| 1 | LRP1, PID1, SLC2A4
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| PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.
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| Fischer AW, Albers K, Schlein C, Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J
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| Biochim Biophys Acta Mol Basis Dis. Jun 1;1865(6):1592-1603. doi: 10.1016/j.bbadis.2019.03.010. Epub 2019 Mar 21. 2019
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| 2 | LRP1, PID1
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| The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins
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| Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J.
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| Mol Metab. Oct;16:88-99. doi: 10.1016/j.molmet.2018.07.010. Epub 2018 Jul 30. 2018
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| 3 | LRP1, ULK4
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| Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections.
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| Guo DC, Grove ML, Prakash SK, Eriksson P, Hostetler EM, LeMaire SA, Body SC, Shalhub S, Estrera AL, Safi HJ, Regalado ES, Zhou W, Mathis MR; GenTAC Investigators; BAVCon Investigators, Eagle KA, Yang B, Willer CJ, Boerwinkle E, Milewicz DM.
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| Am J Hum Genet 99(3):762-9. doi: 10.1016/j.ajhg.2016.06.034. Epub 2016 Aug 25.
2016
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| 4 | F8, LRP1
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| Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.
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| van den Biggelaar M, Madsen JJ, Faber JH, Zuurveld MG, van der Zwaan C, Olsen OH, Stennicke HR, Mertens K, Meijer AB.
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| J Biol Chem 290(27):16463-76. doi: 10.1074/jbc.M115.650911.
2015
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| 5 | F8, LRP1
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| Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII.
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| Kurasawa JH, Shestopal SA, Woodle SA, Ovanesov MV, Lee TK, Sarafanov AG.
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| Biochemistry 54(2):481-9. doi: 10.1021/bi5011688.
2015
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| 6 | CTSS, LRP1
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| Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S.
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| Samouillan V, Revuelta-López E, Dandurand J, Nasarre L, Badimon L, Lacabanne C, Llorente-Cortés V.
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| Int J Biochem Cell Biol 55:209-19. doi: 10.1016/j.biocel.2014.09.005. Epub 2014 Sep 16.
2014
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| 7 | LRP1
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| LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
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| Mantuano E, Lam MS, Gonias SL.
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| J Biol Chem 288(47):34009-18. doi: 10.1074/jbc.M113.509133. Epub 2013 Oct 15.
2013
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| 8 | LRP1
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| A pilot study on low-density lipoprotein receptor-related protein-1 in Chinese patients with abdominal aortic aneurysm.
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| Chan CY, Chan YC, Cheuk BL, Cheng SW.
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| Eur J Vasc Endovasc Surg 46(5):549-56. doi: 10.1016/j.ejvs.2013.08.006. Epub 2013 Aug 23.
2013
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| 9 | LDLR, LRP1, PCSK9
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| Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1).
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| Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG.
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| PLoS One 8(5):e64145. doi: 10.1371/journal.pone.0064145. Print 2013.
2013
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| 10 | CHFR, LRP1
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| Aggregated low-density lipoprotein induces LRP1 stabilization through E3 ubiquitin ligase CHFR downregulation in human vascular smooth muscle cells.
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| Cal R, García-Arguinzonis M, Revuelta-López E, Castellano J, Padró T, Badimon L, Llorente-Cortés V.
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| Arterioscler Thromb Vasc Biol 33(2):369-77. doi: 10.1161/ATVBAHA.112.300748. Epub 2012 Dec 13.
2013
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| 11 | APBB1, APP, GULP1, LRP1
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| Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
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| Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA.
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| Biochem J 450(2):333-43. doi: 10.1042/BJ20121100.
2013
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| 12 | ADAMTS5, LRP1
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| LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
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| Yamamoto K, Troeberg L, Scilabra SD, Pelosi M, Murphy CL, Strickland DK, Nagase H.
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| FASEB J 27(2):511-21. doi: 10.1096/fj.12-216671. Epub 2012 Oct 11.
2013
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| 13 | LRP1, TIMP3
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| Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
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| Scilabra SD, Troeberg L, Yamamoto K, Emonard H, Thøgersen I, Enghild JJ, Strickland DK, Nagase H.
