| 1 | CTDNEP1, LPIN1
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| Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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| Merta H, Carrasquillo Rodríguez JW, Anjur-Dietrich MI, Vitale T, Granade ME, Harris TE, Needleman DJ, Bahmanyar S.
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| Dev Cell. Dec 20;56(24):3364-3379.e10. doi: 10.1016/j.devcel.2021.11.009. Epub 2021 Nov 30. 2021
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| 2 | IRS1, LPIN1
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| LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
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| Kim JY, Kim G, Lim SC, Choi HS.
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| Carcinogenesis 37(12):1199-1209. Epub 2016 Oct 11.
2016
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| 3 | LPIN1, MGAR
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| Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
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| Schweitzer GG, Collier SL, Chen Z, Eaton JM, Connolly AM, Bucelli RC, Pestronk A, Harris TE, Finck BN.
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| JIMD Rep IMD Rep. 2015 May 13. [Epub ahead of print]
2015
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| 4 | LPIN1, LPIN2, LPIN3
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| Lipin family proteins--key regulators in lipid metabolism.
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| Chen Y, Rui BB, Tang LY, Hu CM.
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| Ann Nutr Metab 66(1):10-8. doi: 10.1159/000368661. Review.
2015
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| 5 | LPIN1, PPP1CC
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| Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity.
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| Kok BP, Skene-Arnold TD, Ling J, Benesch MG, Dewald J, Harris TE, Holmes CF, Brindley DN.
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| J Biol Chem 289(15):10876-86. doi: 10.1074/jbc.M114.552612. Epub 2014 Feb 20.
2014
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| 6 | LPIN1
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| Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages.
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| Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA.
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| J Immunol 193(9):4614-22. doi: 10.4049/jimmunol.1400238. Epub 2014 Sep 24.
2014
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| 7 | LPIN1
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| Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages.
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| Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA.
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| J Immunol 193(9):4614-22. doi: 10.4049/jimmunol.1400238. Epub 2014 Sep 24.
2014
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| 8 | LPIN1, LPIN2
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| Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
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| Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE.
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| J Biol Chem 289(26):18055-66. doi: 10.1074/jbc.M114.547604.
2014
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| 9 | LPIN1
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| Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
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| Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.
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| J Biol Chem 288(48):34502-13. doi: 10.1074/jbc.M113.488445. Epub 2013 Oct 16.
2013
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| 10 | LPIN1, PPARG
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| Lipin1 regulates PPARγ transcriptional activity.
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| Kim HE, Bae E, Jeong DY, Kim MJ, Jin WJ, Park SW, Han GS, Carman GM, Koh E, Kim KS.
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| Biochem J 453(1):49-60. doi: 10.1042/BJ20121598.
2013
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| 11 | LPIN1
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| Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes.
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| Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M.
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| Biochem Biophys Res Commun 431(1):25-30. doi: 10.1016/j.bbrc.2012.12.112. Epub 2013 Jan 3.
2013
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| 12 | LPIN1, LPIN2
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| Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
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| Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.
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| J Biol Chem 288(48):34502-13. doi: 10.1074/jbc.M113.488445.
2013
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| 13 | LPIN1
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| Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
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| Kok BP, Dyck JR, Harris TE, Brindley DN.
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| J Lipid Res 54(6):1662-77. doi: 10.1194/jlr.M036624.
2013
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| 14 | LPIN1, LPIN2, LPIN3
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| Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
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| Michot C, Hubert L, Romero NB, Gouda A, Mamoune A, Mathew S, Kirk E, Viollet L, Rahman S, Bekri S, Peters H, McGill J, Glamuzina E, Farrar M, von der Hagen M, Alexander IE, Kirmse B, Barth M, Laforet P, Benlian P, Munnich A, Jeanpierre M, Elpeleg O, Pines O, Delahodde A, de Keyzer Y, de Lonlay P.
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| J Inherit Metab Dis 35(6):1119-28. doi: 10.1007/s10545-012-9461-6. Epub 2012 Apr 6.
2012
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| 15 | LPIN1, PPARG
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| Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.
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| Zhang P, Takeuchi K, Csaki LS, Reue K.
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| J Biol Chem 287(5):3485-94. doi: 10.1074/jbc.M111.296681. Epub 2011 Dec 6.
