| 1 | MAP2K7, MAPK8, SENP3
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| DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
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| Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J.
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| J Biol Chem 293(11):3965-3980. doi: 10.1074/jbc.M117.816769. Epub 2018 Jan 19.
2018
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| 2 | CAMK2D, MAPK8, MAPK9
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| Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium
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| Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X.
|
| Cardiovasc Res. Apr 1;114(5):737-746. doi: 10.1093/cvr/cvy011. 2018
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| 3 | MAP2K7, MAPK8
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| Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
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| Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.
|
| Sci Rep 7(1):7348. doi: 10.1038/s41598-017-07845-x.
2017
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| 4 | MAPK8, TRAF5
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| Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis.
|
| Gao L, Wang PX, Zhang Y, Yu CJ, Ji Y, Wang X, Zhang P, Jiang X, Jin H, Huang Z, Zhang ZR, Li H.
|
| J Hepatol 65(1):125-136. doi: 10.1016/j.jhep.2016.03.006. Epub 2016 Mar 23.
2016
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| 5 | AURKA, MAPK8, MAPK9, WDR62
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| Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.
|
| Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Williamson NA, Xu Z, Bogoyevitch MA, Ng DC.
|
| J Cell Sci 128(3):527-40.
2015
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| 6 | MAPK8, MAPK9, TNFRSF1B, XPNPEP3
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| Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
|
| Inoue M, Kamada H, Abe Y, Higashisaka K, Nagano K, Mukai Y, Yoshioka Y, Tsutsumi Y, Tsunoda S.
|
| J Cell Sci 128(4):656-69. doi: 10.1242/jcs.149385. Epub 2015 Jan 20. 2015
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| 7 | MAP2K4, MAPK8, TGFB1I1
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| Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.
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| Lei XF, Kim-Kaneyama JR, Arita-Okubo S, Offermanns S, Itabe H, Miyazaki T, Miyazaki A.
|
| J Am Heart Assoc 3(3):e000747. doi: 10.1161/JAHA.113.000747.
2014
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| 8 | MAPK8, SH3BP5
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| JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
|
| Win S, Than TA, Fernandez-Checa JC, Kaplowitz N.
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| Cell Death Dis 5:e989. doi: 10.1038/cddis.2013.522.
2014
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| 9 | MAPK8, MUC1
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| MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress.
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| Chen Q, Li D, Ren J, Li C, Xiao ZX.
|
| Biochem Biophys Res Commun 440(1):179-83. doi: 10.1016/j.bbrc.2013.09.055. Epub 2013 Sep 18.
2013
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| 10 | DCC, DSCAM, MAPK8, NTN1, UNC5C
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| c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance.
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| Qu C, Li W, Shao Q, Dwyer T, Huang H, Yang T, Liu G.
|
| J Biol Chem 288(3):1883-95. doi: 10.1074/jbc.M112.417881. Epub 2012 Dec 6.
2013
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| 11 | AJUBA, MAPK8
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| Ajuba family proteins link JNK to Hippo signaling.
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| Sun G, Irvine KD.
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| Sci Signal 6(292):ra81. doi: 10.1126/scisignal.2004324.
2013
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| 12 | IRS2, MAPK8, MAPK9, MAPK9
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| JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.
|
| Abdelli S, Bonny C.
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| PLoS One 7(5):e35997. doi: 10.1371/journal.pone.0035997. Epub 2012 May 1.
2012
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| 13 | LPIN2, MAPK8
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| Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
|
| Valdearcos M, Esquinas E, Meana C, Peńa L, Gil-de-Gómez L, Balsinde J, Balboa MA.
|
| J Biol Chem 287(14):10894-904. doi: 10.1074/jbc.M112.342915. Epub 2012 Feb 8.
2012
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| 14 | MAP2K7, MAPK8, TNFRSF18
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| Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
|
| Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, Gelfand EW.
|
| J Biol Chem 287(21):17100-8. doi: 10.1074/jbc.M111.316943. Epub 2012 Mar 29.
