.1038/onc.2014.91. Epub 2014 Apr 7.
2015
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| 11 | ADGRB1, DLG4, MDM2
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| BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.
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| Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG.
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| J Clin Invest. Apr;125(4):1497-508. doi: 10.1172/JCI74603. Epub 2015 Mar 9. 2015
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| 12 | MDM2, RBBP6, TP53
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| The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning
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| Hull R, Oosthuysen B, Cajee UF, Mokgohloa L, Nweke E, Antunes RJ, Coetzer TH, Ntwasa M.
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| Int J Mol Sci. May 6;16(5):10242-66. doi: 10.3390/ijms160510242. 2015
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| 13 | MDM2, NEDD8, TP53, UBE2M
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| Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.
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| Batuello CN, Hauck PM, Gendron JM, Lehman JA, Mayo LD.
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| Proc Natl Acad Sci U S A. Feb 10;112(6):1749-54. doi: 10.1073/pnas.1416656112. Epub 2015 Jan 26 2015
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| 14 | MDM2, MDM4, TP53
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| The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury
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| Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Marine JC, Puttagunta R, Di Giovanni S.
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| Brain Jul;138(Pt 7):1843-62. doi: 10.1093/brain/awv125. Epub 2015 May 16. Erratum in: Brain. 2016 Jan;139(Pt 1):e7. Magali, Cucchiari 2015
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| 15 | MDM2, MDM4
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| Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.
|
| Yu Q, Li Y, Mu K, Li Z, Meng Q, Wu X, Wang Y, Li L.
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| Diagn Pathol 9(1):71. doi: 10.1186/1746-1596-9-71.
2014
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| 16 | CCNG1, MDM2, NOTCH3, TP53
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| Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma.
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| Giovannini C, Minguzzi M, Baglioni M, Fornari F, Giannone F, Ravaioli M, Cescon M, Chieco P, Bolondi L, Gramantieri L.
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| Oncotarget 5(21):10607-20.
2014
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| 17 | EID1, MDM2, PCID2
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| Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.
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| Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z.
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| Stem Cells 32(3):623-35. doi: 10.1002/stem.1580.
2014
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| 18 | MDM2, PIAS3, TP53
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| p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth.
|
| Zhao Z, Wu L, Shi H, Wu C.
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| Mol Med Rep 9(5):1903-8. doi: 10.3892/mmr.2014.1993. Epub 2014 Feb 27.
2014
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| 19 | DNAJB1, MDM2
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| DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner.
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| Qi M, Zhang J, Zeng W, Chen X.
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| Biochim Biophys Acta 1839(1):62-9. doi: 10.1016/j.bbagrm.2013.12.003. Epub 2013 Dec 19.
2014
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| 20 | MDM2, TP53, XAF1
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| XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
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| Lee MG, Han J, Jeong SI, Her NG, Lee JH, Ha TK, Kang MJ, Ryu BK, Chi SG.
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| Proc Natl Acad Sci U S A 111(43):15532-7. doi: 10.1073/pnas.1411746111. Epub 2014 Oct 13.
2014
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| 21 | FUBP1, MDM2
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| The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.
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| Jacob AG, Singh RK, Mohammad F, Bebee TW, Chandler DS.
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| J Biol Chem. Jun 20;289(25):17350-64. doi: 10.1074/jbc.M114.554717. Epub 2014 May 5 2014
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| 22 | MDM2, RPS26
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| The ribosomal protein S26 regulates p53 activity in response to DNA damage. .
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| Cui D, Li L, Lou H, Sun H, Ngai SM, Shao G, Tang J.
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| Oncogene Apr 24;33(17):2225-35. doi: 10.1038/onc.2013.170. Epub 2013 Jun 3. 2014
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| 23 | AXIN1, MDM2
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| MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.
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| He Y, Lian G, Lin S, Ye Z, Li Q.
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| PLoS One 8(6):e67529. Print 2013.
2013
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| 24 | MDM2, MDM4
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| MDMX contains an autoinhibitory sequence element.
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| Bista M, Petrovich M, Fersht AR.
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| Proc Natl Acad Sci U S A 110(44):17814-9. doi: 10.1073/pnas.1317398110. Epub 2013 Oct 14.
2013
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| 25 | MDM2, MDM4
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| MDMX contains an autoinhibitory sequence element.
