| 1 | MC4R, SIM1
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| Sim1 Neurons Are Sufficient for MC4R-Mediated Sexual Function in Male Mice.
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| Semple E, Hill JW.
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| Endocrinology 159(1):439-449. doi: 10.1210/en.2017-00488.
2018
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| 2 | MC4R, MRAP2
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| Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor.
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| Soletto L, Hernández-Balfagó S, Rocha A, Scheerer P, Kleinau G, Cerdá-Reverter JM.
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| J Endocr Soc. Dec 6;3(2):314-323. doi: 10.1210/js.2018-00370. eCollection 2019 Feb 1 2018
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| 3 | MC3R, MC4R
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| Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.
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| Yang LK, Tao YX.
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| Biochim Biophys Acta iochim Biophys Acta. 2017 Apr 19. pii: S0925-4439(17)30122-9. doi: 10.1016/j.bbadis.2017.04.010. [Epub ahead of print]
2017
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| 4 | MC4R
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| Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity.
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| Paolini B, Maltese PE, Del Ciondolo I, Tavian D, Missaglia S, Ciuoli C, Zuntini M, Cecchin S, Bertelli M, Pompucci G.
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| Genet Mol Res 15(3). doi: 10.4238/gmr.15038718.
2016
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| 5 | MC4R
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| A common variant and the transcript levels of MC4R gene are associated with adiposity in children: the IDEFICS Study.
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| Lauria F, Siani A, Picó C, Ahrens W, Bammann K, De Henauw S, Foraita R, Iacoviello L, Kourides Y, Marild S, Molnar D, Moreno LA, Pitsiladis Y, Sánchez J, Veidebaum T, Wang G, Russo P; IDEFICS consortium.
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| J Clin Endocrinol Metab Clin Endocrinol Metab. 2016 Sep 1:jc20161992. [Epub ahead of print]
2016
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| 6 | MC4R
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| Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone.
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| Tan HY, Steyn FJ, Huang L, Cowley M, Veldhuis JD, Chen C.
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| J Physiol Physiol. 2016 Aug 25. doi: 10.1113/JP272770.
2016
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| 7 | MC3R, MC4R, RNF11
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| Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.
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| Müller A, Niederstadt L, Jonas W, Yi CX, Meyer F, Wiedmer P, Fischer J, Grötzinger C, Schürmann A, Tschöp M, Kleinau G, Grüters A, Krude H, Biebermann H.
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| Front Endocrinol (Lausanne) 7:109. doi: 10.3389/fendo.2016.00109. eCollection 2016.
2016
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| 8 | MC4R
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| Melanocortin-4 receptor-regulated energy homeostasis.
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| Krashes MJ, Lowell BB, Garfield AS.
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| Nat Neurosci 19(2):206-19. doi: 10.1038/nn.4202. Review.
2016
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| 9 | MC3R, MC4R
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| Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.
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| You P, Hu H, Chen Y, Zhao Y, Yang Y, Wang T, Xing R, Shao Y, Zhang W, Li D, Chen H, Liu M.
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| Sci Rep 6:34938. doi: 10.1038/srep34938.
2016
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| 10 | AGRP, KCNJ13, MC4R
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| G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
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| Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD.
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| Nature 520(7545):94-8. doi: 10.1038/nature14051. Epub 2015 Jan 19.
2015
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| 11 | FTO, MC4R
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| Interaction between common variants of FTO and MC4R is associated with risk of PCOS.
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| Yuan H, Zhu G, Wang F, Wang X, Guo H, Shen M.
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| Reprod Biol Endocrinol 13:55. doi: 10.1186/s12958-015-0050-z.
2015
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| 12 | MC4R
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| The melanocortin-4 receptor integrates circadian light cues and metabolism.
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| Arble DM, Holland J, Ottaway N, Sorrell J, Pressler JW, Morano R, Woods SC, Seeley RJ, Herman JP, Sandoval DA, Perez-Tilve D.
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| Endocrinology 156(5):1685-91. doi: 10.1210/en.2014-1937. Epub 2015 Mar 2.
2015
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| 13 | MC4R
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| Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats.
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| do Carmo JM, da Silva AA, Hall JE.
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| J Hypertens 33(6):1201-6. doi: 10.1097/HJH.0000000000000530.
2015
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| 14 | MC4R, MRAP2
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| Melanocortin receptor accessory proteins in adrenal disease and obesity.
