Citations for
MKK6 controls T3-mediated browning of white adipose tissue.
Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G.
Nat Commun 8(1):856. doi: 10.1038/s41467-017-00948-z. 2017
Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation.
Sturchler E, Feurstein D, McDonald P, Duckett D.
Biochemistry 49(19):4094-102. 2010
MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.
Harraz MM, Park A, Abbott D, Zhou W, Zhang Y, Engelhardt JF.
Antioxid Redox Signal 9(11):1803-13. 2007
Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.
Huang H, Ryu J, Ha J, Chang EJ, Kim HJ, Kim HM, Kitamura T, Lee ZH, Kim HH.
Cell Death Differ 13(11):1879-91. Epub 2006 Feb 24. 2006
Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.
Inoue T, Hammaker D, Boyle DL, Firestein GS.
J Immunol 174(7):4301-6. 2005
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.
Takekawa M, Tatebayashi K, Saito H.
Mol Cell 18(3):295-306. 2005
p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts.
Frevel MA, Bakheet T, Silva AM, Hissong JG, Khabar KS, Williams BR.
Mol Cell Biol 23(2):425-36. 2003
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts.
Kozawa O, Hatakeyama D, Uematsu T.
J Cell Biochem 84(3):583-9. 2002
The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.
Bode JG, Ludwig S, Freitas CA, Schaper F, Ruhl M, Melmed S, Heinrich PC, Haussinger D.
Biol Chem 382(10):1447-53. 2001
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells.
Goebeler M, et al.
Blood 93(3):857-65. 1999
11ABL1, MAP2K6
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation.
Cong F, Goff SP.
Proc Natl Acad Sci U S A 96(24):13819-24 1999
Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha.
Roulston A, et al.
J Biol Chem 273(17):10232-9. 1998
13MAP2K6, MAPK11
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.
Enslen H, Raingeaud J, Davis RJ.
J Biol Chem 273(3):1741-8. 1998
14MAP2K3, MAP2K6
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
Raingeaud J, et al.
Mol Cell Biol 16(3):1247-55. 1996
Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
Han J, et al.
J Biol Chem 271(6):2886-91. 1996
16MAP2K3, MAP2K6
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.
Cuenda A, Alonso G, Morrice N, Jones M, Meier R, Cohen P, Nebreda AR.
EMBO J 15(16):4156-64. 1996
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M.
J Biol Chem 271(23):13675-9. 1996
Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade.
Stein B, Brady H, Yang MX, Young DB, Barbosa MS.
J Biol Chem 271(19):11427-33. 1996