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| J Biol Chem 288(1):332-42. doi: 10.1074/jbc.M112.393322. Epub 2012 Nov 19.
2013
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| 14 | LRP1, NTRK3
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| Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration.
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| Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S, Tuszynski MH, Campana WM.
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| J Biol Chem 288(37):26557-68. doi: 10.1074/jbc.M113.478552. Epub 2013 Jul 18.
2013
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| 15 | LRP1, MAG
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| LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
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| Mantuano E, Lam MS, Gonias SL.
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| J Biol Chem 288(47):34009-18. doi: 10.1074/jbc.M113.509133. Epub 2013 Oct 15.
2013
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| 16 | HTRA1, LRP1
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| LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1.
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| Muratoglu SC, Belgrave S, Hampton B, Migliorini M, Coksaygan T, Chen L, Mikhailenko I, Strickland DK.
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| Arterioscler Thromb Vasc Biol 33(9):2137-46. doi: 10.1161/ATVBAHA.113.301893. Epub 2013 Jul 18.
2013
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| 17 | LRP1
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| Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes
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| Nakajima C, Kulik A, Frotscher M, Herz J, Schäfer M, Bock HH, May P.
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| J Biol Chem. Jul 26;288(30):21909-23. doi: 10.1074/jbc.M112.444364. Epub 2013 Jun 11. 2013
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| 18 | LRP1
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| Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids.
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| Nilsson A, Vesterlund L, Oldenborg PA.
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| Biochem Biophys Res Commun 417(4):1304-9. doi: 10.1016/j.bbrc.2011.12.137. Epub 2012 Jan 3.
2012
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| 19 | CD44, LRP1
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| LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.
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| Perrot G, Langlois B, Devy J, Jeanne A, Verzeaux L, Almagro S, Sartelet H, Hachet C, Schneider C, Sick E, David M, Khrestchatisky M, Emonard H, Martiny L, Dedieu S.
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| Mol Cell Biol 32(16):3293-307. doi: 10.1128/MCB.00228-12. Epub 2012 Jun 18.
2012
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| 20 | CTGF, LRP1
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| Role of LRP1 in transport of CCN2 protein in chondrocytes.
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| Kawata K, Kubota S, Eguchi T, Aoyama E, Moritani NH, Kondo S, Nishida T, Takigawa M.
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| J Cell Sci 125(Pt 12):2965-72. doi: 10.1242/jcs.101956. Epub 2012 Mar 27.
2012
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| 21 | LRP1
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| Low density lipoprotein receptor-related protein 1 modulates the proliferation and migration of human hepatic stellate cells.
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| Llorente-Cortes V, Barbarigo V, Badimon L.
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| J Cell Physiol 227(10):3528-33. doi: 10.1002/jcp.24080.
2012
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| 22 | CTSD, LRP1
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| Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.
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| Derocq D, Prébois C, Beaujouin M, Laurent-Matha V, Pattingre S, Smith GK, Liaudet-Coopman E.
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| Oncogene 31(26):3202-12. doi: 10.1038/onc.2011.501. Epub 2011 Nov 14.
2012
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| 23 | LRP1
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| Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
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| Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA, Bradley DT, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJ, Futers S, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JA, Wijmenga C, de Graaf J, Kiemeney LA, Assimes TL, McPherson R; CARDIoGRAM Consortium; Global BPgen Consortium; DIAGRAM Consortium; VRCNZ Consortium, Folkersen L, Franco-Cereceda A, Palmen J, Smith AJ, Sylvius N, Wild JB, Refstrup M, Edkins S, Gwilliam R, Hunt SE, Potter S, Lindholt JS, Frikke-Schmidt R, Tybjærg-Hansen A, Hughes AE, Golledge J, Norman PE, van Rij A, Powell JT, Eriksson P, Stefansson K, Thompson JR, Humphries SE, Sayers RD, Deloukas P, Samani NJ.
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| Am J Hum Genet 89(5):619-27. Epub 2011 Nov 4.
2011
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| 24 | APBB1, APP, LRP1
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| Phosphorylation of LRP1 regulates the interaction with Fe65.
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| Klug W, Dietl A, Simon B, Sinning I, Wild K.
