Citations for
1LIMK1
LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains.
Ou S, Tan MH, Weng T, Li H, Koh CG.
Open Biol 8(6). pii: 170202. doi: 10.1098/rsob.170202. 2018
2CFL1, LIMK1, WDR1
Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation.
Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, Xiang Y, Liu W, Chen J, Yi Z, Li L.
J Biol Chem 292(4):1438-1448. doi: 10.1074/jbc.M116.759886. Epub 2016 Dec 19. 2017
3LIMK1
Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.
Su J, Zhou Y, Pan Z, Shi L, Yang J, Liao A, Liao Q, Su Q.
Sci Rep 7:45624. doi: 10.1038/srep45624. 2017
4LIMK1
Aberrant expression of LIMK1 impairs neuronal migration during neocortex development.
Xie J, Li X, Zhang W, Chai X, Huang Y, Li K, Cheng X, Zhao S.
Histochem Cell Biol 147(4):471-479. doi: 10.1007/s00418-016-1514-8. Epub 2016 Nov 14. 2017
5LIMK1, LIMK2, ROCK1
ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
Kapur R, Shi J, Ghosh J, Munugalavadla V, Sims E, Martin H, Wei L, Mali RS.
Oncotarget 7(13):16936-47. doi: 10.18632/oncotarget.7851. 2016
6LIMK1, PLCH2
Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth.
Arastoo M, Hacker C, Popovics P, Lucocq JM, Stewart AJ.
Histochem Cell Biol Feb;145(2):163-73. doi: 10.1007/s00418-015-1390-7. Epub 2015 Dec 15. Erratum in: Histochem Cell Biol. 2016 Jun;145(6):681 2016
7LIMK1
Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice.
An L, Liu J, Li WW, Shi YJ, Lin XH, Yu DM, Deng JB, Ren XQ.
Genet Mol Res 14(4):17244-51. doi: 10.4238/2015.December.16.24. 2015
8LIMK1
Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity.
George J, Soares C, Montersino A, Beique JC, Thomas GM.
Elife 4:e06327. doi: 10.7554/eLife.06327. 2015
9CREB1, LIMK1
LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB.
Todorovski Z, Asrar S, Liu J, Saw NM, Joshi K, Cortez MA, Snead OC 3rd, Xie W, Jia Z.
Mol Cell Biol 35(8):1316-28. doi: 10.1128/MCB.01263-14. Epub 2015 Feb 2. 2015
10EIF4H, LIMK1
A Novel Recurrent Breakpoint Responsible for Rearrangements in the Williams-Beuren Region.
Plaja A, Castells N, Cueto-González AM, del Campo M, Vendrell T, Lloveras E, Izquierdo L, Borregan M, Rodríguez-Santiago B, Carrió A, Miró R, Tizzano E.
Cytogenet Genome Res 146(3):181-6. doi: 10.1159/000439463. Epub 2015 Sep 18. 2015
11LIMK1
LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E.
Am J Pathol 184(12):3321-31. doi: 10.1016/j.ajpath.2014.08.013. Epub 2014 Oct 13. 2014
12CDC42BPA, FAM89B, LIMK1
Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.
Lee IC, Leung T, Tan I.
J Biol Chem 289(39):26989-7003. doi: 10.1074/jbc.M114.588079. Epub 2014 Aug 8. 2014
13LIMK1, PAK4
PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity.
Whale AD, Dart A, Holt M, Jones GE, Wells CM.
Oncogene 32(16):2114-20. doi: 10.1038/onc.2012.233. Epub 2012 Jun 11. 2013
14LIMK1, RELA, SSH1
Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.
Leonard A, Marando C, Rahman A, Fazal F.
Am J Physiol Lung Cell Mol Physiol 305(9):L651-64. doi: 10.1152/ajplung.00071.2013. Epub 2013 Sep 13. 2013
15CDKN1C, LIMK1
p57(KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect.
