Citations for
1LEP, RETN
Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia.
Song Y, Gao J, Qu Y, Wang S, Wang X, Liu J.
Clin Chim Acta 458:133-7. doi: 10.1016/j.cca.2016.04.036. Epub 2016 May 3. 2016
2CRP, LEP
Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS.
Li J, Wei D, McCrory MA, Szalai AJ, Yang G, Li L, Li F, Zhao AZ.
Biochem J 473(9):1215-24. doi: 10.1042/BJ20151282. Epub 2016 Mar 1. 2016
3ADIPOQ, LEP, RETN
Validity of adiponectin-to-leptin and adiponectin-to-resistin ratios as predictors of polycystic ovary syndrome.
Sarray S, Madan S, Saleh LR, Mahmoud N, Almawi WY.
Fertil Steril 104(2):460-6. doi: 10.1016/j.fertnstert.2015.05.007. Epub 2015 Jun 6. 2015
4GHRL, LEP
Role of leptin and ghrelin in induction of differentiation of IL-17-producing and T-regulatory cells.
Orlova EG, Shirshev SV.
Bull Exp Biol Med 156(6):819-22. doi: 10.1007/s10517-014-2459-3. 2014
5CRP, LEP
Role of C reactive protein (CRP) in leptin resistance.
Hribal ML, Fiorentino TV, Sesti G.
Curr Pharm Des 20(4):609-15. Review. 2014
6CRP, LEP
Role of C reactive protein (CRP) in leptin resistance.
Hribal ML, Fiorentino TV, Sesti G.
Curr Pharm Des 20(4):609-15. Review. 2014
7LEP, SFTPA1, TTF1
Leptin promotes fetal lung maturity and upregulates SP-A expression in pulmonary alveoli type-II epithelial cells involving TTF-1 activation.
Chen H, Zhang JP, Huang H, Wang ZH, Cheng R, Cai WB.
PLoS One 8(7):e69297. doi: 10.1371/journal.pone.0069297. Print 2013. 2013
8HSPD1, LEP
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
Kleinridders A, Lauritzen HP, Ussar S, Christensen JH, Mori MA, Bross P, Kahn CR.
J Clin Invest 123(11):4667-80. 2013
9LEP, RETN, TNF
Serum leptin, resistin and TNF-α levels in patients with systemic sclerosis: the role of adipokines in scleroderma.
Pehlivan Y, Onat AM, Ceylan N, Turkbeyler IH, Buyukhatipoglu H, Comez G, Babacan T, Tarakcioglu M.
Int J Rheum Dis 15(4):374-9. doi: 10.1111/j.1756-185X.2012.01755.x. Epub 2012 Jun 29. 2012
10GABBR1, LEP
Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes.
Nakamura Y, Hinoi E, Takarada T, Takahata Y, Yamamoto T, Fujita H, Takada S, Hashizume S, Yoneda Y.
PLoS One 6(5):e20167. doi: 10.1371/journal.pone.0020167. Epub 2011 May 31. 2011
11CCK, EGR1, LEP
EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.
de Lartigue G, Lur G, Dimaline R, Varro A, Raybould H, Dockray GJ.
Endocrinology 151(8):3589-99. Epub 2010 Jun 9.PMID: 20534729 2010
12LEP, MUC5B
Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway.
Woo HJ, Yoo WJ, Bae CH, Song SY, Kim YW, Park SY, Kim YD.
Exp Lung Res 36(5):262-9. 2010
13IL6, LEP, STEAP4, TNF
STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes.
Chen X, Zhu C, Ji C, Zhao Y, Zhang C, Chen F, Gao C, Zhu J, Qian L, Guo X.
Int J Mol Med 25(3):361-7. 2010
14ACE, LEP
Leptin regulates ACE activity in mice.
Hilzendeger AM, Morais RL, Todiras M, Plehm R, da Costa Goncalves A, Qadri F, Araujo RC, Gross V, Nakaie CR, Casarini DE, Carmona AK, Bader M, Pesquero JB.
J Mol Med (Berl) 88(9):899-907. doi: 10.1007/s00109-010-0649-7. Epub 2010 Jul 8. 2010
15LEP, PRKAA1
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Greco SJ, Sarkar S, Johnston JM, Tezapsidis N.
Biochem Biophys Res Commun 380(1):98-104. Epub 2009 Jan 21. 2009
16CNTF, IL6, LEP, LIF
Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function.
Dozio E, Ruscica M, Galliera E, Corsi MM, Magni P.
Curr Protein Pept Sci 10(6):577-84. Review.PMID: 19751193 2009
17CCK, LEP, LEPR
Levels of serum leptin, cholecystokinin, plasma lipid and lipoprotein differ between patients with gallstone or/and those with hepatolithiasis.
Lei ZM, Ye MX, Fu WG, Chen Y, Fang C, Li J.
Hepatobiliary Pancreat Dis Int 7(1):65-9. 2008
18CTNNAL1, FLT1, GSTP1, LEP, PAPPA2, S100A8, WWTR1
Seven placental transcripts characterize HELLP-syndrome.
Buimer M, Keijser R, Jebbink JM, Wehkamp D, van Kampen AH, Boer K, van der Post JA, Ris-Stalpers C.
Placenta 29(5):444-53. 2008
19LEP
Leptin regulates striatal regions and human eating behavior.
Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC.
Science 317(5843):1355. Epub 2007 Aug 9. 2007
20CCK, LEP, LEPR
Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns.
de Krom M, van der Schouw YT, Hendriks J, Ophoff RA, van Gils CH, Stolk RP, Grobbee DE, Adan R.