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| Bista M, Petrovich M, Fersht AR.
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| Proc Natl Acad Sci U S A 110(44):17814-9. doi: 10.1073/pnas.1317398110. Epub 2013 Oct 14.
2013
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| 26 | MDM2, MDM4, RPL37, RPS15, RPS20
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| Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
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| Daftuar L, Zhu Y, Jacq X, Prives C.
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| PLoS One 8(7):e68667. doi: 10.1371/journal.pone.0068667. Print 2013.
2013
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| 27 | MDM2
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| Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.
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| Ranaweera RS, Yang X.
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| J Biol Chem 288(26):18939-46. doi: 10.1074/jbc.M113.454470. Epub 2013 May 13.
2013
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| 28 | MDM2, RASSF6
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| The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein.
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| Iwasa H, Kudo T, Maimaiti S, Ikeda M, Maruyama J, Nakagawa K, Hata Y.
|
| J Biol Chem 288(42):30320-9. doi: 10.1074/jbc.M113.507384. Epub 2013 Sep 3.
2013
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| 29 | DNAJC7, MDM2, NR1I3, TP53
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| Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2.
|
| Kubo N, Wu D, Yoshihara Y, Sang M, Nakagawara A, Ozaki T.
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| Biochem Biophys Res Commun 430(3):1034-9. doi: 10.1016/j.bbrc.2012.11.121. Epub 2012 Dec 21.
2013
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| 30 | MDM2, RPS14
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| Ribosomal protein S14 negatively regulates c-Myc activity.
|
| Zhou X, Hao Q, Liao JM, Liao P, Lu H.
|
| J Biol Chem 288(30):21793-801. doi: 10.1074/jbc.M112.445122. Epub 2013 Jun 17.
2013
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| 31 | MDM2, RPS25
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| Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop
|
| Zhang X, Wang W, Wang H, Wang MH, Xu W, Zhang R.
|
| Oncogene May 30;32(22):2782-91. doi: 10.1038/onc.2012.289. Epub 2012 Jul 9. 2013
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| 32 | MDM2, RPL11, TP53
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| Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.
|
| Dai MS, Challagundla KB, Sun XX, Palam LR, Zeng SX, Wek RC, Lu H.
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| J Biol Chem 287(21):17120-9. Epub 2012 Mar 30.
2012
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| 33 | APOC3, MDM2
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| Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition.
|
| Yang Z, Zhang Y, Wang L.
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| Biochem Biophys Res Commun 417(2):744-6. Epub 2011 Dec 16.
2012
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| 34 | MDM2, RPL11
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| Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner.
|
| Mahata B, Sundqvist A, Xirodimas DP.
|
| Oncogene 31(25):3060-71. doi: 10.1038/onc.2011.482. Epub 2011 Nov 14.
2012
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| 35 | MDM2, TP53
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| Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.
|
| Dolezelova P, Cetkovska K, Vousden KH, Uldrijan S.
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| FEBS Lett 586(16):2225-31. doi: 10.1016/j.febslet.2012.05.034. Epub 2012 May 31.
2012
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| 36 | MDM2, MDM4
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| Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.
|
| McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA.
|
| PLoS One 7(8):e42739. doi: 10.1371/journal.pone.0042739. Epub 2012 Aug 20.
2012
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| 37 | MDM2, MDM4
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| Regulation of p53: a collaboration between Mdm2 and Mdmx.
|
| Pei D, Zhang Y, Zheng J.
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| Oncotarget 3(3):228-35. Review.
2012
|
| 38 | MDM2, MDM4
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| MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.
|
| Biderman L, Poyurovsky MV, Assia Y, Manley JL, Prives C.
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| Mol Cell Biol 32(7):1214-25. doi: 10.1128/MCB.06150-11. Epub 2012 Jan 30.
2012
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| 39 | MDM2, TTF1
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| The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation.
|
| Lessard F, Stefanovsky V, Tremblay MG, Moss T.
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| Nucleic Acids Res 40(12):5357-67. doi: 10.1093/nar/gks198. Epub 2012 Mar 1.
2012
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| 40 | MDM2, RWDD3, SKI, SRSF1, UBE2I
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| Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
|
| Ding B, Sun Y, Huang J.
|
| J Biol Chem 287(18):14621-30. doi: 10.1074/jbc.M111.301523. Epub 2012 Mar 12.
