| 1 | MAPK1
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| Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum
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| Motta M, Pannone L, Pantaleoni F, Bocchinfuso G, Radio FC, Cecchetti S, Ciolfi A, Di Rocco M, Elting MW, Brilstra EH, Boni S, Mazzanti L, Tamburrino F, Walsh L, Payne K, Fernández-Jaén A, Ganapathi M, Chung WK, Grange DK, Dave-Wala A, Reshmi SC, Bartholomew DW, Mouhlas D, Carpentieri G, Bruselles A, Pizzi S, Bellacchio E, Piceci-Sparascio F, Lißewski C, Brinkmann J, Waclaw RR, Waisfisz Q, van Gassen K, Wentzensen IM, Morrow MM, Álvarez S, Martínez-García M, De Luca A, Memo L, Zampino G, Rossi C, Seri M, Gelb BD, Zenker M, Dallapiccola B, Stella L, Prada CE, Martinelli S, Flex E, Tartaglia M.
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| Am J Hum Genet. Sep 3;107(3):499-513. doi: 10.1016/j.ajhg.2020.06.018. Epub 2020 Jul 27. 2020
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| 2 | DEL22Q11.2, MAPK1
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| Immunodeficiency in a Patient with 22q11.2 Distal Deletion Syndrome and a p.Ala7dup Variant in the MAPK1 Gene.
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| Sánchez AI, García-Acero MA, Paredes A, Quero R, Ortega RI, Rojas JA, Herrera D, Parra M, Prieto K, Ángel J, Rodríguez LS, Prieto JC, Franco M.
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| Mol Syndromol. Feb;11(1):15-23. doi: 10.1159/000506032. Epub 2020 Feb 5. 2020
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| 3 | MAPK1, MAPK3
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| Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis.
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| Ricard N, Zhang J, Zhuang ZW, Simons M.
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| Cells Dec 21;9(1):38. doi: 10.3390/cells9010038 2019
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| 4 | MAPK1, PCBP1
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| The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
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| Zhang Y, Meng L, Xiao L, Liu R, Li Z, Wang YL.
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| Cell Physiol Biochem. 48(4):1747-1754. doi: 10.1159/000492315. Epub 2018 Aug 3 2018
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| 5 | AKT1, BCL3, MAPK1
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| Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
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| Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G.
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| Mol Cell. Aug 3;67(3):484-497.e5. doi: 10.1016/j.molcel.2017.06.011. Epub 2017 Jul 6. 2017
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| 6 | MAPK1
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| A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors.
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| Zou Y, Deng W, Wang F, Yu XH, Liu FY, Yang BC, Huang MZ, Guo JB, Xie QH, He M, Huang OP.
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| Oncol Rep. Feb;35(2):725-30. doi: 10.3892/or.2015.4402. Epub 2015 Nov 5. 2016
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| 7 | MAPK1, MAPK14, RAB9A, RAB9B
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| Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways.
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| Hirota Y, Yamashita S, Kurihara Y, Jin X, Aihara M, Saigusa T, Kang D, Kanki T.
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| Autophagy 11(2):332-43. doi: 10.1080/15548627.2015.1023047.
2015
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| 8 | MAPK1, TPR
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| Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function.
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| Rajanala K, Sarkar A, Jhingan GD, Priyadarshini R, Jalan M, Sengupta S, Nandicoori VK.
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| J Cell Sci 127(Pt 16):3505-20. doi: 10.1242/jcs.149112. Epub 2014 Jun 17.
2014
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| 9 | MAPK1, MYO1C, PRKCDBP
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| Cavin-3 dictates the balance between ERK and Akt signaling.
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| Hernandez VJ, Weng J, Ly P, Pompey S, Dong H, Mishra L, Schwarz M, Anderson RG, Michaely P.
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| Elife 2:e00905. doi: 10.7554/eLife.00905.
2013
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| 10 | KIF3A, MAPK1, PARD3
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| ERK2-mediated phosphorylation of Par3 regulates neuronal polarization.
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| Funahashi Y, Namba T, Fujisue S, Itoh N, Nakamuta S, Kato K, Shimada A, Xu C, Shan W, Nishioka T, Kaibuchi K.
