| 1 | MAP4K1, PDIA6
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| PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway.
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| Bai Y, Liu X, Qi X, Liu X, Peng F, Li H, Fu H, Pei S, Chen L, Chi X, Zhang L, Zhu X, Song Y, Wang Y, Meng S, Jiang T, Shao S.
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| EBioMedicine 42:311-325. doi: 10.1016/j.ebiom.2019.03.045. Epub 2019 Mar 25.
2019
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| 2 | FBXW8, MAP4K1
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| The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
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| Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan TH, Wang H.
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| J Biol Chem 289(7):4009-17. doi: 10.1074/jbc.M113.520106. Epub 2013 Dec 20.
2014
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| 3 | CARD11, MAP4K1
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| Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
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| Brenner D, Brechmann M, Röhling S, Tapernoux M, Mock T, Winter D, Lehmann WD, Kiefer F, Thome M, Krammer PH, Arnold R.
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| Proc Natl Acad Sci U S A 106(34):14508-13. Epub 2009 Aug 11.PMID: 19706536 2009
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| 4 | MAP4K1
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| Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer.
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| Wang H, Song X, Logsdon C, Zhou G, Evans DB, Abbruzzese JL, Hamilton SR, Tan TH, Wang H.
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| Cancer Res 69(3):1063-70. Epub 2009 Jan 13.PMID: 19141650 2009
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| 5 | MAP4K1
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| Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes.
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| Brenner D, Golks A, Becker M, Müller W, Frey CR, Novak R, Melamed D, Kiefer F, Krammer PH, Arnold R.
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| Blood 110(12):3968-77. Epub 2007 Aug 21.PMID: 17712048 2007
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| 6 | MAP4K1
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| Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation.
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| Arnold R, Frey CR, Müller W, Brenner D, Krammer PH, Kiefer F.
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| Cell Death Differ 14(3):568-75. Epub 2006 Oct 6.PMID: 17024227 2007
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| 7 | MAP4K1
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| Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.
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| Brenner D, Golks A, Kiefer F, Krammer PH, Arnold R.
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| EMBO J 24(24):4279-90. Epub 2005 Dec 8.PMID: 16341093 2005
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| 8 | MAP4K1
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| Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.
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| Hu MC, et al.
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| Genes Dev 10(18):2251-64 1996
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