| 1 | LRP6, PUM1
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| PUM1 modulates trophoblast cell proliferation and migration through LRP6.
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| Wang Y, Sun L, Wang L, Yu H, Yu X, Zou Y.
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| Biochem Cell Biol. Dec;99(6):735-740. doi: 10.1139/bcb-2021-0044. Epub 2021 Nov 4. 2021
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| 2 | LRP6, UBA2
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| Comprehensive clinical and molecular studies in split-hand/foot malformation: identification of two plausible candidate genes (LRP6 and UBA2).
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| Yamoto K, Saitsu H, Nishimura G, Kosaki R, Takayama S, Haga N, Tonoki H, Okumura A, Horii E, Okamoto N, Suzumura H, Ikegawa S, Kato F, Fujisawa Y, Nagata E, Takada S, Fukami M, Ogata T.
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| Eur J Hum Genet ur J Hum Genet. 2019 Jul 22. doi: 10.1038/s41431-019-0473-7. [Epub ahead of print]
2019
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| 3 | LRP6, NDN
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| Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
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| Hu YH, Chen Q, Lu YX, Zhang JM, Lin C, Zhang F, Zhang WJ, Li XM, Zhang W, Li XN.
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| Oncotarget 8(28):46191-46203. doi: 10.18632/oncotarget.17580.
2017
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| 4 | LRP6, S100A4
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| Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.
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| Ma J, Lu W, Chen D, Xu B, Li Y.
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| J Cell Biochem 118(9):2968-2976. doi: 10.1002/jcb.25956. Epub 2017 May 30.
2017
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| 5 | DKK4, LRP6
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| Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.
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| Sima J, Piao Y, Chen Y, Schlessinger D.
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| Development 143(24):4723-4735.
2016
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| 6 | LRP6, OLD3
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| Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.
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| Massink MP, Créton MA, Spanevello F, Fennis WM, Cune MS, Savelberg SM, Nijman IJ, Maurice MM, van den Boogaard MJ, van Haaften G.
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| Am J Hum Genet 97(4):621-6. doi: 10.1016/j.ajhg.2015.08.014. Epub 2015 Sep 17.
2015
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| 7 | LRP6, PTK7
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| PTK7 modulates Wnt signaling activity via LRP6.
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| Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D.
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| Development 141(2):410-21. doi: 10.1242/dev.095984. Epub 2013 Dec 18.
2014
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| 8 | DKK1, LRP6
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| LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.
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| Ren S, Johnson BG, Kida Y, Ip C, Davidson KC, Lin SL, Kobayashi A, Lang RA, Hadjantonakis AK, Moon RT, Duffield JS.
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| Proc Natl Acad Sci U S A 110(4):1440-5. doi: 10.1073/pnas.1211179110. Epub 2013 Jan 9.
2013
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| 9 | LRP6, PTH
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| Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH.
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| Li C, Xing Q, Yu B, Xie H, Wang W, Shi C, Crane JL, Cao X, Wan M.
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| J Bone Miner Res 28(10):2094-108. doi: 10.1002/jbmr.1962.
2013
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| 10 | FZD4, LRP5, LRP6, NDP
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| Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
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| Ke J, Harikumar KG, Erice C, Chen C, Gu X, Wang L, Parker N, Cheng Z, Xu W, Williams BO, Melcher K, Miller LJ, Xu HE.
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| Genes Dev 27(21):2305-19. doi: 10.1101/gad.228544.113.
2013
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| 11 | LRP6, TGM2
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| Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling.
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| Deasey S, Nurminsky D, Shanmugasundaram S, Lima F, Nurminskaya M.
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| Cell Signal 25(12):2646-51. doi: 10.1016/j.cellsig.2013.08.016. Epub 2013 Aug 29.
2013
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| 12 | LRP5, LRP6, MESD
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| The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.
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| Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y.
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| PLoS One 8(2):e58102. doi: 10.1371/journal.pone.0058102. Epub 2013 Feb 28.
2013
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| 13 | LDLR, LRP6
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| LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.
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| Ye ZJ, Go GW, Singh R, Liu W, Keramati AR, Mani A.
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| J Biol Chem 287(2):1335-44. doi: 10.1074/jbc.M111.295287. Epub 2011 Nov 28.
2012
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| 14 | DAB2, LRP6
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| Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.
|
| Jiang Y, He X, Howe PH.
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| EMBO J 31(10):2336-49. doi: 10.1038/emboj.2012.83. Epub 2012 Apr 10.