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| J Neurosci 33(33):13270-85. doi: 10.1523/JNEUROSCI.4210-12.2013.
2013
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| 11 | MAPK1
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| MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development.
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| Upadhya D, Ogata M, Reneker LW.
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| Development Apr;140(7):1573-82. doi: 10.1242/dev.08104 2013
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| 12 | CRKL, DEL22Q11D, MAPK1
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| Congenital heart defects in a novel recurrent 22q11.2 deletion harboring the genes CRKL and MAPK1.
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| Breckpot J, Thienpont B, Bauters M, Tranchevent LC, Gewillig M, Allegaert K, Vermeesch JR, Moreau Y, Devriendt K.
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| Am J Med Genet A 158A(3):574-80. doi: 10.1002/ajmg.a.35217. Epub 2012 Feb 8.
2012
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| 13 | DEL22Q11D, MAPK1
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| Heart defects and other features of the 22q11 distal deletion syndrome.
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| Fagerberg CR, Graakjaer J, Heinl UD, Ousager LB, Dreyer I, Kirchhoff M, Rasmussen AA, Lautrup CK, Birkebaek N, Sorensen K.
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| Eur J Med Genet ur J Med Genet. 2012 Oct 10. pii: S1769-7212(12)00276-5. doi: 10.1016/j.ejmg.2012.09.009. [Epub ahead of print] 2012
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| 14 | HSPA8, MAPK1
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| Stress-induced interaction between p38 MAPK and HSP70.
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| Gong X, Luo T, Deng P, Liu Z, Xiu J, Shi H, Jiang Y.
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| Biochem Biophys Res Commun 425(2):357-62. doi: 10.1016/j.bbrc.2012.07.096. Epub 2012 Jul 25.
2012
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| 15 | MAPK1, MAPK3, MAPK8
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| Differential roles of ERK1/2 and JNK in retinal development and degeneration.
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| Donovan M, Doonan F, Cotter TG.
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| J Neurochem. 116(1):33-42. 2011
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| 16 | MAPK1, MAPK3
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| Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice.
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| Satoh Y, Kobayashi Y, Takeuchi A, Pagès G, Pouysségur J, Kazama T.
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| J Neurosci. 31(3):1149-55. 2011
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| 17 | MAPK1, WASF2
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| ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
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| Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J.
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| Mol Cell 41(6):661-71.
2011
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| 18 | HIF1A, MAPK1
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| Biochemical and molecular analysis of the interaction between ERK2 MAP kinase and hypoxia inducible factor-1α.
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| Karapetsas A, Giannakakis A, Pavlaki M, Panayiotidis M, Sandaltzopoulos R, Galanis A.
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| Int J Biochem Cell Biol 43(11):1582-90. doi: 10.1016/j.biocel.2011.07.007. Epub 2011 Jul 22.
2011
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| 19 | MAPK1, MAPK3, P2RX7, PRX7
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| Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function.
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| Lenertz LY, Wang Z, Guadarrama A, Hill LM, Gavala ML, Bertics PJ.
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| Biochemistry 49(22):4611-9. 2010
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| 20 | MAPK1, MAPK3
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| ERK1 nucleocytoplasmic shuttling rate depends on specific N-terminal aminoacids.
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| Marchi M, Pancrazi L, Maffei M, Ratto GM, Costa M.
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| Biochem Biophys Res Commun 398(2):166-72. Epub 2010 Jun 15.
2010
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| 21 | MAPK1, MAPK3
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| A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.
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| Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ.
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| Nat Med 15(1):75-83. Epub 2008 Dec 7. 2009
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| 22 | MAP2K1, MAP2K4, MAP3K5, MAPK1, MAPK10, RAF1
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| How does arrestin assemble MAPKs into a signaling complex?
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| Song X, Coffa S, Fu H, Gurevich VV.
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| J Biol Chem 284(1):685-95. Epub 2008 Nov 10. 2009
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| 23 | MAPK1, MAPK3
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| Quality Measures for Supportive Cancer Care: The Cancer Quality-ASSIST Project.
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| Lorenz KA, Dy SM, Naeim A, Walling AM, Sanati H, Smith P, Shanman R, Roth CP, Asch SM.
