| 1 | LRIG1
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| LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.
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| Li Q, Liu B, Chao HP, Ji Y, Lu Y, Mehmood R, Jeter C, Chen T, Moore JR, Li W, Liu C, Rycaj K, Tracz A, Kirk J, Calhoun-Davis T, Xiong J, Deng Q, Huang J, Foster BA, Gokhale A, Chen X, Tang DG.
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| Nat Commun 10(1):5494. doi: 10.1038/s41467-019-13532-4.
2019
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| 2 | LRIG1
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| LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial-mesenchymal transition.
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| Li W, Zhou Y.
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| Biosci Rep 39(1). pii: BSR20181165. doi: 10.1042/BSR20181165. Print 2019 Jan 31.
2019
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| 3 | LRIG1
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| A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors.
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| Faraz M, Herdenberg C, Holmlund C, Henriksson R, Hedman H.
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| J Biol Chem 293(9):3421-3435. doi: 10.1074/jbc.M117.807487. Epub 2018 Jan 9.
2018
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| 4 | LRIG1
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| LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer.
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| Lindquist D, Alsina FC, Herdenberg C, Larsson C, Höppener J, Wang N, Paratcha G, Tarján M, Tot T, Henriksson R, Hedman H.
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| Int J Oncol 52(4):1189-1197. doi: 10.3892/ijo.2018.4273. Epub 2018 Feb 9.
2018
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| 5 | LRIG1, LRIG2, LRIG3
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| LRIG proteins in glioma: Functional roles, molecular mechanisms, and potential clinical implications.
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| Mao F, Wang B, Xiao Q, Cheng F, Lei T, Guo D.
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| J Neurol Sci 383:56-60. doi: 10.1016/j.jns.2017.10.025. Epub 2017 Oct 18. Review.
2017
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| 6 | BDNF, LRIG1, NTRK2
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| Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling.
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| Alsina FC, Hita FJ, Fontanet PA, Irala D, Hedman H, Ledda F, Paratcha G.
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| EMBO Rep 17(4):601-16. doi: 10.15252/embr.201541218. Epub 2016 Mar 2.
2016
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| 7 | LRIG1
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| LRIG1 expression during homeostasis and skin wound healing in mice.
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| Murad S, Anwar A, Piracha ZZ, Sultan A.
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| J Biol Regul Homeost Agents 29(4):829-33.
2015
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| 8 | LRIG1
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| LRIG1 is a prognostic biomarker in non-small cell lung cancer.
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| Kvarnbrink S, Karlsson T, Edlund K, Botling J, Lindquist D, Jirström K, Micke P, Henriksson R, Johansson M, Hedman H.
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| Acta Oncol 54(8):1113-9. doi: 10.3109/0284186X.2015.1021427. Epub 2015 Mar 27.
2015
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| 9 | LRIG1, MET, USP8
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| USP8 modulates ubiquitination of LRIG1 for Met degradation.
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| Oh YM, Lee SB, Choi J, Suh HY, Shim S, Song YJ, Kim B, Lee JM, Oh SJ, Jeong Y, Cheong KH, Song PH, Kim KA.
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| Sci Rep 4:4980. doi: 10.1038/srep04980.
2014
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| 10 | LRIG1
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| LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.
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| Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood NJ, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S.
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| J Clin Invest 124(1):385-97. doi: 10.1172/JCI71488. Epub 2013 Dec 9.
2014
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| 11 | LRIG1, LRIG2, LRIG3
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| Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma.
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| Muller S, Lindquist D, Kanter L, Flores-Staino C, Henriksson R, Hedman H, Andersson S.
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| Int J Oncol 42(1):247-52. doi: 10.3892/ijo.2012.1702. Epub 2012 Nov 16.
2013
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| 12 | LRIG1, LRIG2, LRIG3
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| In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
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| Del Rio T, Nishitani AM, Yu WM, Goodrich LV.
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| PLoS Genet 9(9):e1003824. doi: 10.1371/journal.pgen.1003824. Epub 2013 Sep 26.
2013
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| 13 | LRIG1, LRIG2
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| Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression.
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| Ghasimi S, Haapasalo H, Eray M, Korhonen K, Brännström T, Hedman H, Andersson U.
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| J Neurooncol 108(3):435-41. doi: 10.1007/s11060-012-0856-x. Epub 2012 Apr 8.
2012
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| 14 | LRIG1, LRIG2
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| LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous cell carcinoma of the uterine cervix.
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| Hedman H, Lindström AK, Tot T, Stendahl U, Henriksson R, Hellberg D.
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| Acta Oncol 49(6):812-5. doi: 10.3109/0284186X.2010.492789.
2010
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| 15 | LRIG1
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| Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity.
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| Ye F, Gao Q, Xu T, Zeng L, Ou Y, Mao F, Wang H, He Y, Wang B, Yang Z, Guo D, Lei T.
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| J Neurooncol 94(2):183-94. Epub 2009 Mar 20.PMID: 19300910 2009
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| 16 | LRIG1
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| Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF.
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| Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G.
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| J Neurosci 28(1):39-49.PMID: 18171921 2008
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| 17 | LRIG1
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| LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII.
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| Stutz MA, Shattuck DL, Laederich MB, Carraway KL 3rd, Sweeney C.
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| Oncogene 27(43):5741-52. Epub 2008 Jun 9.PMID: 18542056 2008
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| 18 | LRIG1, MET
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| LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy.
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| Shattuck DL, Miller JK, Laederich M, Funes M, Petersen H, Carraway KL 3rd, Sweeney C.
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| Mol Cell Biol 27(5):1934-46. Epub 2006 Dec 18.
2007
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| 19 | LRIG1, LSAMP
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| Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement.
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| Rodriguez-Perales S, Melendez B, Gribble SM, Valle L, Carter NP, Santamaria I, Conde L, Urioste M, Benitez J, Cigudosa JC.
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| Hum Mol Genet 13(9):983-90. Epub 2004 Mar 11. 2004
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| 20 | LRIG1
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| The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.
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| Laederich MB, Funes-Duran M, Yen L, Ingalla E, Wu X, Carraway KL 3rd, Sweeney C.
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| J Biol Chem 279(45):47050-6. Epub 2004 Sep 1. 2004
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| 21 | LRIG1
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| LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis.
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| Thomasson M, Hedman H, Guo D, Ljungberg B, Henriksson R.
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| Br J Cancer 89(7):1285-9. Erratum in: Br J Cancer. 2004 Jun 14;90(12):2425. 2003
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| 22 | LRIG1
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| LRIG1 protein in human cells and tissues.
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| Nilsson J, Starefeldt A, Henriksson R, Hedman H.
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| Cell Tissue Res 312(1):65-71. Epub 2003 Mar 18.
2003
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| 23 | LRIG1
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| Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?
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| Hedman H, Nilsson J, Guo D, Henriksson R.
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| Acta Oncol 41(4):352-4. 2002
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| 24 | LRIG1
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| Cloning, characterization, and expression of human LIG1.
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| Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H.
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| Biochem Biophys Res Commun 284(5):1155-61. 2001
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| 25 | LRIG1
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| cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains.
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| Suzuki Y, Sato N, Tohyama M, Wanaka A, Takagi T.
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| J Biol Chem 271(37):22522-7. 1996
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