Citations for
1HERPUD1, MAVS, TBK1
HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K, Liu Y, Wu J.
J Immunol 199(9):3280-3292. doi: 10.4049/jimmunol.1700376. Epub 2017 Sep 27. 2017
2BST2, DHX58, MAVS
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J.
Mol Cell 68(2):308-322.e4. doi: 10.1016/j.molcel.2017.09.005. Epub 2017 Sep 28. 2017
3DHX58, MAVS, ZYX
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.
Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, Oshiumi H.
Sci Rep 7(1):11905. doi: 10.1038/s41598-017-12224-7. 2017
4MAVS, RIPK3
RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection.
Downey J, Pernet E, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin JG, Joubert P, Divangahi M.
PLoS Pathog 13(4):e1006326. doi: 10.1371/journal.ppat.1006326. eCollection 2017 Apr. 2017
5ITCH, MAVS, TAX1BP1
TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.
Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW.
Mol Cell Biol 37(1). pii: e00422-16. Print 2017 Jan 1. 2016
6MARCH5, MAVS
The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling.
Yoo YS, Park YY, Kim JH, Cho H, Kim SH, Lee HS, Kim TH, Sun Kim Y, Lee Y, Kim CJ, Jung JU, Lee JS, Cho H.
Nat Commun 6:7910. doi: 10.1038/ncomms8910. 2015
7MAVS
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response.
Shi Y, Yuan B, Qi N, Zhu W, Su J, Li X, Qi P, Zhang D, Hou F.
Nat Commun 6:7811. doi: 10.1038/ncomms8811. 2015
8MAVS, PYCARD
MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.
Guan K, Wei C, Zheng Z, Song T, Wu F, Zhang Y, Cao Y, Ma S, Chen W, Xu Q, Xia W, Gu J, He X, Zhong H.
J Immunol 194(10):4880-90. doi: 10.4049/jimmunol.1402851. Epub 2015 Apr 6. 2015
9CGAS, DDX58, MAVS, TMEM173
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ.
Science 347(6227):aaa2630. doi: 10.1126/science.aaa2630. Epub 2015 Jan 29. 2015
10DHX58, MAVS
MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors.
Chen WQ, Hu YW, Zou PF, Ren SS, Nie P, Chang MX.
Dev Comp Immunol 49(1):19-30. doi: 10.1016/j.dci.2014.10.017. Epub 2014 Nov 11. 2015
11DHX15, MAVS
The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.
Mosallanejad K, Sekine Y, Ishikura-Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, Takeda K, Naguro I, Ichijo H.
Sci Signal 7(323):ra40. doi: 10.1126/scisignal.2004841. 2014
12MAVS, SMURF2
Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation.
Pan Y, Li R, Meng JL, Mao HT, Zhang Y, Zhang J.
J Immunol 192(10):4758-64. doi: 10.4049/jimmunol.1302632. Epub 2014 Apr 11. 2014
13MAVS
Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX.
Elife 3:e01489. doi: 10.7554/eLife.01489. Erratum in: Elife. 2015;4. doi: 10.7554/eLife.07546. 2014
14DHX15, MAVS
DHX15 senses double-stranded RNA in myeloid dendritic cells.
Lu H, Lu N, Weng L, Yuan B, Liu YJ, Zhang Z.
J Immunol 193(3):1364-72. doi: 10.4049/jimmunol.1303322. Epub 2014 Jul 2. 2014
15MAVS, TRIM14
TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response.
Zhou Z, Jia X, Xue Q, Dou Z, Ma Y, Zhao Z, Jiang Z, He B, Jin Q, Wang J.
Proc Natl Acad Sci U S A 111(2):E245-54. doi: 10.1073/pnas.1316941111. Epub 2013 Dec 30. 2014
16DHX33, MAVS
The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells.
Liu Y, Lu N, Yuan B, Weng L, Wang F, Liu YJ, Zhang Z.
Cell Mol Immunol ell Mol Immunol. 2013 Sep 16. doi: 10.1038/cmi.2013.40. [Epub ahead of print] 2013
17DDX58, IFIT5, MAVS
IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways.
Zhang B, Liu X, Chen W, Chen L.
Acta Biochim Biophys Sin (Shanghai) 45(10):867-74. doi: 10.1093/abbs/gmt088. Epub 2013 Aug 13. 2013
18MAVS, NLRP3
The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity.
Park S, Juliana C, Hong S, Datta P, Hwang I, Fernandes-Alnemri T, Yu JW, Alnemri ES.
J Immunol 191(8):4358-66. doi: 10.4049/jimmunol.1301170. Epub 2013 Sep 18. 2013
19MAVS
Identification of tyrosine-9 of MAVS as critical target for inducible phosphorylation that determines activation.
Wen C, Yan Z, Yang X, Guan K, Xu C, Song T, Zheng Z, Wang W, Wang Y, Zhao M, Zhang Y, Xu T, Dou J, Liu J, Xu Q, He X, Wei C, Zhong H.
