| 1 | LINGO1, MRT64
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| Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay.
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| Ansar M, Riazuddin S, Sarwar MT, Makrythanasis P, Paracha SA, Iqbal Z, Khan J, Assir MZ, Hussain M, Razzaq A, Polla DL, Taj AS, Holmgren A, Batool N, Misceo D, Iwaszkiewicz J, de Brouwer APM, Guipponi M, Hanquinet S, Zoete V, Santoni FA, Frengen E, Ahmed J, Riazuddin S, van Bokhoven H, Antonarakis SE.
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| Genet Med enet Med. 2017 Aug 24. doi: 10.1038/gim.2017.113. [Epub ahead of print] 2017
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| 2 | LINGO1
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| LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
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| Shao Z, Lee X, Huang G, Sheng G, Henderson CE, Louvard D, Sohn J, Pepinsky B, Mi S.
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| J Neurosci 37(12):3127-3137. doi: 10.1523/JNEUROSCI.3722-16.2017. Epub 2017 Feb 13.
2017
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| 3 | LINGO1, NTRK1, NTRK2, NTRK3
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| Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
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| Meabon JS, de Laat R, Ieguchi K, Serbzhinsky D, Hudson MP, Huber BR, Wiley JC, Bothwell M.
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| Mol Cell Neurosci 70:1-10. doi: 10.1016/j.mcn.2015.11.002. Epub 2015 Nov 3.
2016
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| 4 | LINGO1, NGFR
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| LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.
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| Meabon JS, De Laat R, Ieguchi K, Wiley JC, Hudson MP, Bothwell M.
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| J Biol Chem 290(15):9511-20. doi: 10.1074/jbc.M114.608018. Epub 2015 Feb 9.
2015
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| 5 | ERBB2, LINGO1
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| LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts.
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| Lee X, Shao Z, Sheng G, Pepinsky B, Mi S.
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| Mol Cell Neurosci 60:36-42. doi: 10.1016/j.mcn.2014.02.006. Epub 2014 Feb 28.
2014
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| 6 | LINGO1, WNK3
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| LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
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| Zhang Z, Xu X, Xiang Z, Yu Z, Feng J, He C.
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| J Biol Chem 288(17):12152-60. doi: 10.1074/jbc.M112.447771. Epub 2013 Mar 12.
2013
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| 7 | LINGO1
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| LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.
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| Jepson S, Vought B, Gross CH, Gan L, Austen D, Frantz JD, Zwahlen J, Lowe D, Markland W, Krauss R.
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| J Biol Chem 287(26):22184-95. doi: 10.1074/jbc.M112.366179. Epub 2012 Apr 18.
2012
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| 8 | LINGO1
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| LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808.
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| Jiménez-Jiménez FJ, García-Martín E, Lorenzo-Betancor O, Pastor P, Alonso-Navarro H, Agúndez JA.
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| J Neurol Sci 317(1-2):52-7. doi: 10.1016/j.jns.2012.02.030. Epub 2012 Mar 17.
2012
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| 9 | LINGO1, NGFR
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| The leucine-rich repeats of LINGO-1 are not required for self-interaction or interaction with the amyloid precursor protein.
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| Stein T, Walmsley AR.
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| Neurosci Lett 509(1):9-12. doi: 10.1016/j.neulet.2011.11.029. Epub 2011 Nov 25.
2012
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| 10 | LINGO1, OLFM1, RTN4R
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| Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth.
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| Nakaya N, Sultana A, Lee HS, Tomarev SI.
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| J Biol Chem 287(44):37171-84. doi: 10.1074/jbc.M112.389916. Epub 2012 Aug 24.
2012
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| 11 | LINGO1, NGFR, RTN4, RTN4R
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| Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1.
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| Saha N, Kolev MV, Semavina M, Himanen J, Nikolov DB.
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| Biochem Biophys Res Commun 413(1):92-7. Epub 2011 Aug 22.
2011
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| 12 | LINGO1
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| LINGO1 and essential tremor: linking the shakes. Linking LINGO1 to essential tremor.
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| Tan EK.
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| Eur J Hum Genet 18(7):739-40. Epub 2010 Apr 7. No abstract available. PMID: 20372187 2010
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| 13 | LINGO1
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| Replication of the LINGO1 gene association with essential tremor in a North American population.