2012
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| 15 | CTGF, MAPK8
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| Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.
|
| Shi L, Chang Y, Yang Y, Zhang Y, Yu FS, Wu X.
|
| PLoS One 7(2):e32128. doi: 10.1371/journal.pone.0032128. Epub 2012 Feb 21.
2012
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| 16 | MAPK8, PXN
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| Paxillin is the target of c-Jun N-terminal kinase in Schwann cells and regulates migration.
|
| Miyamoto Y, Torii T, Yamamori N, Eguchi T, Nagao M, Nakamura K, Tanoue A, Yamauchi J.
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| Cell Signal 24(11):2061-9. doi: 10.1016/j.cellsig.2012.06.013. Epub 2012 Jun 30.
2012
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| 17 | MAPK8, RAD18
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| c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks.
|
| Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C.
|
| Mol Biol Cell 23(10):1943-54. doi: 10.1091/mbc.E11-10-0829. Epub 2012 Mar 28.
2012
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| 18 | ADARB1, MAPK8
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| c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.
|
| Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S, Gan Z, Lin A, Li W, Liu Y.
|
| PLoS One 7(11):e48611. doi: 10.1371/journal.pone.0048611. Epub 2012 Nov 6.
2012
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| 19 | MAPK1, MAPK3, MAPK8
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| Differential roles of ERK1/2 and JNK in retinal development and degeneration.
|
| Donovan M, Doonan F, Cotter TG.
|
| J Neurochem. 116(1):33-42. 2011
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| 20 | MAPK8, MAPK9
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| Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.
|
| Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ.
|
| Mol Cell Biol 31(7):1565-76. Epub 2011 Jan 31.
2011
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| 21 | MAPK8, SIRT1
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| Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
|
| Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J.
|
| J Biol Chem 286(25):22227-34. Epub 2011 May 3.
2011
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| 22 | GNA12, MAPK8, ROCK1
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| G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
|
| Juneja J, Cushman I, Casey PJ.
|
| PLoS One 6(11):e26085. doi: 10.1371/journal.pone.0026085. Epub 2011 Nov 7.
2011
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| 23 | MAPK8
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| Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.
|
| Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ.
|
| Genes Dev 24(3):256-64. Epub 2010 Jan 15.
2010
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| 24 | MAPK8
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| Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism.
|
| Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, Spohn G, Brönneke HS, Brodesser S, Hampel B, Schauss AC, Brüning JC.
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| Proc Natl Acad Sci U S A 107(13):6028-33. Epub 2010 Mar 15. 2010
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| 25 | MAPK8, MAPK9
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| JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells.
|
| Utsugi M, Dobashi K, Ono A, Ishizuka T, Hisada T, Koga Y, Shimizu Y, Kawata T, Matsuzaki S, Aoki H, Kamide Y, Mori M.
|
| Cytokine 51(2):127-31. Epub 2010 May 18.
2010
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| 26 | BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
|
| Microtubule assembly, organization and dynamics in axons and dendrites.
|
| Conde C, Caceres A.
|
| Nat Rev Neurosci. 10(5):319-32. 2009
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| 27 | MAPK8, SIRT1
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| JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.
|
| Nasrin N, Kaushik VK, Fortier E, Wall D, Pearson KJ, de Cabo R, Bordone L.
|
| PLoS One. 4(12):e8414. 2009
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| 28 | MAPK8, MAPK9
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| Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.
|
| Gancz D, Donin N, Fishelson Z.
|
| Mol Immunol 47(2-3):310-7. Epub 2009 Oct 27.
