| 1 | MAPK7
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| ERK5 plays an essential role in gestational beta-cell proliferation.
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| Chen C, Wu S, Lin X, Wu D, Fischbach S, Xiao X.
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| Cell Prolif 51(3):e12410. doi: 10.1111/cpr.12410. Epub 2017 Nov 21.
2018
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| 2 | MAPK7, PPARGC1A
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| Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling.
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| Liu W, Ruiz-Velasco A, Wang S, Khan S, Zi M, Jungmann A, Dolores Camacho-Muñoz M, Guo J, Du G, Xie L, Oceandy D, Nicolaou A, Galli G, Müller OJ, Cartwright EJ, Ji Y, Wang X.
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| Nat Commun 8(1):494. doi: 10.1038/s41467-017-00664-8.
2017
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| 3 | MAP2K5, MAPK7, YAP1
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| YAP promotes myogenic differentiation via the MEK5-ERK5 pathway.
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| Chen TH, Chen CY, Wen HC, Chang CC, Wang HD, Chuu CP, Chang CH.
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| FASEB J 31(7):2963-2972. doi: 10.1096/fj.201601090R. Epub 2017 Mar 29.
2017
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| 4 | MAPK7, VHL
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| Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.
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| Serrano-Oviedo L, Giménez-Bachs JM, Nam-Cha SY, Cimas FJ, García-Cano J, Sánchez-Prieto R, Salinas-Sánchez AS.
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| Urol Oncol 35(3):114.e15-114.e22. doi: 10.1016/j.urolonc.2016.10.010. Epub 2016 Nov 8.
2017
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| 5 | MAP3K3, MAPK7, YAP1
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| YAP promotes myogenic differentiation via the MEK5-ERK5 pathway.
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| Chen TH, Chen CY, Wen HC, Chang CC, Wang HD, Chuu CP, Chang CH.
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| FASEB J. Jul;31(7):2963-2972. doi: 10.1096/fj.201601090R. Epub 2017 Mar 29. 2017
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| 6 | MAPK7
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| Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
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| Williams CA, Fernandez-Alonso R, Wang J, Toth R, Gray NS, Findlay GM.
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| Cell Rep 16(7):1820-8. doi: 10.1016/j.celrep.2016.07.033. Epub 2016 Aug 4.
2016
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| 7 | ANKRD1, MAPK7
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| ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.
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| Obara Y, Nagasawa R, Nemoto W, Pellegrino MJ, Takahashi M, Habecker BA, Stork PJS, Ichiyanagi O, Ito H, Tomita Y, Ishii K, Nakahata N.
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| Cell Signal 28(3):177-189. doi: 10.1016/j.cellsig.2015.12.016. Epub 2015 Dec 29.
2016
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| 8 | MAPK7
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| Role of MAPK7 in cell proliferation and metastasis in ovarian cancer.
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| Dai J, Wang T, Wang W, Zhang S, Liao Y, Chen J.
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| Int J Clin Exp Pathol 8(9):10444-51. eCollection 2015.
2015
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| 9 | MAPK7, TLR2
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| Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
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| Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J.
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| Sci Signal 8(391):ra86. doi: 10.1126/scisignal.aaa3206.
2015
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| 10 | MAPK7, TNFSF13B
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| BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
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| Jacque E, Schweighoffer E, Tybulewicz VL, Ley SC.
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| J Exp Med 212(6):883-92. doi: 10.1084/jem.20142127. Epub 2015 May 18.
2015
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| 11 | CSF1R, FOS, MAP2K5, MAPK7
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| ERK5 activation is essential for osteoclast differentiation.
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| Amano S, Chang YT, Fukui Y.
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| PLoS One 10(4):e0125054. doi: 10.1371/journal.pone.0125054. eCollection 2015.
2015
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| 12 | MAPK7
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| ERK5 is a critical mediator of inflammation-driven cancer.
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| Finegan KG, Perez-Madrigal D, Hitchin JR, Davies CC, Jordan AM, Tournier C.
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| Cancer Res 75(4):742-53. doi: 10.1158/0008-5472.CAN-13-3043. Epub 2015 Feb 3.
2015
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| 13 | MAPK7
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| ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis.
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| Heo KS, Cushman HJ, Akaike M, Woo CH, Wang X, Qiu X, Fujiwara K, Abe J.
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| Circulation 130(2):180-91. doi: 10.1161/CIRCULATIONAHA.113.005991. Epub 2014 Apr 28.
2014
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| 14 | MAPK7, NFATC4
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| Role of extracellular signal-regulated kinase 5 in adipocyte signaling.
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| Zhu H, Guariglia S, Li W, Brancho D, Wang ZV, Scherer PE, Chow CW.
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| J Biol Chem 289(9):6311-22. doi: 10.1074/jbc.M113.506584. Epub 2014 Jan 14.