Diabetes 56(1):276-80. 2007
21LEP, LEPR
Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels.
Zhang YY, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, Marescotti MC, Gervino EV, Johnstone MT, Mantzoros CS, Avogaro A, Doria A.
Atherosclerosis 191(1):121-7. Epub 2006 Apr 3. 2007
22LEP
Leptin stimulates endogenous cholesterol synthesis in human monocytes: New role of an old player in atherosclerotic plaque formation. Leptin-induced increase in cholesterol synthesis.
Kosztáczky B, Fóris G, Paragh G Jr, Seres I, Zsiros E, Koncsos P, Balogh Z, Paragh G.
Int J Biochem Cell Biol 39(9):1637-45. Epub 2007 Apr 25. 2007
23LEP
Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling.
Cohen MM Jr.
Am J Med Genet A 140(5):515-24. 2006
24CRP, LEP
Induction of leptin resistance through direct interaction of C-reactive protein with leptin.
Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ.
Nat Med 12(4):425-32. Epub 2006 Apr 2. 2006
25LEP
Leptin regulation of bone resorption by the sympathetic nervous system and CART.
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G.
Nature 434(7032):514-20. Epub 2005 Feb 20. 2005
26LEP
Trophic action of leptin on hypothalamic neurons that regulate feeding.
Bouret SG, Draper SJ, Simerly RB.
Science 304(5667):108-10. 2004
27LEP
Leptin regulates bone formation via the sympathetic nervous system.
Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G.
Cell 111(3):305-17. 2002
28LEP
Leptin gene polymorphism is associated with hypertension independent of obesity.
Shintani M, Ikegami H, Fujisawa T, Kawaguchi Y, Ohishi M, Katsuya T, Higaki J, Shimamoto K, Ogihara T.
J Clin Endocrinol Metab 87(6):2909-12. 2002
29LEP
Genetic diversity and evolution of the human leptin locus tetranucleotide repeat.
Moffett S, Martinson J, Shriver MD, Deka R, McGarvey ST, Barrantes R, Ferrell RE.
Hum Genet 110(5):412-7. 2002
30LEP
Leptin and metabolic syndrome in obese and non-obese children.
Moreno LA, Pineda I, Rodriguez G, Fleta J, Giner A, Juste MG, Sarria A, Bueno M.
Horm Metab Res 34(7):394-9. 2002
31LEP
A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.
Le Stunff C, Le Bihan C, Schork NJ, Bougneres P.
Diabetes 49(12):2196-200. 2000
32LEP
Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women.
Li WD,Reed DR, Lee JH, Xu W, Kilker RL, Sodam BR, Price RA.
Ann Hum Genet 63:227-234 1999
33LEP, OBS1
A leptin missense mutation associated with hypogonadism and morbid obesity.
Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD.
Nat Genet 18(3):213-5. 1998
34LEP
Novel polymorphisms in the 5' region of the LEP gene. Association with leptin levels and response to low-calorie diet in human obesity.
Mamms O, et al.
Diabetes 47 : 487-489. 1998
35LEP, LEPR
Biological action of leptin as an angiogenic factor.
Sierra-Honigmann MR, et al.
Science 281 : 1683-1686. 1998
36LEP
Circulating leptin level and growth hormone response to stimulation tests in obese and normal children.
Coutant R, Lahlou N, Bouvattier C, Bougneres P.
Eur J Endocrinol 139(6):591-7. 1998
37OBS1, LEP
Markers for the gene ob and serum leptin levels in human morbid obesity.
Oksanen L, Ohman M, Heiman M, Kainulainen K, Kaprio J, Mustajoki P, Koivisto V, Koskenvuo M, Janne OA, Peltonen L, Kontula K.
Hum Genet 99(5):559-64. 1997
38LEP, OBS1
Congenital leptin deficiency is associated with severe early-onset obesity in humans.
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S.
Nature 387(6636):903-8. 1997
39LEP
Mutation screening and identification of a sequence variation in the human OB gene coding region.
Considine RV, et al.
Biochem Biophys Res Commun 220 : 735-739. 1996
40LEP, OBS1
Indication for linkage of the human OB gene region with extreme obesity.
Clement K, et al.
Diabetes 45 : 687-690. 1996
41LEP, OBS1
Extreme obesity may be linked to markers flanking the human OB gene.
Reed DR, et al.
Diabetes 45 : 691-694. 1996
42OBS1, LEP
A novel microsatellite polymorphism in the human OB gene : a highly polymorphic marker for linkage analysis.
Shintani M, et al.
Diabetologia 39 : 1398-1401. 1996
43LEP
Weight-reducing effects of the plasma protein encoded by the obese gene.
Halaas JL, et al.
Science 269 : 543-546. 1995
44LEP
Recombinant mouse OB protein : evidence for a peripheral signal linking adiposity and central neural networks.
Campfield LA, et al.
Science 269 : 546-549. 1995
45LEP
Structural organization and chromosomal assignment of the human obese gene.
Isse N, et al.
J Biol Chem 270 : 27728-27733. 1995
46LEP
Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.
Stirling B, et al.
Diabetes 44 : 999-1001. 1995
47LEP
Localization of the human OB gene (OBS) to chromosome 7q32 by fluorescence in situ hybridization.
Geffroy S, et al.
Genomics 28 : 603-604. 1995
48LEP
Positional cloning of the mouse obese gene and its human homologue.
Zhang Y, et al.
Nature 372 : 425-432. 1994