| 1 | MAP3K12
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| DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
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| Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW.
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| Proc Natl Acad Sci U S A 110(10):4039-44. doi: 10.1073/pnas.1211074110. Epub 2013 Feb 19.
2013
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| 2 | MAP3K12
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| DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.
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| Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW.
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| J Cell Biol 194(5):751-64.
2011
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| 3 | MAP3K12
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| ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons.
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| Itoh A, Horiuchi M, Wakayama K, Xu J, Bannerman P, Pleasure D, Itoh T.
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| J Neurosci 31(20):7223-8.
2011
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| 4 | MAP3K12
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| The DLK gene is a transcriptional target of PPARγ.
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| Couture JP, Blouin R.
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| Biochem J 438(1):93-101.
2011
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| 5 | MAP3K12
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| Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway.
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| Hirai S, Banba Y, Satake T, Ohno S.
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| J Neurosci 31(17):6468-80.
2011
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| 6 | MAP3K12
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| Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest.
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| Daviau A, Couture JP, Blouin R.
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| Biochem Biophys Res Commun 413(2):282-7. Epub 2011 Aug 27.
2011
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| 7 | HSPB1, MAP3K12
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| The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression.
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| Robitaille H, Simard-Bisson C, Larouche D, Tanguay RM, Blouin R, Germain L.
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| J Invest Dermatol 130(1):74-85. Epub .
2010
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| 8 | MAP3K12
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| Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.
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| Itoh A, Horiuchi M, Bannerman P, Pleasure D, Itoh T.
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| Biochem Biophys Res Commun 383(2):258-62. Epub 2009 Apr 7.
2009
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| 9 | MAP3K12
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| The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF).
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| Daviau A, Di Fruscio M, Blouin R.
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| Cell Signal 21(4):577-87. Epub 2008 Dec 25.
2009
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| 10 | MAP3K12
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| The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.
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| Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S.
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| J Neurosci 26(46):11992-2002.
2006
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| 11 | MAP3K12
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| The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.
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| Robitaille H, Proulx R, Robitaille K, Blouin R, Germain L.
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| J Biol Chem 280(13):12732-41. Epub 2005 Jan 28.
2005
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| 12 | MAP3K12
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| SP3 acts as a positive regulator on the core promoter of human ZPK gene.
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| Itoh A, Wang Z, Ito Y, Reddy UR, Itoh T.
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| Biochem Biophys Res Commun 313(3):612-8. 2004
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| 13 | MAP3K12
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| Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.
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| Hirai S, Izawa M, Osada S, Spyrou G, Ohno S.
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| Oncogene 12(3):641-50. 1996
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| 14 | MAP3K12
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| Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin.
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| Mata M, Merritt SE, Fan G, Yu GG, Holzman LB.
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| J Biol Chem 271(28):16888-96. 1996
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| 15 | MAP3K12
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| Localization of the human zipper protein kinase gene (ZPK) to chromosome12q13 by fluorescence in situ hybridization and somatic cell hybrid analysis.
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| Reddy UR, et al.
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| Genomics 25 : 597-598. 1995
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| 16 | MAP3K12
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| Cloning of a novel putative protein kinase having a leucine zipper domain from human brain.
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| Reddy UR, et al.
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| Biochem Biophys Res Commun 202 : 613-620. 1994
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| 17 | MAP3K12
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| Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases.
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| Holzman LB, Merritt SE, Fan G.
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| J Biol Chem 269(49):30808-17. 1994
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