2009
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| 29 | MAPK8
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| A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
|
| Sabio, G.; Das, M.; Mora, A.; Zhang, Z.; Jun, J. Y.; Ko, H. J.; Barrett, T.; Kim, J. K.; Davis, R. J.
|
| Science. 322: 1539-1543 2008
|
| 30 | MAPK8, MPRIP
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| M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
|
| Ono R, Matsuoka J, Yamatsuji T, Naomoto Y, Tanaka N, Matsui H, Matsushita M.
|
| Int J Mol Med 22(2):199-203.
2008
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| 31 | IFIT3, IFNA1, MAPK8, PRKCD
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| Sequential activation of protein kinase C delta and JNK is required for interferon-alpha-induced expression of IFIT4.
|
| Huang X, Yang N, Ou X, Li D, Wang Z, Xie Q, Chen Y, Lin H, Yin G, Wen F.
|
| Cell Signal 20(1):112-9.
2008
|
| 32 | ALDH1L1, MAPK8, MAPK9
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| Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway.
|
| Oleinik NV, Krupenko NI, Krupenko SA.
|
| Oncogene 26(51):7222-30. Epub 2007 May 21.PMID: 17525747 2007
|
| 33 | MAPK8
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| Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.
|
| Tuncman, G.; Hirosumi, J.; Solinas, G.; Chang, L.; Karin, M.; Hotamisligil, G. S.
|
| Proc. Nat. Acad. Sci. 103: 10741-10746 2006
|
| 34 | MAPK8
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| Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
|
| Tran, E. H.; Azuma, Y.-T.; Chen, M.; Weston, C.; Davis, R. J.; Flavell, R. A.
|
| Proc. Nat. Acad. Sci. 103: 13451-13456 2006
|
| 35 | JUN, MAPK8
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| Neuroprotection by histone deacetylase-related protein.
|
| Morrison BE, Majdzadeh N, Zhang X, Lyles A, Bassel-Duby R, Olson EN, D'Mello SR.
|
| Mol Cell Biol. 26(9):3550-64. 2006
|
| 36 | RP1, MAPK8, MAPK9, MAPK10, MAP2K4 , MAP2, JUN
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| Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations.
|
| Liu J, Huang Q, Higdon J, Liu W, Xie T, Yamashita T, Cheon K, Cheng C, Zuo J.
|
| Hum Mol Genet 14(19):2945-58. Epub 2005 Aug 26. 2005
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| 37 | ARHGAP1, MAPK8
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| Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion and engraftment.
|
| Wang L, Yang L, Filippi MD, Williams DA, Zheng Y.
|
| Blood [Epub ahead of print] 2005
|
| 38 | MAPK8
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| Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase.
|
| Yoshimura K, Aoki H, Ikeda Y, Fujii K, Akiyama N, Furutani A, Hoshii Y, Tanaka N, Ricci R, Ishihara T, Esato K, Hamano K, Matsuzaki M.
|
| Nat Med 11(12):1330-8. Epub 2005 Nov 27. 2005
|
| 39 | MAP4K4, MAPK8, MMP9, SPP1
|
| JNK1 differentially regulates osteopontin-induced nuclear factor-inducing kinase/MEKK1-dependent activating protein-1-mediated promatrix metalloproteinase-9 activation.
|
| Rangaswami H, Bulbule A, Kundu GC.
|
| J Biol Chem 280(19):19381-92. Epub 2005 Mar 9. 2005
|
| 40 | JKAMP, MAPK8
|
| JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.
|
| Kadoya T, Khurana A, Tcherpakov M, Bromberg KD, Didier C, Broday L, Asahara T, Bhoumik A, Ronai Z.
|
| Mol Cell Biol 25(19):8619-30. 2005
|
| 41 | MAP3K7, MAPK8, XIAP
|
| X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1).
|
| Kaur S, Wang F, Venkatraman M, Arsura M.
|
| J Biol Chem 280(46):38599-608. Epub 2005 Sep 12. 2005
|
| 42 | DUSP1, MAPK8
|
| DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.
