| 1 | ERBB2, MAP3K11
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| Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival.
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| Das S, Sondarva G, Viswakarma N, Nair RS, Osipo C, Tzivion G, Rana B, Rana A.
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| J Biol Chem 290(35):21705-12. doi: 10.1074/jbc.M115.655563. Epub 2015 Jul 7.
2015
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| 2 | MAP3K11, PRKAA1, STK11
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| MLK3 phophorylates AMPK independently of LKB1.
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| Luo L, Jiang S, Huang D, Lu N, Luo Z.
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| PLoS One 10(4):e0123927. doi: 10.1371/journal.pone.0123927. eCollection 2015.
2015
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| 3 | MAP3K11
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| MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.
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| Lee HS, Hwang CY, Shin SY, Kwon KS, Cho KH.
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| Sci Signal 7(328):ra52. doi: 10.1126/scisignal.2005260.
2014
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| 4 | MAP3K11
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| Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells.
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| Gadang V, Konaniah E, Hui DY, Jaeschke A.
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| Arterioscler Thromb Vasc Biol 34(7):1429-36. doi: 10.1161/ATVBAHA.114.303439. Epub 2014 May 1.
2014
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| 5 | MAP3K11
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| MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet.
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| Gadang V, Kohli R, Myronovych A, Hui DY, Perez-Tilve D, Jaeschke A.
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| Am J Physiol Endocrinol Metab 305(4):E549-56. doi: 10.1152/ajpendo.00197.2013. Epub 2013 Jul 16.
2013
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| 6 | MAP3K11
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| Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.
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| Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US.
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| J Biol Chem 288(4):2428-40. doi: 10.1074/jbc.M112.425884. Epub 2012 Nov 21.
2013
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| 7 | MAP3K11, PIN1
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| Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
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| Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A.
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| Proc Natl Acad Sci U S A 109(21):8149-54. doi: 10.1073/pnas.1200804109. Epub 2012 May 7.
2012
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| 8 | MAP3K11
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| Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells.
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| Zhan Y, Abi Saab WF, Modi N, Stewart AM, Liu J, Chadee DN.
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| Exp Cell Res 318(14):1641-8. doi: 10.1016/j.yexcr.2012.05.002. Epub 2012 May 28.
2012
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| 9 | FGD1, MAP3K11
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| MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.
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| Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH.
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| J Clin Invest 121(11):4383-92. doi: 10.1172/JCI59041. Epub 2011 Oct 3.
2011
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| 10 | MAP3K11
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| Mixed lineage kinase 3 modulates β-catenin signaling in cancer cells.
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| Thylur RP, Senthivinayagam S, Campbell EM, Rangasamy V, Thorenoor N, Sondarva G, Mehrotra S, Mishra P, Zook E, Le PT, Rana A, Rana B.
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| J Biol Chem 286(43):37470-82. doi: 10.1074/jbc.M111.298943. Epub 2011 Aug 31.
2011
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| 11 | MAP3K11
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| Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.
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| Velho S, Oliveira C, Paredes J, Sousa S, Leite M, Matos P, Milanezi F, Ribeiro AS, Mendes N, Licastro D, Karhu A, Oliveira MJ, Ligtenberg M, Hamelin R, Carneiro F, Lindblom A, Peltomaki P, Castedo S, Schwartz S Jr, Jordan P, Aaltonen LA, Hofstra RM, Suriano G, Stupka E, Fialho AM, Seruca R.
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| Hum Mol Genet 19(4):697-706. Epub 2009 Dec 2.PMID: 19955118 2010
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| 12 | MAP3K11
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| Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling.
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| Liou GY, Zhang H, Miller EM, Seibold SA, Chen W, Gallo KA.
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| Biochem J 427(3):435-43.PMID: 20158498 2010
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| 13 | MAP3K11, MAPK11
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| MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.
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| Chen J, Miller EM, Gallo KA.
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| Oncogene 29(31):4399-411. Epub 2010 May 31.PMID: 20514022 2010
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| 14 | MAP3K11
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| Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6.
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| Korchnak AC, Zhan Y, Aguilar MT, Chadee DN.
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| Cell Signal 21(11):1620-5. Epub 2009 Jul 5.PMID: 19586614 2009
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| 15 | GSK3B, MAP3K11
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| Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.
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| Mishra R, Barthwal MK, Sondarva G, Rana B, Wong L, Chatterjee M, Woodgett JR, Rana A.
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| J Biol Chem 282(42):30393-405. Epub 2007 Aug 21.PMID: 17711861 2007
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| 16 | MAP3K11
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| Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.
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| Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM.
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| Proc Natl Acad Sci U S A 103(12):4463-8. Epub 2006 Mar 13.PMID: 16537381 2006
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| 17 | MAP3K11
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| Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.
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| Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ.
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| Mol Cell Biol 25(9):3670-81. 2005
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| 18 | MAP3K11
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| A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.
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| Swenson KI, Winkler KE, Means AR.
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| Mol Biol Cell 14(1):156-72. 2003
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| 19 | CDC42, MAP3K11
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| Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation.
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| Bock BC, Vacratsis PO, Qamirani E, Gallo KA.
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| J Biol Chem 275(19):14231-41. 2000
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| 20 | MAP3K11
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| Fine mapping of the MLK-3 gene within 11q13 and its exclusion as the MEN1 susceptibility gene.
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| Lassam NJ, Lin Z, Shennan MG, Courseaux A, Teh BT, Gaudray P, Larsson C.
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| Hum Genet 99(6):776-80. 1997
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| 21 | CAPN1, FAU, KAT5, MAP3K11, MEN1, PABYL, PLCB3, PYGM, RELA, SEA, SF1, SIPA1
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| A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.
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| Sawicki M, Arnold E, Ebrahimi S, Duell T, Jin S, Wood T, Chakrabarti R, Peters J, Wan Y, Samara G, Weier HU, Udar N, Passaro E Jr, Srivatsan ES.
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| Genomics 42(3):405-12. 1997
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| 22 | MAP3K11
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| A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13.
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| Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS.
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| Genome Res 7(8):835-42. 1997
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| 23 | MAP3K11
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| MLK-3 : identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain.
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| Ing YL, et al.
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| Oncogene 9 : 1745-1750. 1994
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| 24 | MAP3K11
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| PTK1, a novel protein kinase required for proliferation of human melanocytes.
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| Ezoe K, et al.
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| Oncogene 9 : 935-938. 1994
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| 25 | MAP3K11
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| Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.
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| Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ.
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| J Biol Chem 269(21):15092-100. 1994
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