| 1 | LIMK1
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| LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains.
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| Ou S, Tan MH, Weng T, Li H, Koh CG.
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| Open Biol 8(6). pii: 170202. doi: 10.1098/rsob.170202.
2018
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| 2 | CFL1, LIMK1, WDR1
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| Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation.
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| Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, Xiang Y, Liu W, Chen J, Yi Z, Li L.
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| J Biol Chem 292(4):1438-1448. doi: 10.1074/jbc.M116.759886. Epub 2016 Dec 19.
2017
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| 3 | LIMK1
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| Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.
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| Su J, Zhou Y, Pan Z, Shi L, Yang J, Liao A, Liao Q, Su Q.
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| Sci Rep 7:45624. doi: 10.1038/srep45624.
2017
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| 4 | LIMK1
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| Aberrant expression of LIMK1 impairs neuronal migration during neocortex development.
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| Xie J, Li X, Zhang W, Chai X, Huang Y, Li K, Cheng X, Zhao S.
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| Histochem Cell Biol 147(4):471-479. doi: 10.1007/s00418-016-1514-8. Epub 2016 Nov 14.
2017
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| 5 | LIMK1, LIMK2, ROCK1
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| ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
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| Kapur R, Shi J, Ghosh J, Munugalavadla V, Sims E, Martin H, Wei L, Mali RS.
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| Oncotarget 7(13):16936-47. doi: 10.18632/oncotarget.7851.
2016
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| 6 | LIMK1, PLCH2
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| Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth.
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| Arastoo M, Hacker C, Popovics P, Lucocq JM, Stewart AJ.
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| Histochem Cell Biol Feb;145(2):163-73. doi: 10.1007/s00418-015-1390-7. Epub 2015 Dec 15. Erratum in: Histochem Cell Biol. 2016 Jun;145(6):681 2016
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| 7 | LIMK1
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| Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice.
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| An L, Liu J, Li WW, Shi YJ, Lin XH, Yu DM, Deng JB, Ren XQ.
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| Genet Mol Res 14(4):17244-51. doi: 10.4238/2015.December.16.24.
2015
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| 8 | LIMK1
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| Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity.
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| George J, Soares C, Montersino A, Beique JC, Thomas GM.
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| Elife 4:e06327. doi: 10.7554/eLife.06327.
2015
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| 9 | CREB1, LIMK1
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| LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB.
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| Todorovski Z, Asrar S, Liu J, Saw NM, Joshi K, Cortez MA, Snead OC 3rd, Xie W, Jia Z.
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| Mol Cell Biol 35(8):1316-28. doi: 10.1128/MCB.01263-14. Epub 2015 Feb 2.
2015
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| 10 | EIF4H, LIMK1
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| A Novel Recurrent Breakpoint Responsible for Rearrangements in the Williams-Beuren Region.
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| Plaja A, Castells N, Cueto-González AM, del Campo M, Vendrell T, Lloveras E, Izquierdo L, Borregan M, Rodríguez-Santiago B, Carrió A, Miró R, Tizzano E.
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| Cytogenet Genome Res 146(3):181-6. doi: 10.1159/000439463. Epub 2015 Sep 18.
2015
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| 11 | LIMK1
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| LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
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| Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E.
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| Am J Pathol 184(12):3321-31. doi: 10.1016/j.ajpath.2014.08.013. Epub 2014 Oct 13.
2014
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| 12 | CDC42BPA, FAM89B, LIMK1
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| Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.
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| Lee IC, Leung T, Tan I.
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| J Biol Chem 289(39):26989-7003. doi: 10.1074/jbc.M114.588079. Epub 2014 Aug 8.
2014
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| 13 | LIMK1, PAK4
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| PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity.
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| Whale AD, Dart A, Holt M, Jones GE, Wells CM.
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| Oncogene 32(16):2114-20. doi: 10.1038/onc.2012.233. Epub 2012 Jun 11.
2013
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| 14 | LIMK1, RELA, SSH1
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| Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.
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| Leonard A, Marando C, Rahman A, Fazal F.
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| Am J Physiol Lung Cell Mol Physiol 305(9):L651-64. doi: 10.1152/ajplung.00071.2013. Epub 2013 Sep 13.
2013
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| 15 | CDKN1C, LIMK1
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| p57(KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect.
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| Kavanagh E, Vlachos P, Emourgeon V, Rodhe J, Joseph B.