|
| Hamdi M, Kool J, Cornelissen-Steijger P, Carlotti F, Popeijus HE, van der Burgt C, Janssen JM, Yasui A, Hoeben RC, Terleth C, Mullenders LH, van Dam H.
|
| Oncogene 24(48):7135-44. 2005
|
| 43 | MAPK8
|
| The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.
|
| Choi BY, Choi HS, Ko K, Cho YY, Zhu F, Kang BS, Ermakova SP, Ma WY, Bode AM, Dong Z.
|
| Nat Struct Mol Biol. 12(8):699-707. 2005
|
| 44 | MAPK8, XBP1, IRS1
|
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
|
| Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS.
|
| Science 306(5695):457-61. 2004
|
| 45 | MAPK8, MAPK9
|
| The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
|
| Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ.
|
| Proc Natl Acad Sci U S A 101(39):14114-9. Epub 2004 Sep 16. 2004
|
| 46 | CYLD, IKBKB, IKBKG, MAPK8, MAP2K7
|
| Negative regulation of JNK signaling by the tumor suppressor CYLD.
|
| Reiley W, Zhang M, Sun SC.
|
| J Biol Chem 279(53):55161-7. Epub 2004 Oct 20. 2004
|
| 47 | MAPK8
|
| Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
|
| Kaneto, H.; Nakatani, Y.; Miyatsuka, T.; Kawamori, D.; Matsuoka, T.; Matsuhisa, M.; Kajimoto, Y.; Ichijo, H.; Yamasaki, Y.; Hori, M.
|
| Nat Med. 10: 1128-1132 2004
|
| 48 | MAPK8
|
| JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.
|
| Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A.
|
| Mol Cell. 13(3):329-40. 2004
|
| 49 | BID, CASP8, DIABLO, MAPK8, TNF
|
| A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
|
| Deng Y, Ren X, Yang L, Lin Y, Wu X.
|
| Cell 115(1):61-70. 2003
|
| 50 | MAPK8
|
| JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.
|
| Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M.
|
| Dev Cell. 4(4):521-33. 2003
|
| 51 | MAPK8
|
| A central role for JNK in obesity and insulin resistance.
|
| Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS.
|
| Nature 420(6913):333-6. 2002
|
| 52 | CREB1, MAPK8, SKI, JUN, SMAD2
|
| c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.
|
| Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A.
|
| J Biol Chem 277(32):29094-100. 2002
|
| 53 | MAPK8, SH3BP5
|
| A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.
|
| Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH.
|
| Biochem J 367(Pt 3):577-85. 2002
|
| 54 | MAP3K7, MAPK8
|
| IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
|
| Sanna MG, da Silva Correia J, Ducrey O, Lee J, Nomoto K, Schrantz N, Deveraux QL, Ulevitch RJ.
|
| Mol Cell Biol. 22(6):1754-66. 2002
|
| 55 | MAPK8
|
| Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.
|
| Pan ZZ, Bruening W, Giasson BI, Lee VM, Godwin AK.
|
| J Biol Chem. 277(38):35050-60 2002
|
| 56 | JUN, MAPK8
|
| Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus.
|
| Hurd C, Waldron RT, Rozengurt E.
|
| Oncogene. 21(14):2154-60 2002
|
| 57 | MAPK8
|
| Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts.
|
| Hess, P.; Pihan, G.; Sawyers, C. L.; Flavell, R. A.; Davis, R. J.
|
| Nature Genet. 32: 201-205 2002
|
| 58 | MAPK8
|
| The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.
|
| Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M, Meyer CF, Jurecic R, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher F, Tan TH, Belmont JW.
|
| J Biol Chem. 277(39):36592-601. 2002
|
| 59 | ELP1, MAPK8
|
| A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.
|
| Holmberg C, Katz S, Lerdrup M, Herdegen T, Jäättelä M, Aronheim A, Kallunki T.
