| 1 | HDAC6, MAP3K4
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| MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.
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| Mobley RJ, Raghu D, Duke LD, Abell-Hart K, Zawistowski JS, Lutz K, Gomez SM, Roy S, Homayouni R, Johnson GL, Abell AN.
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| Cell Rep 18(10):2387-2400. doi: 10.1016/j.celrep.2017.02.030.
2017
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| 2 | GADD45A, MAP3K4
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| Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4.
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| Bullard SA, Seo S, Schilling B, Dyle MC, Dierdorff JM, Ebert SM, DeLau AD, Gibson BW, Adams CM.
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| J Biol Chem 291(34):17496-17509. doi: 10.1074/jbc.M116.740308. Epub 2016 Jun 29.
2016
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| 3 | FGF21, FGFR1, MAP3K4
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| MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.
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| Haque K, Pandey AK, Zheng HW, Riazuddin S, Sha SH, Puligilla C.
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| J Neurosci 36(4):1347-61. doi: 10.1523/JNEUROSCI.1853-15.2016.
2016
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| 4 | HSPB1, MAP3K4, SH3KBP1, TNFSF10
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| TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex.
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| Kim J, Kang D, Sun BK, Kim JH, Song JJ.
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| Cell Signal 25(1):372-9. doi: 10.1016/j.cellsig.2012.10.010. Epub 2012 Oct 23.
2013
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| 5 | GADD45B, MAP3K4, MAPK14
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| Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy.
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| Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I.
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| Cell Death Differ 20(2):321-32. doi: 10.1038/cdd.2012.129. Epub 2012 Oct 12.
2013
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| 6 | MAP3K10, MAP3K4, MAPK14
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| The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1
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| Sapkota GP.
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| Open Biol. Jun 12;3(6):130067. doi: 10.1098/rsob.130067. 2013
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| 7 | GADD45G, MAP3K4
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| Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.
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| Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A.
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| Dev Cell 23(5):1020-31. doi: 10.1016/j.devcel.2012.09.016. Epub 2012 Oct 25.
2012
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| 8 | CREBBP, MAP3K4
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| MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.
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| Abell AN, Jordan NV, Huang W, Prat A, Midland AA, Johnson NL, Granger DA, Mieczkowski PA, Perou CM, Gomez SM, Li L, Johnson GL.
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| Cell Stem Cell 8(5):525-37. doi: 10.1016/j.stem.2011.03.008.
2011
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| 9 | MAP3K4
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| Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
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| Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K.
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| J Mol Cell Cardiol 48(2):302-9. doi: 10.1016/j.yjmcc.2009.10.010. Epub 2009 Oct 20.
2010
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| 10 | FGF4, MAP3K4
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| Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.
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| Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL.
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| Mol Cell Biol 29(10):2748-61. Epub 2009 Mar 16.
2009
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| 11 | MAP3K4
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| Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.
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| Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A.
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| PLoS Biol 7(9):e1000196. Epub 2009 Sep 15. 2009
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| 12 | MAP3K4
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| MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
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| Abell AN, Granger DA, Johnson GL.
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| J Biol Chem 282(42):30476-84. Epub 2007 Aug 28.
2007
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| 13 | FLNA, MAP3K4
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| MEKK4 signaling regulates filamin expression and neuronal migration.
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| Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P.
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| Neuron 52(5):789-801.
2006
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| 14 | MAPK14, MAP3K4, SH3KBP1
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| CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
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| Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P.
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| Biochem Biophys Res Commun 338(2):808-14. Epub 2005 Oct 18. 2005
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| 15 | MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K4
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| Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.
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| Takekawa M, Tatebayashi K, Saito H.
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| Mol Cell 18(3):295-306.
2005
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| 16 | MAP3K4, TRAF4
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| MEKK4 is an effector of the embryonic TRAF4 for JNK activation.
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| Abell AN, Johnson GL.
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| J Biol Chem 280(43):35793-6. Epub 2005 Sep 12.PMID: 16157600 2005
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| 17 | DIXDC1, AXIN1, MAP3K4, MAP3K1, DVL1
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| The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
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| Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC.
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| J Biol Chem 279(38):39366-73. Epub 2004 Jul 15. 2004
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| 18 | GADD45A, GADD45B, MAP3K4
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| A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
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| Takekawa M, et al.
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| Cell 95(4):521-30 1998
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| 19 | MAP3K4
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| A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways.
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| Takekawa M, Posas F, Saito H.
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| EMBO J 16(16):4973-82. 1997
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| 20 | MAP3K4, TSG17E, MAP2K4
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| Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.
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| Teng DH, Perry WL 3rd, Hogan JK, Baumgard M, Bell R, Berry S, Davis T, Frank D, Frye C, Hattier T, Hu R, Jammulapati S, Janecki T, Leavitt A, Mitchell JT, Pero R, Sexton D, Schroeder M, Su PH, Swedlund B, Kyriakis JM, Avruch J, Bartel P, Wong AK, Tavtigian SV, et al.
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| Cancer Res 57(19):4177-82. 1997
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| 21 | MAP3K1, MAP3K4
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| Independent human MAP-kinase signal transduction pathways defined by MEK, and MKK isoforms.
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| Derijard B, et al.
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| Science 267 : 682-685. 1995
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