Citations for
The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.
Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD.
EMBO J 36(16):2419-2434. doi: 10.15252/embj.201797291. Epub 2017 Jun 28. 2017
Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.
Marks DH, Thomas R, Chin Y, Shah R, Khoo C, Benezra R.
Cell Rep 19(9):1832-1845. doi: 10.1016/j.celrep.2017.05.021. 2017
Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy.
Faisal I, Kauppi L.
Development 144(11):1988-1996. doi: 10.1242/dev.149492. Epub 2017 May 15. 2017
Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.
Brulotte ML, Jeong BC, Li F, Li B, Yu EB, Wu Q, Brautigam CA, Yu H, Luo X.
Nat Commun 8(1):1956. doi: 10.1038/s41467-017-02012-2. 2017
Regulation of AURORA B function by mitotic checkpoint protein MAD2.
Shandilya J, Medler KF, Roberts SG.
Cell Cycle 15(16):2196-2201. Epub 2016 Jun 24. 2016
p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.
Shin HJ, Park ER, Yun SH, Kim SH, Jung WH, Woo SR, Joo HY, Jang SH, Chung HY, Hong SH, Cho MH, Park JJ, Yun M, Lee KH.
PLoS One 10(11):e0141523. doi: 10.1371/journal.pone.0141523. eCollection 2015. 2015
DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
Lawrence KS, Chau T, Engebrecht J.
PLoS Genet 11(4):e1005150. doi: 10.1371/journal.pgen.1005150. eCollection 2015 Apr. 2015
8FAT10, MAD2L1
Disruption of FAT10-MAD2 binding inhibits tumor progression.
Theng SS, Wang W, Mah WC, Chan C, Zhuo J, Gao Y, Qin H, Lim L, Chong SS, Song J, Lee CG.
Proc Natl Acad Sci U S A 111(49):E5282-91. doi: 10.1073/pnas.1403383111. Epub 2014 Nov 24. 2014
9MAD2L1, WT1
WT1 interacts with MAD2 and regulates mitotic checkpoint function.
Shandilya J, Toska E, Richard DJ, Medler KF, Roberts SG.
Nat Commun 5:4903. doi: 10.1038/ncomms5903. 2014
10CDC20, CHEK1, MAD2L1
Chk1 is required for the metaphase-anaphase transition via regulating the expression and localization of Cdc20 and Mad2.
Yang X, Xu W, Hu Z, Zhang Y, Xu N.
Life Sci 106(1-2):12-8. doi: 10.1016/j.lfs.2014.04.011. Epub 2014 Apr 18. 2014
Phosphorylation regulates the p31Comet-mitotic arrest-deficient 2 (Mad2) interaction to promote spindle assembly checkpoint (SAC) activity.
Date DA, Burrows AC, Summers MK.
J Biol Chem 289(16):11367-73. doi: 10.1074/jbc.M113.520841. Epub 2014 Mar 4. 2014
Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis.
Schweizer N, Ferrás C, Kern DM, Logarinho E, Cheeseman IM, Maiato H.
J Cell Biol 203(6):883-93. 2013
13CDC20, MAD2L1
High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis in urothelial bladder cancer.
Choi JW, Kim Y, Lee JH, Kim YS.
Virchows Arch 463(5):681-7. doi: 10.1007/s00428-013-1473-6. Epub 2013 Aug 31. 2013
Chk1-Mad2 interaction: a crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint.
Chilà R, Celenza C, Lupi M, Damia G, Carrassa L.
Cell Cycle 12(7):1083-90. doi: 10.4161/cc.24090. Epub 2013 Mar 1. 2013
Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation.
Date DA, Burrows AC, Venere M, Jackson MW, Summers MK.
Cell Cycle 12(24):3824-32. doi: 10.4161/cc.26811. Epub 2013 Oct 15. 2013
16CDC20, MAD2L1
Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.
Izawa D, Pines J.
J Cell Biol 199(1):27-37. doi: 10.1083/jcb.201205170. Epub 2012 Sep 24. 2012
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.
Kabeche L, Compton DA.
Curr Biol 22(7):638-44. doi: 10.1016/j.cub.2012.02.030. Epub 2012 Mar 8. 2012
Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex.
Miniowitz-Shemtov S, Eytan E, Ganoth D, Sitry-Shevah D, Dumin E, Hershko A.
Proc Natl Acad Sci U S A 109(21):8056-60. doi: 10.1073/pnas.1204081109. Epub 2012 May 7. 2012
19MAD1L1, MAD2L1
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation.
Maldonado M, Kapoor TM.
Nat Cell Biol 13(4):475-82. Epub 2011 Mar 13. Erratum in: Nat Cell Biol. 2011 May;13(5):633. 2011
Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.
Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R.
Cancer Cell 19(6):701-14. doi: 10.1016/j.ccr.2011.04.017. 2011
CHFR binds to and regulates MAD2 in the spindle checkpoint through its cysteine-rich domain.
Keller JA, Petty EM.
Biochem Biophys Res Commun 409(3):389-93. Epub 2011 May 7. 2011
22BUB1, MAD2L1
Reduced expression of Mad2 and Bub1 proteins is associated with spontaneous miscarriages.
Shi Q, Hu M, Luo M, Liu Q, Jiang F, Zhang Y, Wang S, Yan C, Weng Y.
Mol Hum Reprod 17(1):14-21. Epub 2010 Jul 19. 2011
Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression.
Ma HT, Poon RY.
J Biol Chem 286(15):13052-9. Epub 2011 Feb 18. 2011
BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.
Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST.
J Biol Chem 286(24):21173-9. Epub 2011 Apr 27. 2011
25MAD2L1, SGO2
Shugoshin is a Mad1/Cdc20-like interactor of Mad2.
