| 1 | LCR-HBA@, LCR-HB-B@
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| Activation of the beta-like globin genes in transgenic mice is dependent on the presence of the beta-locus control region.
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| Navas PA, Li Q, Peterson KR, Swank RA, Rohde A, Roy J, Stamatoyannopoulos G.
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| Hum Mol Genet 11(8):893-903. 2002
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| 2 | HPFH, LCR-HB-B@, TGDB
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| Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and delta beta-thalassemia affects beta- but not gamma-globin gene expression.
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| Calzolari R, et al.
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| EMBO J 18 : 949-958. 1999
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| 3 | LCR-HB-B@
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| Nucleotide changes in the gamma-globin promoter and the (AT)xNy(AT)z polymorphic sequence of beta LCRHS-2 region associated with altered levels of HbF.
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| Samakoglu S, et al.
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| Eur J Hum Genet 7(3):345-56. 1999
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| 4 | LCR-HB-B@
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| Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region.
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| Li Q, et al.
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| Genomics 61(2):183-93 1999
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| 5 | HB-NA@, LCR-HB-B@
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| A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region.
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| Long Q, Bengra C, Li C, Kutlar F, Tuan D.
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| Genomics 54 : 542-555. 1998
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| 6 | KLF1, LCR-HB-B@
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| Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
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| Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F, Philipsen S.
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| Genes Dev 12(18):2863-73. 1998
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| 7 | LCR-HB-B@
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| A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.
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| Ellis J, et al.
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| EMBO J 15 : 562-568. 1996
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| 8 | LCR-HB-B@
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| A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.
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| Morley BJ, et al.
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| Mol Cell Biol 12 : 2057-2066. 1992
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| 9 | LCR-HB-B@
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| The proximal element of the beta globin locus control region is not functionally required in vivo.
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| Kulozik AE, et al.
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| J Clin Invest 87 : 2142-2146. 1991
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| 10 | LCR-HB-B@
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| Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.
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| Jarman AP, et al.
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| Mol Cell Biol 11(9):4679-89. 1991
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| 11 | LCR-HB-B@, TGDB
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| A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.
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| Forrester WC, et al.
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| Genes Dev 4 : 1637-1649. 1990
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| 12 | LCR-HB-B@
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| beta-globin locus activation regions: conservation of organization, structure, and function.
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| Li Q, et al.
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| Proc Natl Acad Sci U S A 87 : 8207-8211. 1990
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| 13 | LCR-HBA@, LCR-HB-B@, TBX1
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| Globin gene regulation and switching: circa 1990.
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| Orkin SH.
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| Cell 63 : 665-672. 1990
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| 14 | LCR-HB-B@
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| Autonomous developmental control of human embryonic globin gene switching in transgenic mice.
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| Raich N, et al.
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| Science 250 : 1147-1149. 1990
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| 15 | LCR-HB-B@, TGDB
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| Gamma delta beta-thalassemia due to a de novo mutation deleting the 5'beta-globin gene activation-region hypersensitive sites.
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| Driscoll MC, et al.
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| Proc Natl Acad Sci U S A 86 : 7470-7474. 1989
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| 16 | LCR-HB-B@
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| Developmental regulation of beta-globin gene switching.
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| Choi OR, Engel JD.
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| Cell 55 : 17-26. 1988
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