| 1 | LPL, ZHX2
|
| Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake.
|
| Wu Z, Ma H, Wang L, Song X, Zhang J, Liu W, Ge Y, Sun Y, Yu X, Wang Z, Wang J, Zhang Y, Li C, Li N, Gao L, Liang X, Yue X, Ma C.
|
| Cell Death Differ. May;27(5):1693-1708. doi: 10.1038/s41418-019-0453-z. Epub 2019 Nov 18 2020
|
| 2 | GPIHBP1, LMF1, LPL
|
| Structure of lipoprotein lipase in complex with GPIHBP1.
|
| Arora R, Nimonkar AV, Baird D, Wang C, Chiu CH, Horton PA, Hanrahan S, Cubbon R, Weldon S, Tschantz WR, Mueller S, Brunner R, Lehr P, Meier P, Ottl J, Voznesensky A, Pandey P, Smith TM, Stojanovic A, Flyer A, Benson TE, Romanowski MJ, Trauger JW.
|
| Proc Natl Acad Sci U S A 116(21):10360-10365. doi: 10.1073/pnas.1820171116. Epub 2019 May 9. 2019
|
| 3 | ANGPTL4, LPL
|
| Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition.
|
| Gutgsell AR, Ghodge SV, Bowers AA, Neher SB.
|
| J Biol Chem. Feb 22;294(8):2678-2689. doi: 10.1074/jbc.RA118.005932. Epub 2018 Dec 27 2019
|
| 4 | GIPHB1, LPL
|
| GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism.
|
| Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M.
|
| Cell Metab Jul 2;30(1):51-65. doi: 10.1016/j.cmet.2019.05.023 2019
|
| 5 | ANGPTL3, ANGPTL3, ANGPTL4, LPL
|
| On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity.
|
| Kovrov O, Kristensen KK, Larsson E, Ploug M, Olivecrona G.
|
| J Lipid Res. Apr;60(4):783-793. doi: 10.1194/jlr.M088807. Epub 2019 Jan 27 2019
|
| 6 | GPIHBP1, LPL
|
| Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
|
| Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M.
|
| Proc Natl Acad Sci U S A. Jan 29;116(5):1723-1732. doi: 10.1073/pnas.1817984116. Epub 2018 Dec 17. 2019
|
| 7 | LPL
|
| Lipoprotein lipase is active as a monomer.
|
| Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE 4th, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG.
|
| Proc Natl Acad Sci U S A. Mar 26;116(13):6319-6328. doi: 10.1073/pnas.1900983116. Epub 2019 Mar 8 2019
|
| 8 | LPL, TCF21
|
| A Novel Regulator of Preadipocyte Differentiation, Transcription Factor TCF21, Functions Partially Through Promoting LPL Expression.
|
| Zhang X, Cheng B, Liu C, Du Z, Zhang H, Wang N, Wu M, Li Y, Cao Z, Li H.
|
| Front Physiol. Apr 23;10:458. doi: 10.3389/fphys.2019.00458. eCollection 2019 2019
|
| 9 | LPL
|
| Rare LPL gene missense mutation in an infant with hypertriglyceridemia.
|
| Qin YY, Wei AQ, Shan QW, Xian XY, Wu YY, Liao L, Yan J, Lai ZF, Lin FQ.
|
| J Clin Lab Anal. Jul;32(6):e22414. doi: 10.1002/jcla.22414. Epub 2018 Feb 25 2018
|
| 10 | LPL
|
| Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity.
|
| Wu MJ, Wolska A, Roberts BS, Pearson EM, Gutgsell AR, Remaley AT, Neher SB.
|
| J Lipid Res. Dec;59(12):2456-2465. doi: 10.1194/jlr.D086793. Epub 2018 Oct 14 2018
|
| 11 | ANGPTL4, LPL, PCSK1
|
| Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes.
|
| Dijk W, Ruppert PMM, Oost LJ, Kersten S.
|
| J Biol Chem. Sep 7;293(36):14134-14145. doi: 10.1074/jbc.RA118.002426. Epub 2018 Jul 18 2018
|
| 12 | LPL
|
| Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination.
|
| Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH.
