| 1 | MAP3K1, XYDSDM
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| MAP3K1-related gonadal dysgenesis: Six new cases and review of the literature.
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| Granados A, Alaniz VI, Mohnach L, Barseghyan H, Vilain E, Ostrer H, Quint EH, Chen M, Keegan CE.
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| Am J Med Genet C Semin Med Genet 175(2):253-259. doi: 10.1002/ajmg.c.31559. Epub 2017 May 15.
2017
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| 2 | CNN3, MAP3K1
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| MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility.
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| Hirata H, Ku WC, Yip AK, Ursekar CP, Kawauchi K, Roy A, Guo AK, Vedula SR, Harada I, Chiam KH, Ishihama Y, Lim CT, Sawada Y, Sokabe M.
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| J Cell Sci 129(19):3574-3582. Epub 2016 Aug 15.
2016
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| 3 | MAP3K1
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| MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells.
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| Yousaf R, Meng Q, Hufnagel RB, Xia Y, Puligilla C, Ahmed ZM, Riazuddin S.
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| Dis Model Mech 8(12):1543-53. doi: 10.1242/dmm.023077. Epub 2015 Oct 23.
2015
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| 4 | COPS6, JUN, MAP3K1
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| CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
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| Shin J, Phan L, Chen J, Lu Z, Lee MH.
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| Cell Cycle 14(19):3079-87. doi: 10.1080/15384101.2015.1078030. Epub 2015 Aug 3.
2015
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| 5 | BAALC, KLF4, MAP3K1
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| BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.
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| Morita K, Masamoto Y, Kataoka K, Koya J, Kagoya Y, Yashiroda H, Sato T, Murata S, Kurokawa M.
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| Leukemia 29(11):2248-56. doi: 10.1038/leu.2015.137. Epub 2015 Jun 8.
2015
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| 6 | MAP3K1
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| Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1).
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| Chipps E, Protzman A, Muhi MZ, Ando S, Calvet JP, Islam MR.
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| J Cell Biochem 116(12):2903-14. doi: 10.1002/jcb.25238.
2015
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| 7 | MAP3K1, TAB1
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| The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
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| Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E.
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| EMBO J 33(21):2581-96. doi: 10.15252/embj.201488351. Epub 2014 Sep 26.
2014
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| 8 | MAP3K1
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| Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.
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| Meng Q, Mongan M, Wang J, Tang X, Zhang J, Kao W, Xia Y.
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| Dev Biol 395(1):29-37. doi: 10.1016/j.ydbio.2014.09.001. Epub 2014 Sep 16.
2014
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| 9 | MAP3K1
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| Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.
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| Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM, Zhou X, Medvedovic M, Xia Y.
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| Dev Biol 374(1):96-107. doi: 10.1016/j.ydbio.2012.11.020. Epub 2012 Nov 30.
2013
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| 10 | MAP3K1
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| Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.
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| Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM, Zhou X, Medvedovic M, Xia Y.
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| Dev Biol 374(1):96-107. doi: 10.1016/j.ydbio.2012.11.020. Epub 2012 Nov 30.
2013
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| 11 | MAP3K1
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| The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation.
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| Rieger MA, Duellman T, Hooper C, Ameka M, Bakowska JC, Cuevas BD.
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| Biochem J 445(3):431-9.
2012
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| 12 | MAP3K1
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| Loss of MAP3K1 enhances proliferation and apoptosis during retinal development.
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| Mongan M, Wang J, Liu H, Fan Y, Jin C, Kao WY, Xia Y.
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| Development 138(18):4001-12.
2011
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| 13 | MAP3K1
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| Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure.
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| Geh E, Meng Q, Mongan M, Wang J, Takatori A, Zheng Y, Puga A, Lang RA, Xia Y.
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| Proc Natl Acad Sci U S A 108(42):17349-54. Epub 2011 Oct 3.
2011
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| 14 | MAP3K1
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| Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.
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| Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, Wells S, Cheeseman M, Xia Y, Ostrer H, Greenfield A.
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| PLoS One 6(5):e19572.
2011
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| 15 | MAP3K1
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| Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1.
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| Tricker E, Arvand A, Kwan R, Chen GY, Gallagher E, Cheng G.
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| PLoS One 6(2):e17310.
2011
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| 16 | MAP3K1, XYDSDM
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| Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.