2014
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| 15 | MAP2K5, MAPK7, RUNX2
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| The MEK5/ERK5 pathway mediates fluid shear stress promoted osteoblast differentiation.
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| Zhao LG, Chen SL, Teng YJ, An LP, Wang J, Ma JL, Xia YY.
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| Connect Tissue Res 55(2):96-102. doi: 10.3109/03008207.2013.853755. Epub 2014 Jan 10.
2014
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| 16 | MAPK7
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| Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb.
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| Wang W, Pan YW, Wietecha T, Zou J, Abel GM, Kuo CT, Xia Z.
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| J Biol Chem 288(4):2623-31. doi: 10.1074/jbc.M112.401091. Epub 2012 Dec 5.
2013
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| 17 | MAPK7
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| Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb.
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| Li T, Pan YW, Wang W, Abel G, Zou J, Xu L, Storm DR, Xia Z.
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| PLoS One 8(4):e61948. doi: 10.1371/journal.pone.0061948. Print 2013.
2013
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| 18 | CCL19, CCR7, MAPK7, S1PR1
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| CCR7/CCL19 controls expression of EDG-1 in T cells.
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| Shannon LA, McBurney TM, Wells MA, Roth ME, Calloway PA, Bill CA, Islam S, Vines CM.
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| J Biol Chem 287(15):11656-64. doi: 10.1074/jbc.M111.310045. Epub 2012 Feb 13.
2012
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| 19 | MAP2K4, MAPK7
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| MAPK7 and MAP2K4 as prognostic markers in osteosarcoma.
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| Tesser-Gamba F, Petrilli AS, de Seixas Alves MT, Filho RJ, Juliano Y, Toledo SR.
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| Hum Pathol 43(7):994-1002. doi: 10.1016/j.humpath.2011.08.003. Epub 2011 Dec 9.
2012
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| 20 | MAPK7
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| Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis.
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| Pan YW, Zou J, Wang W, Sakagami H, Garelick MG, Abel G, Kuo CT, Storm DR, Xia Z.
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| J Biol Chem 287(28):23306-17. doi: 10.1074/jbc.M112.344762. Epub 2012 May 29.
2012
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| 21 | MAPK7
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| Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.
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| Zou J, Pan YW, Wang Z, Chang SY, Wang W, Wang X, Tournier C, Storm DR, Xia Z.
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| J Neurosci 32(12):4118-32. doi: 10.1523/JNEUROSCI.6260-11.2012.
2012
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| 22 | MAPK7
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| ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9.
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| Kim SM, Lee H, Park YS, Lee Y, Seo SW.
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| J Orthop Res 30(7):1040-4. doi: 10.1002/jor.22025. Epub 2011 Dec 29.
2012
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| 23 | MAP2K1, MAPK7, TLR2
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| ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
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| Wilhelmsen K, Mesa KR, Lucero J, Xu F, Hellman J.
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| J Biol Chem 287(32):26478-94. doi: 10.1074/jbc.M112.359489. Epub 2012 Jun 15. 2012
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| 24 | BCAR1, MAPK7, PTK6
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| Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.
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| Zheng Y, Asara JM, Tyner AL.
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| J Biol Chem 287(1):148-58. doi: 10.1074/jbc.M111.298117. Epub 2011 Nov 14.
2012
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| 25 | MAPK7, NFE2L2
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| Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation.
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| Kim M, Kim S, Lim JH, Lee C, Choi HC, Woo CH.
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| J Biol Chem 287(48):40722-31. doi: 10.1074/jbc.M112.381509. Epub 2012 Oct 5.
2012
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| 26 | MAPK4, MAPK7, MAPKAPK5
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| Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
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| Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S.
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| J Biol Chem 286(8):6470-8. doi: 10.1074/jbc.M110.181529. Epub 2010 Dec 22.
2011
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| 27 | MAPK7
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| ERK5 regulates muscle cell fusion through Klf transcription factors.
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| Sunadome K, Yamamoto T, Ebisuya M, Kondoh K, Sehara-Fujisawa A, Nishida E.
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| Dev Cell 20(2):192-205. doi: 10.1016/j.devcel.2010.12.005.
2011
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| 28 | MAP2K5, MAPK7
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| MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.
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| Clark PR, Jensen TJ, Kluger MS, Morelock M, Hanidu A, Qi Z, Tatake RJ, Pober JS.
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| Microcirculation 18(2):102-17. doi: 10.1111/j.1549-8719.2010.00071.x.
2011
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| 29 | MAPK7
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| ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis.
|
| Iñesta-Vaquera FA, Campbell DG, Arthur JS, Cuenda A.
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| Biochem Biophys Res Commun 399(1):84-90. Epub 2010 Jul 17.PMID: 20643107 2010
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| 30 | MAPK4, MAPK7
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| Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.
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| Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S.
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| Mol Cell Biol 30(24):5752-63. doi: 10.1128/MCB.01147-10. Epub 2010 Oct 18.