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| Clark LN, Park N, Kisselev S, Rios E, Lee JH, Louis ED.
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| Eur J Hum Genet 18(7):838-43. Epub 2010 Apr 7.PMID: 20372186 2010
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| 14 | LINGO1, NGFR
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| LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75(NTR) antagonists.
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| Bourikas D, Mir A, Walmsley AR.
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| Mol Cell Neurosci 45(4):363-9. Epub 2010 Jul 24.
2010
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| 15 | LINGO1
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| LINGO1 polymorphisms are associated with essential tremor in Europeans.
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| Thier S, Lorenz D, Nothnagel M, Stevanin G, Dürr A, Nebel A, Schreiber S, Kuhlenbäumer G, Deuschl G, Klebe S.
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| Mov Disord 25(6):709-15.
2010
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| 16 | LINGO1, LINGO2
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| LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.
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| Vilariño-Güell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, Soto-Ortolaza AI, Behrouz B, Heckman MG, Diehl NN, Testa CM, Wszolek ZK, Uitti RJ, Jankovic J, Louis ED, Clark LN, Rajput A, Farrer MJ.
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| Neurogenetics 11(4):401-8. Epub 2010 Apr 6.
2010
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| 17 | LINGO1
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| Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
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| Stefansson H, Steinberg S, Petursson H, Gustafsson O, Gudjonsdottir IH, Jonsdottir GA, Palsson ST, Jonsson T, Saemundsdottir J, Bjornsdottir G, Böttcher Y, Thorlacius T, Haubenberger D, Zimprich A, Auff E, Hotzy C, Testa CM, Miyatake LA, Rosen AR, Kristleifsson K, Rye D, Asmus F, Schöls L, Dichgans M, Jakobsson F, Benedikz J, Thorsteinsdottir U, Gulcher J, Kong A, Stefansson K.
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| Nat Genet 41(3):277-9. Epub 2009 Feb 1. Erratum in: Nat Genet. 2009 Apr;41(4):504.
2009
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| 18 | LINGO1, WNK1
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| LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension.
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| Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C.
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| J Biol Chem 284(23):15717-28. Epub 2009 Apr 10. 2009
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| 19 | LINGO1, LINGO2, LINGO3
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| Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.
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| Homma S, Shimada T, Hikake T, Yaginuma H.
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| Gene Expr Patterns 9(1):1-26. Epub 2008 Sep 21.
2009
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| 20 | LINGO1
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| LINGO-1 and its role in CNS repair.
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| Mi S, Sandrock A, Miller RH.
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| Int J Biochem Cell Biol 40(10):1971-8. Epub 2008 Apr 1. Review.
2008
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| 21 | LINGO1, RTN4R
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| Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
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| Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O.
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| Proc Natl Acad Sci U S A 104(36):14430-5. Epub 2007 Aug 28. 2007
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| 22 | LINGO1
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| LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
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| Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, Yuan Q, Wong WM, Wang L, Su H, Chu TH, Guo J, Zhang W, So KF, Pepinsky B, Shao Z, Graff C, Garber E, Jung V, Wu EX, Wu W.
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| Nat Med 13(10):1228-33. Epub 2007 Sep 30. 2007
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| 23 | LINGO1
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| Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan JR, Mi S.
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| NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination.
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| J Neurosci 27(1):220-5.
2007
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| 24 | LINGO1
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| The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
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| Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K, Wilhelm J, Stahl ML, Kriz R, Gao Y, Cao Z, Ling HP, Pangalos MN, Walsh FS, Somers WS.
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| J Biol Chem 281(47):36378-90. Epub 2006 Sep 27. 2006
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| 25 | LINGO1, RTN4R
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| LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury.
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| Ji B, Li M, Wu WT, Yick LW, Lee X, Shao Z, Wang J, So KF, McCoy JM, Pepinsky RB, Mi S, Relton JK.
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| Mol Cell Neurosci 33(3):311-20. Epub 2006 Sep 29.
2006
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| 26 | LINGO1
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| LINGO-1 negatively regulates myelination by oligodendrocytes.
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| Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB.
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| Nat Neurosci 8(6):745-51. Epub 2005 May 15. 2005
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| 27 | LINGO1
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| LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex.
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| Carim-Todd L, Escarceller M, Estivill X, Sumoy L.
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| Eur J Neurosci 18(12):3167-82. 2003
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