Citations for
The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways.
Muro I, Fang G, Gardella KA, Mahajan IM, Wright CW.
Cell Cycle 13(12):1918-27. doi: 10.4161/cc.28895. Epub 2014 Apr 16. 2014
Activation-induced tumor necrosis factor receptor-associated factor 3 (Traf3) alternative splicing controls the noncanonical nuclear factor κB pathway and chemokine expression in human T cells.
Michel M, Wilhelmi I, Schultz AS, Preussner M, Heyd F.
J Biol Chem 289(19):13651-60. doi: 10.1074/jbc.M113.526269. Epub 2014 Mar 26. 2014
Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity.
Döppler H, Liou GY, Storz P.
PLoS One 8(1):e53676. doi: 10.1371/journal.pone.0053676. Epub 2013 Jan 3. 2013
4MAP3K14, SMG1
SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds.
Cheung HH, St Jean M, Beug ST, Lejmi-Mrad R, LaCasse E, Baird SD, Stojdl DF, Screaton RA, Korneluk RG.
Cell Death Dis 2:e146. 2011
NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells.
Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J.
Biochem Biophys Res Commun 388(1):96-101. Epub 2009 Jul 29. 2009
6MAP3K14, MAP3K8
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
Wittwer T, Schmitz ML.
Biochem Biophys Res Commun 371(2):294-7. Epub 2008 Apr 23. 2008
NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.
Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC.
J Biol Chem 283(6):3392-400. Epub 2007 Dec 4. 2008
The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells.
Wang Y, Huang X, Cang H, Gao F, Yamamoto T, Osaki T, Yi J.
Free Radic Res 41(9):963-71. 2007
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC.
Biochem Biophys Res Commun 359(2):379-84. Epub 2007 May 25. 2007
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
Li Q, Engelhardt JF.
J Biol Chem 281(3):1495-505. Epub 2005 Nov 14. 2006
11MAP3K14, TRAF2
Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival.
Yang CH, Murti A, Pfeffer LM.
J Biol Chem 280(36):31530-6. Epub 2005 Jul 11. 2005
TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation.
Hu WH, Mo XM, Walters WM, Brambilla R, Bethea JR.
J Biol Chem 279(34):35975-83. Epub 2004 Jun 18. 2004
Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK.
Birbach A, Bailey ST, Ghosh S, Schmid JA.
J Cell Sci 117(Pt 16):3615-24. 2004
14MAP3K14, TRAF3
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
Liao G, Zhang M, Harhaj EW, Sun SC.
J Biol Chem 279(25):26243-50. Epub 2004 Apr 14. 2004
NIK is a component of the EGF/heregulin receptor signaling complexes.
Chen D, Xu LG, Chen L, Li L, Zhai Z, Shu HB.
Oncogene 22(28):4348-55. 2003
16MAP3K14, PEBP1
Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.
Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM.
Mol Cell Biol 21(21):7207-17. 2001
Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation.
Li X, Josef J, Marasco WA.
Biochem Biophys Res Commun 286(3):587-94. 2001
18MAP3K7, MAP3K14
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K.
Nature 398(6724):252-6. 1999
The NIK protein kinase and C17orf1 genes : chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.
Aronsson FC, et al.
Hum Genet 103 : 340-345. 1998
20MAP3K14, MAP3K7
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
Sakurai H, Shigemori N, Hasegawa K, Sugita T.
Biochem Biophys Res Commun 243(2):545-9. 1998
Molecular determinants of NF-kappaB-inducing kinase action.
Lin X, Mu Y, Cunningham ET Jr, Marcu KB, Geleziunas R, Greene WC.
Mol Cell Biol 18(10):5899-907. 1998
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
Malinin NL, et al.
Nature 385 : 540-544. 1997