|
| J Biol Chem. 277(35):31918-28. 2002
|
| 60 | MAPK8
|
| A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation.
|
| Girardin SE, Yaniv M.
|
| EMBO J. 20(13):3437-46. 2001
|
| 61 | GSTP1, MAPK8
|
| Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus.
|
| Wang T, Arifoglu P, Ronai Z, Tew KD.
|
| J Biol Chem. 276(24):20999-1003 2001
|
| 62 | MAPK1, MAPK3, MAPK8
|
| Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.
|
| Slack DN, Seternes OM, Gabrielsen M, Keyse SM.
|
| J Biol Chem. 276(19):16491-500. 2001
|
| 63 | MAP2K7, MAPK8, MAPK8IP1, MAPK8IP2
|
| cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.
|
| Negri S, Oberson A, Steinmann M, Sauser C, Nicod P, Waeber G, Schorderet DF, Bonny C.
|
| Genomics 64(3):324-30. 2000
|
| 64 | MAPK8
|
| JNK is required for effector T-cell function but not for T-cell activation.
|
| Dong C, Yang DD, Tournier C, Whitmarsh AJ, Xu J, Davis RJ, Flavell RA.
|
| Nature 405(6782):91-4. 2000
|
| 65 | MAPK8
|
| c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.
|
| Dai R, Frejtag W, He B, Zhang Y, Mivechi NF.
|
| J Biol Chem. 275(24):18210-8. 2000
|
| 66 | MAPK8
|
| The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
|
| Aguirre V, Uchida T, Yenush L, Davis R, White MF.
|
| J Biol Chem. 275(12):9047-54. 2000
|
| 67 | MAPK8
|
| Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.
|
| Cheng J, Yang J, Xia Y, Karin M, Su B.
|
| Mol Cell Biol. 20(7):2334-42. 2000
|
| 68 | COPS2, MAPK8
|
| COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK.
|
| Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W.
|
| J Biol Chem 274(50):35297-300. 1999
|
| 69 | MAPK8
|
| Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription.
|
| Engel ME, McDonnell MA, Law BK, Moses HL.
|
| J Biol Chem. 274(52):37413-20. 1999
|
| 70 | DUSP10, MAPK8
|
| Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
|
| Tanoue T, Moriguchi T, Nishida E.
|
| J Biol Chem. 274(28):19949-56. 1999
|
| 71 | MAPK8
|
| Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase.
|
| Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y.
|
| J Biol Chem. 274(46):32580-7. 1999
|
| 72 | MAPK8
|
| JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.
|
| Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI.
|
| Mol Cell Biol. 19(11):7539-48. 1999
|
| 73 | MAPK8, MAP2K6, TNF
|
| Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha.
|
| Roulston A, et al.
|
| J Biol Chem 273(17):10232-9. 1998
|
| 74 | MAPK8
|
| Defective T cell differentiation in the absence of Jnk1.
|
| Dong, C.; Yang, D. D.; Wysk, M.; Whitmarsh, A. J.; Davis, R. J.; Flavell, R. A.
|
| Science. 282: 2092-2095 1998
|
| 75 | MAP2K7, MAPK8
|
| Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.
|
| Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ.
|
| Proc Natl Acad Sci U S A 94(14):7337-42. 1997
|
| 76 | MAPK8
|
| JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases.
|
| Hu MC, Qiu WR, Wang YP.
|
| Oncogene. 15(19):2277-87. 1997
|
| 77 | MAPK8
|
| MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases.
|
| Xu S, Cobb MH.
|
| J Biol Chem. 272(51):32056-60. 1997
|
| 78 | MAPK8
|
| Selective interaction of JNK protein kinase isoforms with transcription factors.
|
| Gupta S, et al.
|
| EMBO J 15 : 2760-2770. 1996
|
| 79 | MAPK8
|
| Differential phosphorylations of Spi-B and Spi-1 transcription factors.
|
| Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F.
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