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| Jackson DS, Ramachandrappa S, Clark AJ, Chan LF.
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| Front Neurosci. Jun 10;9:213. doi: 10.3389/fnins.2015.00213. eCollection 2015 2015
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| 15 | MC4R, SLC24A4
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| An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety.
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| Li XF, Lytton J.
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| J Biol Chem 289(37):25445-59. doi: 10.1074/jbc.M114.564450. Epub 2014 Aug 5.
2014
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| 16 | MC4R
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| Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons.
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| Agosti F, López Soto EJ, Cabral A, Castrogiovanni D, Schioth HB, Perelló M, Raingo J.
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| Eur J Neurosci 40(5):2755-65. doi: 10.1111/ejn.12650. Epub 2014 Jun 18.
2014
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| 17 | MC4R
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| Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons.
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| do Carmo JM, da Silva AA, Rushing JS, Pace B, Hall JE.
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| Am J Physiol Regul Integr Comp Physiol 305(4):R359-68. doi: 10.1152/ajpregu.00518.2012. Epub 2013 Jul 10.
2013
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| 18 | MC4R
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| Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
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| Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK.
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| Cell 152(3):612-9. doi: 10.1016/j.cell.2012.12.022.
2013
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| 19 | MC4R
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| Melanocortin 4 receptor distribution in the human hypothalamus.
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| Siljee JE, Unmehopa UA, Kalsbeek A, Swaab DF, Fliers E, Alkemade A.
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| Eur J Endocrinol 168(3):361-9. doi: 10.1530/EJE-12-0750. Print 2013 Mar.
2013
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| 20 | MC4R
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| Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor.
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| Huang H, Tao YX.
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| J Mol Endocrinol 49(3):237-48. doi: 10.1530/JME-12-0161. Print 2012 Dec.
2012
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| 21 | MC4R
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| Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse.
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| Gautron L, Lee CE, Lee S, Elmquist JK.
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| J Comp Neurol 520(17):3933-48. doi: 10.1002/cne.23137.
2012
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| 22 | MC4R, NHLH2
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| Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2.
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| Wankhade UD, Good DJ.
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| Mol Cell Endocrinol 341(1-2):39-47. doi: 10.1016/j.mce.2011.05.022. Epub 2011 Jun 1.
2011
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| 23 | MC4R, OBS3
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| Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.
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| Cole SA, Butte NF, Voruganti VS, Cai G, Haack K, Kent JW Jr, Blangero J, Comuzzie AG, McPherson JD, Gibbs RA.
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| Am J Clin Nutr 91(1):191-9. Epub 2009 Nov 4.
2010
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| 24 | FTO, MC4R, OBS2
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| Life course variations in the associations between FTO and MC4R gene variants and body size.
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| Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, Loos RJ, Kuh D, Ong KK.
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| Hum Mol Genet 19(3):545-52. Epub 2009 Oct 31.PMID: 19880856 2010
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| 25 | BDNF, FTO, HSPA1B, MC4R, TMEM18
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| Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
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| Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K.
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| Nat Genet 41(1):18-24. Epub 2008 Dec 14. 2009
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| 26 | FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, PCSK1, SH2B1, TMEM18
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| Replication and extension of genome-wide association study results for obesity in 4,923 adults from Northern Sweden.
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| Renström F, Payne F, Nordström A, Brito EC; GIANT Consortium, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW.
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| Hum Mol Genet um Mol Genet. 2009 Jan 22. [Epub ahead of print]
2009
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| 27 | BDNF, FAIM2, GNPDA2, MC4R, SEC16B, TMEM18
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| Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
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| Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y.
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| J Hum Genet 54(12):727-31. Epub 2009 Oct 23.
2009
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| 28 | MC4R
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| Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.
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| Kim DH, Shin SW, Baik JH.
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| Biochem Biophys Res Commun 365(3):439-45. Epub 2007 Nov 5.
2008
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| 29 | MC4R
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| Analysis of single nucleotide polymorphisms in the melanocortin-4 receptor promoter in infantile spasms.
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| Liu ZL, He B, Fang F, Tang CY, Zou LP.
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| Neuropediatrics 38(6):304-9.
2007
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| 30 | MC4R, OBS3
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| Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.
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| Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S.
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| Hum Mol Genet 12(5):561-74. 2003
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| 31 | MC4R
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| Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.
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| Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schafer H, Gudermann T, Hebebrand J.
