| 1 | CXCR4, ISL1, LHX3, STAM
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| Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
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| Nam H, Lee S.
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| Development 143(13):2334-43. doi: 10.1242/dev.135848. Epub 2016 May 9.
2016
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| 2 | LHX3, VSX2
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| Lhx3-Chx10 reticulospinal neurons in locomotor circuits.
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| Bretzner F, Brownstone RM.
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| J Neurosci 33(37):14681-92. doi: 10.1523/JNEUROSCI.5231-12.2013.
2013
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| 3 | ISL1, LHX3
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| A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.
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| Mullen RD, Park S, Rhodes SJ.
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| Mol Endocrinol 26(2):308-19. Epub 2011 Dec 22.
2012
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| 4 | ISL1, LHX3
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| Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
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| Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK.
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| Proc Natl Acad Sci U S A 109(9):3383-8. Epub 2012 Feb 16.
2012
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| 5 | CPHD3, LHX3
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| A novel mutation of LHX3 is associated with combined pituitary hormone deficiency including ACTH deficiency, sensorineural hearing loss, and short neck-a case report and review of the literature.
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| Bonfig W, Krude H, Schmidt H.
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| Eur J Pediatr 170(8):1017-21. Epub 2011 Jan 20. Review.
2011
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| 6 | CPHD3, LHX3
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| Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.
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| Dateki S, Fukami M, Uematsu A, Kaji M, Iso M, Ono M, Mizota M, Yokoya S, Motomura K, Kinoshita E, Moriuchi H, Ogata T.
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| J Clin Endocrinol Metab 95(8):4043-7. Epub 2010 Jun 9.
2010
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| 7 | CPHD3, LHX3
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| A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.
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| Kriström B, Zdunek AM, Rydh A, Jonsson H, Sehlin P, Escher SA.
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| J Clin Endocrinol Metab 94(4):1154-61. Epub 2009 Jan 6.PMID: 19126629 2009
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| 8 | CPHD3, LHX3, SOX2
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| Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.
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| Rajab A, Kelberman D, de Castro SC, Biebermann H, Shaikh H, Pearce K, Hall CM, Shaikh G, Gerrelli D, Grueters A, Krude H, Dattani MT.
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| Hum Mol Genet 17(14):2150-9. Epub 2008 Apr 10.
2008
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| 9 | CPHD3,LHX3
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| Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.
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| Pfaeffle RW, Savage JJ, Hunter CS, Palme C, Ahlmann M, Kumar P, Bellone J, Schoenau E, Korsch E, Bramswig JH, Stobbe HM, Blum WF, Rhodes SJ.
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| J Clin Endocrinol Metab 92(5):1909-19. Epub 2007 Feb 27. 2007
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| 10 | LHX3
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| Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes.
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| Savage JJ, Hunter CS, Clark-Sturm SL, Jacob TM, Pfaeffle RW, Rhodes SJ.
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| Gene 400(1-2):44-51. Epub 2007 Jun 7. 2007
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| 11 | LHX3, LHX4
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| Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.
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| Mullen RD, Colvin SC, Hunter CS, Savage JJ, Walvoord EC, Bhangoo AP, Ten S, Weigel J, Pfäffle RW, Rhodes SJ.
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| Mol Cell Endocrinol 265-266:190-5. Epub 2007 Jan 8. Review.
2007
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| 12 | LHX3
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| Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
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| Hertzano R, Dror AA, Montcouquiol M, Ahmed ZM, Ellsworth B, Camper S, Friedman TB, Kelley MW, Avraham KB.
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| Eur J Neurosci 25(4):999-1005.
2007
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| 13 | LHX3
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| Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1.
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| Yaden BC, Garcia M 3rd, Smith TP, Rhodes SJ.
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| Endocrinology 147(1):324-37. Epub 2005 Sep 22. 2006
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| 14 | LHX3, CPHD3
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| Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.
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| Bhangoo AP, Hunter CS, Savage JJ, Anhalt H, Pavlakis S, Walvoord EC, Ten S, Rhodes SJ.
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| J Clin Endocrinol Metab 91(3):747-53. Epub 2006 Jan 4. 2006
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| 15 | LHX3, FSHB
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| Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.
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| West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW, Rhodes SJ.
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| Endocrinology 145(11):4866-79. Epub 2004 Jul 22. 2004
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| 16 | LHX3
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| LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
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| Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL.
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| Cell 110(2):237-49. 2002
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| 17 | LHX3
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| An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form.
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| Sloop KW, Dwyer CJ, Rhodes SJ.
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| J Biol Chem 276(39):36311-9. Epub 2001 Jul 24. 2001
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| 18 | LHX3, TSC22D4
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| Expression screening for Lhx3 downstream genes identifies Thg-1pit as a novel mouse gene involved in pituitary development.
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| Fiorenza MT, Mukhopadhyay M, Westphal H.
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| Gene 278(1-2):125-30.
2001
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| 19 | CPHD3, LHX3
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| Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.
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| Netchine I, Sobrier ML, Krude H, Schnabel D, Maghnie M, Marcos E, Duriez B, Cacheux V, Moers Av, Goossens M, Gruters A, Amselem S.
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| Nat Genet 25(2):182-6. 2000
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| 20 | LHX3
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| Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9.
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| Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ.
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| Gene 245(2):237-43. 2000
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| 21 | LHX3
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| Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene.
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| Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ.
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| Biochem Biophys Res Commun 274(1):49-56. 2000
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| 22 | LHX3
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| Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties.
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| Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ.
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| Mol Endocrinol 13(12):2212-25. 1999
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| 23 | LHX3, LHX4
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| LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.
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| Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, Potter S, Westphal H, Pfaff SL.
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| Cell 95(6):817-28. 1998
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| 24 | LHX3, LHX4
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| Multistep control of pituitary organogenesis.
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| Sheng HZ, Moriyama K, Yamashita T, Li H, Potter SS, Mahon KA, Westphal H.
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| Science 278(5344):1809-12. 1997
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