1 | HORMAD1, HORMAD2, MAD2L1, MAD2L1BP, TRIP13
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| The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.
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| Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD.
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| EMBO J 36(16):2419-2434. doi: 10.15252/embj.201797291. Epub 2017 Jun 28. 2017
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2 | MAD2L1, TRIP13
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| Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.
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| Marks DH, Thomas R, Chin Y, Shah R, Khoo C, Benezra R.
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| Cell Rep 19(9):1832-1845. doi: 10.1016/j.celrep.2017.05.021.
2017
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3 | MAD2L1
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| Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy.
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| Faisal I, Kauppi L.
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| Development 144(11):1988-1996. doi: 10.1242/dev.149492. Epub 2017 May 15.
2017
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4 | MAD2L1, MAD2L1BP, TRIP13
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| Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.
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| Brulotte ML, Jeong BC, Li F, Li B, Yu EB, Wu Q, Brautigam CA, Yu H, Luo X.
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| Nat Commun 8(1):1956. doi: 10.1038/s41467-017-02012-2.
2017
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5 | AURKB, MAD1L1, MAD2L1
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| Regulation of AURORA B function by mitotic checkpoint protein MAD2.
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| Shandilya J, Medler KF, Roberts SG.
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| Cell Cycle 15(16):2196-2201. Epub 2016 Jun 24.
2016
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6 | MAD2L1, MAD2L1BP
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| p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.
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| Shin HJ, Park ER, Yun SH, Kim SH, Jung WH, Woo SR, Joo HY, Jang SH, Chung HY, Hong SH, Cho MH, Park JJ, Yun M, Lee KH.
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| PLoS One 10(11):e0141523. doi: 10.1371/journal.pone.0141523. eCollection 2015.
2015
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7 | CENPA, MAD2L1
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| DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
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| Lawrence KS, Chau T, Engebrecht J.
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| PLoS Genet 11(4):e1005150. doi: 10.1371/journal.pgen.1005150. eCollection 2015 Apr.
2015
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8 | FAT10, MAD2L1
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| Disruption of FAT10-MAD2 binding inhibits tumor progression.
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| Theng SS, Wang W, Mah WC, Chan C, Zhuo J, Gao Y, Qin H, Lim L, Chong SS, Song J, Lee CG.
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| Proc Natl Acad Sci U S A 111(49):E5282-91. doi: 10.1073/pnas.1403383111. Epub 2014 Nov 24.
2014
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9 | MAD2L1, WT1
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| WT1 interacts with MAD2 and regulates mitotic checkpoint function.
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| Shandilya J, Toska E, Richard DJ, Medler KF, Roberts SG.
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| Nat Commun 5:4903. doi: 10.1038/ncomms5903.
2014
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10 | CDC20, CHEK1, MAD2L1
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| Chk1 is required for the metaphase-anaphase transition via regulating the expression and localization of Cdc20 and Mad2.
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| Yang X, Xu W, Hu Z, Zhang Y, Xu N.
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| Life Sci 106(1-2):12-8. doi: 10.1016/j.lfs.2014.04.011. Epub 2014 Apr 18.
2014
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11 | MAD2L1, MAD2L1BP
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| Phosphorylation regulates the p31Comet-mitotic arrest-deficient 2 (Mad2) interaction to promote spindle assembly checkpoint (SAC) activity.
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| Date DA, Burrows AC, Summers MK.
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| J Biol Chem 289(16):11367-73. doi: 10.1074/jbc.M113.520841. Epub 2014 Mar 4.
2014
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12 | MAD1L1, MAD2L1, TPR
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| Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis.
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| Schweizer N, Ferrás C, Kern DM, Logarinho E, Cheeseman IM, Maiato H.
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| J Cell Biol 203(6):883-93.
2013
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13 | CDC20, MAD2L1
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| High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis in urothelial bladder cancer.
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| Choi JW, Kim Y, Lee JH, Kim YS.
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| Virchows Arch 463(5):681-7. doi: 10.1007/s00428-013-1473-6. Epub 2013 Aug 31.
2013
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14 | CHEK1, MAD2L1
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| Chk1-Mad2 interaction: a crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint.
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| Chilà R, Celenza C, Lupi M, Damia G, Carrassa L.
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| Cell Cycle 12(7):1083-90. doi: 10.4161/cc.24090. Epub 2013 Mar 1.
2013
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15 | MAD2L1, MAD2L1BP
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| Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation.
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| Date DA, Burrows AC, Venere M, Jackson MW, Summers MK.
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| Cell Cycle 12(24):3824-32. doi: 10.4161/cc.26811. Epub 2013 Oct 15.
2013
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16 | CDC20, MAD2L1
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| Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.
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| Izawa D, Pines J.