Orth M, Mayer B, Rehm K, Rothweiler U, Heidmann D, Holak TA, Stemmann O.
EMBO J 30(14):2868-80. doi: 10.1038/emboj.2011.187. 2011
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.
Teichner A, Eytan E, Sitry-Shevah D, Miniowitz-Shemtov S, Dumin E, Gromis J, Hershko A.
Proc Natl Acad Sci U S A 108(8):3187-92. doi: 10.1073/pnas.1100023108. Epub 2011 Feb 7. 2011
27MAD1L1, MAD2L1
Functional evaluation of missense variations in the human MAD1L1 and MAD2L1 genes and their impact on susceptibility to lung cancer.
Guo Y, Zhang X, Yang M, Miao X, Shi Y, Yao J, Tan W, Sun T, Zhao D, Yu D, Liu J, Lin D.
J Med Genet 47(9):616-22. Epub 2010 Jun 1.PMID: 20516147 2010
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.
Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H.
Proc Natl Acad Sci U S A 107(46):19772-7. Epub 2010 Nov 1. 2010
Depression of MAD2 inhibits apoptosis and increases proliferation and multidrug resistance in gastric cancer cells by regulating the activation of phosphorylated survivin.
Wang L, Yin F, Du Y, Chen B, Liang S, Zhang Y, Du W, Wu K, Ding J, Fan D.
Tumour Biol 31(3):225-32. Epub 2010 May 4. 2010
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression.
Nakaya T, Kuwahara K, Ohta K, Kitabatake M, Toda T, Takeda N, Tani T, Kondo E, Sakaguchi N.
J Immunol 185(9):5180-7. doi: 10.4049/jimmunol.1002026. 2010
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.
Sivaram MV, Wadzinski TL, Redick SD, Manna T, Doxsey SJ.
EMBO J 28(7):902-14. Epub 2009 Feb 19. 2009
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator.
Lince-Faria M, Maffini S, Orr B, Ding Y, Cláudia Florindo, Sunkel CE, Tavares A, Johansen J, Johansen KM, Maiato H.
J Cell Biol 184(5):647-57. doi: 10.1083/jcb.200811012. 2009
MAD2DeltaC induces aneuploidy and promotes anchorage-independent growth in human prostate epithelial cells.
To-Ho KW, Cheung HW, Ling MT, Wong YC, Wang X.
Oncogene 27(3):347-57. Epub 2007 Jul 9. 2008
34MAD1L1, MAD2L1, PLK1
Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).
Chi YH, Haller K, Ward MD, Semmes OJ, Li Y, Jeang KT.
J Biol Chem 283(51):35834-44. Epub 2008 Oct 15. 2008
35BUB1B, CDC20, MAD2L1
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.
Nilsson J, Yekezare M, Minshull J, Pines J.
Nat Cell Biol 10(12):1411-20. Epub 2008 Nov 9. 2008
36MAD1L1, MAD2L1
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.
Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X.
PLoS Biol 6(3):e50. 2008
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
Montembault E, Dutertre S, Prigent C, Giet R.
J Cell Biol 179(4):601-9. Epub 2007 Nov 12. 2007
Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma.
Scintu M, Vitale R, Prencipe M, Gallo AP, Bonghi L, Valori VM, Maiello E, Rinaldi M, Signori E, Rabitti C, Carella M, Dallapiccola B, Altomare V, Fazio VM, Parrella P.
Cancer Lett 254(2):298-307. Epub 2007 May 10. 2007
p31comet blocks Mad2 activation through structural mimicry.
Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X.
Cell 131(4):744-55. 2007
40MAD2L1, CDC20
A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint.
Mondal G, Baral RN, Roychoudhury S.
Biochem J 396(2):243-53. 2006
The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.
Cheslock PS, Kemp BJ, Boumil RM, Dawson DS.
Nat Genet 37(7):756-60. Epub 2005 Jun 12. 2005
Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.
Michel L, Diaz-Rodriguez E, Narayan G, Hernando E, Murty VV, Benezra R.
Proc Natl Acad Sci U S A 101(13):4459-64. Epub 2004 Mar 15. 2004
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.
Xia G, Luo X, Habu T, Rizo J, Matsumoto T, Yu H.
EMBO J 23(15):3133-43. Epub 2004 Jul 15. 2004
44MAD2L1, MAD2L2
Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells.
Wang X, Jin DY, Ng RW, Feng H, Wong YC, Cheung AL, Tsao SW.
Cancer Res 62(6):1662-8. 2002
45MAD1L1, MAD2L1
Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function.
Iwanaga Y, Kasai T, Kibler K, Jeang KT.
J Biol Chem 277(34):31005-13. Epub 2002 May 31. 2002
46MAD2L1, MAD2L2
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells.
Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R.
Nature 409(6818):355-9. 2001
47MAD1L1, MAD2L1
Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5.
Jin DY, et al.
Genomics 55(3):363-4. 1999
A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.
Liu YC, et al.
Proc Natl Acad Sci U S A 96(8):4313-8. 1999
Characterization of MAD2B and other mitotic spindle checkpoint genes.
Cahill DP, et al.
Genomics 58(2):181-7. 1999
Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers.
Imai Y, Shiratori Y, Kato N, Inoue T, Omata M.
Jpn J Cancer Res 90(8):837-40 1999
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
Nelson KK, Schlondorff J, Blobel CP.
Biochem J 343 Pt 3:673-80. 1999
Map location and gene structure of the homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27.
Krishnan R, et al.
Genomics 49 : 475-478. 1998
Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization.
Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T.
Cytogenet Cell Genet 78(1):63-4. 1997
Identification of a human mitotic checkpoint gene : hsMAD2.
Li Y, et al.
Science 274 : 246-248. 1996