Citations for
Association Analysis of the Cubilin (CUBN) and Megalin (LRP2) Genes with ESRD in African Americans.
Ma J, Guan M, Bowden DW, Ng MC, Hicks PJ, Lea JP, Ma L, Gao C, Palmer ND, Freedman BI.
Clin J Am Soc Nephrol 11(6):1034-43. doi: 10.2215/CJN.12971215. Epub 2016 May 19. 2016
Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway.
Gil SY, Youn BS, Byun K, Huang H, Namkoong C, Jang PG, Lee JY, Jo YH, Kang GM, Kim HK, Shin MS, Pietrzik CU, Lee B, Kim YB, Kim MS.
Nat Commun 4:1862. doi: 10.1038/ncomms2896. Erratum in: Nat Commun. 2013;4:2912. 2013
Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.
Burke KA, Jauniaux E, Burton GJ, Cindrova-Davies T.
Placenta 34(11):1105-9. doi: 10.1016/j.placenta.2013.08.003. Epub 2013 Aug 23. 2013
Scan-Statistic Approach Identifies Clusters of Rare Disease Variants in LRP2, a Gene Linked and Associated with Autism Spectrum Disorders, in Three Datasets.
Ionita-Laza I, Makarov V; the ARRA Autism Sequencing Consortium, Buxbaum JD.
Am J Hum Genet 90(6):1002-1013. Epub 2012 May 10. 2012
Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells.
Takeyama A, Sato H, Soma-Nagae T, Kabasawa H, Suzuki A, Yamamoto-Kabasawa K, Hosojima M, Kaneko R, Higuchi F, Kaseda R, Ogasawara S, Narita I, Saito A.
Biochem Biophys Res Commun 407(1):108-12. Epub 2011 Feb 28. 2011
Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin.
Slattery C, Jenkin KA, Lee A, Simcocks AC, McAinch AJ, Poronnik P, Hryciw DH.
Cell Physiol Biochem 27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11. 2011
Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration.
Wunderlich KA, Leveillard T, Penkowa M, Zrenner E, Perez MT.
Invest Ophthalmol Vis Sci 51(9):4809-20. Epub 2010 Mar 31. 2010
Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain.
Chiu-Ugalde J, Theilig F, Behrends T, Drebes J, Sieland C, Subbarayal P, Köhrle J, Hammes A, Schomburg L, Schweizer U.
Biochem J 431(1):103-11. 2010
Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.
Alvira-Botero X, Pérez-Gonzalez R, Spuch C, Vargas T, Antequera D, Garzón M, Bermejo-Pareja F, Carro E.
Mol Cell Neurosci 45(3):306-15. Epub 2010 Jul 14. 2010
Cubilin and megalin co-localize in the neonatal inner ear.
Tauris J, Christensen EI, Nykjaer A, Jacobsen C, Petersen CM, Ovesen T.
Audiol Neurootol 14(4):267-78. Epub 2009 Feb 6. 2009
11DAB2, LRP2, MYH9
Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells.
Hosaka K, Takeda T, Iino N, Hosojima M, Sato H, Kaseda R, Yamamoto K, Kobayashi A, Gejyo F, Saito A.
Kidney Int 75(12):1308-15. Epub 2009 Apr 1. 2009
Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.
Olson GE, Winfrey VP, Hill KE, Burk RF.
J Biol Chem 283(11):6854-60. Epub 2008 Jan 3. 2008
Donnai-Barrow syndrome (DBS/FOAR) in a child with a homozygous LRP2 mutation due to complete chromosome 2 paternal isodisomy.
Kantarci S, Ragge NK, Thomas NS, Robinson DO, Noonan KM, Russell MK, Donnai D, Raymond FL, Walsh CA, Donahoe PK, Pober BR.
Am J Med Genet A 146A(14):1842-7. 2008
Genetic aspects of human congenital diaphragmatic hernia.
Pober BR.
Clin Genet 74(1):1-15. Epub 2008 May 28. 2008
15LCN2, LRP2, SLC22A17
Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells.
Miharada K, Hiroyama T, Sudo K, Danjo I, Nagasawa T, Nakamura Y.
J Cell Physiol 215(2):526-37. 2008
Megalin and cubilin in the human gallbladder epithelium.
Tsaroucha AK, Chatzaki E, Lambropoulou M, Despoudi K, Laftsidis P, Charsou C, Polychronidis A, Papadopoulos N, Simopoulos CE.
Clin Exp Med 8(3):165-70. Epub 2008 Sep 13. 2008
Megalin is a receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid.
Bento-Abreu A, Velasco A, Polo-Hernández E, Pérez-Reyes PL, Tabernero A, Medina JM.
J Neurochem 106(3):1149-59. Epub 2008 May 5. 2008
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes.
Kantarci S, Al-Gazali L, Hill RS, Donnai D, Black GC, Bieth E, Chassaing N, Lacombe D, Devriendt K, Teebi A, Loscertales M, Robson C, Liu T, MacLaughlin DT, Noonan KM, Russell MK, Walsh CA, Donahoe PK, Pober BR.
Nat Genet 39(8):957-9. Epub 2007 Jul 15. 2007
Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.
Naccache SN, Hasson T, Horowitz A.