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| FEBS Lett 585(20):3229-35. doi: 10.1016/j.febslet.2011.09.028. Epub 2011 Sep 29.
2011
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| 25 | LRP1, THBS2
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| Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.
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| Meng H, Zhang X, Lee SJ, Strickland DK, Lawrence DA, Wang MM.
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| J Biol Chem 285(30):23047-55. doi: 10.1074/jbc.M110.144634. Epub 2010 May 14.
2010
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| 26 | BACE1, LRP1
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| The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.
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| von Einem B, Schwanzar D, Rehn F, Beyer AS, Weber P, Wagner M, Schneckenburger H, von Arnim CA.
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| Exp Neurol 225(1):85-93. doi: 10.1016/j.expneurol.2010.05.017. Epub 2010 May 26.
2010
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| 27 | LRP1
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| LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.
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| Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, Zurhove K, Haffner P, Philippe C, Woldt E, Matz RL, Gracia C, Metzger D, Auwerx J, Herz J, Boucher P.
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| J Biol Chem 284(1):381-8. Epub 2008 Nov 6.
2009
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| 28 | LRP1
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| Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain.
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| Betts GN, van der Geer P, Komives EA.
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| J Biol Chem 283(23):15656-64. Epub 2008 Apr 1.
2008
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| 29 | LRP1
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| A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes.
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| Bouchard BA, Meisler NT, Nesheim ME, Liu CX, Strickland DK, Tracy PB.
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| J Thromb Haemost 6(4):638-44. Epub 2008 Jan 9.
2008
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| 30 | LRP1
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| Mutational analysis of the FXNPXY motif within LDL receptor-related protein 1 (LRP1) reveals the functional importance of the tyrosine residues in cell growth regulation and signal transduction.
|
| Zhang H, Lee JM, Wang Y, Dong L, Ko KW, Pelletier L, Yao Z.
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| Biochem J 409(1):53-64.PMID: 17908054 2008
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| 31 | LRP1
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| LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein.
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| Parkyn CJ, Vermeulen EG, Mootoosamy RC, Sunyach C, Jacobsen C, Oxvig C, Moestrup S, Liu Q, Bu G, Jen A, Morris RJ.
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| J Cell Sci 121(Pt 6):773-83. Epub 2008 Feb 19.PMID: 18285446 2008
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| 32 | LRP1
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| The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development.
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| Montel V, Gaultier A, Lester RD, Campana WM, Gonias SL.
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| Cancer Res 67(20):9817-24.
2007
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| 33 | LRP1, SNX17
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| Sorting nexin 17 facilitates LRP recycling in the early endosome.
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| van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G.
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| EMBO J 24(16):2851-61. Epub 2005 Jul 28.
2005
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| 34 | LRP1
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| Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors.
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| Hollborn M, Birkenmeier G, Saalbach A, Iandiev I, Reichenbach A, Wiedemann P, Kohen L.
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| Invest Ophthalmol Vis Sci 45(6):2033-8. 2004
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| 35 | LRP1
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| Genetic and functional characteristics of the human in vivo LRP1/A2MR receptor suggested as a risk marker for Alzheimer's disease and other complex (degenerative) diseases.
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| Glaser C, Schulz S, Handschug K, Huse K, Birkenmeier G.
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| Neurosci Res 50(1):85-101. 2004
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| 36 | LRP1, FZD1
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| The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.
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| Zilberberg A, Yaniv A, Gazit A.
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| J Biol Chem 279(17):17535-42. Epub 2004 Jan 21. 2004
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| 37 | LRP1, MAFB
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| Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.
|
| Petersen HH, Hilpert J, Jacobsen C, Lauwers A, Roebroek AJ, Willnow TE.
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| FEBS Lett 565(1-3):23-7.
2004
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| 38 | FN1, LRP1
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| The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.
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| Salicioni AM, Mizelle KS, Loukinova E, Mikhailenko I, Strickland DK, Gonias SL.
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| J Biol Chem 277(18):16160-6. 2002
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| 39 | APP, LRP1
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| Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.
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| Mettenburg JM, Webb DJ, Gonias SL.
