| 1 | BCL9, CKS1B, IL6R, ILF2, MCL1
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| Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets
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| Burroughs Garcìa J, Eufemiese RA, Storti P, Sammarelli G, Craviotto L, Todaro G, Toscani D, Marchica V, Giuliani N.
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| Cells. Jun 1;10(6):1360. doi: 10.3390/cells10061360 2021
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| 2 | AMBRA1, GSK3B, HUWE1, MCL1
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| HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.
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| Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, Melino G, Cecconi F.
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| Cell Death Differ :.
2019
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| 3 | BCL2, BCL2L1, MCL1, SUFU
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| Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
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| Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.
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| Nat Cell Biol 19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25.
2017
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| 4 | DNM1L, MARCH5, MCL1, MFF, MIEF2
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| Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics.
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| Cherok E, Xu S, Li S, Das S, Meltzer WA, Zalzman M, Wang C, Karbowski M.
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| Mol Biol Cell 28(3):396-410. doi: 10.1091/mbc.E16-04-0208. Epub 2016 Dec 8. 2017
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| 5 | CCR1, MCL1
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| Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia.
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| van Attekum MHA, Terpstra S, Slinger E, von Lindern M, Moerland PD, Jongejan A, Kater AP, Eldering E.
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| Oncogene 36(26):3651-3660. doi: 10.1038/onc.2016.515. Epub 2017 Feb 13.
2017
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| 6 | ASAH1, MCL1
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| Acid ceramidase is upregulated in AML and represents a novel therapeutic target.
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| Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, Liao J, Yun J, Kester M, Claxton DF, Wang HG, Cabot MC, Schuchman EH, Levine RL, Feith DJ, Loughran TP Jr.
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| Oncotarget 7(50):83208-83222. doi: 10.18632/oncotarget.13079.
2016
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| 7 | BCL2, EXOC3, EXOC4, MCL1
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| Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.
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| Tanaka T, Kikuchi N, Goto K, Iino M.
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| Apoptosis 21(5):594-608. doi: 10.1007/s10495-016-1230-9.
2016
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| 8 | BBC3, MCL1
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| Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress.
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| Delbridge AR, Opferman JT, Grabow S, Strasser A.
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| Blood 125(21):3273-80. doi: 10.1182/blood-2015-01-621250. Epub 2015 Apr 6.
2015
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| 9 | BCL2L1, MCL1
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| Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
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| Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT.
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| Blood 119(24):5850-8. doi: 10.1182/blood-2011-12-398834. Epub 2012 Feb 28.
2012
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| 10 | MCL1, NAA10, RELA
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| N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
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| Xu H, Jiang B, Meng L, Ren T, Zeng Y, Wu J, Qu L, Shou C.
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| Carcinogenesis 33(6):1193-202. doi: 10.1093/carcin/bgs144. Epub 2012 Apr 10.
2012
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| 11 | BAX, BCL2L1, MCL1
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| Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.
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| Czabotar PE, Lee EF, Thompson GV, Wardak AZ, Fairlie WD, Colman PM.
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| J Biol Chem 286(9):7123-31. Epub 2011 Jan 3.
2011
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| 12 | MCL1
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| MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
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| Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS, Opferman JT, Slack RS.
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| EMBO J 30(2):395-407. Epub 2010 Dec 7.
2011
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| 13 | MCL1
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| MCL1 meets its end during mitotic arrest.
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| Millman SE, Pagano M.
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| EMBO Rep. 12(5):384-5. 2011
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| 14 | MCL1
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| SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
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| Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.
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| Nature. 471(7336):104-9. 2011
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| 15 | HUWE1, MCL1, PMAIP1, USP9X
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| Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.
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| Gomez-Bougie P, Ménoret E, Juin P, Dousset C, Pellat-Deceunynck C, Amiot M.
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| Biochem Biophys Res Commun. 413(3):460-4. 2011
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| 16 | BCL2L11, MCL1, PMAIP1
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| Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
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| Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X.
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| Cell Death Differ 18(5):864-73. Epub 2010 Nov 26.
2011
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| 17 | ATG12, BCL2, MCL1
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| The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis.
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| Rubinstein AD, Eisenstein M, Ber Y, Bialik S, Kimchi A.
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| Mol Cell 44(5):698-709. doi: 10.1016/j.molcel.2011.10.014.
2011
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| 18 | MCL1, USP9X
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| Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
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| Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DC, Dixit VM.
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| Nature 463(7277):103-7. Epub 2009 Dec 20.PMID: 20023629 2010
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| 19 | MCL1, USP9X
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| Mcl-1; the molecular regulation of protein function.
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| Thomas LW, Lam C, Edwards SW.
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| FEBS Lett 584(14):2981-9. Epub 2010 Jun 11. Review. 2010
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| 20 | BCL2L1, MCL1
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| Mcl-1 is essential for germinal center formation and B cell memory.
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| Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM.
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| Science 330(6007):1095-9. Epub 2010 Oct 7.
2010
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| 21 | MCL1
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| Ubiquitin-independent degradation of antiapoptotic MCL-1.
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| Stewart DP, Koss B, Bathina M, Perciavalle RM, Bisanz K, Opferman JT.
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| Mol Cell Biol 30(12):3099-110. Epub 2010 Apr 12.
2010
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| 22 | MAP2K4, MCL1
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| Genetic and molecular alterations in rhabdomyosarcoma: mRNA overexpression of MCL1 and MAP2K4 genes.
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| Pazzaglia L, Chiechi A, Conti A, Gamberi G, Magagnoli G, Novello C, Morandi L, Picci P, Mercuri M, Benassi MS.
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| Histol Histopathol 24(1):61-7.
