| 1 | MAP2K6, UCP1
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| MKK6 controls T3-mediated browning of white adipose tissue.
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| Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G.
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| Nat Commun 8(1):856. doi: 10.1038/s41467-017-00948-z.
2017
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| 2 | MAP2K6, MAP3K5
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| Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation.
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| Sturchler E, Feurstein D, McDonald P, Duckett D.
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| Biochemistry 49(19):4094-102.
2010
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| 3 | MAP2K6
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| MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.
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| Harraz MM, Park A, Abbott D, Zhou W, Zhang Y, Engelhardt JF.
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| Antioxid Redox Signal 9(11):1803-13.
2007
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| 4 | MAP2K3, MAP2K6
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| Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.
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| Huang H, Ryu J, Ha J, Chang EJ, Kim HJ, Kim HM, Kitamura T, Lee ZH, Kim HH.
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| Cell Death Differ 13(11):1879-91. Epub 2006 Feb 24.
2006
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| 5 | MAP2K3, MAP2K6, MAPK14
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| Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.
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| Inoue T, Hammaker D, Boyle DL, Firestein GS.
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| J Immunol 174(7):4301-6.
2005
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| 6 | MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K4
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| Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.
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| Takekawa M, Tatebayashi K, Saito H.
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| Mol Cell 18(3):295-306.
2005
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| 7 | MAP2K6
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| p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts.
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| Frevel MA, Bakheet T, Silva AM, Hissong JG, Khabar KS, Williams BR.
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| Mol Cell Biol 23(2):425-36. 2003
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| 8 | MAP2K6
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| Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts.
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| Kozawa O, Hatakeyama D, Uematsu T.
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| J Cell Biochem 84(3):583-9. 2002
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| 9 | MAP2K6, SOCS3
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| The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.
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| Bode JG, Ludwig S, Freitas CA, Schaper F, Ruhl M, Melmed S, Heinrich PC, Haussinger D.
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| Biol Chem 382(10):1447-53. 2001
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| 10 | MAP2K6
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| The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells.
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| Goebeler M, et al.
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| Blood 93(3):857-65. 1999
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| 11 | ABL1, MAP2K6
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| c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation.
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| Cong F, Goff SP.
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| Proc Natl Acad Sci U S A 96(24):13819-24 1999
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| 12 | MAPK8, MAP2K6, TNF
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| Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha.
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| Roulston A, et al.
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| J Biol Chem 273(17):10232-9. 1998
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| 13 | MAP2K6, MAPK11
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| Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.
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| Enslen H, Raingeaud J, Davis RJ.
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| J Biol Chem 273(3):1741-8. 1998
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| 14 | MAP2K3, MAP2K6
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| MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
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| Raingeaud J, et al.
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| Mol Cell Biol 16(3):1247-55. 1996
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| 15 | MAP2K6
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| Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
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| Han J, et al.
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| J Biol Chem 271(6):2886-91. 1996
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| 16 | MAP2K3, MAP2K6
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| Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.
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| Cuenda A, Alonso G, Morrice N, Jones M, Meier R, Cohen P, Nebreda AR.
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| EMBO J 15(16):4156-64. 1996
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| 17 | MAP2K6
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| A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
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| Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M.
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| J Biol Chem 271(23):13675-9. 1996
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| 18 | MAP2K6
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| Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade.
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| Stein B, Brady H, Yang MX, Young DB, Barbosa MS.
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| J Biol Chem 271(19):11427-33. 1996
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