2012
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| 41 | MDM2, NUMB
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| MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism.
|
| Sczaniecka M, Gladstone K, Pettersson S, McLaren L, Huart AS, Wallace M.
|
| J Biol Chem 287(17):14052-68. doi: 10.1074/jbc.M111.303875. Epub 2012 Feb 15.
2012
|
| 42 | GORAB, MDM2
|
| SCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathway.
|
| Liu Y, Chen Y, Lu X, Wang Y, Duan Y, Cheng C, Shen A.
|
| Mol Biol Cell 23(23):4506-14. doi: 10.1091/mbc.E12-05-0362. Epub 2012 Oct 10.
2012
|
| 43 | MDM2, SENP3, TP53
|
| The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation.
|
| Nishida T, Yamada Y.
|
| Biochem Biophys Res Commun 406(2):285-91. Epub 2011 Feb 18.
2011
|
| 44 | MDM2, UBE4B
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| UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.
|
| Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP.
|
| Nat Med 17(3):347-55. Epub 2011 Feb 13.
2011
|
| 45 | GNL3L, MDM2
|
| GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
|
| Meng L, Hsu JK, Tsai RY.
|
| Oncogene 30(14):1716-26. Epub 2010 Dec 6.
2011
|
| 46 | MDM2, SUV39H1
|
| Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.
|
| Cross B, Chen L, Cheng Q, Li B, Yuan ZM, Chen J.
|
| J Biol Chem 286(18):16018-29. Epub 2011 Mar 17.
2011
|
| 47 | ARRB2, MDM2
|
| Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.
|
| Yin C, Zhang R, Xu Y, Chen Q, Xie X.
|
| Mol Biol Cell 22(9):1608-16. Epub 2011 Mar 9.
2011
|
| 48 | MDM2, SENP2
|
| SUMO-specific protease 2 in Mdm2-mediated regulation of p53.
|
| Jiang M, Chiu SY, Hsu W.
|
| Cell Death Differ 18(6):1005-15. Epub 2010 Dec 24.
2011
|
| 49 | MDM2, UBE4B
|
| UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation.
|
| Wu H, Leng RP.
|
| Cell Cycle 10(12):1912-5. Epub 2011 Jun 15. Review.
2011
|
| 50 | MDM2, MDM4
|
| The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.
|
| Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM.
|
| Proc Natl Acad Sci U S A 108(29):12001-6. Epub 2011 Jul 5.
2011
|
| 51 | MDM2, RPL11
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| Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation.
|
| Zhang Q, Xiao H, Chai SC, Hoang QQ, Lu H.
|
| J Biol Chem 286(44):38264-74. Epub 2011 Sep 8.
2011
|
| 52 | ARRB1, MDM2
|
| A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
|
| Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.
|
| Nature 477(7364):349-53. doi: 10.1038/nature10368.
2011
|
| 53 | MDM2
|
| MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.
|
| Stindt MH, Carter S, Vigneron AM, Ryan KM, Vousden KH.
|
| Cell Cycle 10(18):3176-88. Epub 2011 Sep 15.
2011
|
| 54 | BAIAP2L1, MDM2, TP53
|
| Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.
|
| Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X.
|
| PLoS One 6(8):e23571. doi: 10.1371/journal.pone.0023571. Epub 2011 Aug 24.
2011
|
| 55 | MDM2
|
| MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
|
| Zhou S, Gu L, He J, Zhang H, Zhou M.
|
| Mol Cell Biol 31(24):4928-37. doi: 10.1128/MCB.06085-11. Epub 2011 Oct 10.
2011
|
| 56 | MDM2
|
| Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
|
| Cheng Q, Cross B, Li B, Chen L, Li Z, Chen J.
|
| Mol Cell Biol 31(24):4951-63. doi: 10.1128/MCB.05553-11. Epub 2011 Oct 10.
2011
|
| 57 | MDM2, MDM4
|
| A critical role for noncoding 5S rRNA in regulating Mdmx stability.
|
| Li M, Gu W.
|
| Mol Cell 43(6):1023-32. doi: 10.1016/j.molcel.2011.08.020.