2012
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| 15 | FZD5, LGR5, LRP6
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| LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.
|
| Carmon KS, Lin Q, Gong X, Thomas A, Liu Q.
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| Mol Cell Biol 32(11):2054-64. doi: 10.1128/MCB.00272-12. Epub 2012 Apr 2.
2012
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| 16 | LRP6, LRRk2
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| LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
|
| Berwick DC, Harvey K.
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| Hum Mol Genet 21(22):4966-79. doi: 10.1093/hmg/dds342. Epub 2012 Aug 16.
2012
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| 17 | LRP6, PDGFRB
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| Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation.
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| Keramati AR, Singh R, Lin A, Faramarzi S, Ye ZJ, Mane S, Tellides G, Lifton RP, Mani A.
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| Proc Natl Acad Sci U S A 108(5):1914-8. Epub 2011 Jan 18.
2011
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| 18 | AMER1, LRP6
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| Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.
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| Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J.
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| EMBO J 30(8):1433-43. Epub 2011 Feb 8. 2011
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| 19 | LRP6, MEST
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| Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation.
|
| Jung H, Lee SK, Jho EH.
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| Biochem J 436(2):263-9.
2011
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| 20 | DKK1, LRP6
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| Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
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| Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W.
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| Nat Struct Mol Biol 18(11):1204-10. doi: 10.1038/nsmb.2139.
2011
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| 21 | LRP6
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| LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.
|
| Liu CC, Prior J, Piwnica-Worms D, Bu G.
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| Proc Natl Acad Sci U S A 107(11):5136-41. Epub 2010 Mar 1.
2010
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| 22 | LRP6
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| Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.
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| Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.
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| J Biol Chem 285(12):9172-9. Epub 2010 Jan 21.PMID: 20093360 2010
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| 23 | DKK1, LRP6
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| LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse.
|
| Sakane H, Yamamoto H, Kikuchi A.
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| J Cell Sci 123(Pt 3):360-8. Epub 2010 Jan 5.PMID: 20053636 2010
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| 24 | LRP6
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| Functional interactions between the LRP6 WNT co-receptor and folate supplementation.
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| Gray JD, Nakouzi G, Slowinska-Castaldo B, Dazard JE, Rao JS, Nadeau JH, Ross ME.
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| Hum Mol Genet 19(23):4560-72. Epub 2010 Sep 15.
2010
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| 25 | LRP5, LRP6, MESD
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| Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.
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| Lu W, Liu CC, Thottassery JV, Bu G, Li Y.
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| Biochemistry 49(22):4635-43. doi: 10.1021/bi1001486.
2010
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| 26 | GRK5, GRK6, LRP6
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| G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
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| Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W.
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| J Biol Chem 284(50):35040-8. Epub 2009 Oct 2.PMID: 19801552 2009
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| 27 | LRP6
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| Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.
|
| Wolf J, Palmby TR, Gavard J, Williams BO, Gutkind JS.
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| FEBS Lett 582(2):255-61. Epub 2007 Dec 18. 2008
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| 28 | LRP6, GSK3A, GSK3B, CTNNB1, AXIN1
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| LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
|
| Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.
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| Proc Natl Acad Sci U S A 105(23):8032-7. Epub 2008 May 28. 2008
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| 29 | DKK1, LRP6
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| DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.
|
| Semënov MV, Zhang X, He X.
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| J Biol Chem 283(31):21427-32. Epub 2008 May 27. 2008
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| 30 | LRP6, PIP5K1A, PIP5K1B, PIP5K1C, WNT3A
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| Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.
|
| Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D.
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| Science 321(5894):1350-3.
2008
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| 31 | CAPRIN2, LRP5, LRP6
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| Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.
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| Ding Y, Xi Y, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L.
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| J Cell Biol 182(5):865-72. Epub 2008 Sep 1.PMID: 18762581 2008
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| 32 | DKK1, LRP6, WNT3A
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| Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.
|
| Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A.
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| Dev Cell 15(1):37-48.
2008
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| 33 | FZD8, IGFBP4, LRP6
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| IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.
|
| Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I.
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| Nature 454(7202):345-9. doi: 10.1038/nature07027. Epub 2008 Jun 4.
2008
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| 34 | LRP6, CADO
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| LRP6 mutation in a family with early coronary disease and metabolic risk factors.
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| Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP.
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| Science 315(5816):1278-82. 2007
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| 35 | GRB10, LRP6
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| GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.
|
| Tezuka N, Brown AM, Yanagawa S.
