| 1 | LHX2
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| Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development.
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| Chou SJ, Tole S.
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| Brain Res rain Res. 2018 Mar 6. pii: S0006-8993(18)30116-1. doi: 10.1016/j.brainres.2018.02.046. [Epub ahead of print] Review.
2018
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| 2 | LHX2, PAX6
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| PAX6 can substitute for LHX2 and override NFIA-induced astrogliogenesis in developing hippocampus in vivo.
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| Kinare V, Shetty AS, Suresh A, Tole S.
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| J Biosci 43(1):75-83.
2018
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| 3 | LHX2
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| Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels.
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| Miyashita K, Kitajima K, Goyama S, Kitamura T, Hara T.
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| Biochem Biophys Res Commun 495(3):2310-2316. doi: 10.1016/j.bbrc.2017.12.135. Epub 2017 Dec 24.
2018
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| 4 | FOXG1, LHX2
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| Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.
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| Godbole G, Shetty AS, Roy A, D'Souza L, Chen B, Miyoshi G, Fishell G, Tole S.
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| Development 145(1). pii: dev154583. doi: 10.1242/dev.154583.
2018
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| 5 | LDB1, LHX2, RLIM
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| Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina.
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| de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S.
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| Development Apr 30;145(9):dev159970. doi: 10.1242/dev.159970 2018
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| 6 | DMRTA2, LHX2
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| Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus.
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| Muralidharan B, Keruzore M, Pradhan SJ, Roy B, Shetty AS, Kinare V, D'Souza L, Maheshwari U, Karmodiya K, Suresh A, Galande S, Bellefroid EJ, Tole S.
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| J Neurosci 37(46):11245-11254. doi: 10.1523/JNEUROSCI.1535-17.2017. Epub 2017 Oct 12.
2017
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| 7 | LHX2, PAX6
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| Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes.
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| Godbole G, Roy A, Shetty AS, Tole S.
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| Neural Dev 12(1):19. doi: 10.1186/s13064-017-0097-y.
2017
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| 8 | BTBD3, LHX2
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| Lhx2 Expression in Postmitotic Cortical Neurons Initiates Assembly of the Thalamocortical Somatosensory Circuit.
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| Wang CF, Hsing HW, Zhuang ZH, Wen MH, Chang WJ, Briz CG, Nieto M, Shyu BC, Chou SJ.
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| Cell Rep 18(4):849-856. doi: 10.1016/j.celrep.2017.01.001.
2017
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| 9 | LHX2
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| Control of lens development by Lhx2-regulated neuroretinal FGFs.
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| Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S.
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| Development 143(21):3994-4002. Epub 2016 Sep 15.
2016
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| 10 | LHX2
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| Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling.
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| de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S.
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| J Neurosci 36(8):2391-405. doi: 10.1523/JNEUROSCI.3145-15.2016.
2016
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| 11 | LHX2
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| LIM Homeobox Domain 2 Is Required for Corneal Epithelial Homeostasis.
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| Sartaj R, Chee RI, Yang J, Wan P, Liu A, Guaiquil V, Fuchs E, Rosenblatt MI.
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| Stem Cells 34(2):493-503. doi: 10.1002/stem.2257. Epub 2016 Jan 5.
2016
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| 12 | LHX2
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| Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis.
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| Hsu LC, Nam S, Cui Y, Chang CP, Wang CF, Kuo HC, Touboul JD, Chou SJ.
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| Proc Natl Acad Sci U S A 112(39):12199-204. doi: 10.1073/pnas.1507145112. Epub 2015 Sep 14.
2015
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| 13 | LHX2
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| Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2.
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| Zembrzycki A, Perez-Garcia CG, Wang CF, Chou SJ, O'Leary DD.
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| Proc Natl Acad Sci U S A 112(21):6736-41. doi: 10.1073/pnas.1424440112. Epub 2015 May 13.
2015
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| 14 | LHX2
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| Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice.
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| Chinn GA, Hirokawa KE, Chuang TM, Urbina C, Patel F, Fong J, Funatsu N, Monuki ES.
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| Cereb Cortex 25(9):2707-18. doi: 10.1093/cercor/bhu067. Epub 2014 Apr 29.
2015
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| 15 | LHX2, PDGFB
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| LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.
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| Kuzmanov A, Hopfer U, Marti P, Meyer-Schaller N, Yilmaz M, Christofori G.
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| Mol Oncol 8(2):401-16. doi: 10.1016/j.molonc.2013.12.009. Epub 2013 Dec 25.
2014
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| 16 | LHX2, RAX
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| The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.
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| Salvatierra J, Lee DA, Zibetti C, Duran-Moreno M, Yoo S, Newman EA, Wang H, Bedont JL, de Melo J, Miranda-Angulo AL, Gil-Perotin S, Garcia-Verdugo JM, Blackshaw S.
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| J Neurosci 34(50):16809-20. doi: 10.1523/JNEUROSCI.1711-14.2014.
2014
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| 17 | LHX2
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| Lhx2 regulates the development of the forebrain hem system.
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| Roy A, Gonzalez-Gomez M, Pierani A, Meyer G, Tole S.
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| Cereb Cortex 24(5):1361-72. doi: 10.1093/cercor/bhs421. Epub 2013 Jan 10.
2014
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| 18 | CER1, LHX2
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| LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1.
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| Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL, Kuo HC.