PLoS One 7(7):e41687. doi: 10.1371/journal.pone.0041687. Epub 2012 Jul 26. 2012
20MAVS
VISA is required for B cell expression of TLR7.
Xu LG, Jin L, Zhang BC, Akerlund LJ, Shu HB, Cambier JC.
J Immunol 188(1):248-58. doi: 10.4049/jimmunol.1100918. Epub 2011 Nov 21. 2012
21DDX58, MAVS, TSPAN6
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner.
Wang Y, Tong X, Omoregie ES, Liu W, Meng S, Ye X.
J Biol Chem 287(41):34626-34. doi: 10.1074/jbc.M112.390401. Epub 2012 Aug 20. 2012
22MAVS
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.
Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ.
Cell 146(3):448-61. doi: 10.1016/j.cell.2011.06.041. Epub 2011 Jul 21. Erratum in: Cell. 2011 Sep 2;146(5):841. 2011
23ABL1, MAVS
c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response.
Song T, Wei C, Zheng Z, Xu Y, Cheng X, Yuan Y, Guan K, Zhang Y, Ma Q, Shi W, Zhong H.
FEBS Lett 584(1):33-8. Epub .PMID: 19914245 2010
24MAVS, WDR5
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation.
Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P, Shu HB.
Proc Natl Acad Sci U S A 107(2):815-20. Epub 2009 Dec 22. 2010
25MAVS, TOMM70A
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Liu XY, Wei B, Shi HX, Shan YF, Wang C.
Cell Res 20(9):994-1011. doi: 10.1038/cr.2010.103. Epub 2010 Jul 13. 2010
26MAVS, RNF5
The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.
Zhong B, Zhang Y, Tan B, Liu TT, Wang YY, Shu HB.
J Immunol 184(11):6249-55. doi: 10.4049/jimmunol.0903748. Epub 2010 May 5. 2010
27IRF3, MAVS, TRAF5
TRAF5 is a downstream target of MAVS in antiviral innate immune signaling.
Tang ED, Wang CY.
PLoS One 5(2):e9172. doi: 10.1371/journal.pone.0009172. 2010
28MAVS, PLK1
Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.
Vitour D, Dabo S, Ahmadi Pour M, Vilasco M, Vidalain PO, Jacob Y, Mezel-Lemoine M, Paz S, Arguello M, Lin R, Tangy F, Hiscott J, Meurs EF.
J Biol Chem 284(33):21797-809. Epub 2009 Jun 22.PMID: 19546225 2009
29MAVS, TICAM1, TLR3
Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing.
Seya T, Matsumoto M, Ebihara T, Oshiumi H.
Immunol Rev 227(1):44-53. Review.PMID: 19120474 2009
30ITCH, MAVS, PCBP2
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z.
Nat Immunol 10(12):1300-8. Epub 2009 Nov 1.PMID: 19881509 2009
31DAP3, MAVS
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation.
Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T.
Cell Death Differ 16(12):1615-21. Epub 2009 Jul 31.PMID: 19644511 2009
32MAVS, PSMA7
Negative regulation of MAVS-mediated innate immune response by PSMA7.
Jia Y, Song T, Wei C, Ni C, Zheng Z, Xu Q, Ma H, Li L, Zhang Y, He X, Xu Y, Shi W, Zhong H.
J Immunol 183(7):4241-8. doi: 10.4049/jimmunol.0901646. Epub 2009 Sep 4. 2009
33MAVS, MYD88
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus.
Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ.
Proc Natl Acad Sci U S A 105(37):14046-51. Epub 2008 Sep 9. 2008
34MAVS
The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosis.
Scott I, Norris KL.
Biochem Biophys Res Commun 375(1):101-6. Epub 2008 Aug 8. 2008
35MAVS, TICAM1
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Rebsamen M, Meylan E, Curran J, Tschopp J.
Cell Death Differ 15(11):1804-11. Epub 2008 Aug 29.PMID: 18756281 2008
36DDX58, IKBKG, MAVS
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Zhao T, Yang L, Sun Q, Arguello M, Ballard DW, Hiscott J, Lin R.
Nat Immunol 8(6):592-600. Epub 2007 Apr 29. 2007
37MAVS, TRAF3
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Saha SK, Pietras EM, He JQ, Kang JR, Liu SY, Oganesyan G, Shahangian A, Zarnegar B, Shiba TL, Wang Y, Cheng G.
EMBO J 25(14):3257-63. Epub 2006 Jul 6. 2006
38MAVS
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
Seth RB, Sun L, Ea CK, Chen ZJ.
Cell 122(5):669-82. 2005
39C18orf32, EEF1D, GPR89A, MAVS, NDFIP1, PLEKHG5, SHISA5, SLC35B2, TIFA, TMED4, TRA2A, TRIM38, USE1, WLS
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T,Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S.
Oncogene 22(21):3307-18. 2003