Citations for
1MAP2K7, MAPK8, SENP3
DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J.
J Biol Chem 293(11):3965-3980. doi: 10.1074/jbc.M117.816769. Epub 2018 Jan 19. 2018
2GADD45A, GADD45B, GADD45G, MAP2K7
GADD45 family proteins suppress JNK signaling by targeting MKK7.
Ueda T, Kohama Y, Kuge A, Kido E, Sakurai H.
Arch Biochem Biophys 635:1-7. doi: 10.1016/j.abb.2017.10.005. Epub 2017 Oct 14. 2017
3MAP2K7, MAPK8
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.
Sci Rep 7(1):7348. doi: 10.1038/s41598-017-07845-x. 2017
4KLF4, MAP2K7
Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.
Shen Y, Park CS, Suppipat K, Mistretta TA, Puppi M, Horton TM, Rabin K, Gray NS, Meijerink JPP, Lacorazza HD.
Leukemia 31(6):1314-1324. doi: 10.1038/leu.2016.339. Epub 2016 Nov 22. 2017
5MAP2K7
High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7.
Kinoshita T, Hashimoto T, Sogabe Y, Fukada H, Matsumoto T, Sawa M.
Biochem Biophys Res Commun 493(1):313-317. doi: 10.1016/j.bbrc.2017.09.025. Epub 2017 Sep 7. 2017
6GADD45G, MAP2K7
Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
Jia M, Zhu M, Zhou F, Wang M, Sun M, Yang Y, Wang X, Wang J, Jin L, Xiang J, Zhang Y, Chang J, Wei Q.
Int J Cancer 140(4):807-817. doi: 10.1002/ijc.30508. Epub 2016 Nov 16. 2017
7MAP2K7
A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7.
Sogabe Y, Hashimoto T, Matsumoto T, Kirii Y, Sawa M, Kinoshita T.
Biochem Biophys Res Commun 473(2):476-81. doi: 10.1016/j.bbrc.2016.03.036. Epub 2016 Mar 15. 2016
8MAP2K7
Neddylation controls basal MKK7 kinase activity in breast cancer cells.
Zhu T, Wang J, Pei Y, Wang Q, Wu Y, Qiu G, Zhang D, Lv M, Li W, Zhang J.
Oncogene 35(20):2624-33. doi: 10.1038/onc.2015.323. Epub 2015 Sep 14. 2016
9MAP2K7
Structure and dynamics of the MKK7-JNK signaling complex.
Kragelj J, Palencia A, Nanao MH, Maurin D, Bouvignies G, Blackledge M, Jensen MR.
Proc Natl Acad Sci U S A 112(11):3409-14. doi: 10.1073/pnas.1419528112. Epub 2015 Mar 3. 2015
10ARR3, MAP2K4, MAP2K7, MAP3K5, MAPK10
JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases.
Zhan X, Kaoud TS, Kook S, Dalby KN, Gurevich VV.
J Biol Chem 288(40):28535-47. doi: 10.1074/jbc.M113.508085. Epub 2013 Aug 19. 2013
11MAP2K7, MAPK8, TNFRSF18
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, Gelfand EW.
J Biol Chem 287(21):17100-8. doi: 10.1074/jbc.M111.316943. Epub 2012 Mar 29. 2012
12MAP2K7
Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia.
Winchester CL, Ohzeki H, Vouyiouklis DA, Thompson R, Penninger JM, Yamagami K, Norrie JD, Hunter R, Pratt JA, Morris BJ.
Hum Mol Genet 21(22):4910-21. doi: 10.1093/hmg/dds331. Epub 2012 Aug 16. 2012
13MAP2K7
Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis.
Wang J, Tang R, Lv M, Wang Q, Zhang X, Guo Y, Chang H, Qiao C, Xiao H, Li X, Li Y, Shen B, Zhang J.
Mol Biol Cell 22(1):117-27. Epub 2010 Dec 9. 2011
14MAP2K7
MKK7γ1 reverses nerve growth factor signals: proliferation and cell death instead of neuritogenesis and protection.
Haeusgen W, Herdegen T, Waetzig V.
Cell Signal 23(8):1281-90. Epub 2011 Mar 23. 2011
15MAP2K4, MAP2K7
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM.
Nat Genet 43(3):212-9. Epub 2011 Feb 13. 2011
16FLNA, MAP2K4, MAP2K7
Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.
Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H.
Biochem J 427(2):237-45.PMID: 20156194 2010
17GADD45B, MAP2K7
GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy.
Wang J, Wang H, Chen J, Wang X, Sun K, Wang Y, Wang J, Yang X, Song X, Xin Y, Liu Z, Hui R.
Biochem Biophys Res Commun 372(4):623-8. Epub 2008 Jun 2. 2008
18MAP2K7, GADD45B
Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2.
Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G.
J Biol Chem 282(26):19029-41. Epub 2007 May 7. 2007
19MAP2K7
Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1.
Michael L, Swantek J, Robinson MJ.
Biochem Biophys Res Commun 341(3):679-83. Epub 2006 Jan 18. 2006
20MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K4
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.
Takekawa M, Tatebayashi K, Saito H.
Mol Cell 18(3):295-306. 2005
21CYLD, IKBKB, IKBKG, MAPK8, MAP2K7
Negative regulation of JNK signaling by the tumor suppressor CYLD.
Reiley W, Zhang M, Sun SC.
J Biol Chem 279(53):55161-7. Epub 2004 Oct 20. 2004
22MAP2K7, MAPK8, MAPK8IP1, MAPK8IP2
cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.
Negri S, Oberson A, Steinmann M, Sauser C, Nicod P, Waeber G, Schorderet DF, Bonny C.
Genomics 64(3):324-30. 2000
23MAP2K7
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli.
Foltz IN, Gerl RE, Wieler JS, Luckach M, Salmon RA, Schrader JW.
J Biol Chem 273(15):9344-51. 1998
24MAP2K7
Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase.
Yang J, New L, Jiang Y, Han J, Su B.
Gene 212(1):95-102. 1998
25MAP2K7
Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38.
Lu X, Nemoto S, Lin A.
J Biol Chem 272(40):24751-4. 1997
26MAP2K7, MAPK8
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.
Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ.
Proc Natl Acad Sci U S A 94(14):7337-42. 1997
27MAP2K7
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.
Wu Z, Wu J, Jacinto E, Karin M.
Mol Cell Biol 17(12):7407-16. 1997