1 | LPIN1, LPIN2, LPIN3
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| Lipin family proteins--key regulators in lipid metabolism.
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| Chen Y, Rui BB, Tang LY, Hu CM.
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| Ann Nutr Metab 66(1):10-8. doi: 10.1159/000368661. Review.
2015
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2 | LPIN1, LPIN2
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| Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
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| Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE.
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| J Biol Chem 289(26):18055-66. doi: 10.1074/jbc.M114.547604.
2014
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3 | LPIN2, NF2, NIPSNAP1, UGT2B17
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| Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes.
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| Malhotra A, Shibata Y, Hall IM, Dutta A.
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| Cancer Biol Ther 14(9):840-52. doi: 10.4161/cbt.25329.
2013
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4 | LPIN2, RMODA
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| Efficacy of anti-IL-1 treatment in Majeed syndrome.
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| Herlin T, Fiirgaard B, Bjerre M, Kerndrup G, Hasle H, Bing X, Ferguson PJ.
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| Ann Rheum Dis 72(3):410-3. doi: 10.1136/annrheumdis-2012-201818.
2013
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5 | LPIN1, LPIN2
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| Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
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| Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.
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| J Biol Chem 288(48):34502-13. doi: 10.1074/jbc.M113.488445.
2013
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6 | LPIN1, LPIN2, LPIN3
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| Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
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| Michot C, Hubert L, Romero NB, Gouda A, Mamoune A, Mathew S, Kirk E, Viollet L, Rahman S, Bekri S, Peters H, McGill J, Glamuzina E, Farrar M, von der Hagen M, Alexander IE, Kirmse B, Barth M, Laforet P, Benlian P, Munnich A, Jeanpierre M, Elpeleg O, Pines O, Delahodde A, de Keyzer Y, de Lonlay P.
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| J Inherit Metab Dis 35(6):1119-28. doi: 10.1007/s10545-012-9461-6. Epub 2012 Apr 6.
2012
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7 | LPIN2, MAPK8
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| Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
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| Valdearcos M, Esquinas E, Meana C, Peña L, Gil-de-Gómez L, Balsinde J, Balboa MA.
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| J Biol Chem 287(14):10894-904. doi: 10.1074/jbc.M112.342915. Epub 2012 Feb 8.
2012
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8 | LPIN1, LPIN2
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| Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
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| Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.
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| Proc Natl Acad Sci U S A 109(37):E2486-95. doi: 10.1073/pnas.1205221109.
2012
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9 | LPIN1, LPIN2, LPIN3, MGAR
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| Role of the lipin family in metabolic muscular diseases: an update
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| Michot and al,
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| in press 2011
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10 | CTDNEP1, LPIN1, LPIN2, LPIN3
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| Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.
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| Wu R, Garland M, Dunaway-Mariano D, Allen KN.
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| Biochemistry 50(15):3045-7. Epub 2011 Mar 23.
2011
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11 | LPIN1, LPIN2, LPIN3
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| Dual function lipin proteins and glycerolipid metabolism.
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| Harris TE, Finck BN.
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| Trends Endocrinol Metab 22(6):226-33. Epub 2011 Apr 4.
2011
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12 | LPIN2
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| Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance.
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| Ryu D, Seo WY, Yoon YS, Kim YN, Kim SS, Kim HJ, Park TS, Choi CS, Koo SH.
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| Diabetes 60(4):1072-81. Epub 2011 Feb 25.
2011
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13 | LPIN1, LPIN2, LPIN3
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| Lipin proteins form homo- and hetero-oligomers.
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| Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE.
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| Biochem J 432(1):65-76.
2010
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14 | LPIN1, LPIN2, RMODA
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| A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
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| Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN, Reue K.
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| J Biol Chem 284(43):29968-78. Epub 2009 Aug 28.
2009
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15 | LPIN2
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| Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
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| Gropler MC, Harris TE, Hall AM, Wolins NE, Gross RW, Han X, Chen Z, Finck BN.