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| J Pain Symptom Manage Pain Symptom Manage. 2009 Apr 7. [Epub ahead of print]
2009
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| 24 | EGFR, IQGAP1, KSR1, MAPK1, MAPK3, PLA2G4A
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| Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.
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| Casar B, Arozarena I, Sanz-Moreno V, Pinto A, Agudo-Ibáñez L, Marais R, Lewis RE, Berciano MT, Crespo P.
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| Mol Cell Biol 29(5):1338-53. Epub 2008 Dec 29.
2009
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| 25 | CEBPB, MAPK1, MAPK3
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| MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.
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| Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS.
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| Science 324(5929):938-41.
2009
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| 26 | MAPK1, MAPK3
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| Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis.
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| Matsushita T, Chan YY, Kawanami A, Balmes G, Landreth GE, Murakami S.
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| Mol Cell Biol 29(21):5843-57. Epub 2009 Sep 8.
2009
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| 27 | MAPK1, MAPK3, NS1
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| Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations.
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| Nakamura T, Gulick J, Pratt R, Robbins J.
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| Proc Natl Acad Sci U S A 106(36):15436-41. Epub 2009 Aug 24.PMID: 19706403 2009
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| 28 | AKT1, MAPK1, MAPK3, TGFB1, VEGFA, VEGFB, VEGFC
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| Transforming growth factor-beta1 enhanced vascular endothelial growth factor synthesis in mesenchymal stem cells.
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| Wang XJ, Dong Z, Zhong XH, Shi RZ, Huang SH, Lou Y, Li QP.
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| Biochem Biophys Res Commun 365(3):548-54. Epub 2007 Nov 20. Erratum in: Biochem Biophys Res Commun. 2008 Aug 8;372(4):950.
2008
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| 29 | BRAF, CFC2, CFC3, COSTS, HRAS, KRAS, LEOPS, MAP2K1, MAPK1, MTOR, NF1, NFNS, NS1, NS3, NS4, NS5, PTPN11, RAF1, SOS1
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| Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.
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| Krab LC, Goorden SM, Elgersma Y.
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| Trends Genet 24(10):498-510. Epub 2008 Sep 4. 2008
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| 30 | MAPK1, MAPK3, MICALCL
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| ERK2-binding domain is required for phosphorylation of EBITEIN1, a potential downstream interactor of ERK2.
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| Miura K.
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| Biochem Biophys Res Commun 375(3):367-71. Epub 2008 Aug 26. 2008
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| 31 | DEL22Q11, DEL22Q11D, MAPK1
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| Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.
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| Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE.
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| Proc Natl Acad Sci U S A 105(44):17115-20. Epub 2008 Oct 24.
2008
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| 32 | DUSP6, ETS2, MAPK1
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| Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells.
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| Furukawa T, Tanji E, Xu S, Horii A.
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| Biochem Biophys Res Commun 377(1):317-20. Epub 2008 Oct 9. 2008
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| 33 | MAPK1, MAPK3, NS1, PTPN11
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| Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.
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| Krenz M, Gulick J, Osinska HE, Colbert MC, Molkentin JD, Robbins J.
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| Proc Natl Acad Sci U S A 105(48):18930-5. Epub 2008 Nov 18.
2008
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| 34 | DUSP1, DUSP2, DUSP4, MAPK1
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| Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.
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| Caunt CJ, Rivers CA, Conway-Campbell BL, Norman MR, McArdle CA.
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| J Biol Chem 283(10):6241-52. Epub 2008 Jan 3.PMID: 18178562 2008
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| 35 | MAPK1
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| ERK2 protein regulates the proliferation of human mesenchymal stem cells without affecting their mobilization and differentiation potential.
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| Cárcamo-Orive I, Tejados N, Delgado J, Gaztelumendi A, Otaegui D, Lang V, Trigueros C.
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| Exp Cell Res 314(8):1777-88. Epub 2008 Feb 6.PMID: 18378228 2008
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| 36 | MAPK1, MAPK3
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| Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.
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| Voong LN, Slater AR, Kratovac S, Cressman DE.
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| J Biol Chem. 283(14):9031-9. 2008
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| 37 | BCL2L11, MAPK1, MAPK3
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| ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.
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| Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ.
