| 1 | CCM4, MAP3K3
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| Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.
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| Weng J, Yang Y, Song D, Huo R, Li H, Chen Y, Nam Y, Zhou Q, Jiao Y, Fu W, Yan Z, Wang J, Xu H, Di L, Li J, Wang S, Zhao J, Wang J, Cao Y
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| Am J Hum Genet. May 6;108(5):942-950. doi: 10.1016/j.ajhg.2021.04.005. Epub 2021 Apr 22 2021
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| 2 | MAP3K3
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| Late-onset multiple venous malformations confined to the upper limb: link to somatic MAP3K3 mutations.
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| Al-Qattan MM, Al-Balwi MA, Al-Zayed EM, Al-Sohaibani M, Gelidan AG, Alsheiban S.
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| J Hand Surg Eur Vol. Dec;45(10):1023-1027. doi: 10.1177/1753193420922459. Epub 2020 May 7. 2020
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| 3 | MAP3K3
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| Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma
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| Zhang Y, Wang SS, Tao L, Pang LJ, Zou H, Liang WH, Liu Z, Guo SL, Jiang JF, Zhang WJ, Jia W, Li F.
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| Sci Rep. Jun 10;9(1):8401. doi: 10.1038/s41598-019-44835-7. 2019
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| 4 | MAP3K3
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| MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity
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| Santoro R, Zanotto M, Carbone C, Piro G, Tortora G, Melisi D.
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| Anticancer Res. Apr;38(4):1937-1946. doi: 10.21873/anticanres.12431. 2018
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| 5 | MAP3K3, MAPK7, YAP1
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| YAP promotes myogenic differentiation via the MEK5-ERK5 pathway.
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| Chen TH, Chen CY, Wen HC, Chang CC, Wang HD, Chuu CP, Chang CH.
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| FASEB J. Jul;31(7):2963-2972. doi: 10.1096/fj.201601090R. Epub 2017 Mar 29. 2017
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| 6 | MAP3K3
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| A Somatic MAP3K3 Mutation Is Associated with Verrucous Venous Malformation.
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| Couto JA, Vivero MP, Kozakewich HP, Taghinia AH, Mulliken JB, Warman ML, Greene AK.
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| Am J Hum Genet 96(3):480-6. doi: 10.1016/j.ajhg.2015.01.007. Epub 2015 Feb 26.
2015
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| 7 | CCM2, CCM2L, MAP2K5, MAP3K3
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| The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3.
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| Cullere X, Plovie E, Bennett PM, MacRae CA, Mayadas TN.
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| Proc Natl Acad Sci U S A 112(46):14284-9. doi: 10.1073/pnas.1510495112. Epub 2015 Nov 4.
2015
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| 8 | CCM2, MAP3K3
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| Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.
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| Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B.
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| Nat Commun 6:7937. doi: 10.1038/ncomms8937.
2015
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| 9 | MAP2K5, MAP3K3, XIAP
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| Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
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| Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K.
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| EMBO J 33(16):1784-801. doi: 10.15252/embj.201487808. Epub 2014 Jun 28.
2014
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| 10 | MAP3K3
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| Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells.
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| Fan Y, Ge N, Wang X, Sun W, Mao R, Bu W, Creighton CJ, Zheng P, Vasudevan S, An L, Yang J, Zhao YJ, Zhang H, Li XN, Rao PH, Leung E, Lu YJ, Gray JW, Schiff R, Hilsenbeck SG, Osborne CK, Yang J, Zhang H.
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| J Pathol 232(1):75-86. doi: 10.1002/path.4283.
2014
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| 11 | MAP3K3
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| Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis.
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| Hasan R, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan R.
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| BMC Cancer 14:2. doi: 10.1186/1471-2407-14-2.
2014
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| 12 | MAP3K3
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| MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.
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| Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B.
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| J Immunol 186(10):5791-800. doi: 10.4049/jimmunol.1002127. Epub 2011 Apr 6.
2011
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| 13 | MAP3K2, MAP3K3
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| The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.
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| Chang X, Liu F, Wang X, Lin A, Zhao H, Su B.
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| Immunity 34(2):201-12. doi: 10.1016/j.immuni.2011.01.017. Epub 2011 Feb 17.
2011
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| 14 | MAP3K3, SQSTM1
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| PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.
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| Nakamura K, Kimple AJ, Siderovski DP, Johnson GL.
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| J Biol Chem 285(3):2077-89. Epub 2009 Nov 10.PMID: 19903815 2010
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| 15 | MAP3K3
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| Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation.
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| Matitau AE, Scheid MP.
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| J Biol Chem 283(19):13261-8. Epub 2008 Feb 28.PMID: 18308725 2008
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| 16 | MAP2K5, MAP3K3
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| Insight into the binding properties of MEKK3 PB1 to MEK5 PB1 from its solution structure.
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| Hu Q, Shen W, Huang H, Liu J, Zhang J, Huang X, Wu J, Shi Y.
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| Biochemistry 46(47):13478-89. Epub 2007 Nov 7.PMID: 17985933 2007
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| 17 | TLR8, IKBKG, MAP3K3
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| TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.
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| Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X.
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| J Biol Chem 281(30):21013-21. Epub 2006 May 31. 2006
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| 18 | MAP3K2, MAP3K3
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| Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.
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| Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B.
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| EMBO J 25(1):97-107. Epub 2005 Dec 15. 2006
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| 19 | MAP3K3
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| Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.
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| Fritz A, Brayer KJ, McCormick N, Adams DG, Wadzinski BE, Vaillancourt RR.
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| J Biol Chem 281(10):6236-45. Epub 2006 Jan 9.PMID: 16407301 2006
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| 20 | KRIT1, CCM2, MAP3K3, CCM1
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| CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.
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| Zawistowski JS, Stalheim L, Uhlik MT, Abell AN, Ancrile BB, Johnson GL, Marchuk DA.
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| Hum Mol Genet 14(17):2521-31. Epub 2005 Jul 21. 2005
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| 21 | MAP3K7, MAP3K3, RIPK1, TNF
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| TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.
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| Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin X.
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| J Biol Chem 280(52):43056-63. Epub 2005 Oct 31. 2005
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| 22 | MAP3K3
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| Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB.
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| Samanta AK, Huang HJ, Bast RC Jr, Liao WS.
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| J Biol Chem 279(9):7576-83. Epub 2003 Dec 8. 2004
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| 23 | MAP3K3
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| Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells.
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| Blonska M, You Y, Geleziunas R, Lin X.
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| Mol Cell Biol 24(24):10757-65. 2004
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| 24 | MAP3K3, TRAF7
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| TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
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| Xu LG, Li LY, Shu HB.
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| J Biol Chem 279(17):17278-82. Epub 2004 Mar 4.PMID: 15001576 2004
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| 25 | MAP3K3
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| Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative.
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| Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U.
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| J Biol Chem 272(5):2668-74. 1997
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| 26 | MAP3K2, MAP3K3
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| Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase.
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| Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL.
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| J Biol Chem 271(10):5361-8. 1996
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