Citations for
Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity.
Döppler H, Liou GY, Storz P.
PLoS One 8(1):e53676. doi: 10.1371/journal.pone.0053676. Epub 2013 Jan 3. 2013
2MAP3K14, SMG1
SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds.
Cheung HH, St Jean M, Beug ST, Lejmi-Mrad R, LaCasse E, Baird SD, Stojdl DF, Screaton RA, Korneluk RG.
Cell Death Dis 2:e146. 2011
NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells.
Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J.
Biochem Biophys Res Commun 388(1):96-101. Epub 2009 Jul 29. 2009
4MAP3K14, MAP3K8
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
Wittwer T, Schmitz ML.
Biochem Biophys Res Commun 371(2):294-7. Epub 2008 Apr 23. 2008
NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.
Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC.
J Biol Chem 283(6):3392-400. Epub 2007 Dec 4. 2008
The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells.
Wang Y, Huang X, Cang H, Gao F, Yamamoto T, Osaki T, Yi J.
Free Radic Res 41(9):963-71. 2007
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC.
Biochem Biophys Res Commun 359(2):379-84. Epub 2007 May 25. 2007
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
Li Q, Engelhardt JF.
J Biol Chem 281(3):1495-505. Epub 2005 Nov 14. 2006
Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival.
Yang CH, Murti A, Pfeffer LM.
J Biol Chem 280(36):31530-6. Epub 2005 Jul 11. 2005
TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation.
Hu WH, Mo XM, Walters WM, Brambilla R, Bethea JR.
J Biol Chem 279(34):35975-83. Epub 2004 Jun 18. 2004
Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK.
Birbach A, Bailey ST, Ghosh S, Schmid JA.
J Cell Sci 117(Pt 16):3615-24. 2004
12MAP3K14, TRAF3
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
Liao G, Zhang M, Harhaj EW, Sun SC.
J Biol Chem 279(25):26243-50. Epub 2004 Apr 14. 2004
NIK is a component of the EGF/heregulin receptor signaling complexes.
Chen D, Xu LG, Chen L, Li L, Zhai Z, Shu HB.
Oncogene 22(28):4348-55. 2003
14MAP3K14, PEBP1
Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.
Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM.
Mol Cell Biol 21(21):7207-17. 2001
Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation.
Li X, Josef J, Marasco WA.
Biochem Biophys Res Commun 286(3):587-94. 2001
16MAP3K7, MAP3K14
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K.
Nature 398(6724):252-6. 1999
The NIK protein kinase and C17orf1 genes : chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.
Aronsson FC, et al.
Hum Genet 103 : 340-345. 1998
18MAP3K14, MAP3K7
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
Sakurai H, Shigemori N, Hasegawa K, Sugita T.
Biochem Biophys Res Commun 243(2):545-9. 1998
Molecular determinants of NF-kappaB-inducing kinase action.
Lin X, Mu Y, Cunningham ET Jr, Marcu KB, Geleziunas R, Greene WC.
Mol Cell Biol 18(10):5899-907. 1998
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
Malinin NL, et al.
Nature 385 : 540-544. 1997