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| EMBO J 26(12):2856-67. Epub 2007 May 24. 2007
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| 38 | MAPK1
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| Evidence for the regulation of contraction-induced fatty acid oxidation via extracellular signal-regulated kinase 1/2 activation independent of changes in fatty acid uptake.
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| Raney MA, Turcotte LP.
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| Metabolism 56(9):1192-200. 2007
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| 39 | MAPK1
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| Mutations in ERK2 binding sites affect nuclear entry.
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| Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH.
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| J Biol Chem 282(39):28759-67. Epub 2007 Jul 26. 2007
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| 40 | MAPK1
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| Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.
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| Yao Z, Duan S, Hou D, Heese K, Wu M.
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| EMBO J. 26(4):1068-80. 2007
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| 41 | GSTP1, MAPK1
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| Human glutathione S-transferase P1 suppresses MEKK1-mediated apoptosis by regulating MEKK1 kinase activity in HEK293 cells.
|
| Zhao X, Fan Y, Shen J, Wu Y, Yin Z.
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| Mol Cells 21(3):395-400. 2006
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| 42 | DAZ, DAZAP1, PABPC1, MAPK1
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| Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.
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| Morton S, Yang HT, Moleleki N, Campbell DG, Cohen P, Rousseau S.
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| Biochem J 399(2):265-73. 2006
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| 43 | MAPK1, MAPK3
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| p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation.
|
| Eymin B, Claverie P, Salon C, Brambilla C, Brambilla E, Gazzeri S.
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| Cell Cycle. 5(7):759-65. 2006
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| 44 | MAPK1
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| Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3.
|
| Vicent GP, Ballaré C, Nacht AS, Clausell J, Subtil-Rodríguez A, Quiles I, Jordan A, Beato M.
|
| Mol Cell 24(3):367-81. 2006
|
| 45 | EPHB2, MAPK1, TSC1, TSC2
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| Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
|
| Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP.
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| Cell 121(2):179-93. 2005
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| 46 | MAPK1, MAPK3, TNTP1, TNTP2, FGFR3
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| Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells.
|
| Nowroozi N, Raffioni S, Wang T, Apostol BL, Bradshaw RA, Thompson LM.
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| Hum Mol Genet 14(11):1529-38. Epub 2005 Apr 20. 2005
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| 47 | DUSP2, MAPK1
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| New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
|
| Zhang Q, Muller M, Chen CH, Zeng L, Farooq A, Zhou MM.
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| J Mol Biol 354(4):777-88. Epub 2005 Oct 21.PMID: 16288922 2005
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| 48 | MAPK1
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| Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.
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| Mandl M, Slack DN, Keyse SM.
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| Mol Cell Biol. 25(5):1830-45. 2005
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| 49 | MAPK1
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| Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.
|
| Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM.
|
| J Biol Chem. 280(3):2055-64. 2005
|
| 50 | MAPK1, MAPK3
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| Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.
|
| Medina MG, Ledesma MD, Domínguez JE, Medina M, Zafra D, Alameda F, Dotti CG, Navarro P.
|
| EMBO J. 24(9):1706-16. 2005
|
| 51 | FHL2, MAPK1
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| Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.
|
| Purcell NH, Darwis D, Bueno OF, Muller JM, Schule R, Molkentin JD.
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| Mol Cell Biol 24(3):1081-95. 2004
|
| 52 | DUSP6, MAPK1
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| Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal.
|
| Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM.
|
| J Biol Chem 279(40):41882-91. Epub 2004 Jul 21. 2004
|
| 53 | MAPK1
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| Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.
|
| Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF, Chen RH.
|
| EMBO J. 24(2):294-304. 2004
|
| 54 | MAPK1
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| SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.
|
| Huang L, Gotoh N, Zhang S, Shibuya M, Yamamoto T, Tsuchida N.
|
| Biochem Biophys Res Commun. 324(3):1011-7. 2004
|
| 55 | MAPK1
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| Nek2A specifies the centrosomal localization of Erk2.
|
| Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB.
|
| Biochem Biophys Res Commun. 321(2):495-501. 2004
|
| 56 | MAPK1, MAPK3
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| Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases.
|
| Datta B, Majumdar A, Datta R, Balusu R.
|
| Biochemistry. 43(46):14821-31. 2004
|
| 57 | MAPK1
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| MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3.