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| Cell Death Dis 3:e311. doi: 10.1038/cddis.2012.51.
2012
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| 16 | LIMK1, NTRK2
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| LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation.
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| Dong Q, Ji YS, Cai C, Chen ZY.
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| J Biol Chem 287(50):41720-31. doi: 10.1074/jbc.M112.405415. Epub 2012 Oct 18.
2012
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| 17 | AURKA, LIMK1
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| A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process.
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| Ritchey L, Ottman R, Roumanos M, Chakrabarti R.
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| Cell Cycle 11(2):296-309. doi: 10.4161/cc.11.2.18734. Epub 2012 Jan 15.
2012
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| 18 | LIMK1, LIMK2, TPPP
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| TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
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| Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG.
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| J Cell Sci 125(Pt 6):1579-90. doi: 10.1242/jcs.096818. Epub 2012 Feb 10.
2012
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| 19 | LIMK1
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| LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization.
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| Ohashi K, Fujiwara S, Watanabe T, Kondo H, Kiuchi T, Sato M, Mizuno K.
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| J Biol Chem 286(42):36340-51. doi: 10.1074/jbc.M111.259135. Epub 2011 Aug 25.
2011
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| 20 | CFL1, LIMK1
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| LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes.
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| Ishaq M, Lin BR, Bosche M, Zheng X, Yang J, Huang D, Lempicki RA, Natarajan V.
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| BMC Mol Biol 12:41. doi: 10.1186/1471-2199-12-41.
2011
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| 21 | CFL1, LIMK1
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| LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin.
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| Yuen GS, McEwen BS, Akama KT.
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| Brain Res 1379:44-52. doi: 10.1016/j.brainres.2010.07.067. Epub 2010 Aug 7.
2011
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| 22 | DUP7Q11, ELN, GTF2I, GTF2IRD1, LIMK1, RFC2, TRIM50, WBS
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| A triplication of the Williams-Beuren syndrome region in a patient with mental retardation, a severe expressive language delay, behavioural problems and dysmorphisms.
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| Beunders G, van de Kamp JM, Veenhoven RH, van Hagen JM, Nieuwint AW, Sistermans EA.
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| J Med Genet 47(4):271-5. Epub 2009 Sep 14.PMID: 19752158 2010
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| 23 | F10, LIMK1
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| Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation.
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| Borensztajn K, Peppelenbosch MP, Spek CA.
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| Thromb Res 125(6):e323-8. doi: 10.1016/j.thromres.2010.02.018. Epub 2010 Mar 26.
2010
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| 24 | CDKN1C, LIMK1
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| p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation.
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| Kremer D, Heinen A, Jadasz J, Göttle P, Zimmermann K, Zickler P, Jander S, Hartung HP, Küry P.
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| Proc Natl Acad Sci U S A 106(22):9087-92. Epub 2009 May 19.
2009
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| 25 | CDKN1C, LIMK1
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| The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics.
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| Vlachos P, Joseph B.
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| Oncogene 28(47):4175-88. doi: 10.1038/onc.2009.269. Epub 2009 Sep 7.
2009
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| 26 | CAMK4, LIMK1
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| Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.
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| Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, Mizuno K.
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| J Biol Chem 284(42):28554-62. doi: 10.1074/jbc.M109.006296. Epub 2009 Aug 20. 2009
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| 27 | LIMK1
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| Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis.
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| Gorovoy M, Koga T, Shen X, Jia Z, Yue BY, Voyno-Yasenetskaya T.
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| Mol Vis 14:1951-9. Epub 2008 Oct 30.
2008
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| 28 | LIMK1
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| LIM kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning.
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| Kaji N, Muramoto A, Mizuno K.
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| J Biol Chem 283(8):4983-92. Epub 2007 Dec 12.
2008
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| 29 | WBS, LIMK1, CLIP2
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| Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.
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| Marenco S, Siuta MA, Kippenhan JS, Grodofsky S, Chang WL, Kohn P, Mervis CB, Morris CA, Weinberger DR, Meyer-Lindenberg A, Pierpaoli C, Berman KF.
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| Proc Natl Acad Sci U S A 104(38):15117-22. Epub 2007 Sep 7. 2007
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| 30 | CYLN2, LIMK1, WBS
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| Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.