2012
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| 16 | LPIN1, NFE2L1, PPARGC1B
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| NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
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| Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
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| Mol Cell Biol 32(14):2760-70. doi: 10.1128/MCB.06706-11. Epub 2012 May 14.
2012
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| 17 | LPIN1, LPIN2
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| Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
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| Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.
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| Proc Natl Acad Sci U S A 109(37):E2486-95. doi: 10.1073/pnas.1205221109.
2012
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| 18 | LPIN1, LPIN2, LPIN3, MGAR
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| Role of the lipin family in metabolic muscular diseases: an update
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| Michot and al,
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| in press 2011
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| 19 | CTDNEP1, LPIN1, LPIN2, LPIN3
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| Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.
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| Wu R, Garland M, Dunaway-Mariano D, Allen KN.
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| Biochemistry 50(15):3045-7. Epub 2011 Mar 23.
2011
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| 20 | LPIN1
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| Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.
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| Wang H, Zhang J, Qiu W, Han GS, Carman GM, Adeli K.
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| FEBS Lett 585(12):1979-84. Epub 2011 May 20.
2011
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| 21 | LPIN1
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| Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.
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| Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN.
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| J Mol Cell Cardiol 51(1):120-8. Epub 2011 Apr 28.
2011
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| 22 | LPIN1
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| Subcellular localization and role of lipin-1 in human macrophages.
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| Valdearcos M, Esquinas E, Meana C, Gil-de-Gómez L, Guijas C, Balsinde J, Balboa MA.
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| J Immunol 186(10):6004-13. Epub 2011 Apr 8.
2011
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| 23 | LPIN1, LPIN2, LPIN3
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| Dual function lipin proteins and glycerolipid metabolism.
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| Harris TE, Finck BN.
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| Trends Endocrinol Metab 22(6):226-33. Epub 2011 Apr 4.
2011
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| 24 | LPIN1
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| A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
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| Mul JD, Nadra K, Jagalur NB, Nijman IJ, Toonen PW, Médard JJ, Grès S, de Bruin A, Han GS, Brouwers JF, Carman GM, Saulnier-Blache JS, Meijer D, Chrast R, Cuppen E.
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| J Biol Chem 286(30):26781-93. Epub 2011 Jun 1.
2011
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| 25 | LPIN1, MTOR
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| mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
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| Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.
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| Cell 146(3):408-20.
2011
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| 26 | LPIN1
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| Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.
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| Han GS, Carman GM.
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| J Biol Chem 285(19):14628-38. Epub 2010 Mar 15.PMID: 20231281 2010
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| 27 | LPIN1, LPIN2, LPIN3
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| Lipin proteins form homo- and hetero-oligomers.
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| Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE.
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| Biochem J 432(1):65-76.
2010
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| 28 | LPIN1
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| A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
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| Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ.
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| Mol Biol Cell 21(18):3171-81. Epub 2010 Jul 21.
2010
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| 29 | LPIN1, MGAR
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| LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.
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| Michot C, Hubert L, Brivet M, De Meirleir L, Valayannopoulos V, Müller-Felber W, Venkateswaran R, Ogier H, Desguerre I, Altuzarra C, Thompson E, Smitka M, Huebner A, Husson M, Horvath R, Chinnery P, Vaz FM, Munnich A, Elpeleg O, Delahodde A, de Keyzer Y, de Lonlay P.
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| Hum Mutat 31(7):E1564-73. 2010
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| 30 | LPIN1
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| Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes.
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| Miranda M, Escoté X, Alcaide MJ, Solano E, Ceperuelo-Mallafré V, Hernández P, Wabitsch M, Vendrell J.
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| Am J Physiol Endocrinol Metab 299(2):E308-17. Epub 2010 Jun 8.
2010
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| 31 | LPIN1
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| Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue.
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| Miranda M, Escoté X, Ceperuelo-Mallafré V, Megía A, Caubet E, Näf S, Gómez JM, González-Clemente JM, Vicente V, Vendrell J.
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| Int J Obes (Lond) 34(4):679-86. Epub 2010 Jan 26.
2010
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| 32 | LPIN1
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| Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes.
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| Péterfy M, Harris TE, Fujita N, Reue K.
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| J Biol Chem 285(6):3857-64. Epub 2009 Dec 2.
2010
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| 33 | LPIN1, NFATC4
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| Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.