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| J Biol Chem 277(15):13338-45. 2002
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| 40 | LRP1
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| Phosphorylation of LRP1: regulation of transport and signal transduction.
|
| van der Geer P.
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| Trends Cardiovasc Med 12(4):160-5. Review. 2002
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| 41 | AD5, LRP1
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| Use of haplotype information to test involvement of the LRP gene in Alzheimer's disease in the French population.
|
| Verpillat P, Bouley S, Campion D, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Agid Y, Brice A, Clerget-Darpoux F.
|
| Eur J Hum Genet 9(6):464-8. 2001
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| 42 | A2M, AD5, LRP1
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| Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity.
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| Scott WK, Grubber JM, Conneally PM, Small GW, Hulette CM, Rosenberg CK, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA.
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| Am J Hum Genet 66(3):922-32. 2000
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| 43 | LRP1
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| The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.
|
| Beffert U, et al.
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| Neurosci Lett 259(1):29-32. 1999
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| 44 | LRP1
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| Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.
|
| Wavrant-DeVrieze F, et al.
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| Hum Genet 104(5):432-4. 1999
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| 45 | LRP1
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| Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): is LRP central to Alzheimer's disease pathogenesis?
|
| Van Uden E, Carlson G, St George-Hyslop P, Westaway D, Orlando R, Mallory M, Rockenstein E, Masliah E.
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| Mol Cell Neurosci 14(2):129-40 1999
|
| 46 | LRP1
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| Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein : identification of one expressed mutation among 48 polymorphisms.
|
| Van Leuven F, et al.
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| Genomics 52 : 138-144. 1998
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| 47 | LRP1
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| LDL receptor-related protein : a multiligand receptor for lipoprotein and proteinase catabolism.
|
| Strickland DK, et al.
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| FASEB J 9 : 890-898. 1995
|
| 48 | LRP1
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| Tetranucleotide length polymorphism 5' of the alpha2-macroglobulin receptor (A2MR)/LDL receptor-related protein (LRP) gene.
|
| Zuliani G, et al.
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| Hum Mol Genet 3 : 215. 1994
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| 49 | LRP1
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| Structure of the gene (LRP1) coding for the human alpha2-macroglobulin receptor lipoprotein receptor-related protein.
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| Van Leuven F, et al.
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| Genomics 24 : 78-89. 1994
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| 50 | LRP1
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| A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans.
|
| Yochem J, Greenwald I.
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| Proc Natl Acad Sci U S A 90(10):4572-6.
1993
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| 51 | LRP1, GLI1
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| Assignment of the gene coding for the alpha2-macroglobulin receptor to mouse chromosome 15 and to human chromosome 12q13-q14 by isotopic and nonisotopic in situ hybridization.
|
| Hilliker C, et al.
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| Genomics 13 : 472-474. 1992
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| 52 | LRP1
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| Putative apolipoprotein receptor gene (LRP,A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14.
|
| Paulien S, et al.
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| Cancer Genet Cytogenet 60 : 125-130. 1992
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| 53 | GLI1, LRP1
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| A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci.
|
| Forus A, et al.
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| Genomics 14 : 117-120. 1992
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| 54 | LRP1
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| Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor.
|
| Orth K, et al.
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| Proc Natl Acad Sci U S A 89 : 7422-7426. 1992
|
| 55 | LRP1, GLI1
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| The genes for the alpha-2-macroglobulin receptor/LDL, receptor-related protein and GLI are located within a chromosomal segment of about 300 kilobases and are coamplified in a rhabdomyosarcoma cell line.
|
| Forus A, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1977. 1991
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| 56 | LRP1
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| Sequence identity between the alpha-2-macroglobulin receptor low density lipoprotein receptor related protein suggests that this molecule is a multifunctional receptor.
|
| Strickland DK, et al.
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| J Biol Chem 265 : 401-404. 1990
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| 57 | LRP1
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| Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha-2-macroglobulin receptor.
|
| Kristensen T, et al.
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| FEBS Lett 276 : 151-155. 1990
|
| 58 | LRP1
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| The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.
|
| Myklebost O, et al.
|
| Genomics 5 : 65-69. 1989
|