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| Marenco S, Siuta MA, Kippenhan JS, Grodofsky S, Chang WL, Kohn P, Mervis CB, Morris CA, Weinberger DR, Meyer-Lindenberg A, Pierpaoli C, Berman KF.
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| Proc Natl Acad Sci U S A 104(38):15117-22. Epub 2007 Sep 7.
2007
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| 31 | CFL1, LIMK1, PRKN
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| Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.
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| Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N.
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| Exp Cell Res 313(13):2858-74. Epub 2007 Apr 20.PMID: 17512523 2007
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| 32 | LIMK1, ELN
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| A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms.
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| Akagawa H, Tajima A, Sakamoto Y, Krischek B, Yoneyama T, Kasuya H, Onda H, Hori T, Kubota M, Machida T, Saeki N, Hata A, Hashiguchi K, Kimura E, Kim CJ, Yang TK, Lee JY, Kimm K, Inoue I.
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| Hum Mol Genet 15(10):1722-34. Epub 2006 Apr 12. 2006
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| 33 | LIMK1, LIMK2
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| Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.
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| Sumi T, Hashigasako A, Matsumoto K, Nakamura T.
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| Exp Cell Res 312(7):1021-30. Epub 2006 Feb 7. 2006
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| 34 | MAPKAPK2, VEGFA, LIMK1
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| MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.
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| Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K.
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| EMBO J 25(4):713-26. Epub 2006 Feb 2. 2006
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| 35 | LIMK1
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| LIM kinase 1 coordinates microtubule stability and actin polymerization in human endothelial cells.
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| Gorovoy M, Niu J, Bernard O, Profirovic J, Minshall R, Neamu R, Voyno-Yasenetskaya T.
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| J Biol Chem 280(28):26533-42. Epub 2005 May 16. 2005
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| 36 | LIMK1
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| Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis.
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| Lee-Hoeflich ST, Causing CG, Podkowa M, Zhao X, Wrana JL, Attisano L.
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| EMBO J 23(24):4792-801. Epub 2004 Nov 11. 2004
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| 37 | LIMK1
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| Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells.
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| Shabahang S, Huwiler A, Pfeilschifter J.
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| Biochem Biophys Res Commun 298(3):408-13. 2002
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| 38 | LIMK1
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| Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
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| Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF.
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| Mamm Genome 11(10):890-8. 2000
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| 39 | LIMK1, STX1A, WBS
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| Williams syndrome : use of chromosomal microdeletions as a tool to dissect cognitive and physical phenotypes.
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| Tassabehji M, et al.
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| Am J Hum Genet 64 : 118-125. 1999
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| 40 | LIMK1
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| LIM-kinase1.
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| Stanyon CA, et al.
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| Int J Biochem Cell Biol 31(3-4):389-94. Review. 1999
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| 41 | LIMK1, ROCK1
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| Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
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| Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S.
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| Science 285(5429):895-8. 1999
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| 42 | CFL1, LIMK1
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| Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
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| Yang N, et al.
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| Nature 393 : 809-812. 1998
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| 43 | LIMK1
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| Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase.
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| Arber S, et al.
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| Nature 393 : 805-809. 1998
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| 44 | ELN, LIMK1, WBS
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| LIM-kinase deleted in Williams syndrome.
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| Tassabehji M, et al.
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| Nat Genet 13 : 272-274. 1996
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| 45 | LIMK1, WBS
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| LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.
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| Frangiskakis JM, et al.
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| Cell 86 : 59-69. 1996
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| 46 | LIMK1
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| Structure and chromosomal localization of the genomic locus encoding the Kiz1 LIM-kinase gene.
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| Bernard O, et al.
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| Genomics 35 : 593-596. 1996
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| 47 | CLIP2, EIF4H, ELN, GTF2IRD1, LAT2, LIMK1, RFC2, WBS, WBS, WBSCR2
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| Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.
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| Osborne LR, et al.
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| Genomics 36 : 328-336. 1996
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| 48 | LIMK1
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| Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1) to chromosome bands 7q11.23 and 5G1, respectively, by in situ hybridization.
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| Mao X, et al.
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| Cytogenet Cell Genet 74 : 190-191. 1996
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| 49 | LIMK1, LIMK2
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| Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
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| Okano I, et al.
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| J Biol Chem 270 : 31321-31330. 1995
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| 50 | LIMK1
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| Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.
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| Mizuno K, et al.
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| Oncogene 9 : 1605-1612. 1994
|