| 1 | IKBKB, MAP3K8
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| IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.
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| Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, Morrice N, Abbott D, Ley SC.
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| Mol Cell Biol 32(22):4684-90. doi: 10.1128/MCB.01065-12. Epub 2012 Sep 17.
2012
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| 2 | BCL11B, MAP3K8
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| BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes.
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| Cismasiu VB, Duque J, Paskaleva E, Califano D, Ghanta S, Young HA, Avram D.
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| Biochem J 417(2):457-66.
2009
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| 3 | IRAK1, MAP3K8, TNIP2
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| IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
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| Handoyo H, Stafford MJ, McManus E, Baltzis D, Peggie M, Cohen P.
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| Biochem J 424(1):109-18.
2009
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| 4 | MAP3K8
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| Effect of fluid flow-induced shear stress on human mesenchymal stem cells: differential gene expression of IL1B and MAP3K8 in MAPK signaling.
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| Glossop JR, Cartmell SH.
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| Gene Expr Patterns 9(5):381-8. Epub 2009 Jan 20.
2009
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| 5 | MAP3K14, MAP3K8
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| NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
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| Wittwer T, Schmitz ML.
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| Biochem Biophys Res Commun 371(2):294-7. Epub 2008 Apr 23.
2008
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| 6 | MAP3K8
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| Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
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| Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ.
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| J Exp Med 205(12):2803-12. Epub 2008 Nov 10.
2008
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| 7 | MAP3K8
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| Serine/threonine kinase, Cot/Tpl2, regulates renal cell apoptosis in ischaemia/reperfusion injury.
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| Yaomura T, Tsuboi N, Urahama Y, Hobo A, Sugimoto K, Miyoshi J, Matsuguchi T, Reiji K, Matsuo S, Yuzawa Y.
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| Nephrology (Carlton) 13(5):397-404. Epub 2008 May 29.
2008
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| 8 | MAP3K8
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| COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration.
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| Rodríguez C, López P, Pozo M, Duce AM, López-Pelaéz M, Fernández M, Alemany S.
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| Cell Signal 20(9):1625-31. Epub 2008 May 23.
2008
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| 9 | MAP3K8
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| Tpl-2/Cot and COX-2 in breast cancer.
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| Krcova Z, Ehrmann J, Krejci V, Eliopoulos A, Kolar Z.
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| Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 152(1):21-5. Review.
2008
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| 10 | MAP3K8
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| Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.
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| Choi HS, Kang BS, Shim JH, Cho YY, Choi BY, Bode AM, Dong Z.
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| FASEB J 22(1):113-26. Epub 2007 Aug 27.
2008
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| 11 | MAP3K8, MAP3K9
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| Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2.
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| Takatori A, Geh E, Chen L, Zhang L, Meller J, Xia Y.
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| Development 135(1):23-32. Epub 2007 Nov 21.
2008
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| 12 | MAP3K8
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| TRAF6 and Src kinase activity regulates Cot activation by IL-1.
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| Rodriguez C, Pozo M, Nieto E, Fernandez M, Alemany S.
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| Cell Signal 18(9):1376-85. Epub 2005 Dec 20. 2006
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| 13 | MAP3K8, IL1A
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| Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
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| Stafford MJ, Morrice NA, Peggie MW, Cohen P.
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| FEBS Lett 580(16):4010-4. Epub 2006 Jun 15. 2006
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| 14 | TNIP2, MAP3K8
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| ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
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| Papoutsopoulou S, Symons A, Tharmalingham T, Belich MP, Kaiser F, Kioussis D, O'Garra A, Tybulewicz V, Ley SC.
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| Nat Immunol 7(6):606-15. Epub 2006 Apr 23. 2006
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| 15 | TNIP2, MAP3K8, NFKB1
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| ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
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| Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC.
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| Mol Cell Biol 24(12):5235-48. 2004
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| 16 | KSR2, MAP3K8
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| Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling.
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| Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y.
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| J Biol Chem 278(47):47089-97. Epub 2003 Sep 15. 2003
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| 17 | MAP3K8
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| COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation.
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| Sanchez-Gongora E, Lisbona C, de Gregorio R, Ballester A, Calvo V, Perez-Jurado L, Alemany S.
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| J Biol Chem 275(40):31379-86. 2000
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| 18 | MAP3K8
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| Overexpression of the Tpl-2/Cot oncogene in human breast cancer.
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| Sourvinos G, Tsatsanis C, Spandidos DA.
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| Oncogene 18(35):4968-73 1999
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| 19 | MAP3K8
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| The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation.
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| Aoki M, Hamada F, Sugimoto T, Sumida S, Akiyama T, Toyoshima K.
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| J Biol Chem 268(30):22723-32 1993
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| 20 | MAP3K8
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| Expression cDNA cloning of a serine kinase transforming gene.
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| Chan AM, Chedid M, McGovern ES, Popescu NC, Miki T, Aaronson SA.
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| Oncogene 8(5):1329-33. 1993
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| 21 | MAP3K8
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| A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.
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| Justice MJ, et al.
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| Genomics 13 : 1281-1288. 1992
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| 22 | MAP3K8
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| Structure and transforming potential of the human cot oncogene encoding a putative protein kinase.
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| Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T.
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| Mol Cell Biol 11(8):4088-96 1991
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