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| J Clin Endocrinol Metab 88(9):4258-67. 2003
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| 32 | MC4R, OBS3
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| The human MC4R promoter: characterization and role in obesity.
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| Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C.
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| Diabetes 52(12):2996-3000. 2003
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| 33 | MC4R, OBS3
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| A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity.
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| Mergen M, Mergen H, Ozata M, Oner R, Oner C.
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| J Clin Endocrinol Metab 86(7):3448. 2001
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| 34 | MC4R
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| Testing of human homologues of murine obesity genes as candidate regions in Finnish obese sib pairs.
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| Ohman M, et al.
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| Eur J Hum Genet 7(2):117-24. 1999
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| 35 | MC4R
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| Identification and functional analysis of novel human melanocortin-4 receptor variants.
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| Gu W, et al.
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| Diabetes 48(3):635-9. 1999
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| 36 | MC4R, OBS3
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| Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.
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| Hinney A, et al.
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| J Clin Endocrinol Metab 84(4):1483-6. 1999
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| 37 | MC4R
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| Haplosufficiency of the melancortin-4 receptor gene in individuals with deletions of 18q.
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| Cody JD, Reveles XT, Hale DE, Lehman D, Coon H, Leach RJ.
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| Hum Genet 105(5):424-7 1999
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| 38 | MC4R, OBS3
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| Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene.
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| Sina M, Hinney A, Ziegler A, Neupert T, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J.
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| Am J Hum Genet 65(6):1501-7 1999
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| 39 | MC4R, OBS3
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| Molecular scanning for mutations in the melanocortin-4 receptor gene in obese/diabetic Japanese.
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| Ohshiro Y, Sanke T, Ueda K, Shimajiri Y, Nakagawa T, Tsunoda K, Nishi M, Sasaki H, Takasu N, Nanjo K.
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| Ann Hum Genet 63 : 483-487. 1999
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| 40 | MC4R
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| Assignment of the melanocortin 4 receptor (MC4R) gene to human chromosome band 18q22 by in situ hybridization and radiation hybrid mapping.
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| Sundaramurthy D, et al.
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| Cytogenet Cell Genet 82 : 97-98. 1998
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| 41 | MC4R, OBS4
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| A frameshift mutation in MC4R associated with dominantly inherited human obesity.
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| Yeo GSH, et al.
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| Nat Genet 20 : 111-112. 1998
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| 42 | MC4R, OBS4
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| A frameshift mutation in human MC4R is associated with a dominant form of obesity.
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| Vaisse C, et al.
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| Nat Genet 20 : 113-114. 1998
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| 43 | AGRP, CLU, CPE, MC4R, NPY5R, NPY6R, PCSK1, POMC, DIDAN, TUB, UCP2
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| Microsatellite marker content mapping of 12 candidate genes for obesity: assembly of seven obesity screening panels for automated genotyping.
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| Winick JD, Friedman JM.
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| Genome Res 8(9):985-94. 1998
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| 44 | MC1R, HADC, MC3R, MC4R
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| Deletions of the N-terminal regions of the human melanocortin receptors.
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| Schioth HB, Petersson S, Muceniece R, Szardenings M, Wikberg JE.
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| FEBS Lett 410(2-3):223-8. 1997
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| 45 | MC4R
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| Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.
|
| Gotoda T, Scott J, Aitman TJ.
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| Diabetologia 40(8):976-9. 1997
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| 46 | MC4R
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| Integration of 28 STSs into the physical map of human chromosome 18.
|
| Gerken S, et al.
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| Genomics 24 : 612-613. 1994
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| 47 | MC1R, HADC, MC3R, MC4R, MC1RH1, MC1RH2
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| Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.
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| Magenis RE, et al.
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| Mamm Genome 5 : 503-508. 1994
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| 48 | MC4R
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| Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
|
| Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD.
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| Mol Endocrinol 8(10):1298-308.
1994
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| 49 | MC1R, MC3R, MC4R
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| Molecular cloning of a novel melanocortin receptor.
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| Gantz I, et al.
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| J Biol Chem 268 : 8246-8250. 1993
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| 50 | MC4R, HADC, MC3R
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| Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.
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| Gantz I, et al.
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| J Biol Chem 268 : 15174-15179. 1993
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| 51 | MC4R, HADC, MC3R
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| Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.
|
| Gantz I, et al.
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| Genomics 18 : 166-167. 1993
|