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| Biochem Biophys Res Commun 356(3):648-54. Epub 2007 Mar 12. 2007
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| 36 | DKK1, KREMEN1, LRP6, RSPO1
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| R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
|
| Binnerts ME, Kim KA, Bright JM, Patel SM, Tran K, Zhou M, Leung JM, Liu Y, Lomas WE 3rd, Dixon M, Hazell SA, Wagle M, Nie WS, Tomasevic N, Williams J, Zhan X, Levy MD, Funk WD, Abo A.
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| Proc Natl Acad Sci U S A 104(37):14700-5. Epub 2007 Sep 5. 2007
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| 37 | LRP6
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| Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.
|
| Khan Z, Vijayakumar S, de la Torre TV, Rotolo S, Bafico A.
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| Mol Cell Biol 27(20):7291-301. Epub 2007 Aug 13.PMID: 17698587 2007
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| 38 | DVL1, LRP6
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| Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.
|
| Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, Niehrs C.
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| Science 316(5831):1619-22.PMID: 17569865 2007
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| 39 | LRP6
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| The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
|
| Wei W, Lu Q, Chaudry GJ, Leppla SH, Cohen SN.
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| Cell 124(6):1141-54. 2006
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| 40 | LRP6,MESDC2
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| Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.
|
| Li Y, Lu W, He X, Bu G.
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| FEBS Lett 580(22):5423-8. Epub 2006 Sep 18. 2006
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| 41 | LRP6, MESD
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| Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.
|
| Li Y, Lu W, He X, Bu G.
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| FEBS Lett 580(22):5423-8. Epub 2006 Sep 18.
2006
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| 42 | CSNK1G1, LRP6
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| Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.
|
| Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C.
|
| Nature 438(7069):867-72. 2005
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| 43 | LRP5, LRP6, SOST
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| SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.
|
| Semenov M, Tamai K, He X.
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| J Biol Chem 280(29):26770-5. Epub 2005 May 20. 2005
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| 44 | LRP6
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| A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.
|
| Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X.
|
| Nature 438(7069):873-7. 2005
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| 45 | LRP6, MESD
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| Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.
|
| Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G.
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| J Cell Sci 118(Pt 22):5305-14. Epub 2005 Nov 1.
2005
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| 46 | LRP6
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| LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution.
|
| Li Y, Lu W, He X, Schwartz AL, Bu G.
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| Oncogene 23(56):9129-35. 2004
|
| 47 | HBM1, LRP5, LRP6, OPPG, HVB2, OPTA1
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| Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.
|
| Van Wesenbeeck L, Cleiren E, Gram J, Beals RK, Benichou O, Scopelliti D, Key L, Renton T, Bartels C, Gong Y, Warman ML, De Vernejoul MC, Bollerslev J, Van Hul W.
|
| Am J Hum Genet 72(3):763-71. 2003
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| 48 | LRP6
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| A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.
|
| Liu G, Bafico A, Harris VK, Aaronson SA.
|
| Mol Cell Biol 23(16):5825-35. 2003
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| 49 | DKK2, LRP6
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| Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.
|
| Li L, Mao J, Sun L, Liu W, Wu D.
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| J Biol Chem 277(8):5977-81. 2002
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| 50 | DKK1, DKK2, DKK3, LRP6
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| LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
|
| Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C.
|
| Nature 411(6835):321-5. 2001
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| 51 | LRP6
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| Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
|
| Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X.
|
| Curr Biol 11(12):951-61. 2001
|
| 52 | LRP5, LRP6
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| arrow encodes an LDL-receptor-related protein essential for Wingless signalling.
|
| Wehrli M, Dougan ST, Caldwell K, O'Keefe L, Schwartz S, Vaizel-Ohayon D, Schejter E, Tomlinson A, DiNardo S.
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| Nature 407(6803):527-30. 2000
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| 53 | LRP6
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| LDL-receptor-related proteins in Wnt signal transduction.
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| Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X.
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| Nature 407(6803):530-5. 2000
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| 54 | LRP6
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| An LDL-receptor-related protein mediates Wnt signalling in mice.
|
| Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC.
|
| Nature 407(6803):535-8. 2000
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| 55 | CDKN1B, AP3S1P, ETV6, LRP6
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| A physical, transcript, and deletion map of chromosome region 12p12. 3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p).
|
| Baens M, et al.
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| Genomics 56(1):40-50. 1999
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| 56 | LRP6
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| Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
|
| Brown SD, et al.
|
| Biochem Biophys Res Commun 248(3):879-88. 1998
|