Citations for
1IRS1, LPIN1
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Kim JY, Kim G, Lim SC, Choi HS.
Carcinogenesis 37(12):1199-1209. Epub 2016 Oct 11. 2016
2LPIN1, MGAR
Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
Schweitzer GG, Collier SL, Chen Z, Eaton JM, Connolly AM, Bucelli RC, Pestronk A, Harris TE, Finck BN.
JIMD Rep IMD Rep. 2015 May 13. [Epub ahead of print] 2015
3LPIN1, LPIN2, LPIN3
Lipin family proteins--key regulators in lipid metabolism.
Chen Y, Rui BB, Tang LY, Hu CM.
Ann Nutr Metab 66(1):10-8. doi: 10.1159/000368661. Review. 2015
4LPIN1, PPP1CC
Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity.
Kok BP, Skene-Arnold TD, Ling J, Benesch MG, Dewald J, Harris TE, Holmes CF, Brindley DN.
J Biol Chem 289(15):10876-86. doi: 10.1074/jbc.M114.552612. Epub 2014 Feb 20. 2014
5LPIN1
Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages.
Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA.
J Immunol 193(9):4614-22. doi: 10.4049/jimmunol.1400238. Epub 2014 Sep 24. 2014
6LPIN1
Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages.
Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA.
J Immunol 193(9):4614-22. doi: 10.4049/jimmunol.1400238. Epub 2014 Sep 24. 2014
7LPIN1, LPIN2
Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE.
J Biol Chem 289(26):18055-66. doi: 10.1074/jbc.M114.547604. 2014
8LPIN1
Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.
J Biol Chem 288(48):34502-13. doi: 10.1074/jbc.M113.488445. Epub 2013 Oct 16. 2013
9LPIN1, PPARG
Lipin1 regulates PPARγ transcriptional activity.
Kim HE, Bae E, Jeong DY, Kim MJ, Jin WJ, Park SW, Han GS, Carman GM, Koh E, Kim KS.
Biochem J 453(1):49-60. doi: 10.1042/BJ20121598. 2013
10LPIN1
Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes.
Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M.
Biochem Biophys Res Commun 431(1):25-30. doi: 10.1016/j.bbrc.2012.12.112. Epub 2013 Jan 3. 2013
11LPIN1, LPIN2
Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.
J Biol Chem 288(48):34502-13. doi: 10.1074/jbc.M113.488445. 2013
12LPIN1
Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
Kok BP, Dyck JR, Harris TE, Brindley DN.
J Lipid Res 54(6):1662-77. doi: 10.1194/jlr.M036624. 2013
13LPIN1, LPIN2, LPIN3
Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
Michot C, Hubert L, Romero NB, Gouda A, Mamoune A, Mathew S, Kirk E, Viollet L, Rahman S, Bekri S, Peters H, McGill J, Glamuzina E, Farrar M, von der Hagen M, Alexander IE, Kirmse B, Barth M, Laforet P, Benlian P, Munnich A, Jeanpierre M, Elpeleg O, Pines O, Delahodde A, de Keyzer Y, de Lonlay P.
J Inherit Metab Dis 35(6):1119-28. doi: 10.1007/s10545-012-9461-6. Epub 2012 Apr 6. 2012
14LPIN1, PPARG
Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.
Zhang P, Takeuchi K, Csaki LS, Reue K.
J Biol Chem 287(5):3485-94. doi: 10.1074/jbc.M111.296681. Epub 2011 Dec 6. 2012
15LPIN1, NFE2L1, PPARGC1B
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
Mol Cell Biol 32(14):2760-70. doi: 10.1128/MCB.06706-11. Epub 2012 May 14. 2012
16LPIN1, LPIN2
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.
Proc Natl Acad Sci U S A 109(37):E2486-95. doi: 10.1073/pnas.1205221109. 2012
17LPIN1, LPIN2, LPIN3, MGAR
Role of the lipin family in metabolic muscular diseases: an update
Michot and al,
in press 2011
18CTDNEP1, LPIN1, LPIN2, LPIN3
Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.
Wu R, Garland M, Dunaway-Mariano D, Allen KN.
Biochemistry 50(15):3045-7. Epub 2011 Mar 23. 2011
19LPIN1
Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.
Wang H, Zhang J, Qiu W, Han GS, Carman GM, Adeli K.
FEBS Lett 585(12):1979-84. Epub 2011 May 20. 2011
20LPIN1
Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.
Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN.
J Mol Cell Cardiol 51(1):120-8. Epub 2011 Apr 28. 2011
21LPIN1
Subcellular localization and role of lipin-1 in human macrophages.
Valdearcos M, Esquinas E, Meana C, Gil-de-Gómez L, Guijas C, Balsinde J, Balboa MA.
J Immunol 186(10):6004-13. Epub 2011 Apr 8. 2011
22LPIN1, LPIN2, LPIN3
Dual function lipin proteins and glycerolipid metabolism.
Harris TE, Finck BN.
Trends Endocrinol Metab 22(6):226-33. Epub 2011 Apr 4. 2011
23LPIN1
A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
Mul JD, Nadra K, Jagalur NB, Nijman IJ, Toonen PW, Médard JJ, Grès S, de Bruin A, Han GS, Brouwers JF, Carman GM, Saulnier-Blache JS, Meijer D, Chrast R, Cuppen E.
J Biol Chem 286(30):26781-93. Epub 2011 Jun 1. 2011
24LPIN1, MTOR
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.