2011
|
| 58 | MDM2, NME2
|
| MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility
|
| Polanski R, Maguire M, Nield PC, Jenkins RE, Park BK, Krawczynska K, Devling T, Ray-Sinha A, Rubbi CP, Vlatkovic N, Boyd MT.
|
| Carcinogenesis. Aug;32(8):1133-42. doi: 10.1093/carcin/bgr070. Epub 2011 Apr 18. 2011
|
| 59 | MDM2, RPL23
|
| Inhibition of the p53-MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer.
|
| Zhang Y, Shi Y, Li X, Du W, Luo G, Gou Y, Wang X, Guo X, Liu J, Ding J, Wu K, Fan D.
|
| J Gene Med 12(2):147-56.PMID: 20020415 2010
|
| 60 | MDM2, MDM4, USP2
|
| MdmX is a substrate for the deubiquitinating enzyme USP2a.
|
| Allende-Vega N, Sparks A, Lane DP, Saville MK.
|
| Oncogene 29(3):432-41. Epub 2009 Oct 19.
2010
|
| 61 | DAXX, MDM2, USP7
|
| Daxx is reciprocally regulated by Mdm2 and Hausp.
|
| Tang J, Qu L, Pang M, Yang X.
|
| Biochem Biophys Res Commun 393(3):542-5. Epub 2010 Feb 12.PMID: 20153724 2010
|
| 62 | ATM, DYRK2, MDM2
|
| ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
|
| Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K.
|
| J Biol Chem 285(7):4909-19. Epub 2009 Dec 4. 2010
|
| 63 | CDK4, MDM2
|
| Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma.
|
| Mejia-Guerrero S, Quejada M, Gokgoz N, Gill M, Parkes RK, Wunder JS, Andrulis IL.
|
| Genes Chromosomes Cancer 49(6):518-25.PMID: 20196171 2010
|
| 64 | MDM2, MDM4
|
| Identification and characterization of the first small molecule inhibitor of MDMX.
|
| Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA.
|
| J Biol Chem 285(14):10786-96. Epub 2010 Jan 15.
2010
|
| 65 | MDM2
|
| Mdm2 facilitates the association of p53 with the proteasome.
|
| Kulikov R, Letienne J, Kaur M, Grossman SR, Arts J, Blattner C.
|
| Proc Natl Acad Sci U S A 107(22):10038-43. Epub 2010 May 17.PMID: 20479273 2010
|
| 66 | ATF3, MDM2
|
| MDM2 mediates ubiquitination and degradation of activating transcription factor 3.
|
| Mo P, Wang H, Lu H, Boyd DD, Yan C.
|
| J Biol Chem 285(35):26908-15. Epub 2010 Jun 30.PMID: 20592017 2010
|
| 67 | MDM2
|
| MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
|
| Chen L, Li Z, Zwolinska AK, Smith MA, Cross B, Koomen J, Yuan ZM, Jenuwein T, Marine JC, Wright KL, Chen J.
|
| EMBO J. 29(15):2538-52. 2010
|
| 68 | DHRS2, MDM2, MYB, TP53
|
| Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
|
| Deisenroth C, Thorner AR, Enomoto T, Perou CM, Zhang Y.
|
| Mol Cell Biol 30(16):3981-93. Epub 2010 Jun 14.PMID: 20547751 2010
|
| 69 | MDM2, MDM4, SMURF1, SMURF2
|
| Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
|
| Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.
|
| J Biol Chem 285(30):22818-30. Epub 2010 May 18.
2010
|
| 70 | MDM2, S100A1, S100A2, S100A4, S100A6, S100B
|
| S100 proteins interact with the N-terminal domain of MDM2.
|
| van Dieck J, Lum JK, Teufel DP, Fersht AR.
|
| FEBS Lett 584(15):3269-74. Epub 2010 Jun 19.PMID: 20591429 2010
|
| 71 | GORAB, MDM2, RCHY1
|
| A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination.
|
| Yan J, Zhang D, Di Y, Shi H, Rao H, Huo K.
|
| FEBS Lett 584(15):3275-8. Epub 2010 Jun 23.PMID: 20598683 2010
|
| 72 | MDM2, TP53
|
| The C terminus of p53 binds the N-terminal domain of MDM2.
|
| Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, Byeon IJ, Gabizon R, Mattia M, Zupnick A, Brown LM, Friedler A, Prives C.
|
| Nat Struct Mol Biol 17(8):982-9. Epub 2010 Jul 18.
2010
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2009
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