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| J Cell Biol 199(1):27-37. doi: 10.1083/jcb.201205170. Epub 2012 Sep 24.
2012
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17 | MAD2L1
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| Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.
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| Kabeche L, Compton DA.
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| Curr Biol 22(7):638-44. doi: 10.1016/j.cub.2012.02.030. Epub 2012 Mar 8.
2012
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18 | BUB1B, MAD2L1, MAD2L1BP
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| Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex.
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| Miniowitz-Shemtov S, Eytan E, Ganoth D, Sitry-Shevah D, Dumin E, Hershko A.
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| Proc Natl Acad Sci U S A 109(21):8056-60. doi: 10.1073/pnas.1204081109. Epub 2012 May 7. 2012
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19 | MAD1L1, MAD2L1
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| Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation.
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| Maldonado M, Kapoor TM.
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| Nat Cell Biol 13(4):475-82. Epub 2011 Mar 13. Erratum in: Nat Cell Biol. 2011 May;13(5):633.
2011
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20 | MAD2L1
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| Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.
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| Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R.
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| Cancer Cell 19(6):701-14. doi: 10.1016/j.ccr.2011.04.017.
2011
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21 | CHFR, MAD2L1
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| CHFR binds to and regulates MAD2 in the spindle checkpoint through its cysteine-rich domain.
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| Keller JA, Petty EM.
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| Biochem Biophys Res Commun 409(3):389-93. Epub 2011 May 7.
2011
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22 | BUB1, MAD2L1
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| Reduced expression of Mad2 and Bub1 proteins is associated with spontaneous miscarriages.
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| Shi Q, Hu M, Luo M, Liu Q, Jiang F, Zhang Y, Wang S, Yan C, Weng Y.
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| Mol Hum Reprod 17(1):14-21. Epub 2010 Jul 19.
2011
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23 | MAD2L1
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| Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression.
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| Ma HT, Poon RY.
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| J Biol Chem 286(15):13052-9. Epub 2011 Feb 18.
2011
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24 | BUB1B, MAD2L1
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| BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.
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| Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST.
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| J Biol Chem 286(24):21173-9. Epub 2011 Apr 27.
2011
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25 | MAD2L1, SGO2
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| Shugoshin is a Mad1/Cdc20-like interactor of Mad2.
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| Orth M, Mayer B, Rehm K, Rothweiler U, Heidmann D, Holak TA, Stemmann O.
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| EMBO J 30(14):2868-80. doi: 10.1038/emboj.2011.187. 2011
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26 | MAD2L1, MAD2L1BP
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| p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.
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| Teichner A, Eytan E, Sitry-Shevah D, Miniowitz-Shemtov S, Dumin E, Gromis J, Hershko A.
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| Proc Natl Acad Sci U S A 108(8):3187-92. doi: 10.1073/pnas.1100023108. Epub 2011 Feb 7.
2011
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27 | MAD1L1, MAD2L1
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| Functional evaluation of missense variations in the human MAD1L1 and MAD2L1 genes and their impact on susceptibility to lung cancer.
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| Guo Y, Zhang X, Yang M, Miao X, Shi Y, Yao J, Tan W, Sun T, Zhao D, Yu D, Liu J, Lin D.
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| J Med Genet 47(9):616-22. Epub 2010 Jun 1.PMID: 20516147 2010
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28 | MAD2L1, TSPY1
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| Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.
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| Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H.
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| Proc Natl Acad Sci U S A 107(46):19772-7. Epub 2010 Nov 1. 2010
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29 | MAD2L1
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| Depression of MAD2 inhibits apoptosis and increases proliferation and multidrug resistance in gastric cancer cells by regulating the activation of phosphorylated survivin.
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| Wang L, Yin F, Du Y, Chen B, Liang S, Zhang Y, Du W, Wu K, Ding J, Fan D.
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| Tumour Biol 31(3):225-32. Epub 2010 May 4.
2010
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30 | MAD2L1, PCID2
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| Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression.
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| Nakaya T, Kuwahara K, Ohta K, Kitabatake M, Toda T, Takeda N, Tani T, Kondo E, Sakaguchi N.
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| J Immunol 185(9):5180-7. doi: 10.4049/jimmunol.1002026.
2010
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31 | BUB1B, DYNC1LI1, MAD1L1, MAD2L1, ZW10
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| Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.
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| Sivaram MV, Wadzinski TL, Redick SD, Manna T, Doxsey SJ.
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| EMBO J 28(7):902-14. Epub 2009 Feb 19. 2009
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32 | MAD2L1, TPR
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| Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator.
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| Lince-Faria M, Maffini S, Orr B, Ding Y, Cláudia Florindo, Sunkel CE, Tavares A, Johansen J, Johansen KM, Maiato H.
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| J Cell Biol 184(5):647-57. doi: 10.1083/jcb.200811012.
