| 1 | LYRM1, LYRM4, LYRM7
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| Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.
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| Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH, Rouault TA.
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| Cell Metab 19(3):445-57. doi: 10.1016/j.cmet.2014.01.015.
2014
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| 2 | HSCB, HSPA9, ISCU, LYRM4, NFS1
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| Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).
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| Cai K, Frederick RO, Kim JH, Reinen NM, Tonelli M, Markley JL.
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| J Biol Chem 288(40):28755-70. doi: 10.1074/jbc.M113.482042. Epub 2013 Aug 12. 2013
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| 3 | COXPD19, LYRM4
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| Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.
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| Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG.
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| Hum Mol Genet 22(22):4460-73. doi: 10.1093/hmg/ddt295. Epub 2013 Jun 28.
2013
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| 4 | LYRM4
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| 6p25 interstitial deletion in two dizygotic twins with gyral pattern anomaly and speech and language disorder.
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| Bozza M, Bernardini L, Novelli A, Brovedani P, Moretti E, Canapicchi R, Doccini V, Filippi T, Battaglia A.
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| Eur J Paediatr Neurol 17(3):225-31. doi: 10.1016/j.ejpn.2012.09.008. Epub 2012 Oct 12. Review.
2013
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| 5 | LYRM4, NFS1
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| The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.
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| Terali K, Beavil RL, Pickersgill RW, van der Giezen M.
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| Biochem Biophys Res Commun 440(2):235-40. doi: 10.1016/j.bbrc.2013.09.039. Epub 2013 Sep 14.
2013
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| 6 | FXN, ISCU, LYRM4, NFS1
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| Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex.
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| Tsai CL, Barondeau DP.
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| Biochemistry 49(43):9132-9.
2010
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| 7 | LYRM4, NFS1
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| Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.
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| Shi Y, Ghosh MC, Tong WH, Rouault TA.
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| Hum Mol Genet 18(16):3014-25. Epub 2009 May 18.PMID: 19454487 2009
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| 8 | LYRM4, MOCS3, NFS1
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| A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.
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| Marelja Z, Stöcklein W, Nimtz M, Leimkühler S.
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| J Biol Chem 283(37):25178-85. Epub 2008 Jul 23. 2008
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| 9 | FXN, LYRM4, FRDA, HSPA9
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| Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones.
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| Shan Y, Napoli E, Cortopassi G.
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| Hum Mol Genet 16(8):929-41. Epub 2007 Mar 1. 2007
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| 10 | LYRM4, NFS1
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| The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria.
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| Adam AC, Bornhövd C, Prokisch H, Neupert W, Hell K.
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| EMBO J 25(1):174-83. Epub 2005 Dec 8.PMID: 16341090 2006
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