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| Nucleic Acids Res 41(16):7753-70. doi: 10.1093/nar/gkt567. Epub 2013 Jun 26.
2013
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| 19 | LHX2
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| Lhx2 regulates a cortex-specific mechanism for barrel formation.
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| Shetty AS, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo HC, Rema V, Tole S.
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| Proc Natl Acad Sci U S A 110(50):E4913-21. doi: 10.1073/pnas.1311158110. Epub 2013 Nov 21.
2013
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| 20 | LHX2
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| Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina.
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| Gordon PJ, Yun S, Clark AM, Monuki ES, Murtaugh LC, Levine EM.
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| J Neurosci 33(30):12197-207. doi: 10.1523/JNEUROSCI.1494-13.2013.
2013
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| 21 | LHX2, ROBO1, ROBO2
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| The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors.
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| Marcos-Mondéjar P, Peregrín S, Li JY, Carlsson L, Tole S, López-Bendito G.
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| J Neurosci 32(13):4372-85. doi: 10.1523/JNEUROSCI.5851-11.2012.
2012
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| 22 | LHX2
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| Histone modification-mediated Lhx2 gene expression.
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| Park KS, Kim KK, Kim KE.
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| Biochem Biophys Res Commun 427(4):718-24. doi: 10.1016/j.bbrc.2012.09.123. Epub 2012 Oct 1.
2012
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| 23 | GBX2, LHX2, LHX9, LMO3, ROBO1, ROBO2
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| Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
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| Chatterjee M, Li K, Chen L, Maisano X, Guo Q, Gan L, Li JY.
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| Development 139(24):4633-43. doi: 10.1242/dev.086991. Epub 2012 Nov 7.
2012
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| 24 | LHX2, NFIA
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| Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.
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| Subramanian L, Sarkar A, Shetty AS, Muralidharan B, Padmanabhan H, Piper M, Monuki ES, Bach I, Gronostajski RM, Richards LJ, Tole S.
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| Proc Natl Acad Sci U S A 108(27):E265-74. Epub 2011 Jun 20.
2011
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| 25 | LHX2
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| Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development.
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| Hägglund AC, Dahl L, Carlsson L.
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| PLoS One 6(8):e23387. doi: 10.1371/journal.pone.0023387. Epub 2011 Aug 19.
2011
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| 26 | LHX2, LHX9
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| Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling.
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| Peukert D, Weber S, Lumsden A, Scholpp S.
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| PLoS Biol 9(12):e1001218. doi: 10.1371/journal.pbio.1001218. Epub 2011 Dec 13.
2011
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| 27 | LHX2
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| A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development.
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| Zhao Y, Mailloux CM, Hermesz E, Palkóvits M, Westphal H.
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| Dev Biol 337(2):313-23. Epub 2009 Nov 6.PMID: 19900438 2010
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| 28 | LHX2
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| Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.
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| Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM.
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| Development 136(23):3895-906.PMID: 19906857 2009
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| 29 | EMX1, LHX2
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| Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex.
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| Chou SJ, Perez-Garcia CG, Kroll TT, O'Leary DD.
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| Nat Neurosci 12(11):1381-9. Epub 2009 Oct 11.PMID: 19820705 2009
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| 30 | LHX2, PAX6
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| The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation.
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| Tétreault N, Champagne MP, Bernier G.
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| Dev Biol 327(2):541-50. Epub 2008 Dec 30.PMID: 19146846 2009
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| 31 | LHX2
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| Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate.
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| Mangale VS, Hirokawa KE, Satyaki PR, Gokulchandran N, Chikbire S, Subramanian L, Shetty AS, Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA, Tole S, Monuki ES.
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| Science 319(5861):304-9.
2008
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| 32 | ARX, DLX1, DLX2, EMX1, EMX2, GSX2, LHX1, LHX5, LHX2, LHX6, LHX8, NKX2-1, OTX1, OTX2, PAX6
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| Homeobox genes in vertebrate forebrain development and disease.
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| Wigle JT, Eisenstat DD.
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| Clin Genet 73(3):212-26. Epub 2008 Jan 31. Review. 2008
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| 33 | LHX2
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| Lhx2 expression promotes self-renewal of a distinct multipotential hematopoietic progenitor cell in embryonic stem cell-derived embryoid bodies.
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| Dahl L, Richter K, Hägglund AC, Carlsson L.
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| PLoS One 3(4):e2025.PMID: 18431502 2008
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| 34 | CGA, LDB1, LHX2, SSBP3
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| Single-stranded DNA-binding proteins regulate the abundance and function of the LIM-homeodomain transcription factor LHX2 in pituitary cells.
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| Cai Y, Xu Z, Nagarajan L, Brandt SJ.
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| Biochem Biophys Res Commun 373(2):303-8. doi: 10.1016/j.bbrc.2008.06.027. Epub 2008 Jun 17.
2008
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| 35 | LHX2, LHX9, ROBO3
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| A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors.
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| Wilson SI, Shafer B, Lee KJ, Dodd J.
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| Neuron 59(3):413-24. doi: 10.1016/j.neuron.2008.07.020.
2008
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| 36 | CITED2, LHX2
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| MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.
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| Glenn DJ, Maurer RA.
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| J Biol Chem 274(51):36159-67. 1999
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| 37 | LHX2
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| Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1.
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| Wu HK, et al.
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| Oncogene 12 : 1205-1212. 1996
|