Kavanagh E, Vlachos P, Emourgeon V, Rodhe J, Joseph B.
Cell Death Dis 3:e311. doi: 10.1038/cddis.2012.51. 2012
16LIMK1, NTRK2
LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation.
Dong Q, Ji YS, Cai C, Chen ZY.
J Biol Chem 287(50):41720-31. doi: 10.1074/jbc.M112.405415. Epub 2012 Oct 18. 2012
17AURKA, LIMK1
A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process.
Ritchey L, Ottman R, Roumanos M, Chakrabarti R.
Cell Cycle 11(2):296-309. doi: 10.4161/cc.11.2.18734. Epub 2012 Jan 15. 2012
18LIMK1, LIMK2, TPPP
TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG.
J Cell Sci 125(Pt 6):1579-90. doi: 10.1242/jcs.096818. Epub 2012 Feb 10. 2012
19LIMK1
LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization.
Ohashi K, Fujiwara S, Watanabe T, Kondo H, Kiuchi T, Sato M, Mizuno K.
J Biol Chem 286(42):36340-51. doi: 10.1074/jbc.M111.259135. Epub 2011 Aug 25. 2011
20CFL1, LIMK1
LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes.
Ishaq M, Lin BR, Bosche M, Zheng X, Yang J, Huang D, Lempicki RA, Natarajan V.
BMC Mol Biol 12:41. doi: 10.1186/1471-2199-12-41. 2011
21CFL1, LIMK1
LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin.
Yuen GS, McEwen BS, Akama KT.
Brain Res 1379:44-52. doi: 10.1016/j.brainres.2010.07.067. Epub 2010 Aug 7. 2011
22DUP7Q11, ELN, GTF2I, GTF2IRD1, LIMK1, RFC2, TRIM50, WBS
A triplication of the Williams-Beuren syndrome region in a patient with mental retardation, a severe expressive language delay, behavioural problems and dysmorphisms.
Beunders G, van de Kamp JM, Veenhoven RH, van Hagen JM, Nieuwint AW, Sistermans EA.
J Med Genet 47(4):271-5. Epub 2009 Sep 14.PMID: 19752158 2010
23F10, LIMK1
Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation.
Borensztajn K, Peppelenbosch MP, Spek CA.
Thromb Res 125(6):e323-8. doi: 10.1016/j.thromres.2010.02.018. Epub 2010 Mar 26. 2010
24CDKN1C, LIMK1
p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation.
Kremer D, Heinen A, Jadasz J, Göttle P, Zimmermann K, Zickler P, Jander S, Hartung HP, Küry P.
Proc Natl Acad Sci U S A 106(22):9087-92. Epub 2009 May 19. 2009
25CDKN1C, LIMK1
The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics.
Vlachos P, Joseph B.
Oncogene 28(47):4175-88. doi: 10.1038/onc.2009.269. Epub 2009 Sep 7. 2009
26CAMK4, LIMK1
Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.
Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, Mizuno K.
J Biol Chem 284(42):28554-62. doi: 10.1074/jbc.M109.006296. Epub 2009 Aug 20. 2009
27LIMK1
Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis.
Gorovoy M, Koga T, Shen X, Jia Z, Yue BY, Voyno-Yasenetskaya T.
Mol Vis 14:1951-9. Epub 2008 Oct 30. 2008
28LIMK1
LIM kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning.
Kaji N, Muramoto A, Mizuno K.
J Biol Chem 283(8):4983-92. Epub 2007 Dec 12. 2008
29WBS, LIMK1, CLIP2
Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.
Marenco S, Siuta MA, Kippenhan JS, Grodofsky S, Chang WL, Kohn P, Mervis CB, Morris CA, Weinberger DR, Meyer-Lindenberg A, Pierpaoli C, Berman KF.
Proc Natl Acad Sci U S A 104(38):15117-22. Epub 2007 Sep 7. 2007
30CYLN2, LIMK1, WBS
Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.