2009
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33 | MAD2L1
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| MAD2DeltaC induces aneuploidy and promotes anchorage-independent growth in human prostate epithelial cells.
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| To-Ho KW, Cheung HW, Ling MT, Wong YC, Wang X.
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| Oncogene 27(3):347-57. Epub 2007 Jul 9. 2008
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34 | MAD1L1, MAD2L1, PLK1
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| Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).
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| Chi YH, Haller K, Ward MD, Semmes OJ, Li Y, Jeang KT.
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| J Biol Chem 283(51):35834-44. Epub 2008 Oct 15.
2008
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35 | BUB1B, CDC20, MAD2L1
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| The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.
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| Nilsson J, Yekezare M, Minshull J, Pines J.
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| Nat Cell Biol 10(12):1411-20. Epub 2008 Nov 9.
2008
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36 | MAD1L1, MAD2L1
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| Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.
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| Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X.
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| PLoS Biol 6(3):e50.
2008
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37 | PRPF4, MAD1L1, MAD2L1
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| PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
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| Montembault E, Dutertre S, Prigent C, Giet R.
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| J Cell Biol 179(4):601-9. Epub 2007 Nov 12. 2007
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38 | BUB1B, MAD2L1
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| Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma.
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| Scintu M, Vitale R, Prencipe M, Gallo AP, Bonghi L, Valori VM, Maiello E, Rinaldi M, Signori E, Rabitti C, Carella M, Dallapiccola B, Altomare V, Fazio VM, Parrella P.
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| Cancer Lett 254(2):298-307. Epub 2007 May 10.
2007
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39 | MAD2L1, MAD2L1BP
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| p31comet blocks Mad2 activation through structural mimicry.
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| Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X.
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| Cell 131(4):744-55.
2007
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40 | MAD2L1, CDC20
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| A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint.
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| Mondal G, Baral RN, Roychoudhury S.
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| Biochem J 396(2):243-53. 2006
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41 | MAD1L1, MAD2L1, BUB1B
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| The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.
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| Cheslock PS, Kemp BJ, Boumil RM, Dawson DS.
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| Nat Genet 37(7):756-60. Epub 2005 Jun 12. 2005
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42 | CCNB1, MAD2L1
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| Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.
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| Michel L, Diaz-Rodriguez E, Narayan G, Hernando E, Murty VV, Benezra R.
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| Proc Natl Acad Sci U S A 101(13):4459-64. Epub 2004 Mar 15. 2004
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43 | MAD2L1, MAD2L1BP
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| Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.
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| Xia G, Luo X, Habu T, Rizo J, Matsumoto T, Yu H.
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| EMBO J 23(15):3133-43. Epub 2004 Jul 15.
2004
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44 | MAD2L1, MAD2L2
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| Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells.
|
| Wang X, Jin DY, Ng RW, Feng H, Wong YC, Cheung AL, Tsao SW.
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| Cancer Res 62(6):1662-8. 2002
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45 | MAD1L1, MAD2L1
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| Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function.
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| Iwanaga Y, Kasai T, Kibler K, Jeang KT.
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| J Biol Chem 277(34):31005-13. Epub 2002 May 31. 2002
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46 | MAD2L1, MAD2L2
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| MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells.
|
| Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R.
|
| Nature 409(6818):355-9. 2001
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47 | MAD1L1, MAD2L1
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| Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5.
|
| Jin DY, et al.
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| Genomics 55(3):363-4. 1999
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48 | UBD, MAD2L1
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| A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.
|
| Liu YC, et al.
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| Proc Natl Acad Sci U S A 96(8):4313-8. 1999
|
49 | BUB1, BUB1B, BUB3, CDC20, MAD1L1, MAD2L1, MAD2L2, TTK
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| Characterization of MAD2B and other mitotic spindle checkpoint genes.
|
| Cahill DP, et al.
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| Genomics 58(2):181-7. 1999
|
50 | BUB1, KRAS, MAD2L1
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| Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers.
|
| Imai Y, Shiratori Y, Kato N, Inoue T, Omata M.
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| Jpn J Cancer Res 90(8):837-40 1999
|
51 | ADAM17, ADAM9, MAD2L1, MAD2L2
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| Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
|
| Nelson KK, Schlondorff J, Blobel CP.
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| Biochem J 343 Pt 3:673-80. 1999
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52 | MAD2L1
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| Map location and gene structure of the homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27.
|
| Krishnan R, et al.
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| Genomics 49 : 475-478. 1998
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53 | MAD2L1
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| Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization.
|
| Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T.
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| Cytogenet Cell Genet 78(1):63-4. 1997
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54 | MAD2L1
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| Identification of a human mitotic checkpoint gene : hsMAD2.
|
| Li Y, et al.
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| Science 274 : 246-248. 1996
|