2009
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| 23 | BCL2L11, IER3, MCL1
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| IEX-1-induced cell death requires BIM and is modulated by MCL-1.
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| Yoon S, Ha HJ, Kim YH, Won M, Park M, Ko JJ, Lee K, Bae J.
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| Biochem Biophys Res Commun 382(2):400-4. Epub 2009 Mar 13.
2009
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| 24 | MCL1
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| MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death.
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| Kim JH, Sim SH, Ha HJ, Ko JJ, Lee K, Bae J.
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| FEBS Lett 583(17):2758-64. Epub 2009 Aug 14.
2009
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| 25 | MCL1, PROK1
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| Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein.
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| Ren LN, Li QF, Xiao FJ, Yan J, Yang YF, Wang LS, Guo XZ, Wang H.
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| Biochem Biophys Res Commun 386(1):35-9. Epub 2009 Jun 10.PMID: 19523441 2009
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| 26 | MCL1
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| Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412.
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| Aichberger KJ, Mayerhofer M, Gleixner KV, Krauth MT, Gruze A, Pickl WF, Wacheck V, Selzer E, Müllauer L, Agis H, Sillaber C, Valent P.
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| Blood 109(7):3031-41.
2007
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| 27 | MCL1, TOMM70A
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| An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway.
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| Chou CH, Lee RS, Yang-Yen HF.
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| Mol Biol Cell 17(9):3952-63. Epub 2006 Jul 5. 2006
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| 28 | HUWE1, MCL1
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| Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.
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| Zhong Q, Gao W, Du F, Wang X.
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| Cell 121(7):1085-95. 2005
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| 29 | MCL1
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| BH3-ligand regulates access of MCL-1 to its E3 ligase.
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| Warr MR, Acoca S, Liu Z, Germain M, Watson M, Blanchette M, Wing SS, Shore GC.
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| FEBS Lett. 579(25):5603-8. 2005
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| 30 | BAK1, MCL1
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| Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.
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| Leu JI, Dumont P, Hafey M, Murphy ME, George DL.
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| Nat Cell Biol. 6(5):443-50. 2004
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| 31 | MCL1
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| Immediate early gene X-1 interacts with proteins that modulate apoptosis.
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| Kumar R, Lutz W, Frank E, Im HJ.
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| Biochem Biophys Res Commun. 323(4):1293-8. 2004
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| 32 | MCL1
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| Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
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| Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ.
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| Nature 426(6967):671-6. 2003
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| 33 | MCL1, TNKS
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| Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis.
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| Bae J, Donigian JR, Hsueh AJ.
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| J Biol Chem 278(7):5195-204. Epub 2002 Dec 9. 2003
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| 34 | PARP1, RANGAP1, BIRC2, TEGT, MCL1, SENP1
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| Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma.
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| Villalva C, Trempat P, Greenland C, Thomas C, Girard JP, Moebius F, Delsol G, Brousset P.
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| Br J Haematol 118(3):791-8. 2002
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| 35 | MCL1
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| Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone.
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| Zhang D, Li F, Weidner D, Mnjoyan ZH, Fujise K.
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| J Biol Chem. 277(40):37430-8. 2002
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| 36 | MCL1
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| Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.
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| Alam NA, Bevan S, Churchman M, Barclay E, Barker K, Jaeger EE, Nelson HM, Healy E, Pembroke AC, Friedmann PS, Dalziel K, Calonje E, Anderson J, August PJ, Davies MG, Felix R, Munro CS, Murdoch M, Rendall J, Kennedy S, Leigh IM, Kelsell DP, Tomlinson IP, Houlston RS.
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| Am J Hum Genet 68(5):1264-9. 2001
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| 37 | MCL1
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| Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.
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| Bae J, Hsu SY, Leo CP, Zell K, Hsueh AJ.
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| Apoptosis. 6(5):319-30. 2001
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| 38 | BAK1, BAX, MCL1
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| MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.
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| Bae J, Leo CP, Hsu SY, Hsueh AJ.
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| J Biol Chem. 275(33):25255-61. 2000
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| 39 | MCL1
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| A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family.
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| Makishima T, Yoshimi M, Komiyama S, Hara N, Nishimoto T.
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| J Biochem. 128(3):399-405. 2000
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| 40 | MCL1
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| Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen.
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| Fujise K, Zhang D, Liu J, Yeh ET.
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| J Biol Chem. 275(50):39458-65. 2000
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| 41 | MCL1
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| Mcl-1 deficiency results in peri-implantation embryonic lethality.
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| Rinkenberger JL, Horning S, Klocke B, Roth K, Korsmeyer SJ.
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| Genes Dev. 14(1):23-7. 2000
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| 42 | GSD3, CDC42, MSUD2, FCER1A, GNAI3, GUCA2A, ITPKB, MATN1, MCL1, NGF, PRDX1, PTPN7, S100A10
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| A comprehensive view of human chromosome 1.
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| White PS, Sulman EP, Porter CJ, Matise TC.
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| Genome Res 9(10):978-88 1999
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| 43 | MCL1
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| Induction of BCL2 family member MCL1 as an early response to DNA damage.
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| Zhan Q, et al.
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| Oncogene 14 : 1031-1039. 1997
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| 44 | MCL1
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| Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.
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| Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ.
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| Proc Natl Acad Sci U S A. 94(23):12401-6. 1997
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| 45 | MCL1
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| Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene : MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease.
|
| Craig RW, et al.
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| Genomics 23 : 457-463. 1994
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| 46 | MCL1
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| MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
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| Kozopas KM, et al.
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| Proc Natl Acad Sci U S A 90 : 3516-3520. 1993
|