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| Kim HB, Kumar A, Wang L, Liu GH, Keller SR, Lawrence JC Jr, Finck BN, Harris TE.
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| Mol Cell Biol 30(12):3126-39. Epub 2010 Apr 12.
2010
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| 34 | LPIN1
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| Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.
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| Liu GH, Gerace L.
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| PLoS One 4(9):e7031.
2009
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| 35 | LPIN1, LPIN2, RMODA
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| A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
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| Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN, Reue K.
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| J Biol Chem 284(43):29968-78. Epub 2009 Aug 28.
2009
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| 36 | CRTC2, LPIN1
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| TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
|
| Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH.
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| Cell Metab 9(3):240-51.
2009
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| 37 | LPIN1, NRCAM
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| Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
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| Douglas DS, Moran JL, Bermingham JR Jr, Chen XJ, Brindley DN, Soliven B, Beier DR, Popko B.
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| J Neurosci 29(39):12089-100.
2009
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| 38 | LPIN1, LPIN2, LPIN3
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| Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
|
| Reue K, Brindley DN.
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| J Lipid Res Lipid Res. 2008 Sep 12. [Epub ahead of print]
2008
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| 39 | LPIN1
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| Potential role of lipin-1 in exercise-induced mitochondrial biogenesis.
|
| Higashida K, Higuchi M, Terada S.
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| Biochem Biophys Res Commun 374(3):587-91. Epub 2008 Jul 24.
2008
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| 40 | LPIN1
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| Decreased lipin 1{beta} expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.
|
| Mlinar B, Pfeifer M, Vrtacnik Bokal E, Jensterle M, Marc J.
|
| Eur J Endocrinol ur J Endocrinol. 2008 Oct 1. [Epub ahead of print]
2008
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| 41 | LPIN1, LPIN2
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| Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
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| Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S.
|
| J Biol Chem Biol Chem. 2008 Aug 11. [Epub ahead of print]
2008
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| 42 | LPIN1, LPIN2, LPIN3
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| The lipin protein family: dual roles in lipid biosynthesis and gene expression.
|
| Reue K, Zhang P.
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| FEBS Lett 582(1):90-6. Epub 2007 Nov 20. 2008
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| 43 | LPIN1
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| Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood.
|
| Zeharia A, Shaag A, Houtkooper RH, Hindi T, de Lonlay P, Erez G, Hubert L, Saada A, de Keyzer Y, Eshel G, Vaz FM, Pines O, Elpeleg O.
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| Am J Hum Genet 83(4):489-94. Epub 2008 Sep 25.
2008
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| 44 | LPIN1
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| Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.
|
| Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS.
|
| J Biol Chem 283(50):34896-906. Epub 2008 Oct 16.
2008
|
| 45 | LPIN1
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| Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans.
|
| Wiedmann S, Fischer M, Koehler M, Neureuther K, Riegger G, Doering A, Schunkert H, Hengstenberg C, Baessler A.
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| Diabetes 57(1):209-17. Epub 2007 Oct 16.
2008
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| 46 | LPIN1
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| Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
|
| Zhang P, O'Loughlin L, Brindley DN, Reue K.
|
| J Lipid Res 49(7):1519-28. Epub 2008 Mar 24.PMID: 18362392 2008
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| 47 | CTDNEP1, LPIN1, LPIN2, LPIN3
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| A conserved phosphatase cascade that regulates nuclear membrane biogenesis.
|
| Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC Jr, Dixon JE.
|
| Proc Natl Acad Sci U S A 104(16):6596-601. Epub 2007 Apr 9.
2007
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| 48 | LPIN1
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| Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism.
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| Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L.
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| Hum Mol Genet 15(3):377-86. Epub 2005 Dec 15. 2006
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| 49 | LPIN1
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| Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
|
| Phan J, Peterfy M, Reue K.
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| J Biol Chem 279(28):29558-64. Epub 2004 Apr 29. 2004
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| 50 | LPIN1
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| Identification of single-nucleotide polymorphisms in the human LPIN1 gene.
|
| Cao H, Hegele RA.
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| J Hum Genet 47(7):370-2. 2002
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| 51 | LPIN1, LPIN2, LPIN3
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| Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.
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| Peterfy M, Phan J, Xu P, Reue K.
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| Nat Genet 27(1):121-4. 2001
|