|
| Xie S, Wang Q, Ruan Q, Liu T, Jhanwar-Uniyal M, Guan K, Dai W.
|
| Oncogene. 23(21):3822-9. 2004
|
| 58 | MAPK1
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| Activation of the mitogen-activated protein kinases Erk1/2 by erythropoietin receptor via a G(i )protein beta gamma-subunit-initiated pathway.
|
| Guillard C, Chrétien S, Pelus AS, Porteu F, Muller O, Mayeux P, Duprez V.
|
| J Biol Chem. 278(13):11050-6. 2003
|
| 59 | MAPK1
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| Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.
|
| Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR.
|
| Nat Cell Biol. 5(7):647-54. 2003
|
| 60 | MAPK1, MAPK3
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| Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction.
|
| Hua H, Munk S, Whiteside CI.
|
| Am J Physiol Renal Physiol. 284(2):F303-12. 2003
|
| 61 | MAPK1
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| Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways.
|
| Habib AA, Chun SJ, Neel BG, Vartanian T.
|
| Mol Cancer Res. 1(3):219-33. 2003
|
| 62 | MAPK1
|
| Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.
|
| Masuda K, Shima H, Katagiri C, Kikuchi K.
|
| J Biol Chem. 278(34):32448-56. 2003
|
| 63 | MAPK1
|
| The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
|
| Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM.
|
| J Biol Chem. 278(8):6258-67. 2003
|
| 64 | MAPK1, MAPK3
|
| p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels.
|
| Sanz-Moreno V, Casar B, Crespo P.
|
| Mol Cell Biol. 23(9):3079-90. 2003
|
| 65 | MAPK1
|
| Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.
|
| Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ.
|
| J Biol Chem. 278(17):14926-35. 2003
|
| 66 | MAPK1
|
| Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.
|
| Ishibe S, Joly D, Zhu X, Cantley LG.
|
| Mol Cell 12(5):1275-85. 2003
|
| 67 | MAPK1, MAPK3
|
| Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.
|
| Toledano-Katchalski H, Kraut J, Sines T, Granot-Attas S, Shohat G, Gil-Henn H, Yung Y, Elson A.
|
| Mol Cancer Res. 1(7):541-50. 2003
|
| 68 | MAPK1
|
| Leukotactin-1-induced ERK activation is mediated via Gi/Go protein/PLC/PKC delta/Ras cascades in HOS cells.
|
| Kim IS, Ryang YS, Kim YS, Jang SW, Sung HJ, Lee YH, Kim J, Na DS, Ko J.
|
| Life Sci. 73(4):447-59. 2003
|
| 69 | MAPK1, MAPK3
|
| Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.
|
| Roux PP, Richards SA, Blenis J.
|
| Mol Cell Biol. 23(14):4796-804. 2003
|
| 70 | DCC, MAPK1, MAPK3, NTN1
|
| Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation.
|
| Forcet C, Stein E, Pays L, Corset V, Llambi F, Tessier-Lavigne M, Mehlen P.
|
| Nature 417(6887):443-7. 2002
|
| 71 | MAPK1, MAP2K1, MAP2K2
|
| Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1.
|
| Robinson FL, Whitehurst AW, Raman M, Cobb MH.
|
| J Biol Chem 277(17):14844-52. Epub 2002 Jan 31. 2002
|
| 72 | MAPK1, TNIP1
|
| A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling.
|
| Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N.
|
| Biochem Biophys Res Commun 297(1):17-23. 2002
|
| 73 | IER3, MAPK1
|
| IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.
|
| Garcia J, Ye Y, Arranz V, Letourneux C, Pezeron G, Porteu F.
|
| EMBO J 21(19):5151-63. 2002
|
| 74 | MAPK1, NR2F1
|
| Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.
|
| Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F.
|
| EMBO J. 21(13):3443-53. 2002
|
| 75 | MAPK1, MAPK3
|
| Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation.
|
| Majumdar M, Meenakshi J, Goswami SK, Datta K.
|
| Biochem Biophys Res Commun. 291(4):829-37. 2002
|
| 76 | MAPK1
|
| Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.
|
| Slagsvold HH, Østvold AC, Fallgren AB, Paulsen RE.
|
| Biochem Biophys Res Commun. 291(5):1146-50. 2002
|
| 77 | MAPK1
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