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| J Biol Chem 284(11):6763-72. Epub 2009 Jan 10.
2009
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16 | LPIN1, LPIN2, LPIN3
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| Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
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| Reue K, Brindley DN.
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| J Lipid Res Lipid Res. 2008 Sep 12. [Epub ahead of print]
2008
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17 | LPIN1, LPIN2
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| Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
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| Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S.
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| J Biol Chem Biol Chem. 2008 Aug 11. [Epub ahead of print]
2008
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18 | LPIN1, LPIN2, LPIN3
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| The lipin protein family: dual roles in lipid biosynthesis and gene expression.
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| Reue K, Zhang P.
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| FEBS Lett 582(1):90-6. Epub 2007 Nov 20. 2008
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19 | LPIN2
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| LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition.
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| Aulchenko YS, Pullen J, Kloosterman WP, Yazdanpanah M, Hofman A, Vaessen N, Snijders PJ, Zubakov D, Mackay I, Olavesen M, Sidhu B, Smith VE, Carey A, Berezikov E, Uitterlinden AG, Plasterk RH, Oostra BA, van Duijn CM.
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| Diabetes 56(12):3020-6. Epub 2007 Sep 5.PMID: 17804763 2007
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20 | CTDNEP1, LPIN1, LPIN2, LPIN3
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| A conserved phosphatase cascade that regulates nuclear membrane biogenesis.
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| Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC Jr, Dixon JE.
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| Proc Natl Acad Sci U S A 104(16):6596-601. Epub 2007 Apr 9.
2007
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21 | ABL2, AKAP8, ANKRD13D, AP3D1, ARFGAP3, ARMCX6, ASUN, BAT2L, BCl2L13, BNIP3L, BPTF, BRD7, BZW1, BZW2, C12orf43, C19orf26, C1orf105, C2orf49, C6orf81, CA10, CAD, CARHSP1, CBX4, CCDC55, CCDC61, CCNK, CDC42BPB, CDC42EP3, CDC42EP4, CDS2, CENPN, CLK1, COPA, CSDA, CTPS2, DBN1, DCP1A, DECR2, DPF2, DPM1, EIF2AK1, EPB41L4A, EPN1, FAM91A1, FOSL2, FOXK1, GDF5OS, GFOD2, GIGYF2, GPATCH8, GTPBP1, HES7, HNRNPUL1, KIF1C, LPIN2, LRCH4, MAN2C1, MAST1, MED13, MED24, MED26, MINK1, MISP, MYO10, NKTR, OSBP, PAM, PCDH7, PEX14, PHF16, PHRF1, PLCB4, PLXNC1, POM121, POM121L2, PPHLN1, PRICKLE3, PRX, PUM2, RABGGTB, RBEL1, RIMS1, RIMS2, RPL14, RRP1B, RRP8, SAFB, SCAMP3, SCMH1, SCYL1, SENP6, SERBP1, SFRS13A, SFRS17A, SIPA1L1, SLC26A6, SLIRP, SLMAP, SNTA1, SORBS3, SPICE1, SSFA2, STAM, SUB1, TFIP11, TLN2, TMC6, TMEM104, TMEM106B, TMEM22, TOM1, UHRF1, UTP14A, WDR43, ZNF324, ZNF648
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| Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
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| Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
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| Cell. 127(3):635-48. 2006
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22 | LPIN2, RMODA
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| Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome).
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| Ferguson PJ, Chen S, Tayeh MK, Ochoa L, Leal SM, Pelet A, Munnich A, Lyonnet S, Majeed HA, El-Shanti H.
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| J Med Genet 42(7):551-7. 2005
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23 | LPIN1, LPIN2, LPIN3
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| Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.
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| Peterfy M, Phan J, Xu P, Reue K.
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| Nat Genet 27(1):121-4. 2001
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