|
| Front Mol Neurosci. Mar 15;11:57. doi: 10.3389/fnmol.2018.00057. eCollection 2018 2018
|
| 13 | ANGPTL3, ANGPTL8, LPL
|
| ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.
|
| Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J.
|
| J Lipid Res. Jun;58(6):1166-1173. doi: 10.1194/jlr.M075689. Epub 2017 Apr 15 2017
|
| 14 | ANGPTL3, ANGPTL8, LPL
|
| ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.
|
| Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ.
|
| Mol Metab. Oct;6(10):1137-1149. doi: 10.1016/j.molmet.2017.06.014. Epub 2017 Jun 29 2017
|
| 15 | LPL
|
| Pathogenic classification of LPL gene variants reported to be associated with LPL deficiency.
|
| Rodrigues R, Artieda M, Tejedor D, Martínez A, Konstantinova P, Petry H, Meyer C, Corzo D, Sundgreen C, Klor HU, Gouni-Berthold I, Westphal S, Steinhagen-Thiessen E, Julius U, Winkler K, Stroes E, Vogt A, Hardt P, Prophet H, Otte B, Nordestgaard BG, Deeb SS, Brunzell JD.
|
| J Clin Lipidol. Mar-Apr;10(2):394-409. doi: 10.1016/j.jacl.2015.12.015. Epub 2015 Dec 24 2016
|
| 16 | LPL
|
| Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia.
|
| Pingitore P, Lepore SM, Pirazzi C, Mancina RM, Motta BM, Valenti L, Berge KE, Retterstøl K, Leren TP, Wiklund O, Romeo S.
|
| J Clin Lipidol. Jul-Aug;10(4):816-823. doi: 10.1016/j.jacl.2016.02.015. Epub 2016 Mar 10 2016
|
| 17 | ANGPTL4, GPIHBP1, LPL
|
| Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1.
|
| Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS.
|
| J Biol Chem 290(19):11865-77. doi: 10.1074/jbc.M114.623769. Epub 2015 Mar 25. 2015
|
| 18 | ANGPTL4, LPL
|
| Lipoprotein lipase and angiopoietin-like 4 - Cardiomyocyte secretory proteins that regulate metabolism during diabetic heart disease.
|
| Puthanveetil P, Wan A, Rodrigues B.
|
| Crit Rev Clin Lab Sci. 52(3):138-49. doi: 10.3109/10408363.2014.997931. Epub 2015 Jan 19 2015
|
| 19 | LPL
|
| Lipoprotein lipase is an important modulator of lipid uptake and storage in hypothalamic neurons.
|
| Libby AE, Wang H, Mittal R, Sungelo M, Potma E, Eckel RH.
|
| Biochem Biophys Res Commun. Sep 18;465(2):287-92. doi: 10.1016/j.bbrc.2015.08.026. Epub 2015 2015
|
| 20 | GPIHBP1, LPL
|
| Physiological regulation of lipoprotein lipase.
|
| Kersten S.
|
| Biochim Biophys Acta Jul;1841(7):919-33. doi: 10.1016/j.bbalip.2014.03.013. Epub 2014 Apr 8 2014
|
| 21 | LPL
|
| Lipoprotein lipase (LPL) is associated with neurite pathology and its levels are markedly reduced in the dentate gyrus of Alzheimer's disease brains.
|
| Gong H, Dong W, Rostad SW, Marcovina SM, Albers JJ, Brunzell JD, Vuletic S.
|
| J Histochem Cytochem. Dec;61(12):857-68. doi: 10.1369/0022155413505601. Epub 2013 Sep 4. 2013
|
| 22 | GPIHBP1, LPL
|
| Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1.
|
| Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BS, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG.
|
| Hum Mol Genet 21(13):2961-72. doi: 10.1093/hmg/dds127. Epub 2012 Apr 6.
2012
|
| 23 | GPIHBP1, LPL
|
| Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1.
|
| Voss CV, Davies BS, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG.
|
| Proc Natl Acad Sci U S A 108(19):7980-4. Epub 2011 Apr 25.