Marenco S, Siuta MA, Kippenhan JS, Grodofsky S, Chang WL, Kohn P, Mervis CB, Morris CA, Weinberger DR, Meyer-Lindenberg A, Pierpaoli C, Berman KF.
Proc Natl Acad Sci U S A 104(38):15117-22. Epub 2007 Sep 7. 2007
31CFL1, LIMK1, PRKN
Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.
Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N.
Exp Cell Res 313(13):2858-74. Epub 2007 Apr 20.PMID: 17512523 2007
32LIMK1, ELN
A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms.
Akagawa H, Tajima A, Sakamoto Y, Krischek B, Yoneyama T, Kasuya H, Onda H, Hori T, Kubota M, Machida T, Saeki N, Hata A, Hashiguchi K, Kimura E, Kim CJ, Yang TK, Lee JY, Kimm K, Inoue I.
Hum Mol Genet 15(10):1722-34. Epub 2006 Apr 12. 2006
33LIMK1, LIMK2
Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.
Sumi T, Hashigasako A, Matsumoto K, Nakamura T.
Exp Cell Res 312(7):1021-30. Epub 2006 Feb 7. 2006
34MAPKAPK2, VEGFA, LIMK1
MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.
Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K.
EMBO J 25(4):713-26. Epub 2006 Feb 2. 2006
35LIMK1
LIM kinase 1 coordinates microtubule stability and actin polymerization in human endothelial cells.
Gorovoy M, Niu J, Bernard O, Profirovic J, Minshall R, Neamu R, Voyno-Yasenetskaya T.
J Biol Chem 280(28):26533-42. Epub 2005 May 16. 2005
36LIMK1
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis.
Lee-Hoeflich ST, Causing CG, Podkowa M, Zhao X, Wrana JL, Attisano L.
EMBO J 23(24):4792-801. Epub 2004 Nov 11. 2004
37LIMK1
Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells.
Shabahang S, Huwiler A, Pfeilschifter J.
Biochem Biophys Res Commun 298(3):408-13. 2002
38LIMK1
Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF.
Mamm Genome 11(10):890-8. 2000
39LIMK1, STX1A, WBS
Williams syndrome : use of chromosomal microdeletions as a tool to dissect cognitive and physical phenotypes.
Tassabehji M, et al.
Am J Hum Genet 64 : 118-125. 1999
40LIMK1
LIM-kinase1.
Stanyon CA, et al.
Int J Biochem Cell Biol 31(3-4):389-94. Review. 1999
41LIMK1, ROCK1
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S.
Science 285(5429):895-8. 1999
42CFL1, LIMK1
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
Yang N, et al.
Nature 393 : 809-812. 1998
43LIMK1
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase.
Arber S, et al.
Nature 393 : 805-809. 1998
44ELN, LIMK1, WBS
LIM-kinase deleted in Williams syndrome.
Tassabehji M, et al.
Nat Genet 13 : 272-274. 1996
45LIMK1, WBS
LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.
Frangiskakis JM, et al.
Cell 86 : 59-69. 1996
46LIMK1
Structure and chromosomal localization of the genomic locus encoding the Kiz1 LIM-kinase gene.
Bernard O, et al.
Genomics 35 : 593-596. 1996
47CLIP2, EIF4H, ELN, GTF2IRD1, LAT2, LIMK1, RFC2, WBS, WBS, WBSCR2
Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.
Osborne LR, et al.
Genomics 36 : 328-336. 1996
48LIMK1
Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1) to chromosome bands 7q11.23 and 5G1, respectively, by in situ hybridization.
Mao X, et al.
Cytogenet Cell Genet 74 : 190-191. 1996
49LIMK1, LIMK2
Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
Okano I, et al.
J Biol Chem 270 : 31321-31330. 1995
50LIMK1
Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.
Mizuno K, et al.
Oncogene 9 : 1605-1612. 1994