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| Pearlman A, Loke J, Le Caignec C, White S, Chin L, Friedman A, Warr N, Willan J, Brauer D, Farmer C, Brooks E, Oddoux C, Riley B, Shajahan S, Camerino G, Homfray T, Crosby AH, Couper J, David A, Greenfield A, Sinclair A, Ostrer H.
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| Am J Hum Genet 87(6):898-904.PMID: 21129722 2010
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| 17 | DCAF7, DYRK1A, DYRK1B, HIPK2, MAP3K1
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| The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
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| Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML.
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| EMBO J 29(22):3750-61. Epub 2010 Oct 12. 2010
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| 18 | MAP3K1
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| MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.
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| Sue Ng S, Mahmoudi T, Li VS, Hatzis P, Boersema PJ, Mohammed S, Heck AJ, Clevers H.
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| Biol Chem 391(2-3):171-80.
2010
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| 19 | MAP3K1
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| Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells.
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| Su F, Li H, Yan C, Jia B, Zhang Y, Chen X.
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| J Cancer Res Clin Oncol 135(12):1655-63. Epub 2009 Jun 10.
2009
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| 20 | MAP3K1, REG3A
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| ERK is a novel regulatory kinase for poly(A) polymerase.
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| Lee SH, Choi HS, Kim H, Lee Y.
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| Nucleic Acids Res 36(3):803-13. Epub 2007 Dec 15. 2008
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| 21 | HSPPD2A, MAP3K1, TRAF6
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| TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
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| Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T.
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| J Biol Chem 283(52):36211-20. Epub 2008 Nov 4.
2008
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| 22 | CRTC1, MAP3K1
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| Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation.
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| Siu YT, Ching YP, Jin DY.
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| Mol Biol Cell 19(11):4750-61. Epub 2008 Sep 10.
2008
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| 23 | MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K4
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| Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.
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| Takekawa M, Tatebayashi K, Saito H.
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| Mol Cell 18(3):295-306.
2005
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| 24 | DIXDC1, AXIN1, MAP3K4, MAP3K1, DVL1
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| The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
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| Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC.
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| J Biol Chem 279(38):39366-73. Epub 2004 Jul 15. 2004
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| 25 | CEBPB, MAP3K1
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| MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.
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| Roy SK, Hu J, Meng Q, Xia Y, Shapiro PS, Reddy SP, Platanias LC, Lindner DJ, Johnson PF, Pritchard C, Pages G, Pouyssegur J, Kalvakolanu DV.
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| Proc Natl Acad Sci U S A 99(12):7945-50. 2002
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| 26 | MAP3K1
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| Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments.
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| Schlesinger TK, Bonvin C, Jarpe MB, Fanger GR, Cardinaux JR, Johnson GL, Widmann C.
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| J Biol Chem 277(12):10283-91. 2002
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| 27 | MAP3K1
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| The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
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| Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T.
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| Mol Cell 9(5):945-56. 2002
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| 28 | IL2, MAP3K1, STK10
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| Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.
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| Tao L, Wadsworth S, Mercer J, Mueller C, Lynn K, Siekierka J, August A.
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| Biochem J 363(Pt 1):175-82.
2002
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| 29 | MAP3K1, SMAD2
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| MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells.
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| Brown JD, et al.
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| J Biol Chem 274(13):8797-805. 1999
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| 30 | MAP3K1
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| Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents.
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| Gibson S, et al.
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| J Biol Chem 274(16):10916-22. 1999
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| 31 | MAP3K1
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| MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.
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| Yujiri T, et al.
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| J Biol Chem 274(18):12605-10. 1999
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| 32 | MAP3K1
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| Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.
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| Yujiri T, et al.
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| Science 282 : 1911-1914. 1998
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| 33 | MAP3K1
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| MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.
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| Widmann C, et al.
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| Mol Cell Biol 18 : 2416-2429. 1998
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| 34 | MAP3K1
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| JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
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| Xia Y, Wu Z, Su B, Murray B, Karin M.
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| Genes Dev 12(21):3369-81. 1998
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| 35 | CHUK, MAP3K1
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| Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.
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| Lee FS, et al.
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| Cell 88 : 213-222. 1997
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| 36 | MAP3K1
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| Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.
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| Vinik BS, et al.
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| Mamm Genome 6 : 782-783. 1995
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| 37 | MAP3K1, MAP3K4
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| Independent human MAP-kinase signal transduction pathways defined by MEK, and MKK isoforms.
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| Derijard B, et al.
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| Science 267 : 682-685. 1995
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