2010
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| 31 | MAPK7
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| ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells.
|
| Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ.
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| J Cell Sci 123(Pt 18):3189-200. doi: 10.1242/jcs.072801. Epub 2010 Aug 24. Erratum in: J Cell Sci. 2010 Oct 1;123(Pt 19):3413.
2010
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| 32 | MAPK7, NOS3, PRKCZ
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| PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
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| Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC.
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| Blood 116(11):1971-9. doi: 10.1182/blood-2010-02-269134. Epub 2010 Jun 10.
2010
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| 33 | MAPK7
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| ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry.
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| Zen K, Yasui K, Nakajima T, Zen Y, Zen K, Gen Y, Mitsuyoshi H, Minami M, Mitsufuji S, Tanaka S, Itoh Y, Nakanuma Y, Taniwaki M, Arii S, Okanoue T, Yoshikawa T.
|
| Genes Chromosomes Cancer 48(2):109-20.
2009
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| 34 | MAPK7, PTK2
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| A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.
|
| Sawhney RS, Liu W, Brattain MG.
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| J Cell Physiol 219(1):152-61.
2009
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| 35 | MAP2K5, MAPK7
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| MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.
|
| Spiering D, Schmolke M, Ohnesorge N, Schmidt M, Goebeler M, Wegener J, Wixler V, Ludwig S.
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| J Biol Chem 284(37):24972-80. Epub 2009 Jul 15.PMID: 19605361 2009
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| 36 | MAPK4, MAPK7
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| Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.
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| Aberg E, Torgersen KM, Johansen B, Keyse SM, Perander M, Seternes OM.
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| J Biol Chem 284(29):19392-401. doi: 10.1074/jbc.M109.023283. Epub 2009 May 27.
2009
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| 37 | MAP2K5, MAPK7
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| Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer.
|
| McCracken SR, Ramsay A, Heer R, Mathers ME, Jenkins BL, Edwards J, Robson CN, Marquez R, Cohen P, Leung HY.
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| Oncogene 27(21):2978-88. Epub 2007 Dec 10.PMID: 18071319 2008
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| 38 | AGT, INS, MAPK7, MODY10
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| Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.
|
| Sharma G, Goalstone ML.
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| Biochem Biophys Res Commun 354(4):1078-83. Epub 2007 Jan 26. 2007
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| 39 | MAPK7
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| Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate.
|
| Liu L, Cundiff P, Abel G, Wang Y, Faigle R, Sakagami H, Xu M, Xia Z.
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| Proc Natl Acad Sci U S A 103(25):9697-702. Epub 2006 Jun 9. 2006
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| 40 | MAPK7, UBR1
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| Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role.
|
| Sasaki T, Kojima H, Kishimoto R, Ikeda A, Kunimoto H, Nakajima K.
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| Mol Cell 24(1):63-75.
2006
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| 41 | MAPK7
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| Multifunctional role of Erk5 in multiple myeloma.
|
| Carvajal-Vergara X, Tabera S, Montero JC, Esparis-Ogando A, Lopez-Perez R, Mateo G, Gutierrez N, Parmo-Cabanas M, Teixido J, San Miguel JF, Pandiella A.
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| Blood 105(11):4492-9. Epub 2005 Feb 3. 2005
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| 42 | MAPK7, HIF1A
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| BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha.
|
| Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC.
|
| Circ Res 96(11):1145-51. Epub 2005 May 5. 2005
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| 43 | YWHAB, MAPK7
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| 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.
|
| Zheng Q, Yin G, Yan C, Cavet M, Berk BC.
|
| J Biol Chem 279(10):8787-91. Epub 2003 Dec 16. 2004
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| 44 | MAP2K5, MAPK7
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| MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.
|
| Raviv Z, Kalie E, Seger R.
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| J Cell Sci 117(Pt 9):1773-84. Epub 2004 Mar 16.PMID: 15075238 2004
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| 45 | MAPK7
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| Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids.
|
| Purandare SM, et al.
|
| Cytogenet Cell Genet 83(3-4):258-9. No abstract available 1998
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| 46 | MEF2C, MAPK7
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| BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.
|
| Kato Y, et al.
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| EMBO J 16(23):7054-66. 1997
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| 47 | MAPK7
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| Primary structure of BMK1 : a new mammalian map kinase.
|
| Lee JD, et al.
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| Biochem Biophys Res Commun 213 : 715-724. 1995
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| 48 | MAP2K5, MAPK7
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| Components of a new human protein kinase signal transduction pathway.
|
| Zhou G, Bao ZQ, Dixon JE.
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| J Biol Chem 270(21):12665-9. 1995
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| 49 | MAPK1, MAPK4, MAPK6, MAPK7
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| ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
|
| Boulton TG, et al.
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| Cell 65(4):663-75. 1991
|