Proc Natl Acad Sci U S A 103(34):12735-40. Epub 2006 Aug 14. 2006
20LRP2, AKT1
PKB and megalin determine the survival or death of renal proximal tubule cells.
Caruso-Neves C, Pinheiro AA, Cai H, Souza-Menezes J, Guggino WB.
Proc Natl Acad Sci U S A 103(49):18810-5. Epub 2006 Nov 22. 2006
The role of megalin (LRP-2/Gp330) during development.
Fisher CE, Howie SE.
Dev Biol 296(2):279-97. Epub 2006 Jun 8. Review. 2006
Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis.
Saito A, Takeda T, Hama H, Oyama Y, Hosaka K, Tanuma A, Kaseda R, Ueno M, Nishi S, Ogasawara S, Gondaira F, Suzuki Y, Gejyo F.
Nephrology (Carlton) 10 Suppl:S26-31. Review. 2005
Megalin binds and mediates cellular internalization of folate binding protein.
Birn H, Zhai X, Holm J, Hansen SI, Jacobsen C, Christensen EI, Moestrup SK.
FEBS J 272(17):4423-30. 2005
24DLG4, LRP2, PSD95
Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.
Larsson M, Hjalm G, Sakwe AM, Engstrom A, Hoglund AS, Larsson E, Robinson RC, Sundberg C, Rask L.
Biochem J 373(Pt 2):381-91. 2003
The adaptor protein ARH escorts megalin to and through endosomes.
Nagai M, Meerloo T, Takeda T, Farquhar MG.
Mol Biol Cell 14(12):4984-96. Epub 2003 Oct 3. 2003
Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases.
Ooka S, Matsui T, Nishioka K, Kato T.
Arthritis Res Ther 5(3):R174-80. Epub 2003 Apr 4. 2003
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.
Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE.
J Cell Sci 116(Pt 3):453-61. 2003
Megalin functions as an endocytic sonic hedgehog receptor.
McCarthy RA, Barth JL, Chintalapudi MR, Knaak C, Argraves WS.
J Biol Chem 277(28):25660-7. Epub 2002 Apr 18. 2002
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Nykjaer A, Fyfe JC, Kozyraki R, Leheste JR, Jacobsen C, Nielsen MS, Verroust PJ, Aminoff M, de la Chapelle A, Moestrup SK, Ray R, Gliemann J, Willnow TE, Christensen EI.
Proc Natl Acad Sci U S A 98(24):13895-900. 2001
Megalin antagonizes activation of the parathyroid hormone receptor.
Hilpert J, et al.
J Biol Chem 274(9):5620-5. 1999
Identification of low density lipoprotein receptor-related protein-2/megalin as an endocytic receptor for seminal vesicle secretory protein II.
Ranganathan S, et al.
J Biol Chem 274(9):5557-63. 1999
Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.
Niemeier A, et al.
Arterioscler Thromb Vasc Biol 19(3):552-61. 1999
Megalin knockout mice as an animal model of low molecular weight proteinuria.
Leheste JR, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, Aucouturier P, Moskaug JO, Otto A, Christensen EI, Willnow TE.
Am J Pathol 155(4):1361-70. 1999
34CYP27B1, LRP2
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI, Willnow TE.
Cell 96(4):507-15. 1999
Evidence for an essential role of megalin in transepithelial transport of retinol.
Christensen EI, Moskaug JO, Vorum H, Jacobsen C, Gundersen TE, Nykjaer A, Blomhoff R, Willnow TE, Moestrup SK.
J Am Soc Nephrol 10(4):685-95. 1999
Characterization of the human megalin/LRP-2 promoter in vitro and in primary parathyroid cells.
Knutson A, et al.
DNA Cell Biol 17 : 551-560. 1998
The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.
Moestrup SK, Kozyraki R, Kristiansen M, Kaysen JH, Rasmussen HH, Brault D, Pontillon F, Goda FO, Christensen EI, Hammond TG, Verroust PJ.
J Biol Chem 273(9):5235-42. 1998
Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.
Birn H, Verroust PJ, Nexo E, Hager H, Jacobsen C, Christensen EI, Moestrup SK.
J Biol Chem 272(42):26497-504. 1997
Mapping rat megalin : the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis.
Saito A, et al.
Proc Natl Acad Sci U S A 93 : 8601-8605. 1996
Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.
Moestrup SK, et al.
Proc Natl Acad Sci U S A 93 : 8612-8617. 1996
Cloning and sequencing of human gp330, a Ca2+-binding receptor with potential intracellular signaling properties.
HjŠlm G, et al.
Eur J Biochem 239 : 132-137. 1996
Defective forebrain development in mice lacking gp330/megalin.
Willnow TE, et al.
Proc Natl Acad Sci U S A 93 : 8460-8464. 1996
In situ hybridization mapping of a 500-kDa calcium-sensing protein gene (LRP2) to human chromosome region 2q31->q32.1 and porcine chromosome region 15q22->q24.
Chowdhary BP, et al.
Cytogenet Cell Genet 71 : 120-123. 1995
The unfolding story of megalin (gp330): now recognized as a drug receptor.
Farquhar MG.
J Clin Invest 96(3):1184. Review. No abstract available. 1995
Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1).
Korenberg JR, et al.
Genomics 22 : 88-93. 1994