Cell 146(3):408-20. 2011
25LPIN1
Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.
Han GS, Carman GM.
J Biol Chem 285(19):14628-38. Epub 2010 Mar 15.PMID: 20231281 2010
26LPIN1, LPIN2, LPIN3
Lipin proteins form homo- and hetero-oligomers.
Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE.
Biochem J 432(1):65-76. 2010
27LPIN1
A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ.
Mol Biol Cell 21(18):3171-81. Epub 2010 Jul 21. 2010
28LPIN1, MGAR
LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.
Michot C, Hubert L, Brivet M, De Meirleir L, Valayannopoulos V, Müller-Felber W, Venkateswaran R, Ogier H, Desguerre I, Altuzarra C, Thompson E, Smitka M, Huebner A, Husson M, Horvath R, Chinnery P, Vaz FM, Munnich A, Elpeleg O, Delahodde A, de Keyzer Y, de Lonlay P.
Hum Mutat 31(7):E1564-73. 2010
29LPIN1
Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes.
Miranda M, Escoté X, Alcaide MJ, Solano E, Ceperuelo-Mallafré V, Hernández P, Wabitsch M, Vendrell J.
Am J Physiol Endocrinol Metab 299(2):E308-17. Epub 2010 Jun 8. 2010
30LPIN1
Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue.
Miranda M, Escoté X, Ceperuelo-Mallafré V, Megía A, Caubet E, Näf S, Gómez JM, González-Clemente JM, Vicente V, Vendrell J.
Int J Obes (Lond) 34(4):679-86. Epub 2010 Jan 26. 2010
31LPIN1
Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes.
Péterfy M, Harris TE, Fujita N, Reue K.
J Biol Chem 285(6):3857-64. Epub 2009 Dec 2. 2010
32LPIN1, NFATC4
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.
Kim HB, Kumar A, Wang L, Liu GH, Keller SR, Lawrence JC Jr, Finck BN, Harris TE.
Mol Cell Biol 30(12):3126-39. Epub 2010 Apr 12. 2010
33LPIN1
Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.
Liu GH, Gerace L.
PLoS One 4(9):e7031. 2009
34LPIN1, LPIN2, RMODA
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN, Reue K.
J Biol Chem 284(43):29968-78. Epub 2009 Aug 28. 2009
35CRTC2, LPIN1
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH.
Cell Metab 9(3):240-51. 2009
36LPIN1, NRCAM
Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Douglas DS, Moran JL, Bermingham JR Jr, Chen XJ, Brindley DN, Soliven B, Beier DR, Popko B.
J Neurosci 29(39):12089-100. 2009
37LPIN1, LPIN2, LPIN3
Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Reue K, Brindley DN.
J Lipid Res Lipid Res. 2008 Sep 12. [Epub ahead of print] 2008
38LPIN1
Potential role of lipin-1 in exercise-induced mitochondrial biogenesis.
Higashida K, Higuchi M, Terada S.
Biochem Biophys Res Commun 374(3):587-91. Epub 2008 Jul 24. 2008
39LPIN1
Decreased lipin 1{beta} expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.
Mlinar B, Pfeifer M, Vrtacnik Bokal E, Jensterle M, Marc J.
Eur J Endocrinol ur J Endocrinol. 2008 Oct 1. [Epub ahead of print] 2008
40LPIN1, LPIN2
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S.
J Biol Chem Biol Chem. 2008 Aug 11. [Epub ahead of print] 2008
41LPIN1, LPIN2, LPIN3
The lipin protein family: dual roles in lipid biosynthesis and gene expression.
Reue K, Zhang P.
FEBS Lett 582(1):90-6. Epub 2007 Nov 20. 2008
42LPIN1
Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood.
Zeharia A, Shaag A, Houtkooper RH, Hindi T, de Lonlay P, Erez G, Hubert L, Saada A, de Keyzer Y, Eshel G, Vaz FM, Pines O, Elpeleg O.
Am J Hum Genet 83(4):489-94. Epub 2008 Sep 25. 2008
43LPIN1
Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.
Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS.
J Biol Chem 283(50):34896-906. Epub 2008 Oct 16. 2008
44LPIN1
Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans.
Wiedmann S, Fischer M, Koehler M, Neureuther K, Riegger G, Doering A, Schunkert H, Hengstenberg C, Baessler A.
Diabetes 57(1):209-17. Epub 2007 Oct 16. 2008
45LPIN1
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Zhang P, O'Loughlin L, Brindley DN, Reue K.
J Lipid Res 49(7):1519-28. Epub 2008 Mar 24.PMID: 18362392 2008
46CTDNEP1, LPIN1, LPIN2, LPIN3
A conserved phosphatase cascade that regulates nuclear membrane biogenesis.
Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC Jr, Dixon JE.
Proc Natl Acad Sci U S A 104(16):6596-601. Epub 2007 Apr 9. 2007
47LPIN1
Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism.
Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L.
Hum Mol Genet 15(3):377-86. Epub 2005 Dec 15. 2006
48LPIN1
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
Phan J, Peterfy M, Reue K.
J Biol Chem 279(28):29558-64. Epub 2004 Apr 29. 2004
49LPIN1
Identification of single-nucleotide polymorphisms in the human LPIN1 gene.
Cao H, Hegele RA.
J Hum Genet 47(7):370-2. 2002
50LPIN1, LPIN2, LPIN3
Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.
Peterfy M, Phan J, Xu P, Reue K.
Nat Genet 27(1):121-4. 2001