2011
|
| 24 | LPL
|
| Uptake of dietary retinoids at the maternal-fetal barrier: in vivo evidence for the role of lipoprotein lipase and alternative pathways.
|
| Wassef L, Quadro L.
|
| J Biol Chem 286(37):32198-207. Epub 2011 Jul 27.
2011
|
| 25 | LPL
|
| LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia.
|
| Kaderi MA, Kanduri M, Buhl AM, Sevov M, Cahill N, Gunnarsson R, Jansson M, Smedby KE, Hjalgrim H, Jurlander J, Juliusson G, Mansouri L, Rosenquist R.
|
| Haematologica 96(8):1153-60. Epub 2011 Apr 20.
2011
|
| 26 | GPHIBP1, LPL
|
| Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase.
|
| Beigneux AP, Davies BS, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG.
|
| J Biol Chem 286(22):19735-43. Epub 2011 Apr 7.
2011
|
| 27 | LPL
|
| Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes.
|
| Nishitsuji K, Hosono T, Uchimura K, Michikawa M.
|
| J Biol Chem 286(8):6393-401. Epub 2010 Dec 21.
2011
|
| 28 | GIP, LPL
|
| GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene.
|
| Kim SJ, Nian C, McIntosh CH.
|
| J Lipid Res 51(11):3145-57. Epub 2010 Aug 7.
2010
|
| 29 | ANGPTL3, LPL, PCSK5
|
| Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases.
|
| Liu J, Afroza H, Rader DJ, Jin W.
|
| J Biol Chem 285(36):27561-70. Epub 2010 Jun 26. 2010
|
| 30 | LIPG, LPL
|
| Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms.
|
| Nielsen JE, Lindegaard ML, Friis-Hansen L, Almstrup K, Leffers H, Nielsen LB, Rajpert-De Meyts E.
|
| Int J Androl 33(1):e207-15. Epub 2009 Sep 23.
2010
|
| 31 | LPL
|
| Increased lipoprotein lipase activity in non-small cell lung cancer tissue predicts shorter patient survival.
|
| Trost Z, Sok M, Marc J, Cerne D.
|
| Arch Med Res 40(5):364-8. Epub 2009 Jul 25.
2009
|
| 32 | GPHIBP1, LPL
|
| Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase.
|
| Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG.
|
| J Biol Chem 284(44):30240-7. Epub 2009 Sep 2.
2009
|
| 33 | ADAM29, LPL
|
| IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide.
|
| Maloum K, Settegrana C, Chapiro E, Cazin B, Leprêtre S, Delmer A, Leporrier M, Dreyfus B, Tournilhac O, Mahe B, Nguyen-Khac F, Lesty C, Davi F, Merle-Béral H.
|
| Ann Hematol 88(12):1215-21. Epub 2009 Apr 2.
2009
|
| 34 | ABCA1, ABCG5, ABCG8, ABLP, APOB, APOB, APOC2, ARH, FDB, FHBL1, HCHOLA3, HDLDT1, LDLR, LDLRAP1, LIPAD, LPL, MTTP, PBAM, PCSK9, SLC10A2, STSL
|
| Monogenic pediatric dyslipidemias: classification, genetics and clinical spectrum.
|
| Rahalkar AR, Hegele RA.
|
| Mol Genet Metab 93(3):282-94. Epub 2007 Nov 26. Review. 2008
|
| 35 | LPL
|
| Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
| Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR.
|
| Nat Genet 40(2):161-9. Epub 2008 Jan 13. 2008
|
| 36 | CETP, LPL, MTHFR, NOS3, OLR1, PAPPA, SERPINE1
|
| Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes.
|
| Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C.
|
| Trends Mol Med rends Mol Med. 2008 Sep 9. [Epub ahead of print]
2008
|
| 37 | AHR, IGFBP1, LPL
|
| Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor.
|
| Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T.
|
| J Toxicol Sci 33(4):405-13.
