Citations for
Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
Nam H, Lee S.
Development 143(13):2334-43. doi: 10.1242/dev.135848. Epub 2016 May 9. 2016
Lhx3-Chx10 reticulospinal neurons in locomotor circuits.
Bretzner F, Brownstone RM.
J Neurosci 33(37):14681-92. doi: 10.1523/JNEUROSCI.5231-12.2013. 2013
A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.
Mullen RD, Park S, Rhodes SJ.
Mol Endocrinol 26(2):308-19. Epub 2011 Dec 22. 2012
Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK.
Proc Natl Acad Sci U S A 109(9):3383-8. Epub 2012 Feb 16. 2012
A novel mutation of LHX3 is associated with combined pituitary hormone deficiency including ACTH deficiency, sensorineural hearing loss, and short neck-a case report and review of the literature.
Bonfig W, Krude H, Schmidt H.
Eur J Pediatr 170(8):1017-21. Epub 2011 Jan 20. Review. 2011
Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.
Dateki S, Fukami M, Uematsu A, Kaji M, Iso M, Ono M, Mizota M, Yokoya S, Motomura K, Kinoshita E, Moriuchi H, Ogata T.
J Clin Endocrinol Metab 95(8):4043-7. Epub 2010 Jun 9. 2010
A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.
Kriström B, Zdunek AM, Rydh A, Jonsson H, Sehlin P, Escher SA.
J Clin Endocrinol Metab 94(4):1154-61. Epub 2009 Jan 6.PMID: 19126629 2009
Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.
Rajab A, Kelberman D, de Castro SC, Biebermann H, Shaikh H, Pearce K, Hall CM, Shaikh G, Gerrelli D, Grueters A, Krude H, Dattani MT.
Hum Mol Genet 17(14):2150-9. Epub 2008 Apr 10. 2008
Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.
Pfaeffle RW, Savage JJ, Hunter CS, Palme C, Ahlmann M, Kumar P, Bellone J, Schoenau E, Korsch E, Bramswig JH, Stobbe HM, Blum WF, Rhodes SJ.
J Clin Endocrinol Metab 92(5):1909-19. Epub 2007 Feb 27. 2007
Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes.
Savage JJ, Hunter CS, Clark-Sturm SL, Jacob TM, Pfaeffle RW, Rhodes SJ.
Gene 400(1-2):44-51. Epub 2007 Jun 7. 2007
11LHX3, LHX4
Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.
Mullen RD, Colvin SC, Hunter CS, Savage JJ, Walvoord EC, Bhangoo AP, Ten S, Weigel J, Pfäffle RW, Rhodes SJ.
Mol Cell Endocrinol 265-266:190-5. Epub 2007 Jan 8. Review. 2007
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
Hertzano R, Dror AA, Montcouquiol M, Ahmed ZM, Ellsworth B, Camper S, Friedman TB, Kelley MW, Avraham KB.
Eur J Neurosci 25(4):999-1005. 2007
Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1.
Yaden BC, Garcia M 3rd, Smith TP, Rhodes SJ.
Endocrinology 147(1):324-37. Epub 2005 Sep 22. 2006
Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.
Bhangoo AP, Hunter CS, Savage JJ, Anhalt H, Pavlakis S, Walvoord EC, Ten S, Rhodes SJ.
J Clin Endocrinol Metab 91(3):747-53. Epub 2006 Jan 4. 2006
Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.
West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW, Rhodes SJ.
Endocrinology 145(11):4866-79. Epub 2004 Jul 22. 2004
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL.
Cell 110(2):237-49. 2002
An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form.
Sloop KW, Dwyer CJ, Rhodes SJ.
J Biol Chem 276(39):36311-9. Epub 2001 Jul 24. 2001
18LHX3, TSC22D4
Expression screening for Lhx3 downstream genes identifies Thg-1pit as a novel mouse gene involved in pituitary development.
Fiorenza MT, Mukhopadhyay M, Westphal H.
Gene 278(1-2):125-30. 2001
Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.
Netchine I, Sobrier ML, Krude H, Schnabel D, Maghnie M, Marcos E, Duriez B, Cacheux V, Moers Av, Goossens M, Gruters A, Amselem S.
Nat Genet 25(2):182-6. 2000
Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9.
Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ.
Gene 245(2):237-43. 2000
Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene.
Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ.
Biochem Biophys Res Commun 274(1):49-56. 2000
Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties.
Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ.
Mol Endocrinol 13(12):2212-25. 1999
23LHX3, LHX4
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.
Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, Potter S, Westphal H, Pfaff SL.
Cell 95(6):817-28. 1998
24LHX3, LHX4
Multistep control of pituitary organogenesis.
Sheng HZ, Moriyama K, Yamashita T, Li H, Potter SS, Mahon KA, Westphal H.
Science 278(5344):1809-12. 1997