Citations for
LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer).
Simonik EA, Cai Y, Kimmelshue KN, Brantley-Sieders DM, Loomans HA, Andl CD, Westlake GM, Youngblood VM, Chen J, Yarbrough WG, Brown BT, Nagarajan L, Brandt SJ.
PLoS One 11(10):e0164804. doi: 10.1371/journal.pone.0164804. eCollection 2016. 2016
The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
Salmans ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen B.
PLoS Genet 10(7):e1004520. doi: 10.1371/journal.pgen.1004520. eCollection 2014 Jul. 2014
Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8.
Stokes PH, Liew CW, Kwan AH, Foo P, Barker HE, Djamirze A, O'Reilly V, Visvader JE, Mackay JP, Matthews JM.
J Mol Biol 425(7):1101-10. doi: 10.1016/j.jmb.2013.01.017. Epub 2013 Jan 23. 2013
LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.
Asprer JS, Lee B, Wu CS, Vadakkan T, Dickinson ME, Lu HC, Lee SK.
Development 138(13):2823-32. 2011
Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.
Duquette PM, Zhou X, Yap NL, MacLaren EJ, Lu JJ, Wallace VA, Chen HH.
PLoS One 5(10):e13232. 2010
A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2.
Michell AC, Braganša J, Broadbent C, Joyce B, Franklyn A, Schneider JE, Bhattacharya S, Bamforth SD.
Dev Dyn 239(7):1988-94. 2010
Repression of Lim only protein 4-activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.
Tian Y, Wang N, Lu Z.
Clin Exp Metastasis 27(7):455-63. Epub 2010 Jun 6. 2010
LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression.
Monta˝ez-Wiscovich ME, Seachrist DD, Landis MD, Visvader J, Andersen B, Keri RA.
Oncogene 28(41):3608-18. Epub 2009 Aug 3. 2009
Grhl3 and Lmo4 play coordinate roles in epidermal migration.
Hislop NR, Caddy J, Ting SB, Auden A, Vasudevan S, King SL, Lindeman GJ, Visvader JE, Cunningham JM, Jane SM.
Dev Biol 321(1):263-72. Epub 2008 Jun 26. 2008
LIM only 4 is overexpressed in late stage pancreas cancer.
Yu J, Ohuchida K, Nakata K, Mizumoto K, Cui L, Fujita H, Yamaguchi H, Egami T, Kitada H, Tanaka M.
Mol Cancer 7:93. 2008
Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.
Sum EY, Segara D, Duscio B, Bath ML, Field AS, Sutherland RL, Lindeman GJ, Visvader JE.
Proc Natl Acad Sci U S A 102(21):7659-64. Epub 2005 May 16. 2005
Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein.
Singh RR, Barnes CJ, Talukder AH, Fuqua SA, Kumar R.
Cancer Res 65(22):10594-601. 2005
Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1.
Hahm K, Sum EY, Fujiwara Y, Lindeman GJ, Visvader JE, Orkin SH.
Mol Cell Biol 24(5):2074-82. 2004
14LMO4, LDB1
The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity.
Mizunuma H, Miyazawa J, Sanada K, Imai K.
Br J Cancer 88(10):1543-8. 2003
The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.
Manetopoulos C, Hansson A, Karlsson J, Jonsson JI, Axelson H.
Biochem Biophys Res Commun 307(4):891-9. 2003
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.
Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE.
J Biol Chem 277(10):7849-56. 2002
The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.
Visvader JE, Venter D, Hahm K, Santamaria M, Sum EY, O'Reilly L, White D, Williams R, Armes J, Lindeman GJ.
Proc Natl Acad Sci U S A 98(25):14452-7. 2001
Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.
Tse E, Grutz G, Garner AA, Ramsey Y, Carter NP, Copeland N, Gilbert DJ, Jenkins NA, Agulnick A, Forster A, Rabbitts TH.
Mamm Genome 10(11):1089-94. 1999