2008
|
| 38 | APOE, LPL
|
| Subsets of SNPs define rare genotype classes that predict ischemic heart disease.
|
| Frikke-Schmidt R, Sing CF, Nordestgaard BG, Steffensen R, Tybjaerg-Hansen A.
|
| Hum Genet 120(6):865-877. Epub 2006 Sep 28. 2007
|
| 39 | LIPG,LPL
|
| Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies.
|
| Gauster M, Hiden U, Blaschitz A, Frank S, Lang U, Alvino G, Cetin I, Desoye G, Wadsack C.
|
| J Clin Endocrinol Metab 92(6):2256-63. Epub 2007 Mar 13. 2007
|
| 40 | LPL
|
| Genetic screening of the LPL gene in hypertriglyceridaemic patients.
|
| Wright WT, Young IS, Nicholls DP, Graham CA.
|
| Atherosclerosis [Epub ahead of print] 2007
|
| 41 | LPL
|
| Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non-Hispanic Caucasian women.
|
| Zhang C, Austin MA, Edwards KL, Farin FM, Li N, Hsu L, Srinouanprachanh SL, Williams MA.
|
| Clin Genet 69(1):33-9. 2006
|
| 42 | LPL
|
| Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum.
|
| Osibow K, Frank S, Malli R, Zechner R, Graier WF.
|
| Biochem J 396(1):173-82. 2006
|
| 43 | CETP, ABCA1, LPL, APOC3, APOA4
|
| Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia.
|
| van Aalst-Cohen ES, Jansen AC, Boekholdt SM, Tanck MW, Fontecha MR, Cheng S, Li J, Defesche JC, Kuivenhoven JA, Kastelein JJ.
|
| Eur J Hum Genet 13(10):1137-42. 2005
|
| 44 | APOA5, HLP5, LPL
|
| Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment.
|
| Marçais C, Verges B, Charrière S, Pruneta V, Merlin M, Billon S, Perrot L, Drai J, Sassolas A, Pennacchio LA, Fruchart-Najib J, Fruchart JC, Durlach V, Moulin P.
|
| J Clin Invest 115(10):2862-9. 2005
|
| 45 | PRL, LPL, PRLR
|
| Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue.
|
| Ling C, Svensson L, Oden B, Weijdegard B, Eden B, Eden S, Billig H.
|
| J Clin Endocrinol Metab 88(4):1804-8. 2003
|
| 46 | CAV1, CD44, CDH1, LPL, PMEPA1
|
| Cytogenetics and molecular genetics of cancer of the prostate.
|
| Brothman AR.
|
| Am J Med Genet 115(3):150-6. 2002
|
| 47 | LPL
|
| Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene.
|
| Peterson J, Ayyobi AF, Ma Y, Henderson H, Reina M, Deeb SS, Santamarina-Fojo S, Hayden MR, Brunzell JD.
|
| J Lipid Res 43(3):398-406. 2002
|
| 48 | LPL
|
| Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain.
|
| Kobayashi Y, Nakajima T, Inoue I.
|
| Eur J Biochem 269(18):4701-10. 2002
|
| 49 | LPL
|
| Lipoprotein lipase: structure, function, regulation, and role in disease.
|
| Mead JR, Irvine SA, Ramji DP.
|
| J Mol Med 80(12):753-69. Epub 2002 Oct 24. Review. 2002
|
| 50 | LPL
|
| Lipoprotein lipase (LPL) deficiency: a new patient homozygote for the preponderant mutation Gly188Glu in the human LPL gene and review of reported mutations: 75 % are clustered in exons 5 and 6.
|
| Gilbert B, Rouis M, Griglio S, de Lumley L, Laplaud P.
|
| Ann Genet 44(1):25-32. 2001
|
| 51 | LPL
|
| The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.
|
| Clee S, Loubser O, Collins J, Kastelein J, Hayden M.
|
| Clin Genet 60(4):293-300. 2001
|
| 52 | LPL
|
| Association of pre-eclampsia with common coding sequence variations in the lipoprotein lipase gene.
|
| Hubel CA, Roberts JM, Ferrell RE.
|
| Clin Genet 56(4):289-96 1999
|
| 53 | LPL
|
| A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia.
|
| Wittekoek ME, Moll E, Pimstone SN, Trip MD, Lansberg PJ, Defesche JC, van Doormaal JJ, Hayden MR, Kastelein JJ.
|
| Arterioscler Thromb Vasc Biol 19(11):2708-13 1999
|